Hub : Genes

KCNH6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0400 0.0170 0.00018 0.018 0.036 0.039 0.034 0.036 0.00250 0.00003 1.4e-05 4.3e-05 2.8e-05
2 TCGA Brain Lower Grade Glioma 0.0661 0.0473 0.00860 0.043 0.018 0.027 NA 0.040 0.00001 0.00370 4.0e-04 NA 2.1e-05
3 TCGA Lung Adenocarcinoma 0.0271 0.0168 0.00097 0.006 0.026 0.021 NA 0.015 0.05300 0.00044 1.4e-03 NA 6.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.2 -0.4 0.3 -0.4
Bipolar Disorder or Schizophrenia 0.7 1.7 2.9 0.4 1.4 1.7
Depressed Affect (Nagel 2018) 0.9 1.9 3.7 -1.9 1.4 -0.4
Depression (Nagel 2018) 0.8 1.3 3.5 -1.9 0.4 0.5
Intelligence (Savage-Jansen 2018) 1.6 4.9 13.2 3.6 0.8 0.9
Neuroticism (Nagel 2018) 0.9 2.0 5.2 -0.9 2.3 -0.3
Schizophrenia (2018) 1.5 3.2 6.3 0.9 1.6 2.5
Schizophrenia vs Biploar Disorder 1.1 1.4 3.1 -0.9 0.6 1.8
Worry (Nagel 2018) 0.4 0.8 2.4 0.1 -0.0 -1.5
Alzheimer’s Disease (in mother) 1.7 2.0 3.5 -0.2 1.6 1.9
Alzheimer’s Disease (in father) 4.9 5.3 7.7 -2.8 -0.8 2.8
Alzheimer’s Disease (including proxy) 4.1 5.9 14.5 -1.5 1.0 3.8
Crohns Disease (2017) 0.6 1.3 2.8 -0.1 -1.7 1.0
Irritable Bowel Disease (IBD) 0.8 1.9 4.3 0.9 -0.7 2.1
Ulcerative Colitis (UC) 1.7 3.2 5.8 1.7 0.9 2.4
Major Depression (MDD) 0.1 0.1 0.2 0.4 -0.1 -0.2
Reaction Time 1.9 3.7 6.3 -0.4 2.1 2.5
Verbal and Numeric Reasoning (VNR) 1.9 4.6 6.2 2.5 1.5 2.4
Breast Cancer 0.6 1.4 2.7 -1.6 0.9 0.8
Ovarian Cancer 0.9 1.2 1.9 -0.9 -1.4 -0.9
Prostate Cancer 4.5 6.4 10.2 -3.2 2.5 1.6
Age at First Birth 2.0 2.9 4.1 2.0 1.9 0.9
Bipolar Disorder (2011) 0.7 0.7 2.0 1.4 0.0 0.0
Body Mass Index (BMI) (2010) 5.2 7.1 8.1 -2.6 -2.8 -2.6
Coronary Artery Disease (CAD) 0.1 0.1 0.3 0.2 0.0 -0.6
Crohns Disease (2012) 0.8 1.2 3.5 -0.3 -1.9 0.1
Mean Putamen Volume 0.2 0.2 0.4 -0.4 0.6 -0.1
Fasting Glucose 1.4 1.7 4.6 -2.1 -0.5 -0.3
HbA1C 0.6 0.7 1.3 -1.1 -0.7 -0.5
HDL Cholesterol 0.5 0.8 1.4 -0.4 1.2 1.0
LDL Cholesterol 0.4 0.6 0.8 -0.9 -0.4 -0.9
Lupus 0.3 0.4 1.1 -1.1 0.4 -0.0
Neuroticism (2016) 0.3 0.4 1.1 0.2 0.3 -1.0
Primary Biliary Cirrhosis 1.4 2.0 3.1 -1.7 -0.1 1.8
Rheumatoid Arthritis 0.9 1.2 1.8 -0.8 1.3 1.0
Schizophrenia (2014) 1.9 4.2 7.2 0.8 2.2 2.7
Triglycerides 0.4 0.7 1.1 0.4 -0.8 -1.1
Type 2 Diabetes (T2D) (2012) 2.0 2.3 3.7 -1.9 -1.2 -1.4
Ulcerative Colitis 0.4 0.7 1.9 1.4 0.1 -0.3
Blood Eosinophil Count 0.3 2.3 3.8 -1.3 -2.0 -1.1
Blood Platelet Count 0.7 8.0 13.4 -3.7 -2.5 -2.1
Blood Red Count 2.0 19.8 41.2 1.3 -6.4 -4.1
Blood White Count 2.6 19.4 25.4 -4.0 -5.0 -4.1
Heel T-Score 1.2 9.9 18.5 -4.3 -3.2 0.8
BMI 2.0 11.6 18.1 -4.3 -2.6 -3.1
Height 9.5 182.6 501.8 22.4 3.6 5.7
Waist Hip Ratio (WHR) 2.8 12.7 21.2 -4.6 3.2 2.5
Systolic Blood Pressure 1.2 6.2 12.5 2.2 -1.1 -3.5
Smoking Status 2.0 4.8 8.2 -2.9 1.2 2.2
Allergy or Eczema 0.6 1.5 2.6 -0.9 -1.6 -1.0
Cardiovascular Disease 5.5 18.0 39.2 -1.2 -3.7 -6.3
Hypothyroidism (self reported) 0.7 1.5 3.6 1.0 1.9 0.0
Respiratory disease 2.2 4.9 8.5 -2.9 -2.3 -1.0
Type 2 Diabetes (T2D) (2018) 4.1 7.8 21.3 -0.5 -1.3 -4.6
Lung FEV1/FVC ratio 0.7 3.4 5.1 -2.2 -2.0 -1.1
Lung FVC 1.7 8.6 21.7 4.7 -1.7 -1.2
Neuroticism 0.8 1.9 4.1 -1.2 2.0 -0.4
Chronotype (morning person) 0.2 0.6 1.6 -0.2 -0.2 -1.3
Hair Pigment 0.1 4.1 6.7 -2.6 1.3 2.0
Tanning 0.1 0.9 2.3 1.5 0.5 0.4
Hand grip strength (left) 3.2 8.3 19.6 4.4 -1.4 -1.9
Number of treatments/medications taken 2.3 4.1 6.8 -2.6 0.7 -2.2
Average weekly spirits intake 0.1 0.1 0.2 -0.5 0.2 0.2
Sensitivity / hurt feelings 1.1 1.8 3.4 -0.7 1.9 -1.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.9 -1.4 0.1 -0.3
Hearing difficulty/problems: Yes 0.7 1.1 2.0 -0.4 1.4 1.1
Relative age of first facial hair 0.4 0.9 2.0 -0.3 1.4 -0.7
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.9 -1.4 -0.6 0.7
Ever used hormone-replacement therapy (HRT) 1.4 1.8 3.2 1.4 -0.2 -1.8
Ever had hysterectomy (womb removed) 1.2 1.3 3.1 0.0 1.8 1.0
Systolic blood pressure, automated reading 0.5 1.5 4.4 0.0 -0.4 -2.1
Eye problems/disorders: Diabetes related eye disease 11.3 12.4 21.4 1.5 -3.7 -4.6
Angina 1.3 1.8 3.4 -1.8 0.7 1.2
Medication for hormone replacement therapy 1.1 1.2 2.3 1.5 0.7 -1.0
Vitamin and mineral supplements 0.9 1.2 3.4 0.1 -1.8 -0.4
Supplements: Zinc 1.0 1.1 3.1 0.1 1.8 0.4
Medication: Co-codamol 1.0 1.1 2.6 -1.6 0.8 -0.3
Medication: Metformin 1.5 2.1 4.2 -0.4 1.4 -2.0
Diabetes (father) 0.7 0.9 1.4 -1.2 1.2 -0.1
Diabetes (mother) 0.3 0.4 0.9 -0.6 0.9 0.2
Severe depression (siblings) 1.9 2.1 3.5 1.6 1.9 0.4
Pack years adult smoking proportion 1.5 2.2 3.5 -1.9 -0.5 1.7
Impedance of leg (right) 1.0 4.7 7.1 -2.6 2.7 -0.5
Leg fat-free mass (left) 4.0 21.1 63.2 8.0 -0.3 0.2
Trunk fat percentage 1.7 6.6 10.4 -3.2 1.8 -2.5
Hand grip strength (right) 5.7 15.6 39.3 6.3 -1.5 -2.3
Townsend deprivation index at recruitment 0.4 0.6 1.5 -1.2 0.5 0.0
Current tobacco smoking 2.9 4.7 5.7 -1.9 2.4 2.2
Average weekly fortified wine intake 1.2 1.4 1.5 1.2 1.2 1.1
Maternal smoking around birth 0.6 0.9 2.0 0.1 -1.4 -0.9
Fed-up feelings 2.1 3.8 6.6 -2.6 -1.2 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 3.5 -1.9 -1.1 -0.2
Relative age voice broke 0.4 0.6 1.3 0.1 0.8 -1.2
Taking other prescription medications 3.6 5.6 16.5 -4.1 0.2 0.6
Age when periods started (menarche) 1.0 2.5 7.4 -0.1 0.2 -2.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 0.5 0.9 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 6.6 -2.6 -1.2 -1.1
Tinnitus: Yes, but not now, but have in the past 2.3 2.4 4.2 -1.7 2.1 0.5
Qualifications: CSEs or equivalent 1.7 2.3 4.0 -1.6 0.7 -2.0
Serious illness, injury or assault to yourself 1.9 2.4 3.6 -1.9 1.4 1.2
High blood pressure 2.5 6.9 14.1 -2.3 -1.1 -3.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.5 -0.6 -1.2 -0.5
Multivitamins +/- minerals 1.4 1.7 4.7 -0.0 2.2 -0.7
Stomach or abdominal pain in last month 0.2 0.2 0.6 0.2 0.4 0.7
Supplements: Glucosamine 0.1 0.1 0.2 -0.5 0.1 -0.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 0.8 0.5 -0.1
Medication: Atenolol 0.3 0.4 1.0 -1.0 0.4 0.3
Medication: Levothyroxine sodium 0.1 0.1 0.2 -0.3 0.5 0.1
Sitting height 7.4 52.6 153.8 12.4 -1.8 0.8
Chronic bronchitis/emphysema (father) 1.1 1.3 2.5 -1.6 0.4 1.1
High blood pressure (mother) 0.6 0.8 2.0 -0.7 -0.2 -1.4
Body mass index (BMI) 1.6 6.7 16.3 -4.0 -0.8 -1.8
Impedance of leg (left) 0.9 4.6 8.3 -2.9 2.4 -0.0
Leg predicted mass (left) 3.9 20.8 62.4 7.9 -0.2 0.2
Trunk fat mass 0.3 1.5 2.8 -0.2 1.3 -1.7
Waist circumference 0.7 2.5 5.6 -2.4 1.3 0.2
Number of incorrect matches in round 0.3 0.5 0.7 -0.7 -0.8 0.4
Past tobacco smoking 1.1 2.1 5.0 2.2 0.1 -1.1
Alcohol usually taken with meals 1.4 2.3 2.5 1.4 -1.5 -1.6
Nervous feelings 0.5 1.0 2.2 -0.4 1.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.1 -1.1 0.7 -0.5
Hearing difficulty/problems with background noise 1.2 1.9 4.3 0.2 2.1 1.1
Hair/balding pattern: Pattern 2 2.1 2.6 6.3 -1.2 -2.5 -0.3
Had menopause 0.0 0.0 0.1 0.2 -0.1 -0.1
Had other major operations 1.1 1.4 3.8 0.3 -2.0 -0.5
Forced vital capacity (FVC) 8.7 33.6 100.0 10.0 0.7 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 6.3 -2.5 -0.7 -0.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.7 -0.8 -0.0 -0.2
Qualifications: None of the above 1.3 2.8 3.5 -1.7 -1.4 -1.9
Financial difficulties in last 2 years 0.5 0.7 1.8 -1.3 -0.6 0.0
Mouth/teeth dental problems 0.1 0.2 0.3 0.5 -0.3 -0.5
Heart attack 1.8 2.3 6.1 -2.5 0.5 0.8
Allergy 1.0 2.3 3.9 1.6 2.0 0.6
Pain all over the body in last month 0.7 0.7 1.9 -1.4 0.2 0.4
Diabetes (self-reported) 1.7 2.6 5.9 -1.2 -0.6 -2.4
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.4 -1.9 -0.1 1.2
Medication: Ramipril 1.4 1.8 4.2 -2.0 0.7 -0.9
Medication: Simvastatin 2.4 3.5 6.6 -1.8 -0.8 -2.6
Fluid intelligence score 2.2 4.6 9.1 3.0 1.9 1.1
Illnesses of siblings 1.9 2.6 5.8 0.8 2.4 1.2
Neuroticism score 0.4 0.9 1.5 -0.3 1.2 -1.0
Weight 1.0 5.1 15.1 3.9 0.2 -0.3
Impedance of arm (right) 1.8 8.4 24.0 -1.0 4.9 -0.2
Arm fat percentage (right) 2.5 9.7 20.9 -4.6 0.7 -2.8
Trunk fat-free mass 7.0 40.2 116.6 10.8 -1.4 1.3
Hip circumference 0.9 3.7 7.1 2.7 -0.1 -2.0
Time employed in main current job 0.9 1.0 1.6 0.6 -1.3 1.1
Alcohol intake versus 10 years previously 0.8 1.1 2.3 -1.5 -1.1 -0.0
Father’s age at death 1.0 1.3 2.6 1.1 1.6 0.3
Worrier / anxious feelings 0.3 0.5 1.0 0.7 -0.0 -1.0
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 7.1 -2.7 1.4 1.4
Falls in the last year 0.1 0.1 0.2 -0.4 0.2 -0.3
Hair/balding pattern: Pattern 3 4.6 6.8 13.8 2.0 3.7 1.6
Number of live births 0.4 0.6 1.6 0.2 1.3 -0.1
Forced expiratory volume in 1-second (FEV1) 6.6 22.1 64.2 8.0 -0.3 -1.4
Pulse rate 0.3 0.4 1.3 -1.1 0.1 -0.0
Happiness 0.3 0.4 1.0 1.0 -0.1 -0.2
Noisy workplace 0.5 0.6 1.5 -1.2 -0.4 -0.3
Qualifications: A levels/AS levels or equivalent 1.1 2.5 4.7 2.2 1.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.0 0.3 0.3
Mouth/teeth dental problems: Dentures 0.8 1.3 2.6 -0.4 -1.6 -1.1
Asthma 1.9 3.7 8.8 -3.0 -1.5 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.9 0.9 -0.4 -0.0
Medication: Cholesterol lowering 2.3 3.6 8.0 -1.6 -0.5 -2.8
Depression (self-reported) 0.5 0.6 1.5 1.2 -0.6 -0.2
Medication: Lansoprazole 0.7 0.8 1.4 -1.2 0.5 -0.9
Prospective memory result 1.2 1.4 2.8 -1.2 -1.7 -0.3
Lung cancer (father) 4.2 4.9 11.7 0.1 1.7 3.4
Illnesses of mother 3.7 4.6 10.8 3.3 -1.2 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 7.1 22.6 63.4 8.0 -0.6 -2.0
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 -0.5 0.7 0.1
Impedance of arm (left) 1.2 5.5 16.0 -0.6 4.0 -0.3
Arm fat mass (right) 0.5 2.0 5.0 -1.1 0.1 -2.2
Trunk predicted mass 6.9 39.4 114.5 10.7 -1.5 1.2
Standing height 10.3 102.0 295.8 17.2 1.9 2.6
Length of working week for main job 1.9 2.1 2.7 -1.4 -1.2 1.6
Exposure to tobacco smoke at home 1.8 2.1 5.2 -2.3 -0.8 0.7
Breastfed as a baby 0.3 0.3 0.8 -0.2 0.4 0.9
Tense / ‘highly strung’ 1.3 2.1 5.9 -0.1 -0.6 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.6 1.3 0.0 -1.0
Hair/balding pattern: Pattern 4 1.5 3.6 10.8 3.3 0.2 -0.2
Birth weight of first child 0.9 1.6 2.7 1.6 -1.5 0.2
Peak expiratory flow (PEF) 6.0 13.8 18.8 4.3 -3.0 -3.7
Pulse wave reflection index 0.8 1.0 2.0 -1.4 -0.9 -0.5
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.1 -0.9 1.1 -0.7
Loud music exposure frequency 0.3 0.3 0.9 0.2 0.3 0.9
Qualifications: O levels/GCSEs or equivalent 2.2 3.4 3.8 1.8 2.0 1.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 0.9 -0.9 -0.8 0.6
Blood clot in the leg (DVT) 0.1 0.2 0.4 0.1 -0.6 -0.3
Medication: Paracetamol 1.7 2.8 4.3 -1.9 0.7 -2.1
Headache pain in last month 0.8 1.4 3.7 -0.8 0.1 -1.9
Medication for cholesterol, blood pressure or diabetes 4.3 7.1 16.9 1.6 1.3 4.1
Glaucoma (self-reported) 0.8 1.0 2.3 -0.8 -0.0 -1.5
Gout (self-reported) 0.6 0.8 2.1 1.4 -0.2 -0.5
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.6 1.1 1.6 -0.2
Medication: Amlodipine 0.8 1.1 1.6 -1.2 0.8 -1.1
Medication: Ventolin 100micrograms inhaler 1.1 1.5 4.0 -2.0 -0.3 0.6
Birth weight 2.0 4.4 6.6 2.6 0.6 2.5
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.7 -0.8 -0.3 -0.3
High blood pressure (siblings) 5.0 7.2 12.0 0.5 -3.5 -3.1
Forced vital capacity (FVC), Best measure 9.1 33.2 97.6 9.9 0.1 -1.4
Body fat percentage 2.3 9.2 19.6 -4.4 1.2 -2.5
Leg fat percentage (right) 3.4 12.2 32.7 -5.7 0.2 -2.0
Arm fat-free mass (right) 5.2 26.7 76.9 8.8 -1.7 0.5
Exposure to tobacco smoke outside home 3.3 4.4 9.7 -3.1 -1.7 -0.9
Comparative body size at age 10 1.6 4.3 12.1 -0.2 0.9 3.5
Number of full brothers 0.1 0.2 0.4 -0.6 0.3 0.1
Worry too long after embarrassment 4.4 7.4 14.9 0.2 3.9 2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 -0.2 0.6 -0.0
Wheeze or whistling in the chest in last year 3.5 6.2 15.3 -3.9 0.9 1.6
Number of children fathered 0.3 0.3 0.7 0.3 -0.4 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.4 -0.3 1.3 1.5
Age at first live birth 0.2 0.4 0.6 0.6 -0.8 0.5
Pulse wave peak to peak time 1.3 1.5 4.2 2.0 -0.6 -0.1
Health satisfaction 0.2 0.3 0.5 -0.2 -0.5 -0.7
Shortness of breath walking on level ground 1.4 1.7 4.9 -2.2 0.1 0.4
Qualifications: College or University degree 2.8 8.9 11.6 3.4 3.2 2.2
Eye problems/disorders: None of the above 1.9 2.2 3.9 2.0 1.6 0.6
Mouth/teeth dental problems: Loose teeth 2.2 2.7 4.2 -0.2 2.0 1.9
Emphysema/chronic bronchitis 0.8 0.9 2.5 -0.2 -1.6 -0.5
Medication for pain relief, constipation, heartburn 1.6 2.8 6.2 2.5 -0.6 1.3
Neck or shoulder pain in last month 1.5 2.2 4.2 -1.0 1.2 2.1
Medication: Blood pressure 2.9 5.2 11.9 -1.9 0.3 -3.5
Angina (self-reported) 1.5 1.9 4.0 -2.0 0.8 1.0
Migraine (self-reported) 0.6 0.7 1.9 -1.4 -0.4 -0.2
Medication: Ibuprofen 0.1 0.2 0.4 0.3 0.1 0.6
Medication: Allopurinol 0.5 0.6 1.3 1.1 -0.3 -0.7
Medication: Omeprazole 2.8 3.3 9.2 -3.0 -0.0 0.8
Medication: Seretide 50 evohaler 1.1 1.3 3.0 -1.7 -0.6 0.7
Mean time to correctly identify matches 4.3 8.2 13.0 -0.6 3.6 3.4
Heart disease (mother) 1.3 1.6 4.4 -2.1 -0.5 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.6 -1.6 1.1 -0.2
Whole body fat mass 0.4 1.7 4.0 -0.6 0.8 -2.0
Leg fat mass (right) 0.4 1.6 3.0 -1.7 0.3 -1.3
Arm predicted mass (right) 4.7 24.3 69.6 8.3 -1.7 0.6
Pulse rate, automated reading 0.1 0.2 0.3 -0.6 -0.3 -0.4
Alcohol intake frequency. 0.4 1.0 2.9 -1.7 0.3 -0.4
Comparative height size at age 10 7.8 43.0 118.8 10.9 1.3 2.9
Number of full sisters 1.5 1.9 4.2 -0.3 -1.1 -2.1
Suffer from ‘nerves’ 0.3 0.5 1.5 -1.2 0.2 0.3
Overall health rating 1.1 2.4 7.2 -2.7 0.2 -0.2
Chest pain or discomfort 2.2 3.2 7.0 -2.6 0.9 1.3
Had major operations 0.2 0.2 0.4 -0.4 0.7 0.3
Age at last live birth 0.6 0.9 0.9 1.0 -0.9 -0.9
Family relationship satisfaction 0.3 0.4 0.7 0.8 0.6 0.2
Leg pain on walking 0.4 0.5 0.9 0.9 0.7 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.4 -1.8 1.1 -0.2
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 -0.9 0.0 -0.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 4.4 2.1 0.3 0.6
Medication: Aspirin 0.8 1.1 2.6 -1.6 0.1 -0.8
Supplements: Vitamin C 1.1 1.3 3.7 -0.3 0.2 1.9
Knee pain experienced in last month 1.8 2.7 7.4 -2.7 0.4 0.8
Hypertension (Self-reported) 2.4 6.6 14.7 -2.0 -1.1 -3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 7.9 -2.8 -0.7 -0.5
Illnesses of father: Heart disease 1.5 2.1 5.2 -2.3 -1.0 -0.3
Illnesses of siblings: Diabetes 1.1 1.4 3.9 -2.0 -0.4 -0.2
Smoking status: Previous 0.5 0.7 1.4 -1.2 -0.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted 5.9 12.2 34.3 5.9 1.5 -0.3
Whole body fat-free mass 5.6 32.3 94.9 9.7 -1.0 1.0
Leg fat-free mass (right) 4.4 23.3 69.2 8.3 -0.5 0.6
Arm fat percentage (left) 2.2 8.8 18.6 -4.3 0.5 -2.8
Average weekly red wine intake 2.3 3.4 8.5 2.9 -1.1 -0.7
Handedness (chirality/laterality): Left-handed 1.3 1.6 1.7 -1.2 1.3 1.2
Mood swings 0.4 0.8 1.1 -1.1 -0.2 -1.1
Loneliness, isolation 0.3 0.4 0.6 -0.2 -0.8 -0.7
Long-standing illness, disability or infirmity 1.0 1.6 4.0 -2.0 -0.8 0.0
Ever had bowel cancer screening 0.8 1.0 2.8 0.3 0.2 1.7
Diabetes diagnosed by doctor 2.5 4.1 12.1 -0.4 0.1 -3.5
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 0.7 0.8 0.4
Friendships satisfaction 0.8 1.0 1.8 1.1 -0.0 -1.4
Qualifications: nursing, teaching 1.1 1.7 3.7 0.7 0.9 1.9
Commuting to job workplace: Walk 0.8 0.9 1.8 1.3 0.2 -0.9
Eye problems/disorders: Cataract 1.6 1.8 3.3 -1.8 0.9 1.2
Mouth/teeth dental problems: Mouth ulcers 2.6 4.2 10.6 1.3 3.3 0.6
Medication for cholesterol 3.2 4.9 8.1 1.7 1.9 2.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.9 0.5 1.7 -0.5
Back pain experienced in last month 0.5 0.7 1.6 -0.6 -1.3 -0.4
Mineral and other dietary supplements 0.1 0.1 0.1 -0.3 -0.2 -0.3
Breast cancer (self-reported) 2.4 2.9 6.0 1.3 -2.4 -1.1
Asthma (self-reported) 2.0 4.0 9.5 -3.1 -1.6 -0.1
Osteoporosis (self-reported) 0.1 0.2 0.4 0.6 -0.2 -0.1
Osteoarthritis (self-reported) 1.1 1.4 2.0 -1.4 0.7 1.4
Medication: Aspirin 0.9 1.1 2.1 -1.4 0.2 -1.1
Medication: Gliclazide 0.7 0.8 1.4 -1.2 0.6 -0.8
Illnesses of father: None of the above (group 1) 2.5 3.1 9.0 3.0 0.0 -0.6
Smoking status: Current 3.0 4.7 5.2 -2.0 2.3 2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.8 8.0 18.2 4.3 -1.8 -1.5
Whole body water mass 5.7 32.7 96.0 9.8 -1.2 0.9
Leg predicted mass (right) 4.4 23.3 69.2 8.3 -0.5 0.6
Arm fat mass (left) 0.5 2.0 5.0 -1.0 0.1 -2.2
Number of self-reported non-cancer illnesses 3.0 5.2 14.2 -3.8 -0.8 -0.8
Average weekly champagne plus white wine intake 1.0 1.4 1.9 1.1 -1.4 -1.0
Miserableness 1.3 2.3 5.5 -0.5 2.4 -1.1
Guilty feelings 3.0 4.5 6.8 0.5 2.6 2.6
Wears glasses or contact lenses 0.1 0.2 0.2 -0.2 0.5 0.5
Ever taken oral contraceptive pill 0.6 0.7 1.7 0.5 1.3 0.4
Hearing aid user 0.7 0.8 1.1 -1.0 -1.1 -0.3
Mother’s age at death 1.8 2.3 4.2 1.4 0.8 2.1
Financial situation satisfaction 0.2 0.2 0.4 0.2 -0.5 -0.7
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.7 1.9 -0.4 0.0
Commuting to job workplace: Public transport 0.6 0.8 2.1 1.5 0.3 0.2
Eye problems/disorders: Glaucoma 1.0 1.1 2.2 -1.5 -0.3 -1.1
Medication: Blood pressure 1.9 3.6 5.9 -1.2 -1.9 -2.4
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.6 -1.3 -0.1 0.6
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.7 1.6 1.0 0.2
High cholesterol (Self-reported) 3.1 5.6 7.3 -1.8 -2.7 -2.5
Medication: Bendroflumethiazide 0.3 0.5 1.5 0.2 0.2 -1.2
Medication: Paracetamol 1.7 2.7 3.8 -1.9 1.4 -1.5
Medication: Lisinopril 0.6 0.8 1.6 -1.3 -0.4 -0.8
Medication: Atorvastatin 1.2 1.5 2.4 -1.5 -1.4 -0.1
Illnesses of father: High blood pressure 1.0 1.2 2.8 -0.9 -0.4 -1.7
Alcohol drinker status: Never 1.9 2.3 4.1 -0.5 2.0 1.6
Ever smoked 1.3 2.3 5.9 -2.4 0.1 1.1
Basal metabolic rate 4.5 24.7 73.3 8.6 -0.8 0.4
Leg fat percentage (left) 3.5 12.7 35.6 -6.0 -0.1 -1.5
Arm fat-free mass (left) 4.4 22.3 65.3 8.1 -1.3 0.2
Number of operations (self-reported) 0.4 0.5 0.7 -0.8 0.5 0.8
Average weekly beer plus cider intake 1.6 2.4 6.3 -2.5 -0.1 0.9
Irritability 1.0 1.7 5.0 0.3 2.2 0.2
Risk taking 1.8 2.7 5.9 -1.2 0.8 2.4
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.1 -0.3 -0.6 -1.0
Fractured/broken bones in last 5 years 0.9 1.2 3.3 1.8 -0.2 0.4
Age started oral contraceptive pill 0.3 0.4 0.9 0.6 0.9 0.0
Diastolic blood pressure, automated reading 0.5 1.7 3.2 1.3 0.3 -1.8
Ever depressed for a whole week 0.8 0.9 2.5 1.6 0.5 -0.1
Unable to work because of sickness or disability 0.3 0.4 1.1 -0.2 0.5 1.0
Commuting to job workplace: Cycle 1.2 1.5 4.1 2.0 -0.1 -0.6
Myopia 0.2 0.3 0.4 0.4 0.6 0.6
Vascular/heart problems diagnosed by doctor 2.4 6.6 10.7 2.8 1.0 3.3
Cholesterol lowering medication 3.6 5.3 10.0 -3.2 -2.3 -0.7
Medication: Omeprazole (e.g. Zanprol) 2.6 3.1 9.0 -3.0 0.1 0.6
Pain experienced in last month 0.9 1.5 3.0 1.7 1.2 -0.1
Supplements: Calcium 0.4 0.5 1.0 1.0 0.2 -0.6
Basal cell carcinoma (self-reported) 0.3 0.3 0.8 0.9 -0.3 0.2
Heart attack/myocardial infarction (self-reported) 1.6 2.1 4.9 -2.2 0.7 0.9
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.0 -0.6 -0.5
Heart disease (siblings) 0.1 0.2 0.3 -0.5 0.0 0.5
Alcohol drinker status: Previous 0.8 0.9 0.9 -0.9 0.9 -0.9
Pack years of smoking 1.8 2.6 3.9 -2.0 -0.8 1.8
Impedance of whole body 1.0 5.2 11.5 -2.0 3.4 -0.5
Leg fat mass (left) 0.4 1.7 3.4 -1.8 0.0 -1.3
Arm predicted mass (left) 3.9 19.7 56.7 7.5 -1.5 0.4