[Hub]/) : Traits : Body mass index (BMI) :

chr5:73,626,450-75,704,085

Best TWAS P=3.26e-31 · Best GWAS P=6.35e-32 conditioned to 0.0125

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ANKRD31 0.10 0.13 lasso 9 0.13 3.9e-15 -8.0 7.6 2.6e-14 -0.33 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex POC5 0.17 0.16 lasso 5 0.15 5.2e-18 -11.4 11.6 3.3e-31 -0.90 0.04 0.96 TRUE
3 GTEx Adipose Subcutaneous POC5 0.08 0.07 lasso 7 0.07 3.2e-06 -7.4 -7.4 9.9e-14 0.56 0.96 0.00 FALSE
4 GTEx Adipose Visceral Omentum POC5 0.13 0.08 lasso 9 0.08 6.1e-05 -7.2 -7.3 2.3e-13 0.60 0.82 0.07 FALSE
5 GTEx Adrenal Gland GCNT4 0.13 0.02 lasso 8 0.01 1.3e-01 -7.7 -9.4 3.9e-21 0.49 0.06 0.83 TRUE
6 GTEx Artery Tibial GCNT4 0.08 0.07 lasso 2 0.04 3.9e-04 -7.7 7.8 7.7e-15 -0.44 0.68 0.06 FALSE
7 GTEx Brain Cerebellar Hemisphere POLK 0.27 0.20 lasso 6 0.16 8.3e-05 -8.1 -9.2 3.5e-20 0.64 0.31 0.24 FALSE
8 GTEx Brain Cerebellar Hemisphere POC5 0.31 0.15 enet 18 0.30 1.6e-08 -7.4 -9.1 1.4e-19 0.61 0.49 0.38 FALSE
9 GTEx Brain Hypothalamus CTC-366B18.4 0.26 0.12 lasso 8 0.07 9.0e-03 -7.4 7.5 5.3e-14 -0.56 0.10 0.09 FALSE
10 GTEx Cells EBV-transformed lymphocytes POC5 0.47 0.36 lasso 4 0.39 1.3e-13 -7.4 -7.3 2.2e-13 0.57 1.00 0.00 FALSE
11 GTEx Cells Transformed fibroblasts POLK 0.06 0.04 lasso 3 0.04 1.0e-03 -7.9 8.2 2.7e-16 -0.61 0.21 0.55 FALSE
12 GTEx Cells Transformed fibroblasts POC5 0.15 0.17 lasso 6 0.16 3.4e-12 -7.2 -7.2 8.1e-13 0.57 1.00 0.00 FALSE
13 GTEx Colon Transverse POC5 0.23 0.16 lasso 4 0.18 6.0e-09 -7.1 -5.3 1.2e-07 0.39 0.96 0.00 FALSE
14 GTEx Esophagus Mucosa COL4A3BP 0.09 0.06 lasso 5 0.05 4.2e-04 -5.5 7.1 1.7e-12 -0.51 0.59 0.29 FALSE
15 GTEx Esophagus Mucosa POC5 0.18 0.16 lasso 1 0.15 4.8e-10 -7.2 -7.2 8.1e-13 0.57 1.00 0.00 FALSE
16 GTEx Nerve Tibial POC5 0.16 0.12 lasso 5 0.10 7.6e-08 -7.1 -7.2 8.4e-13 0.57 0.99 0.00 FALSE
17 GTEx Pancreas POC5 0.32 0.23 lasso 3 0.21 3.5e-09 -7.2 -7.3 3.5e-13 0.57 1.00 0.00 FALSE
18 GTEx Spleen POLK 0.18 -0.01 lasso 16 0.03 5.1e-02 -5.3 -9.8 1.1e-22 0.59 0.16 0.26 FALSE
19 GTEx Spleen POC5 0.42 0.37 lasso 4 0.34 1.3e-09 -7.4 -7.6 3.7e-14 0.57 0.92 0.06 FALSE
20 GTEx Spleen CTC-366B18.2 0.16 0.11 lasso 3 0.14 2.2e-04 -7.4 -9.5 2.4e-21 0.72 0.10 0.64 FALSE
21 GTEx Stomach POC5 0.10 0.06 enet 12 0.08 8.3e-05 -7.9 -5.6 1.9e-08 0.43 0.56 0.02 FALSE
22 GTEx Testis POC5 0.27 0.13 lasso 8 0.09 8.1e-05 -8.5 8.0 8.9e-16 -0.65 0.46 0.38 FALSE
23 GTEx Testis GCNT4 0.42 0.35 enet 62 0.37 3.8e-17 -7.9 -9.0 2.3e-19 0.50 1.00 0.00 FALSE
24 GTEx Thyroid POC5 0.26 0.23 enet 15 0.23 1.8e-17 -7.1 -6.2 4.7e-10 0.49 1.00 0.00 FALSE
25 GTEx Thyroid CTC-366B18.2 0.06 0.03 lasso 9 0.02 6.2e-03 -8.7 -8.5 2.6e-17 0.62 0.25 0.30 FALSE
26 METSIM Adipose POC5 0.11 0.09 enet 29 0.10 7.5e-15 -7.1 -6.0 1.6e-09 0.48 1.00 0.00 FALSE
27 METSIM Adipose POLK 0.05 0.01 enet 16 0.03 4.3e-05 -9.8 -10.5 1.2e-25 0.58 0.92 0.07 FALSE
28 ROSMAP Brain Pre-frontal Cortex POLK 0.03 0.01 lasso 7 0.02 3.9e-03 -8.9 -10.3 6.1e-25 0.81 0.28 0.62 FALSE
29 ROSMAP Brain Pre-frontal Cortex POC5 0.05 0.00 blup 384 0.02 8.6e-04 -7.1 -7.8 7.0e-15 0.57 0.29 0.15 FALSE
30 ROSMAP Brain Pre-frontal Cortex ANKDD1B 0.07 0.00 bslmm 382 0.03 7.0e-05 -5.9 8.8 2.0e-18 -0.63 0.07 0.59 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma GCNT4 0.10 0.06 enet 6 0.05 8.7e-04 -3.6 6.7 2.5e-11 -0.41 0.08 0.55 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma POC5 0.04 0.00 enet 7 0.03 2.1e-04 -11.4 9.1 1.5e-19 -0.77 0.02 0.62 FALSE
33 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HMGCR 0.04 0.02 enet 4 0.03 6.0e-03 -8.5 -8.4 5.2e-17 0.57 0.02 0.73 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma POLK 0.03 0.01 blup 53 0.01 1.6e-02 -5.5 7.9 3.9e-15 -0.57 0.31 0.43 FALSE
35 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma POC5 0.24 0.13 blup 70 0.14 1.2e-04 -8.2 -7.9 2.1e-15 0.73 0.06 0.78 FALSE