Best TWAS P=4.93e-10 · Best GWAS P=1.26e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TMEM180 | 0.25 | 0.23 | enet | 37 | 0.25 | 7.4e-14 | 2.9 | 6.1 | 1.1e-09 | 0.21 | 0.88 | 0.01 | TRUE |
| 2 | GTEx | Brain Cerebellum | TRIM8 | 0.34 | -0.01 | enet | 25 | 0.07 | 4.7e-03 | -3.7 | -6.2 | 4.9e-10 | -0.34 | 0.06 | 0.39 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | SUFU | 0.07 | 0.04 | lasso | 3 | 0.04 | 3.5e-04 | 4.7 | 5.2 | 2.4e-07 | 0.84 | 0.19 | 0.55 | FALSE |
| 4 | GTEx | Thyroid | C10orf95 | 0.10 | 0.02 | enet | 28 | 0.02 | 6.6e-03 | 2.9 | 6.0 | 1.8e-09 | 0.28 | 0.17 | 0.12 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ARL3 | 0.24 | 0.14 | bslmm | 368 | 0.16 | 3.9e-20 | 4.1 | -5.4 | 7.6e-08 | -0.53 | 0.46 | 0.51 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CNNM2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.2e-09 | 5.1 | 5.1 | 2.7e-07 | 0.99 | 0.02 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AS3MT | 0.06 | 0.09 | enet | 6 | 0.07 | 1.3e-06 | 4.5 | -5.2 | 1.9e-07 | -0.68 | 0.08 | 0.89 | FALSE |