TWAS hub - TRIM8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3440	0.1220	5.0e-04	-0.009	NA	0.068	NA	0.011	8.1e-01	NA	4.7e-03	NA	1.5e-01
2	GTEx	Pancreas	0.3240	0.0870	5.9e-06	0.168	NA	0.103	NA	0.190	1.4e-07	NA	4.1e-05	NA	1.9e-08
3	NTR	Blood	0.0151	0.0072	6.2e-04	0.010	0.006	0.007	0.006	0.006	2.8e-04	3.1e-03	2.1e-03	4.7e-03	2.9e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0866	0.0286	1.0e-07	0.030	0.056	0.060	0.057	0.058	7.9e-05	8.7e-08	3.7e-08	7.2e-08	5.5e-08
5	YFS	Blood	0.0429	0.0147	1.1e-12	0.044	0.042	0.047	0.043	0.049	3.8e-14	8.6e-14	4.0e-15	7.0e-14	1.2e-15
6	TCGA	Prostate Adenocarcinoma	0.0642	0.0297	2.4e-05	0.033	0.053	0.054	NA	0.055	2.1e-04	3.2e-06	2.5e-06	NA	1.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Allergy or Eczema	11.4	29.9	70.6	0.3	3.4	-7.6	-6.2	-8.4	1.1
Smoking Status	9.7	23.3	42.2	-2.5	-6.5	5.5	0.2	5.7	-5.4
Hayfever, allergic rhinitis or eczema	9.7	21.0	47.2	1.0	3.2	-6.6	-4.5	-6.9	1.6
Prostate Cancer	8.3	11.6	27.4	-0.0	2.8	-4.9	-2.6	-5.2	2.1
Allergy	8.3	19.2	43.9	-1.4	-3.1	6.6	3.7	6.5	-2.0
Hearing difficulty/problems with background noise	8.1	12.9	25.9	1.7	-3.4	5.1	1.7	5.0	-3.0
Past tobacco smoking	7.6	14.0	30.7	-0.3	3.9	-5.2	-2.7	-5.5	1.9
Height	7.0	134.7	320.4	-1.4	-6.3	15.7	14.1	17.9	0.8
Standing height	6.9	68.5	163.8	-0.5	-5.4	11.5	9.2	12.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	6.6	13.7	29.8	-0.7	-2.9	5.2	4.1	5.5	-0.3
Sitting height	6.4	45.2	112.4	0.3	-2.9	9.0	8.4	10.6	0.1
Ever smoked	6.4	11.2	23.1	0.1	-4.2	4.8	1.6	4.3	-2.3
Current tobacco smoking	6.3	10.2	18.2	-2.1	-4.3	3.2	0.0	3.5	-4.1
Smoking status: Current	6.1	9.7	17.4	-2.1	-4.2	3.0	-0.1	3.3	-4.1
Worrier / anxious feelings	5.5	10.3	18.1	3.2	3.7	-4.2	-1.1	-4.0	1.7
Number of incorrect matches in round	5.2	8.7	15.4	1.9	3.9	-3.3	1.2	-2.6	3.7
Pulse wave peak to peak time	4.9	5.7	12.0	0.1	-3.1	3.5	1.1	2.9	-1.7
Comparative height size at age 10	4.9	26.8	63.4	-1.5	-3.2	6.9	6.1	8.0	0.2
Ulcerative Colitis	4.5	6.6	14.6	1.1	-1.6	3.8	2.7	3.7	0.0
Exposure to tobacco smoke outside home	4.4	5.9	10.0	-2.5	-2.6	3.2	0.9	2.9	-1.8
Trunk fat-free mass	4.3	24.4	42.4	-5.8	-4.5	6.2	2.5	6.5	-2.6
Trunk predicted mass	4.3	24.4	41.2	-5.8	-4.6	6.1	2.3	6.4	-2.7
BMI	4.0	23.1	81.0	-9.0	-2.1	-1.4	-5.3	-2.1	-4.3
Birth weight of first child	4.0	7.2	12.9	-2.2	-3.4	2.5	-1.4	2.4	-3.6
Smoking status: Previous	4.0	5.9	13.0	0.9	-2.3	3.4	2.2	3.6	-0.5
Length of working week for main job	3.9	4.4	11.9	1.0	0.4	2.0	3.4	2.6	1.6
Peak expiratory flow (PEF)	3.9	9.1	17.4	-3.1	-3.1	4.2	1.5	3.6	-1.7
Financial situation satisfaction	3.9	4.8	8.5	-1.1	-2.8	1.9	0.4	2.7	-2.9
Hand grip strength (left)	3.8	10.0	17.8	-2.9	-3.0	4.2	2.6	4.2	-0.7
Arm predicted mass (left)	3.7	18.8	37.5	-6.1	-3.9	4.9	1.4	5.1	-2.8
Reaction Time	3.6	6.9	13.6	2.1	2.7	-3.7	-1.4	-3.6	1.1
Pulse wave Arterial Stiffness index	3.6	4.2	8.9	-0.0	3.0	-2.8	-0.4	-2.1	1.9
Arm fat-free mass (right)	3.6	18.4	35.0	-5.9	-3.8	4.9	1.7	5.2	-2.5
Arm fat-free mass (left)	3.6	18.2	36.1	-6.0	-3.9	4.8	1.3	5.1	-2.7
Body Mass Index (BMI) (2010)	3.5	4.8	15.4	-3.9	-1.6	-0.2	-2.4	-0.7	-2.1
Hearing difficulty/problems: Yes	3.5	5.4	10.8	1.5	-2.1	3.2	1.0	3.3	-2.0
Arm predicted mass (right)	3.5	17.9	34.0	-5.8	-3.8	4.9	1.7	5.1	-2.5
Whole body fat-free mass	3.5	19.8	39.7	-6.3	-4.1	5.0	1.5	5.3	-2.7
Whole body water mass	3.5	19.7	39.4	-6.3	-4.1	5.0	1.4	5.2	-2.8
Worry (Nagel 2018)	3.4	7.1	14.3	3.8	2.8	-2.9	-0.4	-3.0	1.6
Waist Hip Ratio (WHR)	3.3	15.0	38.9	3.1	1.1	3.5	6.2	4.3	3.2
Basal metabolic rate	3.3	18.4	39.5	-6.3	-3.9	4.7	1.2	5.0	-2.8
Crohns Disease (2012)	3.2	5.1	11.2	-0.3	-2.6	3.3	0.9	3.1	-1.4
Impedance of leg (right)	3.1	15.0	45.4	6.7	0.7	2.4	4.8	2.6	2.9
Weight	3.1	15.3	36.8	-6.1	-3.9	3.7	-0.0	3.8	-3.4
Pain type(s) experienced in last month: Hip pain	3.1	3.9	7.5	-1.6	-0.2	-2.3	-2.7	-2.4	-1.5
Maternal smoking around birth	3.0	4.4	7.4	-1.5	-2.6	2.7	0.6	2.6	-1.7
Body mass index (BMI)	3.0	12.7	38.7	-6.2	-1.6	-1.5	-4.3	-2.0	-3.2
Forced vital capacity (FVC)	3.0	11.7	22.9	-1.8	-2.3	4.8	4.1	4.7	0.2
Hayfever/allergic rhinitis (self-reported)	3.0	3.9	8.6	1.3	0.8	-2.9	-2.1	-2.9	0.3
Birth weight	3.0	6.6	15.5	-1.8	-3.9	2.5	-0.8	2.7	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	8.2	2.1	0.2	1.5	2.9	2.4	0.5
Blood White Count	2.9	21.6	45.2	2.3	-2.9	6.6	5.2	6.7	-0.8
Medication: Atenolol	2.9	3.7	9.4	1.5	-0.9	3.1	1.8	2.4	-0.7
Alcohol intake frequency.	2.9	6.8	12.6	-3.5	-3.2	2.6	0.0	2.1	-2.6
Impedance of leg (left)	2.8	13.6	41.0	6.4	0.3	2.7	4.4	2.9	2.4
Nervous feelings	2.8	5.2	16.1	4.0	2.2	-1.5	0.7	-1.7	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	9.1	1.9	2.2	-0.8	3.0	1.0	2.6
Fasting Glucose	2.7	3.2	5.8	-0.1	-1.6	2.3	-1.1	2.1	-2.4
Respiratory disease	2.7	5.9	14.5	1.8	2.2	-3.8	-1.1	-3.0	1.6
Diabetes (mother)	2.7	3.4	7.4	0.7	-0.3	2.1	2.7	2.5	1.4
Hand grip strength (right)	2.7	7.4	12.1	-3.3	-2.9	3.5	2.0	2.9	-0.5
Leg predicted mass (left)	2.7	14.0	38.9	-6.2	-3.4	3.5	0.4	3.7	-2.7
Number of live births	2.7	3.8	8.3	2.4	2.1	-0.9	1.8	-0.6	2.9
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	7.2	-1.3	1.6	-2.1	-0.5	-2.7	2.1
Leg fat-free mass (right)	2.7	14.6	40.2	-6.3	-3.5	3.5	0.3	3.8	-2.9
Leg predicted mass (right)	2.7	14.4	39.7	-6.3	-3.5	3.5	0.3	3.8	-2.8
Blood Eosinophil Count	2.6	20.0	40.4	6.4	2.6	2.4	6.2	3.4	4.2
Leg fat-free mass (left)	2.6	13.9	39.3	-6.3	-3.4	3.4	0.3	3.7	-2.7
Medication: Bendroflumethiazide	2.6	3.9	9.0	1.9	0.0	1.7	2.8	3.0	-0.2
Pack years of smoking	2.6	3.9	8.2	0.2	-2.6	2.0	-0.0	2.0	-2.9
Pack years adult smoking proportion	2.5	3.8	8.4	0.1	-2.7	1.9	-0.1	1.9	-2.9
Hip circumference	2.5	10.6	30.7	-5.5	-3.2	1.7	-2.0	1.6	-3.6
Cardiovascular Disease	2.4	7.9	14.8	3.9	0.3	2.2	3.8	3.5	0.5
Ever used hormone-replacement therapy (HRT)	2.4	3.1	6.2	1.3	2.1	-2.0	1.2	-0.9	2.5
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	11.4	2.9	1.4	1.6	3.4	1.3	2.6
Forced vital capacity (FVC), Best measure	2.4	8.7	16.8	-2.1	-2.6	4.1	2.9	3.9	-0.5
Impedance of whole body	2.4	12.4	50.8	7.1	1.0	1.3	3.5	1.5	2.5
Systolic Blood Pressure	2.3	11.5	36.8	6.1	3.6	-1.7	3.0	-0.6	2.5
Medication: Ramipril	2.3	3.0	6.1	2.5	2.2	-0.8	1.4	-0.8	2.0
Leg fat mass (left)	2.3	8.9	27.8	-5.3	-2.8	1.7	-1.7	1.4	-3.2
Type 2 Diabetes (T2D) (2012)	2.2	2.5	8.5	2.9	0.7	0.2	2.1	0.7	0.9
Blood Platelet Count	2.2	25.5	54.8	4.6	-0.3	5.0	7.4	6.7	2.5
Type 2 Diabetes (T2D) (2018)	2.2	4.2	10.3	-1.3	-0.9	2.9	1.9	3.2	-0.7
Alcohol intake versus 10 years previously	2.2	3.2	8.2	-2.9	-2.0	1.3	-0.8	0.6	-2.1
Forced expiratory volume in 1-second (FEV1)	2.2	7.4	13.8	-2.7	-2.1	3.7	2.9	3.2	0.1
Lung cancer (father)	2.1	2.4	4.8	-0.0	-2.2	1.7	-0.5	1.7	-1.9
Medication: Paracetamol	2.1	3.4	6.6	1.2	2.3	-1.7	1.7	-1.2	2.6
Leg fat mass (right)	2.1	8.2	26.1	-5.1	-2.8	1.7	-1.4	1.4	-2.9
Asthma (self-reported)	2.1	4.2	12.8	1.2	1.3	-3.6	-1.3	-2.6	0.8
Bipolar Disorder (2011)	2.0	1.9	6.6	2.6	0.1	0.8	1.6	0.5	1.2
Lung FEV1/FVC ratio	2.0	10.0	19.2	-3.9	-3.6	0.6	-3.4	-0.9	-4.4
Asthma	2.0	4.0	12.9	0.8	1.1	-3.6	-1.5	-2.5	0.5
Arm fat mass (right)	2.0	8.0	26.8	-5.2	-2.5	0.6	-2.3	0.4	-3.0
Qualifications: nursing, teaching	2.0	3.1	6.4	0.9	1.8	0.8	2.5	1.2	2.4
Major Depression (MDD)	1.9	2.2	4.9	2.1	0.7	1.0	2.2	1.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	9.2	3.0	1.0	1.5	2.7	0.7	2.4
Qualifications: A levels/AS levels or equivalent	1.9	4.2	8.7	1.6	0.2	2.3	3.0	2.8	0.7
Mouth/teeth dental problems: Dentures	1.9	3.2	7.1	-2.2	-2.0	1.0	-1.0	1.2	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	11.6	-2.9	-2.5	3.4	1.8	2.7	-0.7
Medication: Ventolin 100micrograms inhaler	1.9	2.5	4.9	1.2	2.1	-2.2	0.8	-1.0	1.5
Comparative body size at age 10	1.9	5.2	10.7	-3.3	-2.0	0.9	-2.3	0.3	-3.2
Medication for cholesterol	1.9	2.8	8.4	-1.8	-0.3	-0.2	-2.9	-1.8	-1.4
Arm fat mass (left)	1.9	7.9	25.4	-5.0	-2.6	0.7	-2.3	0.4	-3.0
Neuroticism (Nagel 2018)	1.8	4.2	6.7	2.5	2.5	-2.6	0.0	-1.9	1.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	6.4	2.5	1.5	-0.6	1.4	0.0	1.7
Eye problems/disorders: Diabetes related eye disease	1.8	1.9	4.8	0.4	-0.7	1.9	1.6	2.2	0.2
Average weekly fortified wine intake	1.8	2.1	4.0	1.4	2.0	-1.3	0.8	-1.0	1.8
Arm fat percentage (right)	1.8	7.1	17.6	-4.2	-1.8	-0.7	-3.4	-1.2	-2.8
Impedance of arm (left)	1.8	8.3	39.9	6.3	1.0	0.2	2.2	0.3	2.0
Migraine (self-reported)	1.8	2.2	10.2	-3.2	-1.2	0.2	-1.2	-0.2	0.1
Arm fat percentage (left)	1.8	7.2	15.7	-4.0	-1.7	-1.0	-3.6	-1.6	-2.8
Irritable Bowel Disease (IBD)	1.7	4.1	9.0	0.6	-1.7	3.0	1.9	3.0	0.2
Ulcerative Colitis (UC)	1.7	3.3	7.3	0.2	-1.7	2.7	1.4	2.7	-0.1
Neuroticism	1.7	4.1	7.4	2.0	1.8	-2.7	-1.4	-2.7	0.7
High blood pressure	1.7	4.8	10.8	3.3	-0.6	2.1	2.2	2.8	-0.8
Waist circumference	1.7	6.1	16.6	-4.1	-2.3	2.1	-0.1	2.3	-2.2
Impedance of arm (right)	1.7	7.8	36.6	6.0	0.7	0.7	2.3	0.8	1.9
Pulse wave reflection index	1.7	2.1	9.5	-3.1	0.4	0.3	0.9	1.0	0.9
Whole body fat mass	1.7	6.9	21.4	-4.6	-2.6	1.5	-1.4	1.3	-2.8
Ever had bowel cancer screening	1.7	2.0	5.7	0.8	-0.6	1.4	1.8	2.4	0.4
Diabetes diagnosed by doctor	1.7	2.8	7.1	-1.0	-1.2	2.3	1.0	2.7	-0.9
Medication: Aspirin	1.7	2.2	4.6	0.9	0.4	1.9	2.0	2.1	0.3
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.8	1.0	1.0	-1.8	-1.6	-1.9	0.1
Ever depressed for a whole week	1.7	2.1	6.6	1.4	0.3	0.7	2.6	1.8	0.4
Sensitivity / hurt feelings	1.6	2.8	5.2	1.9	2.3	-1.8	0.9	-1.0	1.7
Diabetes (self-reported)	1.6	2.5	6.5	-0.8	-1.0	2.3	1.1	2.5	-0.7
Headache pain in last month	1.6	2.7	5.9	-2.4	0.3	-2.1	-1.3	-1.9	0.7
Gout (self-reported)	1.6	2.2	4.3	1.0	1.9	-0.3	1.9	0.7	2.1
Back pain experienced in last month	1.6	2.4	3.8	-1.3	-1.7	1.9	0.2	1.8	-1.6
Medication: Lisinopril	1.6	2.0	4.0	2.0	0.6	1.1	1.9	1.6	0.3
Leg fat percentage (left)	1.6	5.8	16.8	-4.1	-1.8	0.2	-2.7	-0.3	-2.7
Coronary Artery Disease (CAD)	1.5	1.8	6.6	2.6	0.8	-0.2	1.3	-0.2	1.4
Lupus	1.5	2.3	5.3	-1.5	-2.3	1.0	-0.6	1.3	-1.7
Neuroticism (2016)	1.5	2.2	4.8	0.4	1.9	-2.2	-1.1	-1.8	0.5
Financial difficulties in last 2 years	1.5	2.0	4.0	-1.9	-1.7	0.7	0.0	1.0	-2.0
Medication for pain relief, constipation, heartburn	1.5	2.6	5.1	-0.9	-2.2	1.1	-1.6	1.0	-2.3
Medication: Aspirin	1.5	2.0	4.0	0.7	0.4	2.0	1.8	2.0	0.3
Illnesses of father: Heart disease	1.5	2.1	6.6	0.9	0.4	1.2	2.6	1.4	1.2
Long-standing illness, disability or infirmity	1.5	2.3	5.5	-0.4	-0.7	2.3	1.5	2.3	-0.2
Diastolic blood pressure, automated reading	1.5	4.6	9.7	1.6	0.2	2.4	3.1	3.1	0.1
Vascular/heart problems diagnosed by doctor	1.5	4.1	9.0	-3.0	0.3	-2.1	-2.2	-2.5	0.6
Verbal and Numeric Reasoning (VNR)	1.4	3.4	6.3	0.4	-2.0	2.4	-0.9	1.9	-2.5
Ever had hysterectomy (womb removed)	1.4	1.6	4.5	-0.4	0.7	-1.5	-1.1	-2.1	1.0
Townsend deprivation index at recruitment	1.4	2.0	3.8	0.0	-1.9	1.5	0.3	1.9	-1.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.2	-0.4	0.8	-1.6	-1.0	-2.1	1.0
Trunk fat mass	1.4	6.2	18.3	-4.3	-2.5	1.8	-0.9	1.6	-2.4
Pulse rate	1.4	2.4	4.3	1.1	0.2	-2.1	-2.0	-2.1	-0.7
Hypertension (Self-reported)	1.4	3.8	9.9	3.1	-0.6	1.8	1.7	2.3	-0.9
Friendships satisfaction	1.4	1.7	4.0	-1.6	-0.8	-0.5	-2.0	-0.4	-1.6
Medication: Paracetamol	1.4	2.2	3.7	1.3	1.8	-1.1	1.7	-0.7	1.9
Fractured/broken bones in last 5 years	1.4	1.9	3.6	0.9	1.5	-1.9	-0.5	-1.9	0.8
Schizophrenia (2014)	1.3	3.0	15.6	4.0	0.8	-0.3	0.6	-0.9	0.3
Chronotype (morning person)	1.3	3.1	6.7	-1.6	-2.1	0.3	-2.6	-0.1	-2.2
Medication for hormone replacement therapy	1.3	1.5	3.7	1.1	0.1	-0.2	1.9	0.2	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.6	-0.2	-1.9	1.6	0.5	2.1	-1.1
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.2	-0.6	-1.2	1.8	1.0	1.7	-0.4
Leg fat percentage (right)	1.3	4.6	14.7	-3.8	-1.6	0.1	-2.3	-0.5	-2.2
Worry too long after embarrassment	1.3	2.2	4.6	0.8	1.9	-2.1	-0.3	-1.9	0.9
Eye problems/disorders: None of the above	1.3	1.5	3.8	-2.0	-0.1	-0.5	-1.6	-1.4	-0.6
Mean time to correctly identify matches	1.3	2.5	5.2	2.3	1.8	-1.8	-0.3	-1.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	7.1	-2.7	-1.9	1.1	-1.6	-0.7	-1.5
Basal cell carcinoma (self-reported)	1.3	1.6	3.1	1.6	0.2	1.2	1.8	1.4	0.7
Heart disease (siblings)	1.3	1.6	4.0	1.2	0.5	1.2	2.0	1.1	1.1
Bipolar Disorder or Schizophrenia	1.2	2.9	15.6	4.0	0.2	0.7	1.0	-0.1	0.1
Mean Putamen Volume	1.2	1.4	4.3	0.1	-0.5	1.4	1.3	2.1	-0.4
Number of treatments/medications taken	1.2	2.1	4.4	1.4	1.7	-0.3	2.1	0.4	1.8
Fluid intelligence score	1.2	2.5	4.5	0.0	-1.9	2.1	-0.6	1.5	-2.0
Neuroticism score	1.2	2.4	4.9	1.6	0.9	-2.2	-1.3	-2.2	0.3
Falls in the last year	1.2	1.6	2.8	0.1	-1.3	1.5	0.6	1.6	-1.7
Medication: Ibuprofen	1.2	1.5	2.7	-1.4	0.9	-1.3	-0.2	-1.6	1.4
Mineral and other dietary supplements	1.2	1.6	5.0	2.2	1.3	-0.9	-0.0	-1.0	1.0
Number of self-reported non-cancer illnesses	1.2	2.0	7.1	2.7	1.2	-1.3	0.5	-0.6	1.0
Medication: Blood pressure	1.2	2.2	4.9	1.3	-0.3	1.3	2.2	2.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.7	0.3	1.5	-1.5	0.2	-1.6	1.3
Schizophrenia (2018)	1.1	2.2	12.1	3.5	0.5	0.5	0.4	-0.8	-0.1
Rheumatoid Arthritis	1.1	1.5	3.6	-0.9	-1.4	1.9	0.5	1.5	-0.7
Relative age voice broke	1.1	1.6	3.8	1.2	-1.1	1.9	0.5	1.5	-0.9
Qualifications: None of the above	1.1	2.3	4.2	-2.1	-2.0	0.3	-1.1	0.6	-1.9
Body fat percentage	1.1	4.3	11.2	-3.3	-1.6	-0.0	-2.4	-0.4	-2.4
Family relationship satisfaction	1.1	1.4	2.6	-1.6	-1.1	1.0	-0.2	1.2	-1.5
Breast cancer (self-reported)	1.1	1.3	3.4	-0.5	-1.4	0.7	-1.3	0.4	-1.8
Illnesses of father: None of the above (group 1)	1.1	1.4	3.6	-0.8	-1.3	0.3	-1.9	-0.4	-1.5
Guilty feelings	1.1	1.7	4.2	-0.2	2.1	-1.5	-0.1	-1.3	1.4
Risk taking	1.1	1.7	3.9	-2.0	-1.5	1.5	-0.0	1.0	-0.9
Intelligence (Savage-Jansen 2018)	1.0	3.0	6.3	1.2	-1.3	2.5	0.1	2.3	-1.7
Ovarian Cancer	1.0	1.4	2.5	0.1	1.6	-0.7	1.6	0.6	1.5
Angina	1.0	1.3	2.9	0.1	-0.1	1.7	1.4	1.6	0.2
Severe depression (siblings)	1.0	1.1	2.5	1.6	0.9	-1.3	0.1	-1.0	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	3.1	1.0	-0.4	1.4	1.7	1.8	0.3
Hair/balding pattern: Pattern 4	1.0	2.4	5.1	-0.6	-2.3	1.3	-1.6	0.7	-2.0
Blood clot in the leg (DVT)	1.0	1.3	2.2	0.1	1.4	-1.4	0.1	-1.5	1.1
Medication: Blood pressure	1.0	1.7	5.9	2.4	0.0	1.2	0.9	1.2	-0.8
Heart disease (mother)	1.0	1.2	3.8	1.9	0.8	-0.7	0.8	-0.6	1.2
Leg pain on walking	1.0	1.2	2.0	-1.4	-0.5	-1.0	-1.3	-0.4	-1.4
Alzheimer’s Disease (in father)	0.9	0.9	1.6	-1.0	1.2	-1.1	0.6	-0.2	1.3
Crohns Disease (2017)	0.9	2.0	5.1	-0.3	-1.3	2.3	0.9	2.1	-0.2
Primary Biliary Cirrhosis	0.9	1.2	3.7	0.7	0.3	0.7	1.9	0.5	1.5
Relative age of first facial hair	0.9	1.9	3.5	1.4	-0.8	1.5	1.8	1.9	0.2
Supplements: Zinc	0.9	0.9	2.2	-1.5	-0.4	0.6	1.1	1.2	-0.0
Had menopause	0.9	1.1	2.8	0.2	0.5	-1.2	-1.5	-1.7	-0.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	1.5	-0.3	0.9	1.3	1.4	-0.4
Shortness of breath walking on level ground	0.9	1.1	2.2	-1.0	0.7	-1.5	-1.2	-1.0	-0.7
Angina (self-reported)	0.9	1.2	2.7	0.4	0.2	1.5	1.6	1.4	0.6
Average weekly red wine intake	0.9	1.4	2.6	1.6	1.6	0.0	1.0	-0.3	1.4
Commuting to job workplace: Walk	0.9	1.0	3.8	2.0	0.4	-0.8	-0.4	-1.0	0.5
Heel T-Score	0.8	6.6	13.2	2.5	1.6	2.2	3.3	1.3	3.6
Systolic blood pressure, automated reading	0.8	2.2	8.0	2.8	1.4	-1.5	0.2	-1.2	-0.2
Vitamin and mineral supplements	0.8	1.0	4.2	2.1	0.7	-0.8	-0.6	-0.6	-0.4
Medication: Metformin	0.8	1.2	4.2	-1.0	-0.7	2.0	0.0	1.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.6	0.3	0.3	-1.6	-0.6	-1.4	0.9
Mouth/teeth dental problems	0.8	1.3	4.2	1.1	0.9	-0.3	0.7	-0.9	2.1
Happiness	0.8	0.9	1.6	-1.3	0.5	-1.3	-0.5	-1.1	0.7
Medication: Lansoprazole	0.8	0.9	2.5	1.5	0.8	-1.6	-0.2	-0.4	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.4	0.8	1.0	-1.9	0.6	-0.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.9	-0.4	-0.1	-1.1	-1.7	-1.3	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.2	0.2	0.4	0.9	1.5	1.3	-0.2
Eye problems/disorders: Cataract	0.8	1.0	2.0	1.4	1.1	-0.8	1.0	0.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.6	-0.4	0.7	0.2	1.9	0.6	1.1
Osteoporosis (self-reported)	0.8	0.9	2.3	0.5	0.6	-1.5	-0.8	-1.4	0.0
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-0.9	0.1	-1.2	-1.5	-1.4	0.4
Ever taken oral contraceptive pill	0.8	0.9	4.0	-2.0	0.2	-0.1	0.6	-0.1	1.1
Average weekly beer plus cider intake	0.8	1.2	4.1	2.0	0.5	-0.3	1.2	0.3	1.0
Bipolar Disorder (2018)	0.7	1.0	4.1	2.0	-0.3	0.6	1.1	0.7	0.2
Age at First Birth	0.7	1.0	1.8	-0.2	-1.2	1.0	-0.9	0.8	-1.4
Hair/balding pattern: Pattern 2	0.7	0.9	1.6	-1.0	1.3	-0.9	-0.0	-1.0	1.1
Pain all over the body in last month	0.7	0.7	1.4	0.5	-0.3	-1.2	-1.1	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.2	-0.5	-1.4	0.7	-0.7	0.7	-1.5
Qualifications: College or University degree	0.7	2.2	3.9	2.0	1.8	0.4	1.6	0.3	1.8
Medication: Omeprazole	0.7	0.9	3.7	1.9	0.2	0.4	1.1	0.4	0.3
Suffer from ‘nerves’	0.7	1.1	6.2	2.5	0.3	-0.2	0.1	-0.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.3	-0.4	0.6	0.3	1.5	0.2	1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	-1.1	-0.6	-0.4	-1.3	-0.1	-1.1
Knee pain experienced in last month	0.7	1.0	2.5	-1.6	-1.2	0.8	-0.5	0.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.0	0.4	-0.8	1.4	0.8	1.1	-0.2
Alcohol drinker status: Never	0.7	0.8	2.9	-1.7	-0.7	0.3	-1.1	-0.3	-0.4
Irritability	0.7	1.2	2.2	-0.6	-1.5	1.0	-0.4	1.1	-1.4
Breast Cancer	0.6	1.4	2.9	-1.6	-0.6	-0.7	-1.4	-0.4	-1.7
HbA1C	0.6	0.7	1.5	-0.1	1.1	-0.8	0.5	-0.7	1.2
Lung FVC	0.6	3.0	7.6	-1.9	-0.2	-1.9	-1.8	-2.8	-0.0
Diabetes (father)	0.6	0.7	2.3	-1.5	-0.8	0.7	-0.1	0.6	-0.8
Trunk fat percentage	0.6	2.6	8.0	-2.8	-1.1	-0.1	-1.7	-0.3	-1.7
Taking other prescription medications	0.6	1.0	3.9	2.0	0.6	-0.6	0.8	0.4	0.6
Age when periods started (menarche)	0.6	1.4	3.4	0.5	-0.6	1.8	1.3	1.5	0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	-0.9	-0.6	-1.1	-1.0	-0.5	-0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.7	0.9	-1.3	0.0	-0.9	0.5
Alcohol usually taken with meals	0.6	1.0	2.4	-0.7	0.9	-0.5	-0.3	-1.4	1.5
Illnesses of siblings	0.6	0.8	2.2	-0.2	0.7	-0.3	-1.4	-1.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.4	0.2	1.1	-0.1	1.2	0.2	1.1
High blood pressure (siblings)	0.6	0.9	2.2	0.9	-0.7	0.5	1.2	1.5	0.1
Number of full brothers	0.6	0.8	2.1	-0.2	-1.4	0.5	-0.2	0.6	-1.5
Had major operations	0.6	0.7	1.5	-1.2	-1.1	0.2	-0.8	-0.0	-0.9
Supplements: Vitamin C	0.6	0.7	2.6	-1.6	0.1	0.1	0.9	0.6	0.6
Illnesses of siblings: Diabetes	0.6	0.7	2.2	0.5	-0.4	0.7	1.0	1.5	-0.3
Commuting to job workplace: Cycle	0.6	0.8	1.9	-0.4	-0.4	1.4	0.8	1.1	-0.7
Alcohol drinker status: Previous	0.6	0.7	1.2	0.9	-0.6	0.9	0.2	1.0	-1.1
Schizophrenia vs Biploar Disorder	0.5	0.7	1.6	0.6	0.5	-0.9	-0.9	-1.3	0.1
Triglycerides	0.5	0.9	1.8	0.8	1.0	-0.1	1.1	0.7	1.3
Blood Red Count	0.5	5.0	20.7	4.5	-0.3	0.9	1.9	1.7	1.4
Hypothyroidism (self reported)	0.5	1.2	3.3	0.5	0.7	0.4	1.8	1.2	1.4
Tanning	0.5	6.7	9.6	-2.6	-3.1	2.9	-0.1	2.6	-2.9
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.6	0.8	-1.2	0.1	-0.7	0.7
High blood pressure (mother)	0.5	0.7	1.5	-0.2	0.7	-0.9	-0.9	-1.2	-0.8
Depression (self-reported)	0.5	0.6	1.2	-0.3	1.1	-1.0	0.3	0.0	1.0
Exposure to tobacco smoke at home	0.5	0.5	2.1	-0.3	-0.6	0.4	-0.6	-0.1	-1.5
Medication: Amlodipine	0.5	0.7	2.0	1.4	0.1	-0.6	-0.9	-0.5	-1.0
Medication: Allopurinol	0.5	0.6	1.6	0.0	0.4	0.7	1.3	1.1	0.4
Overall health rating	0.5	1.1	2.1	-0.7	-1.3	-0.5	-1.4	0.1	-1.5
Mood swings	0.5	0.8	2.0	0.4	-0.1	-1.4	-1.3	-1.0	-0.5
Miserableness	0.5	0.8	2.2	-0.5	-1.0	0.7	0.8	1.5	-0.3
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.3	-0.4	-0.0	1.1	0.9	1.0	-0.1
Unable to work because of sickness or disability	0.5	0.6	1.1	-0.1	-0.7	0.9	0.4	1.0	-1.0
Serious illness, injury or assault to yourself	0.4	0.5	1.8	0.5	0.7	-1.4	-0.3	-0.6	0.1
Supplements: Glucosamine	0.4	0.5	1.7	-1.3	-0.7	0.4	0.3	0.7	-0.3
Time employed in main current job	0.4	0.4	0.9	0.9	0.9	-0.5	-0.3	-0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.0	-1.0	0.2	-0.9	-0.6	-0.9	0.8
Health satisfaction	0.4	0.5	1.1	-0.8	-0.4	-0.1	0.0	1.0	-1.1
Pulse rate, automated reading	0.4	1.3	3.2	1.8	-0.5	-0.7	-1.6	-1.0	-0.7
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.9	0.7	-1.1	-0.1	-0.7	0.1
Medication: Gliclazide	0.4	0.5	1.4	-0.1	-0.5	1.0	0.3	1.2	-0.6
Medication: Atorvastatin	0.4	0.5	1.1	0.7	0.3	0.3	0.9	0.7	1.0
Number of operations (self-reported)	0.4	0.5	1.3	-1.1	0.6	-0.6	-0.1	-0.4	0.9
Supplements: Calcium	0.4	0.4	0.9	-0.7	-0.4	-0.6	-0.9	-0.5	-0.7
Depressed Affect (Nagel 2018)	0.3	0.7	2.4	0.1	-0.1	-1.5	-0.9	-0.7	-0.4
LDL Cholesterol	0.3	0.5	0.9	-0.4	0.0	-0.9	-1.0	-0.9	0.2
Average weekly spirits intake	0.3	0.4	1.4	-0.3	0.2	-0.3	1.2	-0.0	0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.9	1.0	-0.4	0.3	0.9	0.8	0.5
Fed-up feelings	0.3	0.6	2.0	0.2	-0.1	-1.4	-0.7	-0.9	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	-0.8	0.1	-0.2	0.4	-0.8
Multivitamins +/- minerals	0.3	0.4	1.7	-1.3	-0.3	0.2	0.5	0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	-0.7	-0.5	-0.7	-0.8	-0.9	-0.3
Had other major operations	0.3	0.4	0.9	-0.7	1.0	-0.5	0.1	-0.3	0.7
Father’s age at death	0.3	0.5	1.6	0.1	0.5	1.3	0.6	0.7	0.1
Tense / ‘highly strung’	0.3	0.4	0.8	0.0	-0.9	0.3	-0.9	-0.5	-0.7
Loud music exposure frequency	0.3	0.4	0.9	-0.1	-0.7	0.5	0.9	0.6	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	0.4	-0.1	0.6	0.9	1.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.7	1.3	0.6	-0.1	1.1	0.3	0.8
Number of children fathered	0.3	0.3	0.7	-0.8	0.6	0.4	0.7	0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.3	-1.1	-0.2	-0.0	0.7	0.7	0.4
Chest pain or discomfort	0.3	0.4	0.8	-0.9	-0.8	-0.2	-0.5	0.1	-0.7
Age at last live birth	0.3	0.5	0.9	0.4	0.6	0.9	0.4	0.6	0.8
Loneliness, isolation	0.3	0.5	1.4	0.2	-0.4	-0.7	-1.2	-0.6	-0.7
Mother’s age at death	0.3	0.4	1.5	0.2	-0.4	1.2	0.2	0.6	0.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	-1.1	-0.4	0.7	-0.2	-0.1	0.2
Depression (Nagel 2018)	0.2	0.4	1.0	0.6	-0.4	-1.0	-0.5	-0.3	-0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.5	0.3	-0.6	-0.4	-0.6	0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.8	0.6	-0.7	0.1	-0.2	0.5
HDL Cholesterol	0.2	0.3	0.6	0.2	-0.5	0.1	-0.8	-0.7	-0.6
Medication: Co-codamol	0.2	0.2	0.4	0.3	0.1	-0.6	-0.1	-0.6	-0.4
Medication: Levothyroxine sodium	0.2	0.4	0.8	0.6	-0.0	-0.9	-0.8	-0.8	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.8	-0.0	-0.3	0.2	0.2	0.7	-0.9
Heart attack	0.2	0.3	0.6	0.6	0.8	0.3	0.8	-0.3	0.4
Breastfed as a baby	0.2	0.3	1.3	1.2	-0.1	0.3	-0.3	-0.2	0.1
Age at first live birth	0.2	0.4	1.1	-0.6	0.4	0.7	-1.1	0.1	-0.2
Medication: Seretide 50 evohaler	0.2	0.2	1.0	0.4	-0.1	0.2	-0.1	0.3	-1.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.2	0.1	0.8	0.4	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	0.5	0.7	-0.7	0.2	0.5	-0.1
Wears glasses or contact lenses	0.2	0.2	0.7	0.3	0.8	0.1	-0.1	0.5	-0.2
Hearing aid user	0.2	0.2	0.5	-0.5	-0.1	-0.3	-0.7	-0.5	-0.5
Commuting to job workplace: Public transport	0.2	0.3	0.8	0.3	0.3	0.4	0.9	0.2	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.9	-0.5	0.3	0.1	0.3	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.0	0.2	-0.1	0.8	0.7	1.0	-0.2
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.9	0.0	0.4	0.3	0.6	-0.6
Cholesterol lowering medication	0.2	0.3	0.9	0.4	0.6	0.0	0.9	0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.9	0.1	0.1	0.7	0.3	0.4
Pain experienced in last month	0.2	0.3	0.9	0.7	0.3	0.9	0.3	0.6	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.6	0.7	0.2	0.7	-0.3	0.2
Hair Pigment	0.1	2.2	4.2	1.9	2.1	-1.0	1.1	-0.6	1.6
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.4	-0.4	-0.5	0.3	0.2	0.3
Medication: Simvastatin	0.1	0.1	0.3	-0.5	0.3	0.1	0.3	0.1	-0.5
Noisy workplace	0.1	0.1	0.3	0.5	-0.2	-0.5	-0.2	-0.2	-0.1
Prospective memory result	0.1	0.1	0.3	-0.0	0.6	-0.2	0.3	0.5	0.1
Illnesses of mother	0.1	0.1	0.3	-0.6	0.3	-0.4	-0.4	0.0	-0.0
Glaucoma (self-reported)	0.1	0.2	0.7	-0.8	-0.1	0.3	-0.3	-0.2	-0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.6	0.1	-0.8	-0.4	-0.2	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	-0.3	-0.3	0.5	0.3	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.4	0.6	0.1	-0.3	0.2	-0.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.2	0.0	-0.3	0.4	0.3	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	-0.5	0.1	0.1	0.2	0.4	0.5
Myopia	0.1	0.2	0.3	0.3	0.1	-0.6	-0.5	0.2	-0.5
Medication: Cholesterol lowering	0.0	0.1	0.4	0.1	-0.1	0.1	-0.1	0.2	-0.6
Number of full sisters	0.0	0.1	0.1	-0.3	-0.1	-0.4	0.2	-0.1	0.3

Hub : Genes

TRIM8

Models

Trait associations