[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted : ← →

chr17:60,916,262-62,694,738

Best TWAS P=9.79e-13 · Best GWAS P=9.83e-12 conditioned to 0.21

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	6.7	5.9	4.6e-09	0.78	0.04	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	6.7	5.9	4.4e-09	0.92	0.03	0.96	FALSE
3	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-5.5	6.1	1.1e-09	0.47	0.98	0.02	FALSE
4	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	6.7	6.5	6.3e-11	0.98	0.03	0.97	FALSE
5	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	6.7	5.3	1.2e-07	0.83	0.03	0.91	FALSE
6	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	6.7	-5.7	1.5e-08	-0.93	0.03	0.97	FALSE
7	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	6.1	6.2	4.4e-10	0.90	0.05	0.94	FALSE
8	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	6.7	-5.7	1.3e-08	-0.87	0.05	0.66	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	6.7	-7.1	9.8e-13	-0.83	0.03	0.84	TRUE
10	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	6.7	6.8	7.5e-12	0.99	0.03	0.97	FALSE
11	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	6.8	6.1	1.3e-09	0.94	0.03	0.79	FALSE
12	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	6.2	6.3	3.5e-10	0.94	0.04	0.53	FALSE
13	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	6.7	6.7	1.7e-11	0.99	0.03	0.52	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	6.7	-6.7	1.8e-11	-0.98	0.03	0.91	FALSE
15	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	6.8	-6.1	1.2e-09	-0.95	0.03	0.96	FALSE
16	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	4.3	5.3	1.4e-07	0.78	0.04	0.86	FALSE
17	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	6.7	6.7	1.8e-11	0.99	0.03	0.96	FALSE
18	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	6.7	5.2	2.6e-07	0.87	0.05	0.91	FALSE
19	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	6.8	6.8	9.8e-12	0.99	0.03	0.97	FALSE
20	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	6.7	6.8	1.5e-11	0.99	0.03	0.97	FALSE
21	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	6.7	-6.0	1.9e-09	-0.96	0.03	0.97	FALSE
22	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	6.7	5.3	8.6e-08	0.89	0.03	0.82	FALSE
23	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	6.7	6.3	3.0e-10	0.97	0.04	0.66	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	6.7	6.7	1.7e-11	0.99	0.03	0.97	FALSE
25	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	6.5	-5.8	5.0e-09	-0.96	0.03	0.97	FALSE
26	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	6.7	6.6	3.0e-11	0.98	0.03	0.97	FALSE
27	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	6.7	6.7	1.6e-11	0.98	0.03	0.93	FALSE
28	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	6.5	-6.7	2.6e-11	-0.98	0.03	0.97	FALSE
29	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	6.1	-6.2	6.5e-10	-0.81	0.26	0.74	FALSE
30	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	6.2	-5.9	3.2e-09	-0.84	0.21	0.79	FALSE
31	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	6.5	5.3	1.1e-07	0.93	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-5.6	5.3	8.8e-08	0.31	0.03	0.17	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-5.6	-5.7	1.1e-08	-0.28	0.40	0.34	TRUE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	6.5	6.0	1.9e-09	0.97	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	6.7	5.9	4.5e-09	0.96	0.00	0.83	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	6.8	-5.7	1.2e-08	-0.94	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	6.8	6.5	1.1e-10	0.99	0.02	0.75	FALSE