[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted : ← →

chr15:84,151,637-85,895,721

Best TWAS P=7.64e-14 · Best GWAS P=2.38e-15 conditioned to 1.02e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC388152	0.14	0.14	enet	20	0.18	6.7e-22	6.1	-6.3	2.6e-10	0.43	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	AC103965.1	0.24	0.14	lasso	6	0.15	2.6e-12	6.1	-6.5	9.2e-11	0.44	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RN7SL417P	0.07	0.06	lasso	7	0.05	1.3e-04	6.2	5.6	2.2e-08	-0.35	0.52	0.02	FALSE
4	GTEx	Adipose Subcutaneous	RP11-182J1.14	0.11	0.11	lasso	9	0.12	8.1e-10	6.2	6.1	1.1e-09	-0.46	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CSPG4P11	0.19	0.17	lasso	5	0.20	7.9e-16	6.1	-6.4	1.7e-10	0.42	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	AC103965.1	0.12	0.13	lasso	5	0.10	1.0e-05	6.1	-6.2	6.8e-10	0.40	0.97	0.01	FALSE
7	GTEx	Adipose Visceral Omentum	CSPG4P11	0.14	0.07	enet	15	0.09	2.9e-05	6.2	-5.7	1.0e-08	0.24	0.89	0.01	FALSE
8	GTEx	Adrenal Gland	AC103965.1	0.09	0.00	enet	5	-0.01	7.7e-01	6.4	-6.3	2.2e-10	0.43	0.09	0.08	FALSE
9	GTEx	Artery Aorta	UBE2Q2P1	0.15	0.00	enet	21	0.05	8.4e-04	-1.8	5.4	5.7e-08	-0.30	0.28	0.10	FALSE
10	GTEx	Artery Aorta	AC103965.1	0.10	0.12	lasso	3	0.10	3.9e-06	6.1	-6.1	8.7e-10	0.40	0.95	0.03	FALSE
11	GTEx	Artery Aorta	RP11-182J1.16	0.11	0.12	lasso	3	0.11	1.6e-06	6.1	-5.9	3.7e-09	0.39	0.94	0.01	FALSE
12	GTEx	Artery Aorta	RP11-182J1.14	0.22	0.17	enet	13	0.20	3.0e-11	6.3	5.2	1.8e-07	-0.38	1.00	0.00	FALSE
13	GTEx	Artery Aorta	CSPG4P11	0.11	0.10	lasso	4	0.08	3.1e-05	6.1	-6.2	7.7e-10	0.41	0.93	0.01	FALSE
14	GTEx	Artery Coronary	AC103965.1	0.15	0.08	enet	21	0.14	2.6e-05	-3.7	-5.6	2.3e-08	0.39	0.14	0.08	FALSE
15	GTEx	Artery Tibial	AC103965.1	0.27	0.26	enet	31	0.30	1.8e-23	6.2	-7.3	4.0e-13	0.56	1.00	0.00	FALSE
16	GTEx	Artery Tibial	RP11-182J1.16	0.11	0.09	enet	14	0.08	4.1e-07	6.1	-5.7	1.0e-08	0.33	0.99	0.00	FALSE
17	GTEx	Artery Tibial	CSPG4P11	0.16	0.24	lasso	4	0.23	3.0e-18	6.2	-6.8	8.5e-12	0.54	1.00	0.00	FALSE
18	GTEx	Brain Caudate basal ganglia	AC103965.1	0.28	0.25	lasso	7	0.25	6.7e-08	6.2	-5.6	2.1e-08	0.39	0.84	0.02	FALSE
19	GTEx	Brain Cerebellar Hemisphere	UBE2Q2P1	0.18	0.08	enet	18	0.12	4.2e-04	5.0	5.9	3.6e-09	-0.45	0.18	0.18	FALSE
20	GTEx	Brain Cerebellar Hemisphere	CSPG4P11	0.30	0.21	lasso	3	0.16	7.6e-05	6.3	6.3	2.2e-10	-0.44	0.39	0.08	FALSE
21	GTEx	Brain Cerebellum	AC103965.1	0.13	0.02	enet	21	0.01	2.1e-01	6.1	-6.9	4.8e-12	0.68	0.04	0.71	FALSE
22	GTEx	Brain Cerebellum	CSPG4P11	0.28	0.23	lasso	5	0.28	9.0e-09	6.2	6.1	1.1e-09	-0.35	0.94	0.01	FALSE
23	GTEx	Brain Cortex	AC103965.1	0.17	0.19	lasso	3	0.16	4.3e-05	6.2	-6.7	2.1e-11	0.46	0.21	0.45	FALSE
24	GTEx	Brain Cortex	RP11-182J1.14	0.24	0.03	enet	14	0.16	3.2e-05	6.4	6.8	8.9e-12	-0.46	0.07	0.21	FALSE
25	GTEx	Brain Frontal Cortex BA9	AC103965.1	0.27	0.17	lasso	7	0.16	6.0e-05	6.2	-5.6	2.1e-08	0.41	0.35	0.08	FALSE
26	GTEx	Brain Hippocampus	AC103965.1	0.26	0.12	lasso	11	0.20	2.1e-05	4.2	-5.7	1.0e-08	0.28	0.31	0.05	FALSE
27	GTEx	Brain Hypothalamus	AC103965.1	0.21	0.24	lasso	6	0.21	1.4e-05	6.4	-5.8	6.2e-09	0.42	0.32	0.18	FALSE
28	GTEx	Brain Nucleus accumbens basal ganglia	AC103965.1	0.29	0.23	enet	21	0.27	6.9e-08	6.4	-6.8	1.1e-11	0.49	0.86	0.08	FALSE
29	GTEx	Brain Putamen basal ganglia	AC103965.1	0.26	0.19	lasso	7	0.22	4.5e-06	6.4	-6.4	1.4e-10	0.39	0.69	0.10	FALSE
30	GTEx	Breast Mammary Tissue	AC103965.1	0.13	0.11	lasso	1	0.13	2.9e-07	6.2	-6.2	6.9e-10	0.41	0.89	0.05	FALSE
31	GTEx	Breast Mammary Tissue	CSPG4P11	0.08	0.08	lasso	2	0.05	1.3e-03	4.3	-5.5	3.1e-08	0.24	0.40	0.04	FALSE
32	GTEx	Breast Mammary Tissue (Male)	AC103965.1	0.24	0.14	lasso	4	0.11	1.4e-03	6.2	-7.2	6.4e-13	0.53	0.12	0.29	FALSE
33	GTEx	Breast Mammary Tissue (Male)	RN7SL417P	0.20	0.12	lasso	3	0.10	3.1e-03	5.0	5.4	7.1e-08	-0.46	0.06	0.12	FALSE
34	GTEx	Breast Mammary Tissue (Male)	RP11-182J1.14	0.04	-0.01	enet	1	-0.01	5.9e-01	6.4	6.4	1.9e-10	-0.43	0.03	0.08	FALSE
35	GTEx	Breast Mammary Tissue (Male)	CSPG4P11	0.05	0.02	lasso	6	0.03	7.1e-02	5.1	-5.1	3.1e-07	0.44	0.03	0.09	FALSE
36	GTEx	Cells Transformed fibroblasts	AC103965.1	0.15	0.09	lasso	7	0.11	1.3e-08	6.1	-7.5	7.6e-14	0.49	0.98	0.01	TRUE
37	GTEx	Cells Transformed fibroblasts	CSPG4P11	0.19	0.18	enet	17	0.17	9.8e-13	6.1	-5.7	1.4e-08	0.37	1.00	0.00	FALSE
38	GTEx	Colon Sigmoid	RN7SL417P	0.17	0.06	lasso	4	0.12	6.1e-05	6.4	6.0	2.1e-09	-0.46	0.28	0.09	FALSE
39	GTEx	Colon Sigmoid	RP11-182J1.14	0.31	0.29	lasso	9	0.30	2.7e-11	6.4	6.6	4.8e-11	-0.46	1.00	0.00	FALSE
40	GTEx	Colon Transverse	AC103965.1	0.15	0.07	enet	33	0.06	7.1e-04	-3.4	-5.4	8.7e-08	0.24	0.17	0.16	FALSE
41	GTEx	Colon Transverse	RP11-182J1.14	0.23	0.19	enet	27	0.18	3.9e-09	6.1	5.4	7.7e-08	-0.46	1.00	0.00	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	AC103965.1	0.13	0.14	lasso	4	0.15	3.2e-06	6.4	-5.9	3.7e-09	0.42	0.48	0.06	FALSE
43	GTEx	Esophagus Gastroesophageal Junction	RP11-182J1.14	0.16	0.16	enet	16	0.17	1.1e-06	4.5	5.3	1.4e-07	-0.26	0.95	0.00	FALSE
44	GTEx	Esophagus Gastroesophageal Junction	CSPG4P11	0.18	0.06	lasso	2	0.06	3.5e-03	6.3	-5.9	4.4e-09	0.43	0.23	0.04	FALSE
45	GTEx	Esophagus Mucosa	UBE2Q2P1	0.38	0.26	enet	37	0.28	3.7e-19	6.2	6.4	1.6e-10	-0.38	1.00	0.00	FALSE
46	GTEx	Esophagus Mucosa	NMB	0.07	0.02	lasso	1	0.02	3.1e-02	5.2	-5.2	2.0e-07	0.27	0.11	0.54	FALSE
47	GTEx	Esophagus Mucosa	AC103965.1	0.20	0.19	enet	47	0.16	8.4e-11	6.2	-6.5	7.2e-11	0.39	1.00	0.00	FALSE
48	GTEx	Esophagus Mucosa	RP11-182J1.16	0.20	0.05	lasso	5	0.10	1.8e-07	6.4	-6.7	1.7e-11	0.42	0.90	0.01	FALSE
49	GTEx	Esophagus Mucosa	CSPG4P11	0.21	0.01	enet	28	0.08	3.7e-06	-3.4	-5.4	5.9e-08	0.47	0.86	0.04	FALSE
50	GTEx	Esophagus Muscularis	AC103965.1	0.18	0.14	enet	16	0.14	7.6e-09	6.3	-6.5	6.0e-11	0.46	1.00	0.00	FALSE
51	GTEx	Esophagus Muscularis	RP11-182J1.16	0.12	0.10	lasso	8	0.11	4.5e-07	6.1	-5.8	5.3e-09	0.28	0.99	0.00	FALSE
52	GTEx	Esophagus Muscularis	CSPG4P11	0.12	0.16	lasso	5	0.18	4.0e-11	6.1	-6.2	6.8e-10	0.38	1.00	0.00	FALSE
53	GTEx	Heart Atrial Appendage	AC103965.1	0.24	0.12	enet	24	0.14	7.2e-07	5.5	-5.6	2.5e-08	0.26	0.98	0.00	FALSE
54	GTEx	Heart Atrial Appendage	RP11-182J1.14	0.06	0.05	lasso	3	0.05	3.6e-03	6.4	6.4	1.5e-10	-0.44	0.17	0.24	FALSE
55	GTEx	Heart Atrial Appendage	CSPG4P11	0.12	0.08	lasso	5	0.10	4.3e-05	6.2	-6.0	2.0e-09	0.32	0.81	0.02	FALSE
56	GTEx	Heart Left Ventricle	AC103965.1	0.16	0.13	enet	14	0.12	7.0e-07	6.4	-6.8	1.3e-11	0.39	0.98	0.00	FALSE
57	GTEx	Heart Left Ventricle	CSPG4P11	0.11	0.02	lasso	5	0.00	2.2e-01	6.1	-6.1	9.9e-10	0.36	0.18	0.07	FALSE
58	GTEx	Lung	AC103965.1	0.20	0.14	lasso	4	0.16	1.8e-12	6.2	-6.1	7.8e-10	0.41	1.00	0.00	FALSE
59	GTEx	Lung	RP11-182J1.16	0.10	0.04	enet	31	0.05	7.6e-05	6.2	-5.8	6.2e-09	0.43	0.78	0.08	FALSE
60	GTEx	Muscle Skeletal	AC103965.1	0.22	0.14	enet	40	0.19	2.4e-18	6.2	-6.4	1.2e-10	0.40	1.00	0.00	FALSE
61	GTEx	Muscle Skeletal	RP11-182J1.16	0.10	0.03	enet	15	0.05	5.4e-06	4.3	-5.5	3.3e-08	0.18	0.44	0.02	FALSE
62	GTEx	Muscle Skeletal	CSPG4P11	0.14	0.07	lasso	5	0.08	1.4e-08	4.3	-5.5	2.9e-08	0.28	1.00	0.00	FALSE
63	GTEx	Nerve Tibial	AC103965.1	0.20	0.22	enet	17	0.27	5.1e-19	6.2	-7.4	1.2e-13	0.58	1.00	0.00	FALSE
64	GTEx	Nerve Tibial	RP11-182J1.16	0.27	0.20	enet	22	0.26	1.5e-18	6.1	-5.8	6.8e-09	0.34	1.00	0.00	FALSE
65	GTEx	Nerve Tibial	CSPG4P11	0.23	0.23	lasso	9	0.27	3.0e-19	6.1	-5.7	1.0e-08	0.40	1.00	0.00	FALSE
66	GTEx	Ovary	AC103965.1	0.27	0.22	lasso	3	0.24	1.6e-06	6.1	-5.9	4.4e-09	0.41	0.37	0.06	FALSE
67	GTEx	Ovary	CSPG4P11	0.21	0.17	lasso	4	0.18	3.1e-05	5.5	-5.9	3.7e-09	0.28	0.41	0.04	FALSE
68	GTEx	Pancreas	NMB	0.17	0.18	lasso	3	0.14	2.3e-06	5.2	-5.1	2.7e-07	0.27	0.62	0.36	FALSE
69	GTEx	Pancreas	AC103965.1	0.29	0.23	lasso	9	0.18	2.8e-08	6.1	-6.7	1.5e-11	0.45	1.00	0.00	FALSE
70	GTEx	Pancreas	RP11-182J1.16	0.08	-0.01	enet	11	-0.01	7.9e-01	-3.4	-6.3	3.6e-10	0.46	0.05	0.16	FALSE
71	GTEx	Pituitary	AC103965.1	0.30	0.16	enet	10	0.24	8.4e-07	6.0	-6.6	5.2e-11	0.46	0.40	0.22	FALSE
72	GTEx	Prostate	RP11-182J1.16	0.24	0.06	enet	27	0.08	6.2e-03	4.2	-7.1	1.7e-12	0.48	0.09	0.10	FALSE
73	GTEx	Skin Not Sun Exposed Suprapubic	AC103965.1	0.23	0.15	lasso	8	0.19	1.9e-10	6.1	-6.1	1.4e-09	0.34	0.96	0.01	FALSE
74	GTEx	Skin Not Sun Exposed Suprapubic	RP11-182J1.16	0.10	0.01	enet	13	0.04	3.1e-03	4.3	-6.3	3.7e-10	0.36	0.35	0.10	FALSE
75	GTEx	Skin Not Sun Exposed Suprapubic	CSPG4P11	0.29	0.07	enet	29	0.13	9.6e-08	6.1	-5.6	2.4e-08	0.30	0.96	0.00	FALSE
76	GTEx	Skin Sun Exposed Lower leg	AC103965.1	0.33	0.17	enet	24	0.23	4.8e-19	6.2	-7.3	3.4e-13	0.45	1.00	0.00	FALSE
77	GTEx	Skin Sun Exposed Lower leg	RP11-182J1.16	0.09	0.04	enet	18	0.04	1.4e-04	6.1	-6.3	2.3e-10	0.36	0.55	0.09	FALSE
78	GTEx	Skin Sun Exposed Lower leg	CSPG4P11	0.18	0.07	lasso	11	0.19	9.1e-16	4.3	-5.6	1.9e-08	0.26	1.00	0.00	FALSE
79	GTEx	Spleen	GOLGA6L4	0.55	0.20	enet	19	0.40	2.6e-11	-3.2	-5.6	2.5e-08	0.40	0.89	0.01	FALSE
80	GTEx	Stomach	AC103965.1	0.14	0.11	lasso	3	0.10	1.1e-05	6.2	-5.9	3.2e-09	0.40	0.84	0.01	FALSE
81	GTEx	Testis	AC103965.1	0.07	0.07	lasso	2	0.06	1.6e-03	6.2	-6.2	6.1e-10	0.39	0.52	0.04	FALSE
82	GTEx	Testis	RN7SL417P	0.09	0.08	lasso	3	0.08	3.1e-04	6.2	5.9	4.0e-09	-0.29	0.34	0.03	FALSE
83	GTEx	Testis	RP11-182J1.14	0.10	0.19	lasso	1	0.17	6.7e-08	6.2	6.2	6.9e-10	-0.41	0.94	0.00	FALSE
84	GTEx	Thyroid	AC103965.1	0.30	0.25	lasso	7	0.25	1.8e-19	6.1	-6.3	2.8e-10	0.42	1.00	0.00	FALSE
85	GTEx	Thyroid	RP11-182J1.16	0.10	0.02	lasso	7	0.05	1.3e-04	-5.6	-6.5	9.9e-11	0.38	0.51	0.09	FALSE
86	GTEx	Thyroid	CSPG4P11	0.17	0.08	enet	20	0.14	6.1e-11	6.2	-6.1	1.1e-09	0.32	1.00	0.00	FALSE
87	GTEx	Whole Blood	GOLGA6L4	0.12	0.08	enet	16	0.11	2.1e-10	-3.9	-5.5	5.0e-08	0.40	0.99	0.00	FALSE
88	YFS	Blood	NMB	0.05	0.09	lasso	4	0.09	1.9e-26	5.5	-5.5	4.5e-08	0.27	0.75	0.25	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOLGA6L5	0.04	0.04	enet	5	0.05	4.6e-11	-2.5	-5.2	1.8e-07	0.44	0.12	0.88	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC388152	0.13	0.10	enet	2	0.11	3.3e-22	6.2	-5.7	1.1e-08	0.32	0.00	1.00	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	LOC388152	0.07	0.04	blup	4	0.05	1.3e-03	6.2	-5.8	8.6e-09	0.32	0.00	0.83	FALSE
92	The Cancer Genome Atlas	Esophageal Carcinoma	LOC388152	0.10	0.08	enet	2	0.08	1.8e-03	6.2	-6.2	5.6e-10	0.41	0.00	0.76	FALSE
93	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC388152	0.12	0.08	lasso	3	0.08	1.9e-03	6.2	-6.2	4.9e-10	0.40	0.00	0.70	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LOC388152	0.03	0.02	enet	4	0.01	8.8e-03	6.2	-5.6	2.0e-08	0.30	0.00	0.74	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC388152	0.05	0.05	blup	4	0.05	3.9e-06	6.2	-6.1	1.1e-09	0.37	0.00	1.00	FALSE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC388152	0.19	0.17	blup	4	0.18	1.8e-10	6.2	-5.9	4.5e-09	0.33	0.00	1.00	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC388152	0.11	0.08	enet	3	0.09	2.1e-10	6.2	-5.7	1.4e-08	0.31	0.00	1.00	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBE2Q2P1	0.07	0.04	blup	22	0.06	1.8e-07	6.1	6.0	1.9e-09	-0.36	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	UBE2Q2P1	0.10	0.00	blup	22	0.03	1.9e-02	-4.5	5.7	9.4e-09	-0.34	0.00	0.48	FALSE
100	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZSCAN2	0.05	0.01	blup	46	0.02	2.7e-02	5.1	5.5	4.8e-08	-0.21	0.01	0.67	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC388152	0.12	0.10	blup	4	0.10	4.9e-12	6.2	-6.0	1.5e-09	0.36	0.00	1.00	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC388152	0.02	0.03	lasso	1	0.02	1.2e-03	6.2	-6.2	5.3e-10	0.41	0.00	0.93	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBE2Q2P1	0.03	0.03	lasso	3	0.02	9.2e-04	6.1	6.4	2.0e-10	-0.43	0.00	0.93	FALSE
104	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC388152	0.04	0.05	enet	2	0.05	4.2e-04	6.2	-6.2	5.9e-10	0.41	0.00	0.90	FALSE
105	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC388152	0.08	0.11	lasso	3	0.11	2.4e-05	6.2	-6.2	4.9e-10	0.40	0.00	0.98	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC388152	0.12	0.09	enet	2	0.10	1.9e-10	6.2	-5.7	9.1e-09	0.32	0.00	1.00	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	NMB	0.17	0.30	enet	12	0.29	5.3e-31	5.5	-5.5	5.0e-08	0.30	0.00	1.00	FALSE
108	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC388152	0.18	0.14	blup	4	0.13	2.1e-05	6.2	-6.1	1.4e-09	0.36	0.00	0.99	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	LOC388152	0.29	0.26	enet	3	0.27	2.1e-26	6.2	-6.1	1.0e-09	0.37	0.00	1.00	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	NMB	0.11	0.11	lasso	3	0.09	1.8e-09	5.2	5.5	4.2e-08	-0.27	0.01	0.99	FALSE