TWAS hub - KCNH6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0170	0.00018	0.018	0.036	0.039	0.034	0.036	0.00250	0.00003	1.4e-05	4.3e-05	2.8e-05
2	TCGA	Brain Lower Grade Glioma	0.0661	0.0473	0.00860	0.043	0.018	0.027	NA	0.040	0.00001	0.00370	4.0e-04	NA	2.1e-05
3	TCGA	Lung Adenocarcinoma	0.0271	0.0168	0.00097	0.006	0.026	0.021	NA	0.015	0.05300	0.00044	1.4e-03	NA	6.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Eye problems/disorders: Diabetes related eye disease	11.3	12.4	21.4	1.5	-3.7	-4.6
Standing height	10.3	102.0	295.8	17.2	1.9	2.6
Height	9.5	182.6	501.8	22.4	3.6	5.7
Forced vital capacity (FVC), Best measure	9.1	33.2	97.6	9.9	0.1	-1.4
Forced vital capacity (FVC)	8.7	33.6	100.0	10.0	0.7	-0.5
Comparative height size at age 10	7.8	43.0	118.8	10.9	1.3	2.9
Sitting height	7.4	52.6	153.8	12.4	-1.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	7.1	22.6	63.4	8.0	-0.6	-2.0
Trunk fat-free mass	7.0	40.2	116.6	10.8	-1.4	1.3
Trunk predicted mass	6.9	39.4	114.5	10.7	-1.5	1.2
Forced expiratory volume in 1-second (FEV1)	6.6	22.1	64.2	8.0	-0.3	-1.4
Peak expiratory flow (PEF)	6.0	13.8	18.8	4.3	-3.0	-3.7
Forced expiratory volume in 1-second (FEV1), predicted	5.9	12.2	34.3	5.9	1.5	-0.3
Hand grip strength (right)	5.7	15.6	39.3	6.3	-1.5	-2.3
Whole body water mass	5.7	32.7	96.0	9.8	-1.2	0.9
Whole body fat-free mass	5.6	32.3	94.9	9.7	-1.0	1.0
Cardiovascular Disease	5.5	18.0	39.2	-1.2	-3.7	-6.3
Body Mass Index (BMI) (2010)	5.2	7.1	8.1	-2.6	-2.8	-2.6
Arm fat-free mass (right)	5.2	26.7	76.9	8.8	-1.7	0.5
High blood pressure (siblings)	5.0	7.2	12.0	0.5	-3.5	-3.1
Alzheimer’s Disease (in father)	4.9	5.3	7.7	-2.8	-0.8	2.8
Arm predicted mass (right)	4.7	24.3	69.6	8.3	-1.7	0.6
Hair/balding pattern: Pattern 3	4.6	6.8	13.8	2.0	3.7	1.6
Prostate Cancer	4.5	6.4	10.2	-3.2	2.5	1.6
Basal metabolic rate	4.5	24.7	73.3	8.6	-0.8	0.4
Worry too long after embarrassment	4.4	7.4	14.9	0.2	3.9	2.7
Leg fat-free mass (right)	4.4	23.3	69.2	8.3	-0.5	0.6
Leg predicted mass (right)	4.4	23.3	69.2	8.3	-0.5	0.6
Arm fat-free mass (left)	4.4	22.3	65.3	8.1	-1.3	0.2
Medication for cholesterol, blood pressure or diabetes	4.3	7.1	16.9	1.6	1.3	4.1
Mean time to correctly identify matches	4.3	8.2	13.0	-0.6	3.6	3.4
Lung cancer (father)	4.2	4.9	11.7	0.1	1.7	3.4
Alzheimer’s Disease (including proxy)	4.1	5.9	14.5	-1.5	1.0	3.8
Type 2 Diabetes (T2D) (2018)	4.1	7.8	21.3	-0.5	-1.3	-4.6
Leg fat-free mass (left)	4.0	21.1	63.2	8.0	-0.3	0.2
Leg predicted mass (left)	3.9	20.8	62.4	7.9	-0.2	0.2
Arm predicted mass (left)	3.9	19.7	56.7	7.5	-1.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.0	18.2	4.3	-1.8	-1.5
Illnesses of mother	3.7	4.6	10.8	3.3	-1.2	-1.3
Taking other prescription medications	3.6	5.6	16.5	-4.1	0.2	0.6
Cholesterol lowering medication	3.6	5.3	10.0	-3.2	-2.3	-0.7
Wheeze or whistling in the chest in last year	3.5	6.2	15.3	-3.9	0.9	1.6
Leg fat percentage (left)	3.5	12.7	35.6	-6.0	-0.1	-1.5
Leg fat percentage (right)	3.4	12.2	32.7	-5.7	0.2	-2.0
Exposure to tobacco smoke outside home	3.3	4.4	9.7	-3.1	-1.7	-0.9
Hand grip strength (left)	3.2	8.3	19.6	4.4	-1.4	-1.9
Medication for cholesterol	3.2	4.9	8.1	1.7	1.9	2.9
High cholesterol (Self-reported)	3.1	5.6	7.3	-1.8	-2.7	-2.5
Smoking status: Current	3.0	4.7	5.2	-2.0	2.3	2.2
Number of self-reported non-cancer illnesses	3.0	5.2	14.2	-3.8	-0.8	-0.8
Guilty feelings	3.0	4.5	6.8	0.5	2.6	2.6
Current tobacco smoking	2.9	4.7	5.7	-1.9	2.4	2.2
Medication: Blood pressure	2.9	5.2	11.9	-1.9	0.3	-3.5
Waist Hip Ratio (WHR)	2.8	12.7	21.2	-4.6	3.2	2.5
Qualifications: College or University degree	2.8	8.9	11.6	3.4	3.2	2.2
Medication: Omeprazole	2.8	3.3	9.2	-3.0	-0.0	0.8
Blood White Count	2.6	19.4	25.4	-4.0	-5.0	-4.1
Mouth/teeth dental problems: Mouth ulcers	2.6	4.2	10.6	1.3	3.3	0.6
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	9.0	-3.0	0.1	0.6
High blood pressure	2.5	6.9	14.1	-2.3	-1.1	-3.8
Arm fat percentage (right)	2.5	9.7	20.9	-4.6	0.7	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	7.9	-2.8	-0.7	-0.5
Diabetes diagnosed by doctor	2.5	4.1	12.1	-0.4	0.1	-3.5
Illnesses of father: None of the above (group 1)	2.5	3.1	9.0	3.0	0.0	-0.6
Medication: Simvastatin	2.4	3.5	6.6	-1.8	-0.8	-2.6
Hypertension (Self-reported)	2.4	6.6	14.7	-2.0	-1.1	-3.8
Breast cancer (self-reported)	2.4	2.9	6.0	1.3	-2.4	-1.1
Vascular/heart problems diagnosed by doctor	2.4	6.6	10.7	2.8	1.0	3.3
Number of treatments/medications taken	2.3	4.1	6.8	-2.6	0.7	-2.2
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	4.2	-1.7	2.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	7.1	-2.7	1.4	1.4
Medication: Cholesterol lowering	2.3	3.6	8.0	-1.6	-0.5	-2.8
Body fat percentage	2.3	9.2	19.6	-4.4	1.2	-2.5
Average weekly red wine intake	2.3	3.4	8.5	2.9	-1.1	-0.7
Respiratory disease	2.2	4.9	8.5	-2.9	-2.3	-1.0
Fluid intelligence score	2.2	4.6	9.1	3.0	1.9	1.1
Qualifications: O levels/GCSEs or equivalent	2.2	3.4	3.8	1.8	2.0	1.8
Mouth/teeth dental problems: Loose teeth	2.2	2.7	4.2	-0.2	2.0	1.9
Chest pain or discomfort	2.2	3.2	7.0	-2.6	0.9	1.3
Arm fat percentage (left)	2.2	8.8	18.6	-4.3	0.5	-2.8
Fed-up feelings	2.1	3.8	6.6	-2.6	-1.2	-1.9
Hair/balding pattern: Pattern 2	2.1	2.6	6.3	-1.2	-2.5	-0.3
Age at First Birth	2.0	2.9	4.1	2.0	1.9	0.9
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.7	-1.9	-1.2	-1.4
Blood Red Count	2.0	19.8	41.2	1.3	-6.4	-4.1
BMI	2.0	11.6	18.1	-4.3	-2.6	-3.1
Smoking Status	2.0	4.8	8.2	-2.9	1.2	2.2
Birth weight	2.0	4.4	6.6	2.6	0.6	2.5
Asthma (self-reported)	2.0	4.0	9.5	-3.1	-1.6	-0.1
Reaction Time	1.9	3.7	6.3	-0.4	2.1	2.5
Verbal and Numeric Reasoning (VNR)	1.9	4.6	6.2	2.5	1.5	2.4
Schizophrenia (2014)	1.9	4.2	7.2	0.8	2.2	2.7
Severe depression (siblings)	1.9	2.1	3.5	1.6	1.9	0.4
Serious illness, injury or assault to yourself	1.9	2.4	3.6	-1.9	1.4	1.2
Illnesses of siblings	1.9	2.6	5.8	0.8	2.4	1.2
Asthma	1.9	3.7	8.8	-3.0	-1.5	-0.2
Length of working week for main job	1.9	2.1	2.7	-1.4	-1.2	1.6
Eye problems/disorders: None of the above	1.9	2.2	3.9	2.0	1.6	0.6
Medication: Blood pressure	1.9	3.6	5.9	-1.2	-1.9	-2.4
Alcohol drinker status: Never	1.9	2.3	4.1	-0.5	2.0	1.6
Heart attack	1.8	2.3	6.1	-2.5	0.5	0.8
Impedance of arm (right)	1.8	8.4	24.0	-1.0	4.9	-0.2
Exposure to tobacco smoke at home	1.8	2.1	5.2	-2.3	-0.8	0.7
Knee pain experienced in last month	1.8	2.7	7.4	-2.7	0.4	0.8
Mother’s age at death	1.8	2.3	4.2	1.4	0.8	2.1
Risk taking	1.8	2.7	5.9	-1.2	0.8	2.4
Pack years of smoking	1.8	2.6	3.9	-2.0	-0.8	1.8
Alzheimer’s Disease (in mother)	1.7	2.0	3.5	-0.2	1.6	1.9
Ulcerative Colitis (UC)	1.7	3.2	5.8	1.7	0.9	2.4
Lung FVC	1.7	8.6	21.7	4.7	-1.7	-1.2
Trunk fat percentage	1.7	6.6	10.4	-3.2	1.8	-2.5
Qualifications: CSEs or equivalent	1.7	2.3	4.0	-1.6	0.7	-2.0
Diabetes (self-reported)	1.7	2.6	5.9	-1.2	-0.6	-2.4
Medication: Paracetamol	1.7	2.8	4.3	-1.9	0.7	-2.1
Medication: Paracetamol	1.7	2.7	3.8	-1.9	1.4	-1.5
Intelligence (Savage-Jansen 2018)	1.6	4.9	13.2	3.6	0.8	0.9
Body mass index (BMI)	1.6	6.7	16.3	-4.0	-0.8	-1.8
Comparative body size at age 10	1.6	4.3	12.1	-0.2	0.9	3.5
Medication for pain relief, constipation, heartburn	1.6	2.8	6.2	2.5	-0.6	1.3
Eye problems/disorders: Cataract	1.6	1.8	3.3	-1.8	0.9	1.2
Average weekly beer plus cider intake	1.6	2.4	6.3	-2.5	-0.1	0.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.9	-2.2	0.7	0.9
Schizophrenia (2018)	1.5	3.2	6.3	0.9	1.6	2.5
Medication: Metformin	1.5	2.1	4.2	-0.4	1.4	-2.0
Pack years adult smoking proportion	1.5	2.2	3.5	-1.9	-0.5	1.7
Hair/balding pattern: Pattern 4	1.5	3.6	10.8	3.3	0.2	-0.2
Neck or shoulder pain in last month	1.5	2.2	4.2	-1.0	1.2	2.1
Angina (self-reported)	1.5	1.9	4.0	-2.0	0.8	1.0
Number of full sisters	1.5	1.9	4.2	-0.3	-1.1	-2.1
Illnesses of father: Heart disease	1.5	2.1	5.2	-2.3	-1.0	-0.3
Fasting Glucose	1.4	1.7	4.6	-2.1	-0.5	-0.3
Primary Biliary Cirrhosis	1.4	2.0	3.1	-1.7	-0.1	1.8
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.2	1.4	-0.2	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	6.6	-2.6	-1.2	-1.1
Multivitamins +/- minerals	1.4	1.7	4.7	-0.0	2.2	-0.7
Alcohol usually taken with meals	1.4	2.3	2.5	1.4	-1.5	-1.6
Medication: Ramipril	1.4	1.8	4.2	-2.0	0.7	-0.9
Shortness of breath walking on level ground	1.4	1.7	4.9	-2.2	0.1	0.4
Angina	1.3	1.8	3.4	-1.8	0.7	1.2
Qualifications: None of the above	1.3	2.8	3.5	-1.7	-1.4	-1.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.4	-1.9	-0.1	1.2
Tense / ‘highly strung’	1.3	2.1	5.9	-0.1	-0.6	-2.4
Pulse wave peak to peak time	1.3	1.5	4.2	2.0	-0.6	-0.1
Heart disease (mother)	1.3	1.6	4.4	-2.1	-0.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.4	-1.8	1.1	-0.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.4	2.1	0.3	0.6
Handedness (chirality/laterality): Left-handed	1.3	1.6	1.7	-1.2	1.3	1.2
Miserableness	1.3	2.3	5.5	-0.5	2.4	-1.1
Ever smoked	1.3	2.3	5.9	-2.4	0.1	1.1
Heel T-Score	1.2	9.9	18.5	-4.3	-3.2	0.8
Systolic Blood Pressure	1.2	6.2	12.5	2.2	-1.1	-3.5
Ever had hysterectomy (womb removed)	1.2	1.3	3.1	0.0	1.8	1.0
Average weekly fortified wine intake	1.2	1.4	1.5	1.2	1.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	3.5	-1.9	-1.1	-0.2
Hearing difficulty/problems with background noise	1.2	1.9	4.3	0.2	2.1	1.1
Prospective memory result	1.2	1.4	2.8	-1.2	-1.7	-0.3
Impedance of arm (left)	1.2	5.5	16.0	-0.6	4.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.4	-0.3	1.3	1.5
Medication: Atorvastatin	1.2	1.5	2.4	-1.5	-1.4	-0.1
Commuting to job workplace: Cycle	1.2	1.5	4.1	2.0	-0.1	-0.6
Schizophrenia vs Biploar Disorder	1.1	1.4	3.1	-0.9	0.6	1.8
Sensitivity / hurt feelings	1.1	1.8	3.4	-0.7	1.9	-1.3
Medication for hormone replacement therapy	1.1	1.2	2.3	1.5	0.7	-1.0
Chronic bronchitis/emphysema (father)	1.1	1.3	2.5	-1.6	0.4	1.1
Past tobacco smoking	1.1	2.1	5.0	2.2	0.1	-1.1
Had other major operations	1.1	1.4	3.8	0.3	-2.0	-0.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.7	2.2	1.2	1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.5	4.0	-2.0	-0.3	0.6
Medication: Seretide 50 evohaler	1.1	1.3	3.0	-1.7	-0.6	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.6	-1.6	1.1	-0.2
Overall health rating	1.1	2.4	7.2	-2.7	0.2	-0.2
Supplements: Vitamin C	1.1	1.3	3.7	-0.3	0.2	1.9
Illnesses of siblings: Diabetes	1.1	1.4	3.9	-2.0	-0.4	-0.2
Qualifications: nursing, teaching	1.1	1.7	3.7	0.7	0.9	1.9
Osteoarthritis (self-reported)	1.1	1.4	2.0	-1.4	0.7	1.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.7	1.9	-0.4	0.0
Supplements: Zinc	1.0	1.1	3.1	0.1	1.8	0.4
Medication: Co-codamol	1.0	1.1	2.6	-1.6	0.8	-0.3
Impedance of leg (right)	1.0	4.7	7.1	-2.6	2.7	-0.5
Age when periods started (menarche)	1.0	2.5	7.4	-0.1	0.2	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	6.3	-2.5	-0.7	-0.0
Allergy	1.0	2.3	3.9	1.6	2.0	0.6
Weight	1.0	5.1	15.1	3.9	0.2	-0.3
Father’s age at death	1.0	1.3	2.6	1.1	1.6	0.3
Long-standing illness, disability or infirmity	1.0	1.6	4.0	-2.0	-0.8	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.9	0.5	1.7	-0.5
Average weekly champagne plus white wine intake	1.0	1.4	1.9	1.1	-1.4	-1.0
Eye problems/disorders: Glaucoma	1.0	1.1	2.2	-1.5	-0.3	-1.1
Illnesses of father: High blood pressure	1.0	1.2	2.8	-0.9	-0.4	-1.7
Irritability	1.0	1.7	5.0	0.3	2.2	0.2
Impedance of whole body	1.0	5.2	11.5	-2.0	3.4	-0.5
Depressed Affect (Nagel 2018)	0.9	1.9	3.7	-1.9	1.4	-0.4
Neuroticism (Nagel 2018)	0.9	2.0	5.2	-0.9	2.3	-0.3
Ovarian Cancer	0.9	1.2	1.9	-0.9	-1.4	-0.9
Rheumatoid Arthritis	0.9	1.2	1.8	-0.8	1.3	1.0
Vitamin and mineral supplements	0.9	1.2	3.4	0.1	-1.8	-0.4
Impedance of leg (left)	0.9	4.6	8.3	-2.9	2.4	-0.0
Hip circumference	0.9	3.7	7.1	2.7	-0.1	-2.0
Time employed in main current job	0.9	1.0	1.6	0.6	-1.3	1.1
Birth weight of first child	0.9	1.6	2.7	1.6	-1.5	0.2
Medication: Aspirin	0.9	1.1	2.1	-1.4	0.2	-1.1
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.7	1.6	1.0	0.2
Fractured/broken bones in last 5 years	0.9	1.2	3.3	1.8	-0.2	0.4
Pain experienced in last month	0.9	1.5	3.0	1.7	1.2	-0.1
Depression (Nagel 2018)	0.8	1.3	3.5	-1.9	0.4	0.5
Irritable Bowel Disease (IBD)	0.8	1.9	4.3	0.9	-0.7	2.1
Crohns Disease (2012)	0.8	1.2	3.5	-0.3	-1.9	0.1
Neuroticism	0.8	1.9	4.1	-1.2	2.0	-0.4
Alcohol intake versus 10 years previously	0.8	1.1	2.3	-1.5	-1.1	-0.0
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	-0.4	-1.6	-1.1
Pulse wave reflection index	0.8	1.0	2.0	-1.4	-0.9	-0.5
Headache pain in last month	0.8	1.4	3.7	-0.8	0.1	-1.9
Glaucoma (self-reported)	0.8	1.0	2.3	-0.8	-0.0	-1.5
Medication: Amlodipine	0.8	1.1	1.6	-1.2	0.8	-1.1
Emphysema/chronic bronchitis	0.8	0.9	2.5	-0.2	-1.6	-0.5
Medication: Aspirin	0.8	1.1	2.6	-1.6	0.1	-0.8
Ever had bowel cancer screening	0.8	1.0	2.8	0.3	0.2	1.7
Friendships satisfaction	0.8	1.0	1.8	1.1	-0.0	-1.4
Commuting to job workplace: Walk	0.8	0.9	1.8	1.3	0.2	-0.9
Ever depressed for a whole week	0.8	0.9	2.5	1.6	0.5	-0.1
Alcohol drinker status: Previous	0.8	0.9	0.9	-0.9	0.9	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.7	2.9	0.4	1.4	1.7
Bipolar Disorder (2011)	0.7	0.7	2.0	1.4	0.0	0.0
Blood Platelet Count	0.7	8.0	13.4	-3.7	-2.5	-2.1
Hypothyroidism (self reported)	0.7	1.5	3.6	1.0	1.9	0.0
Lung FEV1/FVC ratio	0.7	3.4	5.1	-2.2	-2.0	-1.1
Hearing difficulty/problems: Yes	0.7	1.1	2.0	-0.4	1.4	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	-1.4	-0.6	0.7
Diabetes (father)	0.7	0.9	1.4	-1.2	1.2	-0.1
Waist circumference	0.7	2.5	5.6	-2.4	1.3	0.2
Pain all over the body in last month	0.7	0.7	1.9	-1.4	0.2	0.4
Medication: Lansoprazole	0.7	0.8	1.4	-1.2	0.5	-0.9
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.1	-0.9	1.1	-0.7
Medication: Gliclazide	0.7	0.8	1.4	-1.2	0.6	-0.8
Hearing aid user	0.7	0.8	1.1	-1.0	-1.1	-0.3
Crohns Disease (2017)	0.6	1.3	2.8	-0.1	-1.7	1.0
Breast Cancer	0.6	1.4	2.7	-1.6	0.9	0.8
HbA1C	0.6	0.7	1.3	-1.1	-0.7	-0.5
Allergy or Eczema	0.6	1.5	2.6	-0.9	-1.6	-1.0
Maternal smoking around birth	0.6	0.9	2.0	0.1	-1.4	-0.9
High blood pressure (mother)	0.6	0.8	2.0	-0.7	-0.2	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	1.3	0.0	-1.0
Gout (self-reported)	0.6	0.8	2.1	1.4	-0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.6	1.1	1.6	-0.2
Migraine (self-reported)	0.6	0.7	1.9	-1.4	-0.4	-0.2
Age at last live birth	0.6	0.9	0.9	1.0	-0.9	-0.9
Ever taken oral contraceptive pill	0.6	0.7	1.7	0.5	1.3	0.4
Commuting to job workplace: Public transport	0.6	0.8	2.1	1.5	0.3	0.2
Medication: Lisinopril	0.6	0.8	1.6	-1.3	-0.4	-0.8
HDL Cholesterol	0.5	0.8	1.4	-0.4	1.2	1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-1.4	0.1	-0.3
Systolic blood pressure, automated reading	0.5	1.5	4.4	0.0	-0.4	-2.1
Nervous feelings	0.5	1.0	2.2	-0.4	1.5	0.7
Financial difficulties in last 2 years	0.5	0.7	1.8	-1.3	-0.6	0.0
Noisy workplace	0.5	0.6	1.5	-1.2	-0.4	-0.3
Depression (self-reported)	0.5	0.6	1.5	1.2	-0.6	-0.2
Arm fat mass (right)	0.5	2.0	5.0	-1.1	0.1	-2.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.9	-0.9	-0.8	0.6
Medication: Allopurinol	0.5	0.6	1.3	1.1	-0.3	-0.7
Smoking status: Previous	0.5	0.7	1.4	-1.2	-0.9	0.2
Back pain experienced in last month	0.5	0.7	1.6	-0.6	-1.3	-0.4
Arm fat mass (left)	0.5	2.0	5.0	-1.0	0.1	-2.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.6	-1.3	-0.1	0.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-0.3	-0.6	-1.0
Diastolic blood pressure, automated reading	0.5	1.7	3.2	1.3	0.3	-1.8
Worry (Nagel 2018)	0.4	0.8	2.4	0.1	-0.0	-1.5
LDL Cholesterol	0.4	0.6	0.8	-0.9	-0.4	-0.9
Triglycerides	0.4	0.7	1.1	0.4	-0.8	-1.1
Ulcerative Colitis	0.4	0.7	1.9	1.4	0.1	-0.3
Relative age of first facial hair	0.4	0.9	2.0	-0.3	1.4	-0.7
Townsend deprivation index at recruitment	0.4	0.6	1.5	-1.2	0.5	0.0
Relative age voice broke	0.4	0.6	1.3	0.1	0.8	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-1.1	0.7	-0.5
Neuroticism score	0.4	0.9	1.5	-0.3	1.2	-1.0
Number of live births	0.4	0.6	1.6	0.2	1.3	-0.1
Whole body fat mass	0.4	1.7	4.0	-0.6	0.8	-2.0
Leg fat mass (right)	0.4	1.6	3.0	-1.7	0.3	-1.3
Alcohol intake frequency.	0.4	1.0	2.9	-1.7	0.3	-0.4
Leg pain on walking	0.4	0.5	0.9	0.9	0.7	-0.3
Mood swings	0.4	0.8	1.1	-1.1	-0.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.7	0.8	0.4
Number of operations (self-reported)	0.4	0.5	0.7	-0.8	0.5	0.8
Supplements: Calcium	0.4	0.5	1.0	1.0	0.2	-0.6
Leg fat mass (left)	0.4	1.7	3.4	-1.8	0.0	-1.3
Lupus	0.3	0.4	1.1	-1.1	0.4	-0.0
Neuroticism (2016)	0.3	0.4	1.1	0.2	0.3	-1.0
Blood Eosinophil Count	0.3	2.3	3.8	-1.3	-2.0	-1.1
Diabetes (mother)	0.3	0.4	0.9	-0.6	0.9	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.5	0.9	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-0.6	-1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.8	0.5	-0.1
Medication: Atenolol	0.3	0.4	1.0	-1.0	0.4	0.3
Trunk fat mass	0.3	1.5	2.8	-0.2	1.3	-1.7
Number of incorrect matches in round	0.3	0.5	0.7	-0.7	-0.8	0.4
Worrier / anxious feelings	0.3	0.5	1.0	0.7	-0.0	-1.0
Pulse rate	0.3	0.4	1.3	-1.1	0.1	-0.0
Happiness	0.3	0.4	1.0	1.0	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	0.9	-0.4	-0.0
Breastfed as a baby	0.3	0.3	0.8	-0.2	0.4	0.9
Loud music exposure frequency	0.3	0.3	0.9	0.2	0.3	0.9
Number of children fathered	0.3	0.3	0.7	0.3	-0.4	-0.8
Suffer from ‘nerves’	0.3	0.5	1.5	-1.2	0.2	0.3
Family relationship satisfaction	0.3	0.4	0.7	0.8	0.6	0.2
Loneliness, isolation	0.3	0.4	0.6	-0.2	-0.8	-0.7
Medication: Bendroflumethiazide	0.3	0.5	1.5	0.2	0.2	-1.2
Age started oral contraceptive pill	0.3	0.4	0.9	0.6	0.9	0.0
Unable to work because of sickness or disability	0.3	0.4	1.1	-0.2	0.5	1.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	0.9	-0.3	0.2
Mean Putamen Volume	0.2	0.2	0.4	-0.4	0.6	-0.1
Chronotype (morning person)	0.2	0.6	1.6	-0.2	-0.2	-1.3
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.2	0.4	0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.8	-0.0	-0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.5	0.7	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	-0.8	-0.3	-0.3
Age at first live birth	0.2	0.4	0.6	0.6	-0.8	0.5
Health satisfaction	0.2	0.3	0.5	-0.2	-0.5	-0.7
Had major operations	0.2	0.2	0.4	-0.4	0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.8	-0.9	0.0	-0.0
Financial situation satisfaction	0.2	0.2	0.4	0.2	-0.5	-0.7
Myopia	0.2	0.3	0.4	0.4	0.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.0	-0.6	-0.5
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.4	0.3	-0.4
Major Depression (MDD)	0.1	0.1	0.2	0.4	-0.1	-0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.2	0.0	-0.6
Hair Pigment	0.1	4.1	6.7	-2.6	1.3	2.0
Tanning	0.1	0.9	2.3	1.5	0.5	0.4
Average weekly spirits intake	0.1	0.1	0.2	-0.5	0.2	0.2
Supplements: Glucosamine	0.1	0.1	0.2	-0.5	0.1	-0.2
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	0.5	0.1
Mouth/teeth dental problems	0.1	0.2	0.3	0.5	-0.3	-0.5
Falls in the last year	0.1	0.1	0.2	-0.4	0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.0	0.3	0.3
Blood clot in the leg (DVT)	0.1	0.2	0.4	0.1	-0.6	-0.3
Number of full brothers	0.1	0.2	0.4	-0.6	0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.2	0.6	-0.0
Medication: Ibuprofen	0.1	0.2	0.4	0.3	0.1	0.6
Pulse rate, automated reading	0.1	0.2	0.3	-0.6	-0.3	-0.4
Mineral and other dietary supplements	0.1	0.1	0.1	-0.3	-0.2	-0.3
Osteoporosis (self-reported)	0.1	0.2	0.4	0.6	-0.2	-0.1
Wears glasses or contact lenses	0.1	0.2	0.2	-0.2	0.5	0.5
Heart disease (siblings)	0.1	0.2	0.3	-0.5	0.0	0.5
Had menopause	0.0	0.0	0.1	0.2	-0.1	-0.1

Hub : Genes

KCNH6

Models

Trait associations