TWAS hub - ATP13A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0820	0.0280	3.9e-06	0.064	0.048	0.048	0.06	0.079	2.9e-08	1.5e-06	1.6e-06	8e-08	6.8e-10
2	GTEx	Esophagus Mucosa	0.1230	0.0470	3.3e-04	0.126	NA	0.128	NA	0.030	9.0e-09	NA	7.3e-09	NA	4.2e-03
3	GTEx	Nerve Tibial	0.0494	0.0199	1.5e-03	0.034	NA	0.016	NA	0.027	1.8e-03	NA	2.4e-02	NA	4.8e-03
4	TCGA	Breast Invasive Carcinoma	0.0501	0.0283	5.4e-03	-0.001	0.004	0.006	NA	-0.001	7.6e-01	4.2e-02	1.6e-02	NA	7.2e-01
5	TCGA	Colon Adenocarcinoma	0.1120	0.0490	6.2e-05	0.039	0.076	0.057	NA	0.050	2.5e-03	3.4e-05	3.2e-04	NA	7.2e-04
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0527	0.0238	2.6e-07	0.075	0.071	0.071	NA	0.059	8.5e-09	2.3e-08	2.1e-08	NA	3.6e-07
7	TCGA	Brain Lower Grade Glioma	0.0525	0.0220	3.4e-07	0.051	0.061	0.067	NA	0.069	1.8e-06	1.9e-07	4.7e-08	NA	2.6e-08
8	TCGA	Liver Hepatocellular Carcinoma	0.1790	0.0670	2.5e-06	0.077	0.120	0.107	NA	0.115	1.8e-04	3.0e-06	1.1e-05	NA	4.6e-06
9	TCGA	Lung Adenocarcinoma	0.0742	0.0292	9.7e-07	0.046	0.046	0.032	NA	0.055	3.7e-06	3.8e-06	1.1e-04	NA	4.8e-07
10	TCGA	Lung Squamous Cell Carcinoma	0.0606	0.0289	1.8e-06	0.036	0.055	0.054	NA	0.053	4.8e-05	7.7e-07	9.3e-07	NA	1.0e-06
11	TCGA	Pancreatic Adenocarcinoma	0.1380	0.0720	8.2e-04	0.047	0.083	0.035	NA	0.066	4.8e-03	2.5e-04	1.4e-02	NA	9.7e-04
12	TCGA	Rectum Adenocarcinoma	0.1300	0.0740	9.6e-03	0.060	0.046	0.008	NA	0.080	1.7e-02	3.1e-02	2.1e-01	NA	6.4e-03
13	TCGA	Thyroid Carcinoma	0.2030	0.0730	9.6e-10	0.053	0.109	0.102	NA	0.100	6.7e-06	8.8e-11	4.1e-10	NA	5.8e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Lung FEV1/FVC ratio	45.9	232.8	334.9	-16.0	-15.1	-13.3	-18.3	-14.1	-17.0	-15.6	-13.1	-15.1	-15.6	-16.0	-16.1	-11.9
Forced vital capacity (FVC), Best measure	25.2	92.0	148.8	10.5	9.7	8.4	12.2	9.5	10.3	9.3	7.2	9.8	9.5	9.9	9.2	8.3
Forced vital capacity (FVC)	23.4	90.0	139.2	10.4	9.4	8.2	11.8	9.4	10.4	9.2	7.1	9.7	9.8	10.0	9.3	7.8
Height	22.6	436.1	580.8	22.0	18.8	16.8	24.1	17.0	22.9	21.6	19.5	21.8	22.4	23.7	21.3	17.8
Standing height	18.4	182.5	259.2	14.0	13.2	11.5	16.1	11.4	15.0	13.3	12.7	13.9	14.0	14.8	13.3	11.5
Comparative height size at age 10	15.6	85.8	112.4	10.2	8.5	7.4	10.6	7.6	9.9	9.7	8.1	9.9	9.7	10.4	9.4	8.4
Lung FVC	14.1	71.6	99.4	10.0	7.6	7.3	9.1	8.3	9.4	8.5	4.9	9.6	9.5	8.0	8.7	7.8
Forced expiratory volume in 1-second (FEV1), predicted	12.8	26.6	46.6	4.8	5.3	3.9	6.8	4.3	5.8	4.9	5.2	5.2	5.3	6.1	4.9	3.7
Sitting height	11.2	79.4	114.5	9.1	9.0	7.4	10.7	7.5	10.2	8.5	8.6	9.2	9.2	9.9	8.7	7.3
Rheumatoid Arthritis	8.1	11.1	17.9	3.6	2.0	3.6	3.3	3.4	3.7	3.5	3.1	3.0	4.2	3.7	3.7	1.5
Ovarian Cancer	6.4	8.4	14.8	-3.1	-1.2	-2.3	-3.1	-2.0	-2.7	-3.5	-2.9	-3.0	-3.9	-3.5	-2.9	-2.6
Forced expiratory volume in 1-second (FEV1)	6.0	20.3	31.7	5.2	4.4	3.9	5.6	5.0	4.9	4.0	2.5	4.7	4.8	4.7	4.0	3.9
Impedance of whole body	6.0	30.6	40.3	5.8	4.7	5.8	6.3	5.8	6.2	5.5	4.5	5.6	6.3	5.5	5.5	3.7
Impedance of leg (right)	5.9	28.4	38.3	5.8	4.1	5.6	6.1	6.0	5.8	5.5	4.1	5.1	6.2	5.3	5.5	3.0
Forced expiratory volume in 1-second (FEV1), Best measure	5.9	19.0	33.1	5.1	4.5	3.7	5.8	4.7	4.5	3.8	2.3	4.8	4.2	4.4	3.5	4.3
Impedance of arm (left)	5.9	27.4	37.3	5.6	4.1	5.2	5.8	4.8	5.7	5.3	4.5	5.5	6.1	5.5	5.0	4.3
Impedance of arm (right)	5.8	27.0	38.6	5.6	4.1	4.9	5.8	4.6	5.7	5.2	4.5	5.4	6.2	5.8	5.0	4.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.6	6.7	9.1	-3.0	-1.9	-2.3	-3.0	-2.8	-2.7	-2.8	-1.7	-2.7	-2.6	-2.8	-2.6	-2.1
Heart disease (siblings)	5.5	6.7	11.0	2.3	3.0	1.2	2.8	1.8	3.3	2.9	2.5	2.7	2.5	3.1	3.2	1.0
Impedance of leg (left)	5.2	25.4	36.4	5.1	4.5	5.6	6.0	5.8	5.8	4.9	4.1	4.7	5.5	4.7	5.2	2.7
Waist Hip Ratio (WHR)	5.1	22.9	33.6	5.4	3.7	5.4	4.6	4.3	4.5	5.8	4.8	4.3	5.0	4.8	5.5	3.4
Hand grip strength (right)	4.5	12.2	19.4	2.8	4.4	2.0	4.0	1.9	4.4	3.2	3.9	3.9	3.3	4.0	3.5	3.1
Average weekly fortified wine intake	4.4	5.2	10.8	2.3	2.2	1.3	2.6	0.2	1.8	2.5	2.9	2.2	1.7	3.3	2.0	2.8
Ever highly irritable/argumentative for 2 days	4.4	5.3	9.1	-2.4	-1.3	-1.3	-3.0	-1.4	-2.1	-2.5	-2.8	-2.6	-2.7	-3.0	-1.8	-2.0
LDL Cholesterol	3.9	6.2	17.1	1.8	1.3	3.1	2.1	1.0	2.3	2.7	4.1	2.5	2.8	2.0	2.3	2.6
Frequency of depressed mood in last 2 weeks	3.6	5.1	8.7	-3.0	-2.0	-1.7	-2.4	-1.9	-2.2	-2.4	-1.5	-2.5	-2.0	-2.3	-2.1	-2.8
Hair/balding pattern: Pattern 3	3.6	5.4	13.4	-2.7	-1.1	-1.5	-2.2	-1.5	-2.0	-2.7	-2.1	-2.0	-3.0	-3.7	-2.4	-1.9
Average weekly red wine intake	3.6	5.2	7.9	2.8	1.6	1.5	2.4	2.1	2.1	2.8	1.7	2.4	2.8	2.7	2.5	1.8
Alzheimer’s Disease (including proxy)	3.4	4.9	8.2	-2.9	-1.6	-2.4	-2.3	-2.4	-2.0	-2.6	-1.6	-1.9	-2.2	-2.5	-2.5	-1.3
BMI	3.2	18.6	37.6	-4.4	-4.7	-3.5	-6.1	-5.5	-5.5	-3.2	-2.3	-4.1	-4.5	-4.4	-3.8	-2.4
Trunk fat-free mass	3.2	18.3	26.5	4.5	4.3	2.8	4.9	2.8	4.7	4.2	4.3	4.6	4.3	5.2	4.1	4.3
Trunk predicted mass	3.1	17.6	25.3	4.4	4.3	2.8	4.8	2.8	4.6	4.1	4.2	4.5	4.2	5.0	4.0	4.2
Ever had prostate specific antigen (PSA) test	3.1	3.6	6.0	2.3	1.8	1.0	2.3	1.3	1.7	2.0	1.6	1.8	1.9	2.4	2.1	2.0
Peak expiratory flow (PEF)	3.0	6.9	10.7	-2.4	-2.4	-2.2	-2.5	-1.1	-2.8	-3.0	-3.3	-2.6	-2.5	-3.0	-3.0	-2.4
Deep venous thrombosis (DVT) (self-reported)	2.9	3.7	7.3	1.9	0.9	1.6	1.5	1.4	2.1	2.2	2.2	1.9	2.7	2.4	2.1	1.2
Hand grip strength (left)	2.8	7.3	11.8	2.3	3.2	1.3	2.9	1.2	3.3	2.3	2.7	3.4	2.8	3.3	2.3	2.9
Diabetes (mother)	2.8	3.6	6.3	1.3	2.4	1.8	2.0	1.4	2.3	1.9	2.5	1.2	1.7	1.6	2.5	1.1
Illnesses of siblings	2.8	3.9	9.2	-1.5	-2.0	-2.1	-2.4	-1.7	-2.1	-2.2	-3.0	-1.1	-1.4	-1.8	-2.5	-0.5
Medication: Seretide 50 evohaler	2.6	2.9	4.7	1.8	2.2	0.3	2.0	1.6	2.2	1.7	0.4	2.1	1.8	1.5	2.0	1.2
Alzheimer’s Disease (in father)	2.5	2.7	4.9	-2.2	-1.7	-1.0	-1.8	-1.5	-1.6	-1.8	-0.8	-1.8	-1.4	-1.8	-1.8	-1.6
Mouth/teeth dental problems: Loose teeth	2.4	2.8	6.1	-1.7	-1.5	-1.4	-2.5	-1.9	-1.7	-1.8	-1.5	-1.2	-1.6	-1.6	-2.0	-1.0
Body Mass Index (BMI) (2010)	2.3	3.2	6.2	-2.5	-0.8	-1.3	-1.7	-1.8	-1.5	-2.1	-0.8	-2.0	-2.4	-1.8	-2.0	-1.6
Arm predicted mass (right)	2.3	12.0	16.6	3.9	3.3	2.4	3.6	2.0	3.5	3.6	3.4	3.9	3.5	3.9	3.3	4.1
Had major operations	2.3	2.7	6.2	1.7	2.5	1.6	2.1	1.6	2.0	1.2	0.7	1.7	1.3	1.3	1.5	1.1
Whole body fat-free mass	2.3	13.4	20.1	3.9	3.6	2.3	4.1	2.1	3.8	3.6	3.7	4.0	3.6	4.5	3.4	4.1
Whole body water mass	2.3	12.9	19.5	3.8	3.5	2.3	4.0	2.0	3.7	3.5	3.8	3.9	3.5	4.4	3.3	4.1
Basal metabolic rate	2.3	12.5	19.0	3.8	3.3	2.3	3.7	1.7	3.6	3.6	3.7	4.0	3.5	4.4	3.2	4.2
Bipolar Disorder or Schizophrenia	2.2	5.3	12.0	-3.1	-0.9	-3.4	-2.5	-3.5	-1.6	-2.7	-1.6	-1.3	-2.1	-1.9	-2.4	-0.6
Schizophrenia (2014)	2.2	4.9	8.8	-2.9	-1.3	-3.0	-2.7	-2.7	-1.6	-2.7	-1.9	-1.7	-1.8	-1.9	-2.2	-1.5
Vitamin and mineral supplements	2.2	3.0	7.0	1.1	1.2	1.5	1.3	0.1	1.7	1.7	2.5	2.3	2.0	1.5	1.3	2.6
Body mass index (BMI)	2.2	9.5	23.7	-2.7	-3.3	-2.7	-4.9	-4.1	-3.8	-2.4	-2.4	-2.2	-3.0	-2.9	-2.9	-0.9
Alcohol usually taken with meals	2.2	3.6	7.7	2.6	1.9	0.9	1.6	1.6	2.0	1.8	0.6	2.8	2.1	2.0	1.7	1.9
Hip circumference	2.2	9.5	21.8	3.7	2.0	2.3	2.0	0.7	2.6	3.6	2.8	4.2	3.3	3.2	2.8	4.7
Blood clot in the leg (DVT)	2.2	2.8	5.6	1.6	0.6	1.5	1.4	1.2	1.7	2.0	2.3	1.4	2.4	2.2	1.8	0.8
Blood Red Count	2.1	20.5	37.7	5.3	3.5	5.1	5.1	6.1	4.8	4.5	2.8	4.1	4.8	4.2	4.5	2.6
Waist circumference	2.1	7.5	14.8	3.3	1.7	2.7	1.2	0.8	2.2	3.4	2.7	3.4	2.9	2.7	2.8	3.9
Length of working week for main job	2.1	2.3	5.0	-1.4	-1.6	-1.7	-2.2	-1.8	-1.6	-1.1	-1.1	-1.6	-1.4	-0.6	-1.2	-1.7
Chronic bronchitis/emphysema (mother)	2.1	2.5	5.2	-1.7	-1.3	-1.2	-2.3	-1.6	-1.6	-1.6	-1.7	-1.5	-1.6	-1.7	-1.4	-1.0
Arm fat-free mass (right)	2.1	10.6	14.6	3.6	3.2	2.1	3.5	1.9	3.3	3.3	3.2	3.6	3.2	3.8	3.1	3.8
Leg pain on walking	2.1	2.6	4.6	-1.9	-0.7	-1.2	-2.0	-1.7	-1.4	-1.9	-1.6	-1.7	-1.8	-2.1	-1.3	-0.9
Pain type(s) experienced in last month: Hip pain	2.1	2.7	6.0	1.8	2.3	0.5	1.6	1.5	2.0	1.4	0.3	1.3	1.3	2.4	2.1	0.9
Arm predicted mass (left)	2.1	10.7	15.6	3.5	3.3	2.1	3.6	1.8	3.3	3.3	3.5	3.5	3.1	4.0	3.1	3.6
Weight	2.0	10.1	18.4	3.6	2.5	2.4	2.3	1.0	3.0	3.5	3.2	4.0	3.3	3.7	3.0	4.3
Arm fat-free mass (left)	2.0	10.1	14.3	3.4	3.1	2.0	3.3	1.7	3.3	3.3	3.4	3.6	3.1	3.8	3.0	3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	8.6	2.6	1.5	2.5	2.2	2.9	1.9	1.8	0.2	1.8	2.0	1.6	1.8	1.7
Financial situation satisfaction	1.9	2.3	5.5	-2.0	-1.3	-1.1	-2.0	-2.3	-1.7	-1.4	-0.2	-1.5	-1.6	-1.4	-1.4	-0.7
Cholesterol lowering medication	1.9	2.8	5.3	1.4	1.3	2.3	0.8	1.4	2.2	1.6	1.9	2.1	1.9	1.3	1.6	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	9.5	-2.2	-0.8	-2.1	-1.1	-1.6	-2.2	-2.2	-1.7	-2.2	-3.1	-2.0	-2.5	-1.6
Serious illness, injury or assault to yourself	1.8	2.1	4.9	1.1	2.2	0.3	1.7	-0.0	1.7	1.2	1.3	1.6	1.2	1.4	1.5	2.1
Trunk fat mass	1.8	7.8	16.1	3.3	1.8	2.3	1.4	0.5	2.4	3.2	2.7	3.6	3.0	3.3	2.7	4.0
Age at first live birth	1.8	3.2	5.4	2.1	1.1	2.3	2.3	1.7	1.3	2.1	1.5	1.7	1.9	1.2	1.5	2.1
Bipolar Disorder (2018)	1.7	2.6	9.5	-2.1	-0.9	-1.7	-2.0	-3.1	-0.9	-1.9	-0.4	-0.0	-1.1	-1.3	-2.1	0.6
Neuroticism (2016)	1.7	2.4	5.0	-1.7	-1.7	-1.8	-2.2	-2.0	-1.6	-1.6	-1.2	-1.1	-1.0	-1.2	-1.5	-1.0
Ulcerative Colitis	1.7	2.5	4.0	1.4	1.2	1.6	1.7	1.5	2.0	1.6	1.6	1.7	1.9	1.5	1.8	0.7
Supplements: Vitamin C	1.7	2.0	5.3	-0.9	-1.0	-1.2	-0.9	-0.0	-1.3	-1.8	-2.3	-1.7	-1.4	-1.1	-1.6	-1.8
Mineral and other dietary supplements	1.7	2.3	6.1	1.0	0.9	1.5	1.0	-0.1	1.3	1.6	2.5	1.7	1.6	1.4	1.2	2.4
Risk taking	1.7	2.5	6.3	1.6	1.0	0.2	1.2	0.7	1.7	2.1	1.5	2.0	1.8	2.5	1.8	0.6
Ulcerative Colitis (UC)	1.6	3.1	6.6	1.8	0.9	1.9	1.6	1.8	2.2	1.7	1.1	2.2	2.6	1.4	1.7	1.3
Major Depression (MDD)	1.6	1.9	4.0	1.8	1.5	0.6	2.0	1.2	1.6	1.0	0.5	1.9	1.2	1.3	0.7	1.7
Leg fat-free mass (left)	1.6	8.5	16.2	3.3	2.6	1.6	2.9	1.0	2.7	2.9	2.9	3.5	2.9	3.8	2.4	4.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.4	-1.8	-0.1	-1.4	-0.8	-1.6	-1.0	-1.5	-0.0	-1.4	-2.1	-1.4	-1.2	-1.0
Leg predicted mass (left)	1.6	8.4	15.9	3.3	2.6	1.6	2.9	1.1	2.7	2.9	2.9	3.5	2.9	3.7	2.4	4.0
Medication: Cholesterol lowering	1.6	2.5	6.7	-1.1	-2.6	-0.7	-2.4	-1.7	-2.4	-0.6	-0.9	-1.6	-1.1	-1.4	-1.2	-0.7
Eye problems/disorders: Cataract	1.6	1.8	4.9	2.2	1.4	0.1	1.2	1.4	1.0	1.4	-1.0	1.9	0.9	0.6	1.2	1.8
Schizophrenia (2018)	1.5	3.1	9.0	-2.3	-0.4	-3.0	-1.6	-2.0	-1.4	-1.9	-1.7	-1.6	-1.8	-1.4	-1.4	-1.2
Heel T-Score	1.5	12.2	20.7	-3.2	-2.3	-2.9	-3.0	-1.6	-3.8	-3.7	-3.8	-4.2	-4.5	-3.8	-3.3	-4.2
Medication for hormone replacement therapy	1.5	1.7	3.5	1.5	0.4	1.4	0.5	1.0	1.4	1.7	1.2	1.0	1.9	1.4	1.8	0.7
Ever taken oral contraceptive pill	1.5	1.7	3.9	-1.0	-0.9	-1.6	-0.9	-0.3	-1.3	-1.6	-2.0	-1.4	-1.2	-1.1	-1.5	-1.1
Age started oral contraceptive pill	1.5	1.8	3.8	1.4	0.9	1.9	0.5	1.2	1.9	1.3	1.3	1.4	1.6	1.1	1.6	0.9
Commuting to job workplace: Cycle	1.5	1.8	7.6	1.9	-0.6	1.1	0.3	0.5	0.5	1.2	-0.1	1.9	2.1	0.8	0.3	2.8
Medication: Aspirin	1.4	1.8	4.2	-1.3	-1.9	-1.4	-1.9	-2.0	-1.7	-0.7	-0.5	-1.2	-1.1	-1.1	-1.0	-0.3
Illnesses of siblings: Diabetes	1.4	1.8	7.2	0.6	0.6	2.0	1.2	1.3	1.3	1.3	2.7	0.5	1.2	0.7	1.4	-0.1
Loneliness, isolation	1.4	1.9	3.6	-1.4	-0.7	-1.8	-1.9	-1.2	-1.0	-1.3	-1.9	-1.5	-1.2	-0.8	-0.4	-1.6
Tinnitus: Yes, now most or all of the time	1.4	1.7	6.4	-0.2	-1.9	-0.7	-1.5	-0.7	-1.4	-1.0	-2.5	-0.2	-0.1	-1.4	-1.6	0.7
Medication: Bendroflumethiazide	1.4	2.1	5.1	-1.4	-2.3	0.0	-2.1	-1.4	-1.9	-0.9	0.0	-1.8	-0.9	-1.5	-1.3	-1.0
Depression (Nagel 2018)	1.3	1.9	3.6	-1.9	-0.5	-1.9	-1.1	-1.6	-1.3	-1.1	-1.2	-1.2	-1.8	-1.5	-0.9	-1.3
Alzheimer’s Disease (in mother)	1.3	1.6	3.2	-1.8	-0.5	-1.0	-1.3	-1.8	-1.1	-1.4	-0.6	-1.1	-1.5	-1.8	-1.1	-0.2
Bipolar Disorder (2011)	1.3	1.3	4.0	-1.6	-0.2	-1.3	-0.9	-2.0	-0.6	-1.5	-0.2	-0.3	-1.1	-0.7	-1.6	0.1
Number of incorrect matches in round	1.3	2.1	4.8	0.6	1.4	0.9	1.3	0.7	2.2	1.2	1.8	1.6	1.9	1.7	1.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	7.1	-1.7	-0.6	-1.6	-0.7	-0.9	-1.9	-2.1	-2.0	-1.6	-2.7	-2.1	-2.4	-1.0
Alcohol intake versus 10 years previously	1.3	1.9	6.4	-1.7	0.8	-0.3	0.4	0.2	-0.2	-1.9	-0.3	-2.1	-2.2	-0.8	-1.0	-2.5
Birth weight	1.3	2.8	5.3	1.9	1.1	1.7	1.2	1.5	1.8	1.8	2.2	1.4	1.7	2.3	1.8	0.5
Leg fat-free mass (right)	1.3	7.0	13.7	2.8	2.8	1.5	2.8	0.9	2.6	2.5	2.8	3.1	2.4	3.3	2.1	3.7
Qualifications: nursing, teaching	1.3	1.9	4.9	1.9	0.2	-0.2	0.9	0.2	0.9	1.7	0.3	2.1	1.9	1.7	1.1	2.2
Leg predicted mass (right)	1.3	6.8	13.2	2.8	2.7	1.4	2.8	0.9	2.5	2.4	2.8	3.0	2.3	3.3	2.1	3.6
Ever depressed for a whole week	1.3	1.6	4.4	-0.7	0.2	-1.9	-0.8	-1.1	-1.1	-1.4	-2.1	-0.5	-1.9	-1.6	-1.2	0.3
Multivitamins +/- minerals	1.2	1.5	3.1	-0.9	-1.1	-1.3	-1.1	-0.5	-1.3	-1.1	-1.6	-1.3	-1.3	-1.1	-1.1	-1.7
Age at last live birth	1.2	1.8	4.1	1.5	1.1	1.7	2.0	1.6	1.0	1.5	1.1	1.2	0.9	0.6	0.8	1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.0	0.9	1.6	0.5	1.6	1.5	1.7	0.8	0.1	0.8	1.2	1.1	1.5	0.4
Medication: Paracetamol	1.2	1.8	4.4	1.6	0.7	1.7	1.2	2.1	1.5	1.4	0.1	1.0	1.8	0.9	1.4	0.9
Reaction Time	1.1	2.0	3.2	-1.5	-1.8	-1.6	-1.1	-1.0	-1.7	-1.3	-1.7	-1.4	-1.0	-1.3	-1.4	-1.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.3	1.3	-0.3	1.8	0.6	1.8	0.8	1.1	0.9	-0.1	1.3	1.3	1.3	-0.8
Worrier / anxious feelings	1.1	2.1	3.9	-1.6	-1.7	-0.4	-2.0	-1.2	-1.5	-1.6	-1.5	-1.2	-1.1	-1.7	-1.6	-0.8
Breastfed as a baby	1.1	1.4	3.6	0.9	1.1	1.8	0.5	0.7	1.0	1.5	1.9	0.5	0.8	0.4	1.8	0.4
Loud music exposure frequency	1.1	1.2	3.0	-1.5	-0.7	-0.7	-0.6	-0.8	-1.0	-1.7	-0.8	-1.1	-1.3	-1.0	-1.7	-0.6
Medication: Blood pressure	1.1	1.9	4.6	-1.6	-1.4	0.2	-2.2	-1.3	-1.5	-1.0	-0.1	-1.8	-1.4	-1.8	-1.1	-1.2
Pulse rate, automated reading	1.1	3.6	7.5	-2.0	-0.1	-1.6	-2.3	-1.6	-1.3	-2.7	-2.4	-1.8	-2.3	-2.2	-1.8	-1.3
Fractured/broken bones in last 5 years	1.1	1.5	3.3	-1.7	-1.6	-1.8	-1.5	-1.8	-0.8	-1.0	-0.2	-0.5	-0.5	-0.4	-1.0	-1.1
Supplements: Calcium	1.1	1.3	3.2	-0.6	-1.8	0.1	-1.5	-0.2	-1.1	-1.1	-1.3	-1.1	-0.7	-1.7	-1.0	-1.1
Schizophrenia vs Biploar Disorder	1.0	1.3	4.1	0.8	0.8	1.5	0.7	2.0	0.9	1.1	0.4	-0.2	0.7	0.4	1.9	-1.5
Trunk fat percentage	1.0	4.0	10.3	2.4	0.7	1.8	0.2	-0.2	1.4	2.4	1.9	2.7	2.2	2.2	1.8	3.2
Hair/balding pattern: Pattern 2	1.0	1.3	3.1	1.1	0.5	1.8	1.0	1.4	1.1	1.4	1.3	0.7	1.3	0.8	1.3	0.5
Pain all over the body in last month	1.0	1.0	3.7	0.9	0.4	1.9	1.1	0.6	0.6	0.9	1.9	0.4	0.7	0.7	0.8	0.7
Depression (self-reported)	1.0	1.2	3.0	0.6	1.3	1.7	0.7	0.9	1.1	1.1	1.7	0.2	0.5	0.5	1.7	0.0
Medication: Aspirin	1.0	1.3	3.2	-0.9	-1.7	-1.3	-1.7	-1.8	-1.4	-0.4	-0.6	-0.8	-0.8	-0.8	-0.7	-0.1
High cholesterol (Self-reported)	1.0	1.8	3.8	1.3	-0.8	1.8	-0.2	0.7	0.8	1.8	1.8	1.1	1.9	1.6	1.3	0.4
HbA1C	0.9	1.0	2.0	-0.7	-1.2	-0.8	-1.4	-0.8	-1.1	-0.8	-1.4	-1.1	-0.6	-0.8	-0.9	-0.9
Angina	0.9	1.2	3.7	-1.2	-1.2	0.0	-1.9	-1.2	-1.3	-0.1	0.1	-1.0	-0.9	-1.5	-0.1	-1.2
Diabetes (father)	0.9	1.1	5.3	0.5	2.3	0.3	1.2	0.5	1.7	0.4	0.4	1.0	0.2	0.7	1.1	1.1
Age when periods started (menarche)	0.9	2.2	4.5	1.8	0.4	0.4	1.7	1.1	1.2	2.0	1.4	1.6	1.9	2.1	1.5	0.8
Supplements: Glucosamine	0.9	1.2	3.2	-0.7	-0.7	-1.3	-1.3	-0.7	-0.9	-1.3	-1.8	-0.5	-1.0	-1.1	-1.4	-0.6
Financial difficulties in last 2 years	0.9	1.2	3.2	-0.7	-1.8	-1.2	-1.4	-1.5	-1.4	-0.6	-1.3	-0.7	-0.2	-0.4	-0.9	0.1
Father’s age at death	0.9	1.2	3.7	1.2	0.3	0.9	0.2	-0.1	0.8	1.6	0.8	1.5	1.2	0.3	1.4	1.9
Prospective memory result	0.9	1.1	1.9	-1.1	-0.8	-0.6	-1.3	-0.7	-0.9	-1.3	-1.4	-1.2	-1.1	-1.0	-1.1	-0.9
Exposure to tobacco smoke at home	0.9	1.0	3.0	0.9	-1.7	0.2	-0.2	-0.8	-0.9	1.5	0.9	0.7	1.2	0.6	0.5	1.7
Medication: Amlodipine	0.9	1.3	2.4	1.2	0.1	0.9	0.5	1.0	1.1	1.5	1.5	0.8	1.5	1.6	1.5	-0.0
Emphysema/chronic bronchitis	0.9	1.0	4.3	1.1	0.8	0.2	0.2	0.1	1.1	1.1	0.0	2.1	1.2	0.8	1.0	1.2
Whole body fat mass	0.9	3.6	9.4	2.4	0.8	1.6	0.5	-0.1	1.3	2.3	2.0	2.5	2.0	2.2	1.7	3.1
Chest pain or discomfort	0.9	1.4	3.0	-1.7	-1.2	-0.6	-1.7	-1.4	-1.0	-0.8	0.5	-1.3	-0.6	-0.8	-0.6	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	4.3	0.3	0.7	2.1	0.6	1.2	0.6	1.1	1.3	-0.2	0.3	-0.6	1.6	-0.1
Medication: Gliclazide	0.9	1.0	4.2	-0.8	-0.2	-1.2	-1.1	-2.1	-0.5	-0.8	-0.0	0.5	-0.7	-0.9	-1.2	1.3
Guilty feelings	0.9	1.3	3.3	-1.1	-1.8	-1.4	-1.8	-1.8	-1.1	-0.7	-0.5	-0.8	-0.3	-0.5	-0.9	-0.6
Ever smoked	0.9	1.6	4.9	0.9	0.6	0.5	0.7	-0.2	0.7	2.2	2.2	1.3	1.1	1.1	1.9	1.0
Breast Cancer	0.8	1.8	3.1	-1.3	-1.2	-0.7	-1.2	-1.1	-1.8	-1.5	-1.0	-1.7	-1.6	-1.7	-1.5	-0.7
Average weekly spirits intake	0.8	1.0	2.7	0.9	1.6	1.0	1.5	1.4	0.8	1.1	0.6	0.6	-0.0	0.1	1.2	0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.7	0.8	-0.9	1.6	-1.1	0.2	0.5	1.3	1.0	0.4	1.4	0.5	1.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.4	-1.2	-0.7	-1.4	-1.0	-1.1	-1.2	-0.3	-0.7	-1.1	-0.7	-0.9	0.0	-1.6
Chronic bronchitis/emphysema (father)	0.8	1.0	6.6	0.6	0.3	0.8	-0.1	-0.8	0.4	0.8	0.9	0.8	0.8	0.7	0.7	2.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.9	-0.4	-0.2	-1.5	-0.6	-1.2	-0.8	-0.9	-1.7	-0.1	-0.8	-1.1	-0.9	1.1
Number of full brothers	0.8	0.9	3.8	-1.3	-0.9	-0.8	-1.3	-0.9	-0.6	-0.5	0.3	-1.1	-0.8	-0.6	-0.3	-1.9
Eye problems/disorders: None of the above	0.8	0.9	2.8	-1.3	-1.7	0.5	-1.1	-0.6	-0.7	-0.5	0.8	-1.4	-0.2	-0.3	-0.3	-1.6
Alcohol intake frequency.	0.8	1.9	5.0	-1.8	-1.2	-0.2	-1.4	-0.7	-1.1	-1.6	-0.8	-2.2	-1.4	-1.5	-1.0	-1.8
Medication for cholesterol	0.8	1.2	3.6	-1.5	0.4	-1.1	0.5	-0.6	-1.0	-1.2	-0.3	-1.5	-1.9	-1.1	-1.0	-1.0
Osteoporosis (self-reported)	0.8	1.0	2.3	1.3	-0.6	1.5	1.2	1.3	0.3	1.1	0.8	0.3	0.9	0.7	0.7	1.0
Illnesses of father: High blood pressure	0.8	1.0	4.2	0.2	0.8	0.5	1.2	0.3	1.2	0.8	2.1	0.5	0.8	1.7	0.8	0.5
Fasting Glucose	0.7	0.9	1.8	-0.9	-0.4	-1.3	-0.9	-0.8	-1.2	-0.3	-0.8	-1.1	-1.4	-1.0	-0.2	-1.1
Severe depression (siblings)	0.7	0.7	2.8	-0.7	-0.0	0.3	-0.4	0.2	-0.8	-0.4	-0.3	-1.7	-1.4	-0.7	0.1	-1.7
Townsend deprivation index at recruitment	0.7	1.0	2.7	-0.7	-1.5	-1.0	-1.2	-1.2	-1.6	-0.6	-0.6	-1.1	-0.8	-0.5	-0.8	-0.8
Past tobacco smoking	0.7	1.3	3.6	-0.7	-0.8	-0.3	-1.1	-0.1	-0.8	-1.9	-1.9	-1.1	-0.9	-1.3	-1.7	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.1	-0.8	-1.4	-1.0	-1.8	-1.6	-1.1	-0.2	-0.4	-0.2	-0.3	-0.7	-0.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	-1.2	-0.7	-0.5	-1.2	-0.9	-1.0	-0.5	0.1	-0.6	-1.1	-1.1	-0.7	-1.1
Smoking status: Current	0.7	1.1	3.4	0.5	1.8	0.3	0.9	-0.4	1.1	0.7	1.6	1.0	0.1	1.4	0.8	1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.0	-0.8	-1.0	-0.9	-0.8	-0.8	-0.8	-0.9	-0.8	-0.6	-0.9	-0.8	-0.8	-0.7
Cardiovascular Disease	0.6	2.0	5.7	0.9	-1.2	1.8	-0.6	-0.0	0.6	2.0	2.4	1.1	2.2	1.0	1.6	0.6
Ever had hysterectomy (womb removed)	0.6	0.6	1.7	-0.9	0.1	-0.2	-0.7	-0.2	-0.0	-1.3	-0.9	-0.6	-1.0	-1.2	-0.8	-0.9
Maternal smoking around birth	0.6	0.8	3.2	0.1	-1.1	-1.8	-1.0	-1.6	-0.6	0.1	-0.7	1.0	0.3	0.5	-0.5	0.8
Qualifications: CSEs or equivalent	0.6	0.8	2.2	1.5	0.9	0.7	1.2	1.1	0.7	0.7	-0.3	0.9	0.6	1.1	0.5	1.1
Allergy	0.6	1.4	4.4	-0.6	-1.4	-1.4	-0.3	0.4	-1.3	-0.7	-1.3	-1.9	-1.1	-0.3	-0.6	-2.1
Tense / ‘highly strung’	0.6	1.0	2.9	-0.8	-1.2	-0.9	-1.4	-0.6	-1.0	-0.8	-1.7	-0.7	-0.5	-1.1	-1.0	-0.7
Pulse wave reflection index	0.6	0.8	3.0	0.2	-0.4	0.1	-0.1	1.5	-0.5	-0.4	-1.7	-0.9	-0.6	-0.5	-0.2	-1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.9	0.1	-0.3	-1.6	-0.2	-0.5	0.0	-0.8	-1.7	0.8	0.2	0.3	-1.0	0.9
Medication: Paracetamol	0.6	0.9	2.5	0.9	0.6	1.2	0.9	1.6	1.2	0.9	0.1	0.2	1.2	0.7	1.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.4	0.8	1.4	-0.3	1.9	1.3	1.2	0.2	-0.3	0.8	0.6	1.0	0.5	0.3
Migraine (self-reported)	0.6	0.8	2.6	0.6	0.1	-1.6	0.2	-0.8	0.0	0.1	-0.8	1.2	0.5	1.2	-0.2	1.5
Medication: Omeprazole	0.6	0.7	2.8	1.2	-0.7	-0.2	-0.4	-0.0	-0.3	0.4	-1.7	0.7	0.7	0.3	-0.2	1.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	3.2	1.3	-0.7	0.3	-0.4	-0.3	0.0	1.1	-0.3	1.0	1.1	0.8	0.4	1.8
Age at First Birth	0.5	0.8	2.0	-1.1	0.2	0.4	-0.7	-0.8	-0.7	-1.0	0.1	-1.4	-1.2	-1.4	-0.6	-0.2
Mean Putamen Volume	0.5	0.6	2.1	0.6	0.7	-0.6	0.4	0.1	0.8	0.7	-0.3	1.4	1.0	0.4	1.0	0.7
Smoking Status	0.5	1.2	6.0	-0.0	1.5	0.6	0.8	-0.6	1.1	1.0	2.4	0.7	0.2	1.3	1.4	0.3
Current tobacco smoking	0.5	0.8	2.0	0.6	1.4	0.3	0.6	-0.4	0.9	0.7	1.3	0.7	0.2	1.4	0.9	1.0
Medication: Atenolol	0.5	0.7	3.2	-0.2	-1.8	0.5	-0.9	-0.4	-0.8	0.4	1.0	-1.0	0.1	0.6	-0.2	-0.9
Qualifications: None of the above	0.5	1.1	4.2	-0.6	-1.0	0.5	-1.6	0.3	-0.6	-0.6	-1.5	-0.9	-0.6	-1.4	0.0	-2.1
Arm fat percentage (right)	0.5	1.9	7.5	-0.4	-1.8	-0.8	-2.7	-2.6	-1.6	-0.4	-0.6	-0.0	-0.6	-0.5	-1.1	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.0	-0.1	-1.7	-1.3	-0.8	-1.4	-1.3	0.7	-0.2	-0.4	0.4	0.6	0.3	-0.2
Falls in the last year	0.5	0.7	4.6	-0.8	0.3	-1.1	-0.9	-2.2	-0.4	-0.6	0.1	-0.3	-1.0	-0.2	-0.4	0.7
Birth weight of first child	0.5	0.8	2.8	0.3	1.5	1.0	0.7	0.1	1.2	0.6	1.7	0.4	0.3	1.2	0.9	0.1
Headache pain in last month	0.5	0.9	4.2	-0.3	-1.0	-1.4	-0.8	-1.0	-1.0	-0.8	-2.0	-0.5	-0.4	-0.1	-1.0	0.1
Gout (self-reported)	0.5	0.6	2.7	0.1	-0.0	-1.6	-0.2	-1.0	-0.3	-0.3	-0.7	0.9	-0.2	-0.1	-0.7	1.6
Comparative body size at age 10	0.5	1.5	4.6	-1.6	-0.8	-1.3	-1.8	-2.1	-0.9	-1.2	-0.3	-0.5	-1.1	-0.9	-1.1	-0.5
Worry too long after embarrassment	0.5	0.8	2.4	-1.5	-0.6	-0.6	-0.7	-1.5	-0.8	-1.0	0.9	-0.8	-0.6	-0.6	-0.9	-0.5
Number of children fathered	0.5	0.6	3.3	0.6	1.8	-0.0	1.1	0.5	0.5	0.2	-0.6	0.7	-0.7	0.0	0.2	0.7
Angina (self-reported)	0.5	0.7	2.2	-0.9	-0.8	0.3	-1.5	-0.9	-0.9	0.1	0.4	-0.7	-0.7	-1.3	0.2	-0.9
Arm fat percentage (left)	0.5	2.1	8.5	-0.4	-1.9	-0.8	-2.9	-2.6	-1.8	-0.4	-0.8	-0.1	-0.7	-0.7	-1.2	1.2
Average weekly champagne plus white wine intake	0.5	0.6	2.0	1.3	0.2	-1.1	0.2	0.2	-0.2	0.5	-1.2	1.4	0.1	0.3	-0.3	1.1
Miserableness	0.5	0.9	2.0	-1.1	-0.4	0.1	-0.6	0.1	-1.1	-1.1	-0.5	-1.4	-1.1	-1.3	-0.8	-1.2
Medication: Atorvastatin	0.5	0.7	1.7	0.0	-1.3	0.2	-1.1	-1.1	-0.6	1.2	1.2	0.1	0.6	0.3	0.7	0.4
Alcohol drinker status: Previous	0.5	0.6	1.4	0.7	-0.9	0.4	0.2	0.3	-0.0	1.2	0.8	0.1	1.2	1.1	1.0	-0.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	5.4	-0.5	-1.4	-2.3	-0.4	-1.5	-1.2	-0.5	-0.1	-0.3	-0.5	0.5	-1.3	0.1
Crohns Disease (2017)	0.4	0.8	2.0	-0.9	-0.9	-0.7	-1.0	-1.4	-1.0	-1.1	-0.8	-0.4	-0.9	-0.9	-1.2	0.1
Primary Biliary Cirrhosis	0.4	0.5	2.1	-0.1	-0.7	0.1	-0.9	-0.4	-0.7	-0.6	-1.4	-0.2	-0.3	-1.2	-0.8	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.5	0.5	1.2	-0.0	1.0	0.0	0.5	0.1	0.9	0.1	0.2	0.8	0.3	0.8
Number of treatments/medications taken	0.4	0.8	2.5	-0.1	-1.6	-0.0	-1.4	-0.1	-1.3	-0.2	-1.3	-1.0	-0.4	-0.9	-0.5	-0.5
Relative age of first facial hair	0.4	0.9	3.3	-1.8	-0.3	-0.6	-0.1	-1.0	-0.3	-0.6	1.2	-1.7	-0.4	-0.1	0.1	-1.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.2	-1.3	0.6	-0.7	-0.8	-0.4	0.7	1.3	-0.5	0.8	0.4	0.6	0.2
Medication: Co-codamol	0.4	0.5	2.7	-0.3	0.7	0.6	0.3	0.9	0.2	-0.3	0.1	-1.0	-0.7	-0.4	0.6	-1.6
Medication: Metformin	0.4	0.6	2.5	-0.9	-0.4	-0.0	-1.3	-1.6	-0.4	-0.8	0.3	-0.1	-0.3	-0.8	-0.9	0.9
Pack years adult smoking proportion	0.4	0.6	1.9	-1.0	-0.3	-1.2	-0.7	-1.4	-0.7	-0.4	-0.2	-0.5	-0.9	-0.9	-0.3	-0.0
Relative age voice broke	0.4	0.7	2.2	-1.1	-0.3	-1.2	-0.2	-0.8	-0.8	-0.9	-0.3	-1.5	-0.7	0.0	-0.6	-0.9
High blood pressure	0.4	1.1	7.1	-0.5	-2.7	-0.0	-1.9	-1.1	-1.1	0.3	0.5	-0.6	0.7	-0.1	-0.2	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	-0.3	-1.2	-0.3	-1.1	-0.9	-0.7	-0.4	-0.6	0.3	0.0	-0.5	-0.8	0.5
Had other major operations	0.4	0.5	1.6	-0.1	-0.7	-0.5	-0.5	0.1	-0.9	-0.5	-0.8	-1.3	-0.7	0.0	-0.4	-1.1
Medication: Ramipril	0.4	0.5	1.9	-0.5	-0.8	0.5	-1.1	0.0	-0.6	0.1	-0.0	-1.4	-0.4	-0.7	0.4	-1.1
Number of live births	0.4	0.5	1.2	-0.5	-0.5	-0.6	-0.5	-0.1	-0.9	-0.7	-0.6	-0.7	-1.1	-0.8	-1.0	-0.5
Noisy workplace	0.4	0.5	1.8	-0.9	-0.3	-1.2	-0.6	-1.3	-0.6	-0.6	-0.3	-0.7	-0.8	-0.4	-0.4	-0.2
Medication: Lansoprazole	0.4	0.5	1.3	-0.2	-0.8	0.9	-1.2	0.2	-0.4	-0.8	-0.9	-0.9	-0.3	-0.8	-0.6	-0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	0.8	1.3	0.0	0.7	0.3	0.9	0.6	-0.2	1.1	0.5	0.5	0.7	0.7
Body fat percentage	0.4	1.4	5.3	1.3	-0.4	1.0	-1.1	-1.1	0.1	1.4	0.9	1.6	1.1	1.0	0.7	2.3
Wheeze or whistling in the chest in last year	0.4	0.6	3.0	-1.0	0.9	0.2	-0.6	-1.7	0.2	-0.5	0.8	0.2	-0.6	-0.9	-0.1	1.0
Shortness of breath walking on level ground	0.4	0.5	1.7	0.1	-0.4	-0.4	-1.0	-1.1	0.1	0.6	0.2	0.9	0.9	0.1	0.6	1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.5	0.7	-1.6	0.4	-0.4	1.0	-1.0	0.5	-0.7	-0.4	-0.1	-0.2	-0.1	-1.0
Knee pain experienced in last month	0.4	0.6	2.5	-0.3	1.0	-0.3	0.5	1.1	0.5	-0.7	-1.0	-0.7	-0.6	-0.3	0.2	-1.6
Smoking status: Previous	0.4	0.6	2.0	0.8	0.2	0.5	0.8	0.6	0.6	1.4	0.8	0.7	0.8	0.9	1.3	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.4	2.8	0.2	1.7	-0.4	0.3	-0.5	0.7	0.2	-0.0	0.5	-0.1	0.8	0.7	0.7
Long-standing illness, disability or infirmity	0.4	0.6	2.2	0.5	0.1	0.3	-0.4	-0.8	0.5	0.8	0.7	1.0	1.0	0.8	0.8	1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	0.5	-1.0	0.4	-0.3	1.2	-0.3	-0.3	-1.2	-0.2	0.3	-0.4	-0.4	-1.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.3	-0.9	-0.3	-0.5	-0.5	-1.1	-0.8	-0.3	0.4	-0.7	-0.9	-0.7	-0.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	3.2	-0.2	-0.1	-0.6	0.3	1.0	-0.2	-0.7	-0.9	-0.9	-0.6	-0.1	-0.2	-1.8
Irritability	0.4	0.7	1.5	-0.7	-0.8	-1.1	-1.0	-0.6	-1.1	-0.5	-1.2	-0.7	-0.9	-0.8	-0.8	-0.3
Unable to work because of sickness or disability	0.4	0.5	1.3	-0.6	-1.1	-0.9	-0.8	-1.1	-0.9	-0.3	-0.7	-0.9	0.4	-0.3	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	6.3	0.1	2.5	-0.3	1.9	0.8	0.9	-0.8	-0.4	0.3	-0.8	0.0	-0.3	0.6
Pack years of smoking	0.4	0.6	2.2	-1.0	-0.3	-1.0	-0.9	-1.5	-0.8	-0.3	0.0	-0.6	-0.9	-1.2	-0.2	0.1
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	-1.0	-0.2	0.2	-0.7	-0.3	-0.8	-0.8	-0.6	-1.1	-1.1	-1.3	-0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.9	-0.5	-0.5	-1.7	-0.1	-1.4	-0.5	-0.3	0.4	0.6	-0.1	0.1	-1.0	0.9
Triglycerides	0.3	0.4	2.6	-0.4	0.3	-0.1	-0.0	-1.2	0.1	0.4	1.6	-0.2	0.1	0.8	0.6	0.2
Hypothyroidism (self reported)	0.3	0.7	3.7	0.4	-0.9	-0.6	-1.9	-0.9	-0.4	0.1	-1.5	0.7	0.4	-0.3	-0.1	0.7
Respiratory disease	0.3	0.6	2.1	0.1	1.4	1.0	0.3	-0.4	0.9	0.0	0.7	1.2	-0.0	-0.3	-0.1	1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.1	0.2	-0.6	0.8	-0.7	-1.1	-0.1	0.5	1.0	0.5	0.6	0.3	-0.0	1.8
Chronotype (morning person)	0.3	0.7	3.7	0.5	0.6	1.3	0.8	1.9	0.8	0.1	0.1	-0.2	-0.2	0.1	0.3	-1.3
Hearing difficulty/problems: Yes	0.3	0.4	1.0	0.2	0.9	-1.0	0.2	-0.2	1.0	0.4	0.4	0.7	0.7	0.8	1.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.3	0.4	-0.8	-0.6	-0.6	-0.3	-0.6	-0.9	-0.3	-0.7	-0.3	-0.4	-0.0
Supplements: Zinc	0.3	0.3	1.2	0.9	-1.1	-0.4	-0.2	0.5	-0.9	0.6	-0.7	-0.0	0.3	-0.1	0.1	0.1
Stomach or abdominal pain in last month	0.3	0.4	1.1	-1.0	0.3	-0.7	-0.1	-1.1	-0.1	-0.7	0.5	-0.7	-0.5	-0.1	-0.4	-0.4
Medication: Levothyroxine sodium	0.3	0.4	1.5	0.9	-0.3	-0.6	-0.9	-0.0	0.1	0.5	-1.2	0.9	0.6	0.6	0.3	0.3
High blood pressure (mother)	0.3	0.4	1.1	-1.0	0.2	0.3	0.9	0.6	0.2	-1.0	0.6	-0.6	-0.6	-0.4	-0.8	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	-1.1	-0.5	-1.0	-0.7	-1.0	-0.5	-0.5	-0.4	-0.9	-0.1	0.0	-0.1	-1.0
Hearing difficulty/problems with background noise	0.3	0.6	1.7	0.6	0.3	0.5	0.6	1.0	0.8	1.0	0.8	0.3	0.8	0.6	1.3	-0.5
Diabetes (self-reported)	0.3	0.4	2.0	0.0	-0.4	0.4	-0.6	-1.1	-0.1	0.3	1.1	0.6	0.2	-0.1	-0.2	1.4
Fluid intelligence score	0.3	0.6	1.7	-0.4	0.1	-1.3	0.5	-1.0	-0.2	-0.5	0.6	0.8	-0.3	0.4	-1.3	1.1
Neuroticism score	0.3	0.6	1.2	-1.1	-0.9	-0.2	-1.1	-0.8	-0.9	-0.6	-0.3	-0.8	-0.5	-0.9	-0.5	-0.7
Happiness	0.3	0.4	1.3	-0.7	0.4	-0.6	-0.1	-0.7	-0.3	-1.1	-0.5	-0.2	-0.8	-0.4	-1.1	0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	2.1	0.2	-0.8	0.2	-0.1	0.5	-0.0	0.8	0.6	-0.8	0.5	1.1	1.0	-1.4
Asthma	0.3	0.7	2.0	-0.1	1.4	0.6	0.3	-0.8	1.0	-0.1	0.9	1.4	0.1	0.1	-0.2	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.9	-0.3	0.3	-1.4	-0.3	-0.8	-0.4	-0.6	-0.9	-0.0	-0.5	-0.5	-0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.0	0.5	-0.4	-1.1	-1.4	-0.9	-0.3	0.4	-1.3	0.7	0.2	0.1	0.3	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.5	0.0	-0.6	-0.9	-0.7	0.0	-0.8	-1.1	0.5	-0.4	-0.9	-0.8	0.2
High blood pressure (siblings)	0.3	0.4	1.2	0.1	-0.3	0.8	0.3	0.4	-0.2	0.5	1.1	-1.0	0.0	0.4	0.6	-0.8
Leg fat percentage (right)	0.3	1.1	5.9	0.3	-1.7	0.2	-2.4	-1.6	-1.2	0.5	-0.3	0.3	0.1	-0.4	-0.2	0.9
Exposure to tobacco smoke outside home	0.3	0.3	1.2	0.7	-0.8	0.5	0.0	0.3	-0.0	0.8	0.4	0.2	0.9	1.1	0.4	0.1
Health satisfaction	0.3	0.4	2.5	0.4	0.1	-0.2	-0.6	-0.6	-0.0	0.1	-0.4	0.9	0.1	-0.3	-0.2	1.6
Medication for pain relief, constipation, heartburn	0.3	0.6	1.8	0.7	0.7	0.3	1.0	0.7	0.8	0.4	0.5	1.3	0.8	1.0	0.2	0.6
Neck or shoulder pain in last month	0.3	0.4	1.1	-0.7	-0.2	-1.0	-0.3	-0.8	-0.6	-0.6	-0.9	-0.6	-0.5	-0.7	-0.6	0.1
Medication: Ibuprofen	0.3	0.3	1.1	-0.0	0.3	-1.0	-0.2	-0.5	-0.5	-0.5	-0.9	0.2	-0.6	-0.6	-0.8	0.6
Mean time to correctly identify matches	0.3	0.5	1.4	-0.7	-1.2	-0.7	-0.6	-0.3	-0.8	-0.5	-1.0	-0.6	-0.3	-0.8	-0.4	-0.9
Leg fat mass (right)	0.3	1.3	4.8	1.3	-0.2	0.9	-0.9	-0.9	0.1	1.4	1.0	1.4	1.0	1.0	0.7	2.2
Number of full sisters	0.3	0.4	1.6	-0.6	0.2	0.3	0.5	0.1	-0.3	-0.1	1.1	-1.2	-0.6	0.1	0.1	-1.0
Overall health rating	0.3	0.7	2.9	-0.9	-0.6	-1.1	-1.3	-1.7	-0.8	-0.4	-0.3	-0.5	-0.3	-0.5	-0.3	0.2
Family relationship satisfaction	0.3	0.3	1.3	-1.1	0.7	-0.2	-0.0	-0.3	0.4	-0.8	0.7	-0.4	-0.5	-0.1	-0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.6	0.3	-0.6	-0.0	-1.0	-0.5	-0.5	-0.3	-0.7	0.4	-0.1	-0.5	-0.6	1.3
Ever had bowel cancer screening	0.3	0.4	1.4	0.5	-0.4	0.9	0.1	0.3	0.6	0.4	0.4	1.2	1.1	0.2	0.1	0.7
Diabetes diagnosed by doctor	0.3	0.5	2.4	0.1	-0.8	-0.0	-0.9	-1.3	-0.4	0.4	0.5	0.5	0.3	0.0	-0.1	1.6
Commuting to job workplace: Walk	0.3	0.3	1.9	-0.7	-0.1	0.6	-0.4	-0.2	0.1	-0.0	1.4	-0.2	-0.3	-0.6	0.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.1	0.1	-0.0	0.7	0.1	1.2	0.9	-0.0	0.6	-0.0	0.5	1.0	0.3	-1.4
Back pain experienced in last month	0.3	0.4	3.3	-0.2	-0.2	-0.2	0.0	0.5	0.2	0.3	0.0	-0.5	0.2	0.6	0.7	-1.8
Asthma (self-reported)	0.3	0.6	1.9	-0.2	1.4	0.6	0.4	-0.7	1.0	0.0	1.2	1.3	0.1	0.1	-0.0	1.1
Osteoarthritis (self-reported)	0.3	0.3	1.5	0.4	0.1	0.3	0.8	1.2	0.8	0.2	0.2	0.5	0.7	0.2	0.6	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	0.1	-1.2	0.6	-1.0	-0.8	-0.4	0.7	1.1	0.2	0.7	0.4	0.3	0.3
Wears glasses or contact lenses	0.3	0.3	1.6	-0.0	-0.2	-0.1	-1.3	-0.7	-0.5	0.0	-0.6	-0.3	-0.5	-0.8	0.3	-0.2
Medication: Blood pressure	0.3	0.5	1.8	1.1	-0.6	0.3	-0.4	0.5	0.5	0.7	-0.1	1.0	1.4	0.9	0.6	0.4
Alcohol drinker status: Never	0.3	0.4	0.9	-0.5	-1.0	-0.0	-0.7	-0.9	-0.9	-0.2	0.4	-0.5	-0.4	-0.8	-0.5	0.2
Leg fat percentage (left)	0.3	1.1	5.9	-0.2	-1.4	-0.0	-2.4	-1.8	-1.2	-0.0	-0.4	0.1	-0.4	-0.8	-0.5	0.7
Leg fat mass (left)	0.3	1.0	4.3	1.1	0.0	0.9	-0.7	-0.9	0.1	1.2	0.9	1.3	0.7	0.8	0.6	2.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	0.7	0.0	1.0	0.3	0.5	0.8	0.5	0.1	1.2	1.1	0.3	0.4	0.9
Prostate Cancer	0.2	0.3	1.2	-0.0	0.7	0.0	1.1	0.9	0.4	0.1	0.1	-0.2	0.0	0.2	0.2	-0.8
Crohns Disease (2012)	0.2	0.3	1.2	-0.0	-0.5	-0.5	-0.2	-0.9	-0.8	-0.5	-0.5	0.1	-0.4	0.0	-0.8	1.1
Lupus	0.2	0.3	1.3	-0.4	0.1	0.3	-0.7	-1.0	0.2	0.2	1.1	-0.2	0.2	0.2	0.6	0.5
Blood Eosinophil Count	0.2	1.8	6.4	0.2	1.1	0.5	0.2	-1.8	0.7	1.3	2.5	1.3	0.7	1.8	1.1	1.9
Blood Platelet Count	0.2	2.0	5.3	1.8	-0.3	0.9	-0.0	0.1	0.7	2.3	1.2	2.2	1.8	1.2	1.6	1.4
Fed-up feelings	0.2	0.4	1.0	-0.4	-0.8	-0.1	-1.0	-0.3	-0.8	-0.3	-0.9	-0.6	-0.3	-0.6	-0.4	-0.7
Nervous feelings	0.2	0.4	2.0	-0.6	-1.4	0.4	-0.6	-0.6	-0.4	0.1	0.9	-0.3	0.8	0.3	-0.1	-0.4
Had menopause	0.2	0.3	0.7	0.6	-0.6	0.2	-0.8	-0.1	0.1	0.6	0.0	0.4	0.8	0.2	0.7	0.3
Mouth/teeth dental problems	0.2	0.3	1.7	0.3	0.3	0.8	0.2	-0.2	-0.2	0.2	0.2	0.4	-0.0	-0.9	-0.1	1.3
Heart attack	0.2	0.3	0.9	-0.5	-0.2	-0.2	-0.7	0.0	-0.6	-0.2	-0.4	-1.0	-0.6	-0.8	0.1	-0.7
Medication: Simvastatin	0.2	0.4	1.6	0.5	0.3	1.3	0.2	1.1	0.6	0.6	0.4	0.5	0.5	-0.0	0.6	0.0
Time employed in main current job	0.2	0.3	0.5	-0.4	-0.4	-0.2	-0.7	-0.3	-0.3	-0.7	-0.6	-0.5	-0.5	0.1	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.8	0.3	0.4	-0.2	0.8	-0.2	0.4	-0.1	0.2	0.8	0.5	0.3	-0.4	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	-0.1	0.5	1.0	0.4	1.0	0.5	-0.5	0.3	-0.3	-0.0	-0.2	-0.3	-0.8
Lung cancer (father)	0.2	0.2	1.0	-0.2	-1.0	-0.1	-0.5	-0.8	-0.4	-0.1	0.4	0.0	0.5	0.2	-0.4	0.5
Illnesses of mother	0.2	0.2	0.7	0.5	-0.8	-0.2	-0.3	-0.2	-0.2	0.5	-0.1	0.2	0.8	0.6	0.2	0.1
Arm fat mass (right)	0.2	1.0	4.4	0.8	-0.3	0.2	-1.0	-1.6	-0.2	1.0	1.0	1.2	0.5	0.9	0.3	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.8	-0.6	-0.3	-1.4	-0.4	-0.9	-0.6	-0.2	-0.2	-0.4	-0.6	0.0	-0.2	-0.7
Hair/balding pattern: Pattern 4	0.2	0.6	2.6	0.4	0.1	1.2	0.8	1.6	-0.2	0.0	-0.4	-0.8	-0.6	-0.3	0.2	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	0.3	0.3	-1.0	1.0	-0.4	0.1	-0.1	0.0	0.3	0.1	0.8	-0.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.3	-0.6	1.1	-0.4	-0.4	-0.3	0.8	0.8	0.3	0.3	0.0	0.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.8	0.8	-0.3	-0.2	-0.0	-0.2	-0.1	0.4	-0.4	0.5	0.6	0.7	0.1	0.9
Pulse wave peak to peak time	0.2	0.3	1.4	0.1	-0.4	0.8	0.4	0.4	0.1	0.3	1.2	-0.3	0.4	0.5	0.3	-0.0
Qualifications: College or University degree	0.2	0.5	1.6	-0.1	0.6	-1.3	0.7	-1.1	0.4	0.1	0.9	0.6	0.2	0.7	0.1	1.2
Medication: Allopurinol	0.2	0.2	1.4	0.2	-0.1	-1.2	0.2	-0.4	-0.3	0.0	-0.3	0.2	-0.0	0.3	-0.2	0.8
Suffer from ‘nerves’	0.2	0.3	1.2	0.5	0.5	0.4	0.3	1.1	0.9	0.2	-0.3	0.3	0.4	0.3	0.8	-0.5
Hypertension (Self-reported)	0.2	0.7	3.2	-0.1	-1.8	0.4	-1.5	-0.7	-0.4	0.7	0.8	-0.1	0.9	0.1	0.4	-0.3
Illnesses of father: Heart disease	0.2	0.2	1.1	-0.5	0.4	-0.2	0.2	-0.4	-0.3	-0.2	0.7	-1.0	-0.8	-0.1	0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.1	0.5	0.4	-0.1	0.6	0.4	0.2	0.4	0.0	0.2	0.1	1.0	0.2	0.0
Friendships satisfaction	0.2	0.3	1.2	0.5	0.4	-0.5	-0.6	-0.5	-0.2	0.3	-0.5	0.8	0.1	-0.2	0.1	1.1
Arm fat mass (left)	0.2	1.0	4.4	0.7	-0.5	0.1	-1.3	-1.6	-0.4	0.8	0.6	1.0	0.4	0.6	0.1	2.1
Commuting to job workplace: Public transport	0.2	0.2	0.9	-0.2	-0.5	-0.6	-0.3	-0.9	-0.5	0.2	0.5	0.2	-0.4	0.1	-0.4	0.1
Medication: Lisinopril	0.2	0.2	0.8	0.5	-0.6	0.2	0.1	-0.1	-0.2	0.3	0.2	0.9	0.2	-0.1	-0.3	0.9
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.2	-0.5	0.1	0.2	0.5	-0.4	-0.7	-0.7	-0.3	-0.3	-0.6	-0.9	-0.7
Myopia	0.2	0.3	0.7	-0.5	0.7	-0.7	0.4	-0.1	-0.0	-0.9	-0.4	-0.6	-0.8	-0.1	-0.8	-0.1
Pain experienced in last month	0.2	0.4	0.9	0.3	-0.5	0.5	-0.1	-0.1	0.3	0.7	1.0	0.9	0.7	0.2	0.3	1.0
Neuroticism (Nagel 2018)	0.1	0.2	1.0	-0.6	-0.0	0.0	-0.4	-0.5	-0.3	-0.5	-0.6	-0.3	-0.6	-1.0	-0.3	-0.1
Worry (Nagel 2018)	0.1	0.2	0.7	-0.0	0.1	0.8	-0.0	0.4	0.2	-0.1	-0.5	0.3	0.3	-0.9	0.0	0.3
HDL Cholesterol	0.1	0.2	1.2	0.5	0.2	-0.1	0.4	1.1	0.3	-0.0	-1.0	-0.1	0.2	0.0	0.0	-0.3
Allergy or Eczema	0.1	0.3	1.0	-0.3	0.2	0.0	-0.5	-0.9	0.2	-0.5	0.1	0.8	0.1	-0.6	-0.6	1.0
Neuroticism	0.1	0.2	0.9	-0.5	-0.2	0.5	-0.4	0.1	-0.4	-0.2	-0.2	-0.6	-0.3	-0.9	0.1	-0.4
Tanning	0.1	0.8	5.0	-0.4	-0.6	-0.4	0.2	1.2	-0.8	0.1	-0.7	-1.3	-0.6	-0.1	0.3	-2.2
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.6	0.1	0.5	-0.7	-0.6	-0.1	-0.0	0.3	0.0	-0.3	-0.8	0.1	-0.1
Systolic blood pressure, automated reading	0.1	0.4	1.0	-1.0	-0.8	0.0	-0.8	-1.0	-0.4	-0.5	0.6	-0.1	-0.3	-0.9	-0.7	-0.3
Taking other prescription medications	0.1	0.2	0.5	0.5	-0.6	0.7	-0.5	0.3	-0.2	0.4	0.1	-0.5	0.4	0.3	0.5	-0.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.5	-0.1	0.1	0.1	-0.6	-0.9	0.2	-0.1	0.1	0.9	0.4	-0.6	-0.2	1.2
Pulse rate	0.1	0.2	0.7	-0.5	-0.1	0.1	-0.8	-0.7	0.3	-0.1	0.9	-0.5	0.5	0.3	0.3	-0.3
Glaucoma (self-reported)	0.1	0.1	0.4	-0.4	-0.0	-0.2	-0.2	-0.6	-0.2	0.2	0.6	-0.3	-0.1	-0.3	0.4	-0.0
Heart disease (mother)	0.1	0.2	0.4	0.4	0.2	0.4	0.4	0.5	0.4	0.5	0.6	-0.1	0.0	0.4	0.7	0.2
Mood swings	0.1	0.1	0.4	0.1	0.5	0.3	0.3	0.1	0.3	0.3	0.3	0.2	0.3	0.4	0.6	0.1
Breast cancer (self-reported)	0.1	0.1	0.5	0.3	-0.7	-0.2	0.1	-0.2	-0.4	0.1	-0.1	0.6	0.3	0.2	-0.5	0.5
Hearing aid user	0.1	0.2	0.7	-0.1	0.1	-0.3	-0.4	-0.8	0.2	0.2	0.3	0.3	0.3	-0.0	0.4	0.8
Mother’s age at death	0.1	0.2	0.5	0.1	0.7	0.7	0.1	0.5	0.5	-0.3	-0.4	0.2	0.2	-0.6	0.1	0.5
Number of operations (self-reported)	0.1	0.2	1.1	-0.1	-0.5	0.1	-0.5	-0.0	-0.4	-0.1	-0.2	-0.7	-0.2	-0.1	-0.3	-1.0
Diastolic blood pressure, automated reading	0.1	0.3	1.5	0.6	0.5	1.1	0.9	1.2	0.4	0.2	0.1	0.1	0.3	0.1	0.1	0.0
Basal cell carcinoma (self-reported)	0.1	0.2	0.6	0.2	0.2	-0.8	0.3	-0.5	-0.3	0.0	-0.2	0.5	-0.2	-0.1	-0.1	0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.3	0.0	-0.0	-0.3	0.2	-0.3	0.2	-0.0	-0.8	-0.4	-0.6	0.4	-0.7
Blood White Count	0.0	0.2	0.7	0.0	-0.2	0.6	-0.9	-0.4	-0.2	0.7	0.8	-0.0	0.0	-0.0	0.6	-0.4
Systolic Blood Pressure	0.0	0.2	0.8	-0.6	0.3	0.2	-0.3	-0.3	0.1	-0.6	-0.0	0.1	-0.3	-0.9	-0.6	-0.1
Hair Pigment	0.0	0.2	0.7	-0.7	-0.1	-0.0	-0.4	-0.5	-0.3	-0.6	0.0	-0.2	-0.9	-0.8	-0.5	-0.2

Hub : Genes

ATP13A2

Models

Trait associations