[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted percentage : ← →

chr17:36,211,659-38,770,286

Best TWAS P=1.18e-11 · Best GWAS P=2.26e-11 conditioned to 0.391

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PNMT	0.05	0.00	bslmm	327	0.00	8.2e-02	-6.4	5.3	1.0e-07	-0.68	0.03	0.52	FALSE
2	GTEx	Adipose Subcutaneous	PCGF2	0.14	0.12	lasso	2	0.12	6.1e-10	-5.3	-5.3	1.5e-07	0.03	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	PGAP3	0.12	0.11	lasso	6	0.10	7.1e-06	-6.5	-6.5	1.0e-10	0.98	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	PCGF2	0.34	0.09	lasso	6	0.11	8.5e-05	-5.3	-5.4	5.9e-08	0.04	0.01	0.96	FALSE
5	GTEx	Adrenal Gland	PGAP3	0.17	0.14	lasso	2	0.12	3.2e-05	-5.7	-6.0	2.4e-09	0.89	0.12	0.81	FALSE
6	GTEx	Artery Aorta	PGAP3	0.13	0.04	lasso	3	0.10	5.3e-06	-5.7	-5.5	3.5e-08	0.70	0.11	0.87	FALSE
7	GTEx	Artery Coronary	PGAP3	0.16	0.10	lasso	4	0.06	5.9e-03	-6.1	-6.3	2.7e-10	0.96	0.03	0.85	FALSE
8	GTEx	Artery Tibial	PCGF2	0.38	0.27	lasso	8	0.31	4.3e-25	-5.3	-5.2	1.6e-07	0.05	0.00	1.00	FALSE
9	GTEx	Brain Cerebellum	PCGF2	0.25	0.29	lasso	3	0.26	2.4e-08	-5.4	5.6	2.0e-08	-0.05	0.00	1.00	FALSE
10	GTEx	Breast Mammary Tissue	PGAP3	0.10	0.07	lasso	4	0.07	1.5e-04	-6.7	-6.7	2.5e-11	0.92	0.01	0.96	FALSE
11	GTEx	Cells Transformed fibroblasts	PCGF2	0.34	0.28	lasso	4	0.30	3.2e-23	-5.3	-5.5	4.4e-08	0.03	0.00	1.00	FALSE
12	GTEx	Cells Transformed fibroblasts	GSDMB	0.11	0.02	enet	18	0.06	4.9e-05	-4.2	-5.3	1.4e-07	0.45	0.79	0.13	FALSE
13	GTEx	Colon Transverse	PCGF2	0.29	0.21	lasso	5	0.20	6.2e-10	-5.3	-5.3	1.2e-07	0.03	0.00	1.00	FALSE
14	GTEx	Colon Transverse	PGAP3	0.24	0.20	enet	19	0.20	8.3e-10	-6.5	-5.8	7.2e-09	0.90	0.01	0.99	FALSE
15	GTEx	Esophagus Mucosa	PCGF2	0.32	0.24	lasso	7	0.23	1.8e-15	-5.3	-5.4	6.5e-08	0.02	0.00	1.00	FALSE
16	GTEx	Esophagus Muscularis	PCGF2	0.21	0.15	lasso	8	0.13	3.3e-08	-5.3	-5.3	1.2e-07	0.02	0.00	1.00	FALSE
17	GTEx	Esophagus Muscularis	PGAP3	0.11	0.08	enet	10	0.10	1.1e-06	-6.5	-6.0	1.6e-09	0.96	0.02	0.98	FALSE
18	GTEx	Heart Atrial Appendage	PCGF2	0.18	0.13	lasso	3	0.09	6.1e-05	-5.3	-5.3	1.3e-07	0.03	0.00	0.99	FALSE
19	GTEx	Heart Atrial Appendage	PPP1R1B	0.09	0.04	enet	10	0.08	2.2e-04	-3.0	-5.2	1.6e-07	0.74	0.12	0.79	FALSE
20	GTEx	Heart Atrial Appendage	ERBB2	0.13	0.04	enet	18	0.02	4.8e-02	-6.0	-5.2	1.6e-07	0.75	0.05	0.82	FALSE
21	GTEx	Heart Atrial Appendage	PGAP3	0.13	0.16	lasso	3	0.18	2.6e-08	-5.7	-6.0	1.5e-09	0.96	0.04	0.96	FALSE
22	GTEx	Heart Left Ventricle	PNMT	0.06	0.03	lasso	1	0.03	1.3e-02	-5.6	-5.6	2.0e-08	0.67	0.13	0.65	FALSE
23	GTEx	Heart Left Ventricle	PGAP3	0.17	0.14	lasso	5	0.12	4.3e-07	-5.7	-6.0	1.9e-09	0.81	0.12	0.87	FALSE
24	GTEx	Liver	PGAP3	0.27	0.17	lasso	4	0.13	1.7e-04	-6.3	-6.4	1.4e-10	0.94	0.04	0.95	FALSE
25	GTEx	Lung	PCGF2	0.25	0.17	lasso	7	0.17	4.8e-13	-5.3	-5.5	4.2e-08	0.02	0.00	1.00	FALSE
26	GTEx	Lung	PGAP3	0.24	0.14	lasso	7	0.12	2.3e-09	-6.5	-6.2	5.2e-10	0.96	0.02	0.98	FALSE
27	GTEx	Muscle Skeletal	PGAP3	0.04	0.03	lasso	5	0.04	1.3e-04	-6.5	-6.8	1.2e-11	0.89	0.02	0.97	TRUE
28	GTEx	Nerve Tibial	ERBB2	0.08	0.08	lasso	5	0.07	1.3e-05	-5.7	-6.0	1.8e-09	0.93	0.07	0.93	FALSE
29	GTEx	Nerve Tibial	PGAP3	0.19	0.11	lasso	5	0.12	1.1e-08	-6.5	-6.4	1.8e-10	0.90	0.02	0.98	FALSE
30	GTEx	Pancreas	PCGF2	0.29	0.12	lasso	5	0.07	5.3e-04	-5.3	-5.3	1.1e-07	0.01	0.00	0.94	FALSE
31	GTEx	Pancreas	PGAP3	0.37	0.25	lasso	6	0.21	1.9e-09	-6.3	-5.8	8.1e-09	0.93	0.05	0.95	FALSE
32	GTEx	Pituitary	PGAP3	0.15	0.22	lasso	2	0.19	1.8e-05	-6.0	-6.0	1.7e-09	0.95	0.07	0.79	FALSE
33	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	-6.5	-6.7	1.9e-11	0.86	0.04	0.83	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	PCGF2	0.39	0.23	lasso	4	0.21	6.9e-12	-5.3	-5.3	1.4e-07	0.03	0.00	1.00	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	PGAP3	0.22	0.09	enet	33	0.14	3.4e-08	-6.5	-5.2	2.0e-07	0.83	0.02	0.98	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	TCAP	0.07	0.02	enet	7	0.01	1.2e-01	-5.7	-5.9	4.2e-09	0.94	0.04	0.74	FALSE
37	GTEx	Skin Sun Exposed Lower leg	PCGF2	0.36	0.30	lasso	7	0.32	1.3e-26	-5.3	-5.5	3.0e-08	0.03	0.00	1.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	-5.7	-5.4	7.3e-08	0.87	0.06	0.86	FALSE
39	GTEx	Skin Sun Exposed Lower leg	PGAP3	0.14	0.10	lasso	6	0.07	1.1e-06	-6.3	-6.3	3.4e-10	0.94	0.03	0.97	FALSE
40	GTEx	Stomach	PGAP3	0.41	0.18	enet	16	0.25	2.3e-12	-6.5	-5.8	5.1e-09	0.85	0.01	0.99	FALSE
41	GTEx	Thyroid	PGAP3	0.19	0.21	lasso	10	0.24	3.5e-18	-6.0	-6.3	3.9e-10	0.94	0.10	0.90	FALSE
42	GTEx	Thyroid	RP11-690G19.3	0.04	0.03	enet	6	0.02	1.5e-02	-4.9	5.9	4.5e-09	-0.86	0.08	0.75	FALSE
43	METSIM	Adipose	PGAP3	0.06	0.05	lasso	4	0.05	8.8e-08	-6.3	-6.3	3.0e-10	0.93	0.02	0.98	FALSE
44	YFS	Blood	FBXL20	0.05	0.10	lasso	15	0.10	6.5e-30	-5.6	-5.9	3.3e-09	0.67	0.82	0.18	FALSE
45	YFS	Blood	PGAP3	0.08	0.12	lasso	11	0.12	1.7e-35	-6.5	-6.7	1.5e-11	0.98	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PCGF2	0.14	0.06	blup	35	0.11	1.1e-09	-5.4	-5.2	2.1e-07	0.02	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PGAP3	0.07	0.12	blup	37	0.11	1.2e-09	-6.5	-6.6	5.0e-11	0.98	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	PGAP3	0.08	0.07	blup	41	0.08	2.7e-16	-6.3	-6.0	2.2e-09	0.84	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	STARD3	0.04	0.01	blup	50	0.03	4.2e-06	-2.0	-5.2	2.1e-07	0.66	0.02	0.93	FALSE
50	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PGAP3	0.04	0.01	blup	41	0.01	1.2e-01	-6.5	-6.5	6.2e-11	0.97	0.01	0.76	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	PCGF2	0.23	0.23	lasso	3	0.22	9.8e-13	-5.3	-5.3	1.3e-07	0.03	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	PGAP3	0.10	0.17	blup	37	0.17	6.4e-10	-6.3	-6.7	2.3e-11	0.97	0.03	0.97	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	PGAP3	0.19	0.13	blup	37	0.16	1.5e-05	-6.3	-6.4	1.3e-10	0.97	0.02	0.96	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PCGF2	0.13	0.06	blup	37	0.09	7.0e-10	-5.3	-5.6	2.1e-08	0.05	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PGAP3	0.04	0.08	lasso	1	0.07	1.5e-08	-6.3	-6.3	3.9e-10	0.95	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STARD3	0.03	0.04	enet	5	0.02	8.2e-04	-6.0	-6.0	1.5e-09	0.80	0.11	0.85	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MED1	0.03	0.02	blup	29	0.02	1.0e-03	-5.5	-5.5	3.6e-08	0.66	0.01	0.98	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PCGF2	0.24	0.15	lasso	5	0.18	2.2e-19	-5.3	-5.6	2.3e-08	0.04	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PGAP3	0.12	0.12	lasso	4	0.13	5.3e-14	-6.3	-6.6	4.6e-11	0.93	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PGAP3	0.16	0.16	enet	14	0.15	5.1e-09	-6.3	-5.6	2.8e-08	0.79	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	PGAP3	0.05	0.08	lasso	10	0.08	2.1e-09	-6.3	-6.2	5.3e-10	0.97	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PGAP3	0.09	0.11	lasso	4	0.11	5.9e-06	-6.7	-6.6	3.0e-11	0.99	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	PCGF2	0.08	0.05	enet	11	0.08	3.8e-09	-4.9	-5.3	9.5e-08	0.03	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	PGAP3	0.06	0.06	lasso	4	0.06	4.5e-07	-6.0	-6.1	1.2e-09	0.94	0.06	0.94	FALSE
65	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PCGF2	0.05	0.03	lasso	3	0.04	1.0e-05	-4.9	-5.6	1.6e-08	0.05	0.00	0.99	TRUE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PGAP3	0.06	0.10	lasso	2	0.09	1.5e-10	-6.3	-6.3	4.0e-10	0.95	0.06	0.94	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STARD3	0.03	0.03	enet	8	0.04	6.6e-05	-5.7	-5.9	3.8e-09	0.92	0.10	0.84	FALSE
68	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PCGF2	0.28	0.16	lasso	4	0.13	3.4e-06	-5.3	-5.3	1.4e-07	0.04	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGAP3	0.17	0.13	blup	41	0.10	6.8e-05	-6.0	-6.0	2.4e-09	0.91	0.03	0.94	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	PCGF2	0.18	0.14	lasso	4	0.16	2.4e-16	-5.3	-5.2	1.8e-07	0.03	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	PGAP3	0.18	0.26	enet	12	0.28	5.7e-30	-6.3	-6.5	1.1e-10	0.94	0.05	0.95	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	STARD3	0.05	0.04	blup	50	0.05	9.8e-06	-6.5	-6.3	3.6e-10	0.87	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Rectum Adenocarcinoma	CDK12	0.17	0.00	blup	44	0.05	2.5e-02	-5.6	-5.4	6.7e-08	0.66	0.01	0.40	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	PGAP3	0.20	0.14	blup	38	0.16	1.4e-04	-6.7	-6.4	1.9e-10	0.92	0.01	0.81	FALSE
75	The Cancer Genome Atlas	Stomach Adenocarcinoma	PCGF2	0.14	0.04	enet	8	0.16	6.8e-12	2.1	-5.4	5.2e-08	0.06	0.00	0.99	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	PGAP3	0.05	0.05	lasso	4	0.05	1.0e-04	-5.7	-6.0	1.7e-09	0.91	0.05	0.90	FALSE
77	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PGAP3	0.23	0.22	blup	38	0.24	3.6e-09	-5.7	-5.9	3.3e-09	0.88	0.02	0.98	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	STARD3	0.05	0.06	lasso	2	0.04	1.7e-02	-6.5	-6.4	1.1e-10	0.92	0.02	0.73	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	-4.5	-5.1	2.7e-07	0.59	0.06	0.91	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	PCGF2	0.27	0.22	enet	9	0.25	1.4e-24	-5.3	-5.3	9.6e-08	0.05	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	PGAP3	0.10	0.16	lasso	5	0.17	1.4e-16	-6.3	-6.3	2.9e-10	0.95	0.02	0.98	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	PNMT	0.03	0.05	lasso	4	0.04	6.2e-05	-4.9	-5.2	1.8e-07	0.78	0.03	0.95	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	STARD3	0.10	0.06	lasso	5	0.05	2.6e-05	-5.7	-5.5	4.1e-08	0.90	0.05	0.94	FALSE