Best TWAS P=2.14e-13 · Best GWAS P=8.7e-16 conditioned to 5.21e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HAPLN4 | 0.07 | 0.10 | lasso | 6 | 0.10 | 5.3e-12 | -5.99 | -5.6 | 2.1e-08 | -0.05 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Colon Transverse | YJEFN3 | 0.09 | 0.09 | lasso | 3 | 0.07 | 4.3e-04 | -5.46 | 5.9 | 2.9e-09 | 0.07 | 0.04 | 0.91 | FALSE |
| 3 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -6.02 | -6.0 | 1.8e-09 | -0.04 | 0.97 | 0.03 | FALSE |
| 4 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -6.02 | -6.1 | 1.0e-09 | -0.04 | 0.97 | 0.03 | TRUE |
| 5 | GTEx | Thyroid | YJEFN3 | 0.05 | 0.02 | lasso | 3 | 0.02 | 1.2e-02 | -5.82 | 5.5 | 3.3e-08 | 0.08 | 0.05 | 0.79 | FALSE |
| 6 | METSIM | Adipose | CILP2 | 0.04 | 0.03 | lasso | 5 | 0.07 | 2.7e-11 | -3.30 | -5.3 | 9.5e-08 | 0.03 | 0.17 | 0.82 | FALSE |
| 7 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 5.89 | -5.7 | 1.4e-08 | 0.05 | 0.97 | 0.03 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | YJEFN3 | 0.04 | 0.05 | lasso | 7 | 0.04 | 1.6e-04 | -5.60 | 5.4 | 6.7e-08 | 0.04 | 0.01 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CILP2 | 0.02 | 0.02 | blup | 30 | 0.02 | 1.6e-04 | -5.63 | -5.5 | 3.2e-08 | -0.04 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HAPLN4 | 0.04 | 0.07 | lasso | 4 | 0.06 | 1.3e-12 | -6.10 | -5.4 | 5.2e-08 | -0.04 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSSK6 | 0.07 | 0.02 | blup | 32 | 0.04 | 2.9e-03 | -5.46 | -6.2 | 7.2e-10 | -0.06 | 0.01 | 0.83 | TRUE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 7.24 | -7.3 | 2.1e-13 | -0.04 | 0.01 | 0.95 | TRUE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | YJEFN3 | 0.03 | 0.03 | blup | 32 | 0.02 | 3.0e-03 | -5.46 | 5.9 | 4.0e-09 | 0.06 | 0.01 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | YJEFN3 | 0.04 | 0.05 | lasso | 2 | 0.05 | 4.3e-06 | -5.58 | 5.6 | 2.4e-08 | 0.05 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | HAPLN4 | 0.08 | 0.03 | blup | 37 | 0.04 | 7.2e-04 | -6.00 | -5.7 | 1.1e-08 | -0.09 | 0.01 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRTC1 | 0.33 | 0.08 | lasso | 5 | 0.12 | 3.6e-05 | -2.44 | -5.6 | 2.6e-08 | 0.68 | 0.04 | 0.52 | TRUE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 0.56 | -5.2 | 2.2e-07 | 0.04 | 0.02 | 0.56 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 7.24 | -7.3 | 2.8e-13 | -0.04 | 0.01 | 0.89 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | YJEFN3 | 0.08 | 0.06 | blup | 33 | 0.08 | 7.1e-08 | -5.58 | 5.7 | 1.0e-08 | 0.05 | 0.01 | 0.99 | FALSE |