Hub : Genes

TRIM8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.3440 0.1220 5.0e-04 -0.009 NA 0.068 NA 0.011 8.1e-01 NA 4.7e-03 NA 1.5e-01
2 GTEx Pancreas 0.3240 0.0870 5.9e-06 0.168 NA 0.103 NA 0.190 1.4e-07 NA 4.1e-05 NA 1.9e-08
3 NTR Blood 0.0151 0.0072 6.2e-04 0.010 0.006 0.007 0.006 0.006 2.8e-04 3.1e-03 2.1e-03 4.7e-03 2.9e-03
4 ROSMAP Brain Pre-frontal Cortex 0.0866 0.0286 1.0e-07 0.030 0.056 0.060 0.057 0.058 7.9e-05 8.7e-08 3.7e-08 7.2e-08 5.5e-08
5 YFS Blood 0.0429 0.0147 1.1e-12 0.044 0.042 0.047 0.043 0.049 3.8e-14 8.6e-14 4.0e-15 7.0e-14 1.2e-15
6 TCGA Prostate Adenocarcinoma 0.0642 0.0297 2.4e-05 0.033 0.053 0.054 NA 0.055 2.1e-04 3.2e-06 2.5e-06 NA 1.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.7 1.0 4.1 2.0 -0.3 0.6 1.1 0.7 0.2
Bipolar Disorder or Schizophrenia 1.2 2.9 15.6 4.0 0.2 0.7 1.0 -0.1 0.1
Depressed Affect (Nagel 2018) 0.3 0.7 2.4 0.1 -0.1 -1.5 -0.9 -0.7 -0.4
Depression (Nagel 2018) 0.2 0.4 1.0 0.6 -0.4 -1.0 -0.5 -0.3 -0.5
Intelligence (Savage-Jansen 2018) 1.0 3.0 6.3 1.2 -1.3 2.5 0.1 2.3 -1.7
Neuroticism (Nagel 2018) 1.8 4.2 6.7 2.5 2.5 -2.6 0.0 -1.9 1.5
Schizophrenia (2018) 1.1 2.2 12.1 3.5 0.5 0.5 0.4 -0.8 -0.1
Schizophrenia vs Biploar Disorder 0.5 0.7 1.6 0.6 0.5 -0.9 -0.9 -1.3 0.1
Worry (Nagel 2018) 3.4 7.1 14.3 3.8 2.8 -2.9 -0.4 -3.0 1.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 -0.5 0.3 -0.6 -0.4 -0.6 0.3
Alzheimer’s Disease (in father) 0.9 0.9 1.6 -1.0 1.2 -1.1 0.6 -0.2 1.3
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 -0.8 0.6 -0.7 0.1 -0.2 0.5
Crohns Disease (2017) 0.9 2.0 5.1 -0.3 -1.3 2.3 0.9 2.1 -0.2
Irritable Bowel Disease (IBD) 1.7 4.1 9.0 0.6 -1.7 3.0 1.9 3.0 0.2
Ulcerative Colitis (UC) 1.7 3.3 7.3 0.2 -1.7 2.7 1.4 2.7 -0.1
Major Depression (MDD) 1.9 2.2 4.9 2.1 0.7 1.0 2.2 1.6 0.2
Reaction Time 3.6 6.9 13.6 2.1 2.7 -3.7 -1.4 -3.6 1.1
Verbal and Numeric Reasoning (VNR) 1.4 3.4 6.3 0.4 -2.0 2.4 -0.9 1.9 -2.5
Breast Cancer 0.6 1.4 2.9 -1.6 -0.6 -0.7 -1.4 -0.4 -1.7
Ovarian Cancer 1.0 1.4 2.5 0.1 1.6 -0.7 1.6 0.6 1.5
Prostate Cancer 8.3 11.6 27.4 -0.0 2.8 -4.9 -2.6 -5.2 2.1
Age at First Birth 0.7 1.0 1.8 -0.2 -1.2 1.0 -0.9 0.8 -1.4
Bipolar Disorder (2011) 2.0 1.9 6.6 2.6 0.1 0.8 1.6 0.5 1.2
Body Mass Index (BMI) (2010) 3.5 4.8 15.4 -3.9 -1.6 -0.2 -2.4 -0.7 -2.1
Coronary Artery Disease (CAD) 1.5 1.8 6.6 2.6 0.8 -0.2 1.3 -0.2 1.4
Crohns Disease (2012) 3.2 5.1 11.2 -0.3 -2.6 3.3 0.9 3.1 -1.4
Mean Putamen Volume 1.2 1.4 4.3 0.1 -0.5 1.4 1.3 2.1 -0.4
Fasting Glucose 2.7 3.2 5.8 -0.1 -1.6 2.3 -1.1 2.1 -2.4
HbA1C 0.6 0.7 1.5 -0.1 1.1 -0.8 0.5 -0.7 1.2
HDL Cholesterol 0.2 0.3 0.6 0.2 -0.5 0.1 -0.8 -0.7 -0.6
LDL Cholesterol 0.3 0.5 0.9 -0.4 0.0 -0.9 -1.0 -0.9 0.2
Lupus 1.5 2.3 5.3 -1.5 -2.3 1.0 -0.6 1.3 -1.7
Neuroticism (2016) 1.5 2.2 4.8 0.4 1.9 -2.2 -1.1 -1.8 0.5
Primary Biliary Cirrhosis 0.9 1.2 3.7 0.7 0.3 0.7 1.9 0.5 1.5
Rheumatoid Arthritis 1.1 1.5 3.6 -0.9 -1.4 1.9 0.5 1.5 -0.7
Schizophrenia (2014) 1.3 3.0 15.6 4.0 0.8 -0.3 0.6 -0.9 0.3
Triglycerides 0.5 0.9 1.8 0.8 1.0 -0.1 1.1 0.7 1.3
Type 2 Diabetes (T2D) (2012) 2.2 2.5 8.5 2.9 0.7 0.2 2.1 0.7 0.9
Ulcerative Colitis 4.5 6.6 14.6 1.1 -1.6 3.8 2.7 3.7 0.0
Blood Eosinophil Count 2.6 20.0 40.4 6.4 2.6 2.4 6.2 3.4 4.2
Blood Platelet Count 2.2 25.5 54.8 4.6 -0.3 5.0 7.4 6.7 2.5
Blood Red Count 0.5 5.0 20.7 4.5 -0.3 0.9 1.9 1.7 1.4
Blood White Count 2.9 21.6 45.2 2.3 -2.9 6.6 5.2 6.7 -0.8
Heel T-Score 0.8 6.6 13.2 2.5 1.6 2.2 3.3 1.3 3.6
BMI 4.0 23.1 81.0 -9.0 -2.1 -1.4 -5.3 -2.1 -4.3
Height 7.0 134.7 320.4 -1.4 -6.3 15.7 14.1 17.9 0.8
Waist Hip Ratio (WHR) 3.3 15.0 38.9 3.1 1.1 3.5 6.2 4.3 3.2
Systolic Blood Pressure 2.3 11.5 36.8 6.1 3.6 -1.7 3.0 -0.6 2.5
Smoking Status 9.7 23.3 42.2 -2.5 -6.5 5.5 0.2 5.7 -5.4
Allergy or Eczema 11.4 29.9 70.6 0.3 3.4 -7.6 -6.2 -8.4 1.1
Cardiovascular Disease 2.4 7.9 14.8 3.9 0.3 2.2 3.8 3.5 0.5
Hypothyroidism (self reported) 0.5 1.2 3.3 0.5 0.7 0.4 1.8 1.2 1.4
Respiratory disease 2.7 5.9 14.5 1.8 2.2 -3.8 -1.1 -3.0 1.6
Type 2 Diabetes (T2D) (2018) 2.2 4.2 10.3 -1.3 -0.9 2.9 1.9 3.2 -0.7
Lung FEV1/FVC ratio 2.0 10.0 19.2 -3.9 -3.6 0.6 -3.4 -0.9 -4.4
Lung FVC 0.6 3.0 7.6 -1.9 -0.2 -1.9 -1.8 -2.8 -0.0
Neuroticism 1.7 4.1 7.4 2.0 1.8 -2.7 -1.4 -2.7 0.7
Chronotype (morning person) 1.3 3.1 6.7 -1.6 -2.1 0.3 -2.6 -0.1 -2.2
Hair Pigment 0.1 2.2 4.2 1.9 2.1 -1.0 1.1 -0.6 1.6
Tanning 0.5 6.7 9.6 -2.6 -3.1 2.9 -0.1 2.6 -2.9
Hand grip strength (left) 3.8 10.0 17.8 -2.9 -3.0 4.2 2.6 4.2 -0.7
Number of treatments/medications taken 1.2 2.1 4.4 1.4 1.7 -0.3 2.1 0.4 1.8
Average weekly spirits intake 0.3 0.4 1.4 -0.3 0.2 -0.3 1.2 -0.0 0.9
Sensitivity / hurt feelings 1.6 2.8 5.2 1.9 2.3 -1.8 0.9 -1.0 1.7
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.9 1.0 -0.4 0.3 0.9 0.8 0.5
Hearing difficulty/problems: Yes 3.5 5.4 10.8 1.5 -2.1 3.2 1.0 3.3 -2.0
Relative age of first facial hair 0.9 1.9 3.5 1.4 -0.8 1.5 1.8 1.9 0.2
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 6.4 2.5 1.5 -0.6 1.4 0.0 1.7
Ever used hormone-replacement therapy (HRT) 2.4 3.1 6.2 1.3 2.1 -2.0 1.2 -0.9 2.5
Ever had hysterectomy (womb removed) 1.4 1.6 4.5 -0.4 0.7 -1.5 -1.1 -2.1 1.0
Systolic blood pressure, automated reading 0.8 2.2 8.0 2.8 1.4 -1.5 0.2 -1.2 -0.2
Eye problems/disorders: Diabetes related eye disease 1.8 1.9 4.8 0.4 -0.7 1.9 1.6 2.2 0.2
Angina 1.0 1.3 2.9 0.1 -0.1 1.7 1.4 1.6 0.2
Medication for hormone replacement therapy 1.3 1.5 3.7 1.1 0.1 -0.2 1.9 0.2 1.9
Vitamin and mineral supplements 0.8 1.0 4.2 2.1 0.7 -0.8 -0.6 -0.6 -0.4
Supplements: Zinc 0.9 0.9 2.2 -1.5 -0.4 0.6 1.1 1.2 -0.0
Medication: Co-codamol 0.2 0.2 0.4 0.3 0.1 -0.6 -0.1 -0.6 -0.4
Medication: Metformin 0.8 1.2 4.2 -1.0 -0.7 2.0 0.0 1.1 -0.5
Diabetes (father) 0.6 0.7 2.3 -1.5 -0.8 0.7 -0.1 0.6 -0.8
Diabetes (mother) 2.7 3.4 7.4 0.7 -0.3 2.1 2.7 2.5 1.4
Severe depression (siblings) 1.0 1.1 2.5 1.6 0.9 -1.3 0.1 -1.0 0.7
Pack years adult smoking proportion 2.5 3.8 8.4 0.1 -2.7 1.9 -0.1 1.9 -2.9
Impedance of leg (right) 3.1 15.0 45.4 6.7 0.7 2.4 4.8 2.6 2.9
Leg fat-free mass (left) 2.6 13.9 39.3 -6.3 -3.4 3.4 0.3 3.7 -2.7
Trunk fat percentage 0.6 2.6 8.0 -2.8 -1.1 -0.1 -1.7 -0.3 -1.7
Hand grip strength (right) 2.7 7.4 12.1 -3.3 -2.9 3.5 2.0 2.9 -0.5
Townsend deprivation index at recruitment 1.4 2.0 3.8 0.0 -1.9 1.5 0.3 1.9 -1.5
Current tobacco smoking 6.3 10.2 18.2 -2.1 -4.3 3.2 0.0 3.5 -4.1
Average weekly fortified wine intake 1.8 2.1 4.0 1.4 2.0 -1.3 0.8 -1.0 1.8
Maternal smoking around birth 3.0 4.4 7.4 -1.5 -2.6 2.7 0.6 2.6 -1.7
Fed-up feelings 0.3 0.6 2.0 0.2 -0.1 -1.4 -0.7 -0.9 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.8 -0.9 -0.8 0.1 -0.2 0.4 -0.8
Relative age voice broke 1.1 1.6 3.8 1.2 -1.1 1.9 0.5 1.5 -0.9
Taking other prescription medications 0.6 1.0 3.9 2.0 0.6 -0.6 0.8 0.4 0.6
Age when periods started (menarche) 0.6 1.4 3.4 0.5 -0.6 1.8 1.3 1.5 0.7
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 4.2 -0.4 0.8 -1.6 -1.0 -2.1 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.3 9.2 3.0 1.0 1.5 2.7 0.7 2.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.2 -0.9 -0.6 -1.1 -1.0 -0.5 -0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.2 -0.4 -0.4 -0.5 0.3 0.2 0.3
Serious illness, injury or assault to yourself 0.4 0.5 1.8 0.5 0.7 -1.4 -0.3 -0.6 0.1
High blood pressure 1.7 4.8 10.8 3.3 -0.6 2.1 2.2 2.8 -0.8
Hayfever, allergic rhinitis or eczema 9.7 21.0 47.2 1.0 3.2 -6.6 -4.5 -6.9 1.6
Multivitamins +/- minerals 0.3 0.4 1.7 -1.3 -0.3 0.2 0.5 0.3 0.6
Stomach or abdominal pain in last month 0.5 0.6 1.5 -0.6 0.8 -1.2 0.1 -0.7 0.7
Supplements: Glucosamine 0.4 0.5 1.7 -1.3 -0.7 0.4 0.3 0.7 -0.3
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.6 0.3 0.3 -1.6 -0.6 -1.4 0.9
Medication: Atenolol 2.9 3.7 9.4 1.5 -0.9 3.1 1.8 2.4 -0.7
Medication: Levothyroxine sodium 0.2 0.4 0.8 0.6 -0.0 -0.9 -0.8 -0.8 -0.2
Sitting height 6.4 45.2 112.4 0.3 -2.9 9.0 8.4 10.6 0.1
Chronic bronchitis/emphysema (father) 0.6 0.7 1.6 0.7 0.9 -1.3 0.0 -0.9 0.5
High blood pressure (mother) 0.5 0.7 1.5 -0.2 0.7 -0.9 -0.9 -1.2 -0.8
Body mass index (BMI) 3.0 12.7 38.7 -6.2 -1.6 -1.5 -4.3 -2.0 -3.2
Impedance of leg (left) 2.8 13.6 41.0 6.4 0.3 2.7 4.4 2.9 2.4
Leg predicted mass (left) 2.7 14.0 38.9 -6.2 -3.4 3.5 0.4 3.7 -2.7
Trunk fat mass 1.4 6.2 18.3 -4.3 -2.5 1.8 -0.9 1.6 -2.4
Waist circumference 1.7 6.1 16.6 -4.1 -2.3 2.1 -0.1 2.3 -2.2
Number of incorrect matches in round 5.2 8.7 15.4 1.9 3.9 -3.3 1.2 -2.6 3.7
Past tobacco smoking 7.6 14.0 30.7 -0.3 3.9 -5.2 -2.7 -5.5 1.9
Alcohol usually taken with meals 0.6 1.0 2.4 -0.7 0.9 -0.5 -0.3 -1.4 1.5
Nervous feelings 2.8 5.2 16.1 4.0 2.2 -1.5 0.7 -1.7 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.8 -0.7 -0.5 -0.7 -0.8 -0.9 -0.3
Hearing difficulty/problems with background noise 8.1 12.9 25.9 1.7 -3.4 5.1 1.7 5.0 -3.0
Hair/balding pattern: Pattern 2 0.7 0.9 1.6 -1.0 1.3 -0.9 -0.0 -1.0 1.1
Had menopause 0.9 1.1 2.8 0.2 0.5 -1.2 -1.5 -1.7 -0.3
Had other major operations 0.3 0.4 0.9 -0.7 1.0 -0.5 0.1 -0.3 0.7
Forced vital capacity (FVC) 3.0 11.7 22.9 -1.8 -2.3 4.8 4.1 4.7 0.2
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.5 11.4 2.9 1.4 1.6 3.4 1.3 2.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.8 -0.0 -0.3 0.2 0.2 0.7 -0.9
Qualifications: None of the above 1.1 2.3 4.2 -2.1 -2.0 0.3 -1.1 0.6 -1.9
Financial difficulties in last 2 years 1.5 2.0 4.0 -1.9 -1.7 0.7 0.0 1.0 -2.0
Mouth/teeth dental problems 0.8 1.3 4.2 1.1 0.9 -0.3 0.7 -0.9 2.1
Heart attack 0.2 0.3 0.6 0.6 0.8 0.3 0.8 -0.3 0.4
Allergy 8.3 19.2 43.9 -1.4 -3.1 6.6 3.7 6.5 -2.0
Pain all over the body in last month 0.7 0.7 1.4 0.5 -0.3 -1.2 -1.1 -0.8 -0.8
Diabetes (self-reported) 1.6 2.5 6.5 -0.8 -1.0 2.3 1.1 2.5 -0.7
Hayfever/allergic rhinitis (self-reported) 3.0 3.9 8.6 1.3 0.8 -2.9 -2.1 -2.9 0.3
Medication: Ramipril 2.3 3.0 6.1 2.5 2.2 -0.8 1.4 -0.8 2.0
Medication: Simvastatin 0.1 0.1 0.3 -0.5 0.3 0.1 0.3 0.1 -0.5
Fluid intelligence score 1.2 2.5 4.5 0.0 -1.9 2.1 -0.6 1.5 -2.0
Illnesses of siblings 0.6 0.8 2.2 -0.2 0.7 -0.3 -1.4 -1.5 -0.2
Neuroticism score 1.2 2.4 4.9 1.6 0.9 -2.2 -1.3 -2.2 0.3
Weight 3.1 15.3 36.8 -6.1 -3.9 3.7 -0.0 3.8 -3.4
Impedance of arm (right) 1.7 7.8 36.6 6.0 0.7 0.7 2.3 0.8 1.9
Arm fat percentage (right) 1.8 7.1 17.6 -4.2 -1.8 -0.7 -3.4 -1.2 -2.8
Trunk fat-free mass 4.3 24.4 42.4 -5.8 -4.5 6.2 2.5 6.5 -2.6
Hip circumference 2.5 10.6 30.7 -5.5 -3.2 1.7 -2.0 1.6 -3.6
Time employed in main current job 0.4 0.4 0.9 0.9 0.9 -0.5 -0.3 -0.4 0.6
Alcohol intake versus 10 years previously 2.2 3.2 8.2 -2.9 -2.0 1.3 -0.8 0.6 -2.1
Father’s age at death 0.3 0.5 1.6 0.1 0.5 1.3 0.6 0.7 0.1
Worrier / anxious feelings 5.5 10.3 18.1 3.2 3.7 -4.2 -1.1 -4.0 1.7
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 4.6 -0.2 -1.9 1.6 0.5 2.1 -1.1
Falls in the last year 1.2 1.6 2.8 0.1 -1.3 1.5 0.6 1.6 -1.7
Hair/balding pattern: Pattern 3 1.0 1.5 3.1 1.0 -0.4 1.4 1.7 1.8 0.3
Number of live births 2.7 3.8 8.3 2.4 2.1 -0.9 1.8 -0.6 2.9
Forced expiratory volume in 1-second (FEV1) 2.2 7.4 13.8 -2.7 -2.1 3.7 2.9 3.2 0.1
Pulse rate 1.4 2.4 4.3 1.1 0.2 -2.1 -2.0 -2.1 -0.7
Happiness 0.8 0.9 1.6 -1.3 0.5 -1.3 -0.5 -1.1 0.7
Noisy workplace 0.1 0.1 0.3 0.5 -0.2 -0.5 -0.2 -0.2 -0.1
Qualifications: A levels/AS levels or equivalent 1.9 4.2 8.7 1.6 0.2 2.3 3.0 2.8 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 1.4 0.2 1.1 -0.1 1.2 0.2 1.1
Mouth/teeth dental problems: Dentures 1.9 3.2 7.1 -2.2 -2.0 1.0 -1.0 1.2 -2.7
Asthma 2.0 4.0 12.9 0.8 1.1 -3.6 -1.5 -2.5 0.5
Medication: Ibuprofen (e.g. Nurofen) 2.7 3.4 7.2 -1.3 1.6 -2.1 -0.5 -2.7 2.1
Medication: Cholesterol lowering 0.0 0.1 0.4 0.1 -0.1 0.1 -0.1 0.2 -0.6
Depression (self-reported) 0.5 0.6 1.2 -0.3 1.1 -1.0 0.3 0.0 1.0
Medication: Lansoprazole 0.8 0.9 2.5 1.5 0.8 -1.6 -0.2 -0.4 -0.0
Prospective memory result 0.1 0.1 0.3 -0.0 0.6 -0.2 0.3 0.5 0.1
Lung cancer (father) 2.1 2.4 4.8 -0.0 -2.2 1.7 -0.5 1.7 -1.9
Illnesses of mother 0.1 0.1 0.3 -0.6 0.3 -0.4 -0.4 0.0 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.2 11.6 -2.9 -2.5 3.4 1.8 2.7 -0.7
Pulse wave Arterial Stiffness index 3.6 4.2 8.9 -0.0 3.0 -2.8 -0.4 -2.1 1.9
Impedance of arm (left) 1.8 8.3 39.9 6.3 1.0 0.2 2.2 0.3 2.0
Arm fat mass (right) 2.0 8.0 26.8 -5.2 -2.5 0.6 -2.3 0.4 -3.0
Trunk predicted mass 4.3 24.4 41.2 -5.8 -4.6 6.1 2.3 6.4 -2.7
Standing height 6.9 68.5 163.8 -0.5 -5.4 11.5 9.2 12.8 -0.3
Length of working week for main job 3.9 4.4 11.9 1.0 0.4 2.0 3.4 2.6 1.6
Exposure to tobacco smoke at home 0.5 0.5 2.1 -0.3 -0.6 0.4 -0.6 -0.1 -1.5
Breastfed as a baby 0.2 0.3 1.3 1.2 -0.1 0.3 -0.3 -0.2 0.1
Tense / ‘highly strung’ 0.3 0.4 0.8 0.0 -0.9 0.3 -0.9 -0.5 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.3 9.1 1.9 2.2 -0.8 3.0 1.0 2.6
Hair/balding pattern: Pattern 4 1.0 2.4 5.1 -0.6 -2.3 1.3 -1.6 0.7 -2.0
Birth weight of first child 4.0 7.2 12.9 -2.2 -3.4 2.5 -1.4 2.4 -3.6
Peak expiratory flow (PEF) 3.9 9.1 17.4 -3.1 -3.1 4.2 1.5 3.6 -1.7
Pulse wave reflection index 1.7 2.1 9.5 -3.1 0.4 0.3 0.9 1.0 0.9
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.2 1.5 -0.3 0.9 1.3 1.4 -0.4
Loud music exposure frequency 0.3 0.4 0.9 -0.1 -0.7 0.5 0.9 0.6 0.5
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.2 0.4 -0.1 0.6 0.9 1.1 -0.2
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.2 -0.5 -1.4 0.7 -0.7 0.7 -1.5
Blood clot in the leg (DVT) 1.0 1.3 2.2 0.1 1.4 -1.4 0.1 -1.5 1.1
Medication: Paracetamol 2.1 3.4 6.6 1.2 2.3 -1.7 1.7 -1.2 2.6
Headache pain in last month 1.6 2.7 5.9 -2.4 0.3 -2.1 -1.3 -1.9 0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.0 -1.0 0.2 -0.9 -0.6 -0.9 0.8
Glaucoma (self-reported) 0.1 0.2 0.7 -0.8 -0.1 0.3 -0.3 -0.2 -0.0
Gout (self-reported) 1.6 2.2 4.3 1.0 1.9 -0.3 1.9 0.7 2.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.7 1.3 0.6 -0.1 1.1 0.3 0.8
Medication: Amlodipine 0.5 0.7 2.0 1.4 0.1 -0.6 -0.9 -0.5 -1.0
Medication: Ventolin 100micrograms inhaler 1.9 2.5 4.9 1.2 2.1 -2.2 0.8 -1.0 1.5
Birth weight 3.0 6.6 15.5 -1.8 -3.9 2.5 -0.8 2.7 -2.6
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.2 -0.6 -1.2 1.8 1.0 1.7 -0.4
High blood pressure (siblings) 0.6 0.9 2.2 0.9 -0.7 0.5 1.2 1.5 0.1
Forced vital capacity (FVC), Best measure 2.4 8.7 16.8 -2.1 -2.6 4.1 2.9 3.9 -0.5
Body fat percentage 1.1 4.3 11.2 -3.3 -1.6 -0.0 -2.4 -0.4 -2.4
Leg fat percentage (right) 1.3 4.6 14.7 -3.8 -1.6 0.1 -2.3 -0.5 -2.2
Arm fat-free mass (right) 3.6 18.4 35.0 -5.9 -3.8 4.9 1.7 5.2 -2.5
Exposure to tobacco smoke outside home 4.4 5.9 10.0 -2.5 -2.6 3.2 0.9 2.9 -1.8
Comparative body size at age 10 1.9 5.2 10.7 -3.3 -2.0 0.9 -2.3 0.3 -3.2
Number of full brothers 0.6 0.8 2.1 -0.2 -1.4 0.5 -0.2 0.6 -1.5
Worry too long after embarrassment 1.3 2.2 4.6 0.8 1.9 -2.1 -0.3 -1.9 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.4 0.8 1.0 -1.9 0.6 -0.4 0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 0.6 0.1 -0.8 -0.4 -0.2 -0.3
Number of children fathered 0.3 0.3 0.7 -0.8 0.6 0.4 0.7 0.1 0.5
Reason for reducing amount of alcohol drunk: Health precaution 3.0 3.5 8.2 2.1 0.2 1.5 2.9 2.4 0.5
Age at first live birth 0.2 0.4 1.1 -0.6 0.4 0.7 -1.1 0.1 -0.2
Pulse wave peak to peak time 4.9 5.7 12.0 0.1 -3.1 3.5 1.1 2.9 -1.7
Health satisfaction 0.4 0.5 1.1 -0.8 -0.4 -0.1 0.0 1.0 -1.1
Shortness of breath walking on level ground 0.9 1.1 2.2 -1.0 0.7 -1.5 -1.2 -1.0 -0.7
Qualifications: College or University degree 0.7 2.2 3.9 2.0 1.8 0.4 1.6 0.3 1.8
Eye problems/disorders: None of the above 1.3 1.5 3.8 -2.0 -0.1 -0.5 -1.6 -1.4 -0.6
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.3 -1.1 -0.2 -0.0 0.7 0.7 0.4
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.4 -0.3 -0.3 0.5 0.3 -0.1
Medication for pain relief, constipation, heartburn 1.5 2.6 5.1 -0.9 -2.2 1.1 -1.6 1.0 -2.3
Neck or shoulder pain in last month 0.1 0.1 0.4 0.6 0.1 -0.3 0.2 -0.1 0.4
Medication: Blood pressure 1.0 1.7 5.9 2.4 0.0 1.2 0.9 1.2 -0.8
Angina (self-reported) 0.9 1.2 2.7 0.4 0.2 1.5 1.6 1.4 0.6
Migraine (self-reported) 1.8 2.2 10.2 -3.2 -1.2 0.2 -1.2 -0.2 0.1
Medication: Ibuprofen 1.2 1.5 2.7 -1.4 0.9 -1.3 -0.2 -1.6 1.4
Medication: Allopurinol 0.5 0.6 1.6 0.0 0.4 0.7 1.3 1.1 0.4
Medication: Omeprazole 0.7 0.9 3.7 1.9 0.2 0.4 1.1 0.4 0.3
Medication: Seretide 50 evohaler 0.2 0.2 1.0 0.4 -0.1 0.2 -0.1 0.3 -1.0
Mean time to correctly identify matches 1.3 2.5 5.2 2.3 1.8 -1.8 -0.3 -1.6 0.7
Heart disease (mother) 1.0 1.2 3.8 1.9 0.8 -0.7 0.8 -0.6 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.2 0.0 -0.3 0.4 0.3 0.1
Whole body fat mass 1.7 6.9 21.4 -4.6 -2.6 1.5 -1.4 1.3 -2.8
Leg fat mass (right) 2.1 8.2 26.1 -5.1 -2.8 1.7 -1.4 1.4 -2.9
Arm predicted mass (right) 3.5 17.9 34.0 -5.8 -3.8 4.9 1.7 5.1 -2.5
Pulse rate, automated reading 0.4 1.3 3.2 1.8 -0.5 -0.7 -1.6 -1.0 -0.7
Alcohol intake frequency. 2.9 6.8 12.6 -3.5 -3.2 2.6 0.0 2.1 -2.6
Comparative height size at age 10 4.9 26.8 63.4 -1.5 -3.2 6.9 6.1 8.0 0.2
Number of full sisters 0.0 0.1 0.1 -0.3 -0.1 -0.4 0.2 -0.1 0.3
Suffer from ‘nerves’ 0.7 1.1 6.2 2.5 0.3 -0.2 0.1 -0.2 0.1
Overall health rating 0.5 1.1 2.1 -0.7 -1.3 -0.5 -1.4 0.1 -1.5
Chest pain or discomfort 0.3 0.4 0.8 -0.9 -0.8 -0.2 -0.5 0.1 -0.7
Had major operations 0.6 0.7 1.5 -1.2 -1.1 0.2 -0.8 -0.0 -0.9
Age at last live birth 0.3 0.5 0.9 0.4 0.6 0.9 0.4 0.6 0.8
Family relationship satisfaction 1.1 1.4 2.6 -1.6 -1.1 1.0 -0.2 1.2 -1.5
Leg pain on walking 1.0 1.2 2.0 -1.4 -0.5 -1.0 -1.3 -0.4 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.3 -0.4 0.6 0.3 1.5 0.2 1.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.6 -1.1 -0.6 -0.4 -1.3 -0.1 -1.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.9 -0.4 -0.1 -1.1 -1.7 -1.3 0.0
Medication: Aspirin 1.5 2.0 4.0 0.7 0.4 2.0 1.8 2.0 0.3
Supplements: Vitamin C 0.6 0.7 2.6 -1.6 0.1 0.1 0.9 0.6 0.6
Knee pain experienced in last month 0.7 1.0 2.5 -1.6 -1.2 0.8 -0.5 0.6 -1.1
Hypertension (Self-reported) 1.4 3.8 9.9 3.1 -0.6 1.8 1.7 2.3 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.0 0.4 -0.8 1.4 0.8 1.1 -0.2
Illnesses of father: Heart disease 1.5 2.1 6.6 0.9 0.4 1.2 2.6 1.4 1.2
Illnesses of siblings: Diabetes 0.6 0.7 2.2 0.5 -0.4 0.7 1.0 1.5 -0.3
Smoking status: Previous 4.0 5.9 13.0 0.9 -2.3 3.4 2.2 3.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 6.6 13.7 29.8 -0.7 -2.9 5.2 4.1 5.5 -0.3
Whole body fat-free mass 3.5 19.8 39.7 -6.3 -4.1 5.0 1.5 5.3 -2.7
Leg fat-free mass (right) 2.7 14.6 40.2 -6.3 -3.5 3.5 0.3 3.8 -2.9
Arm fat percentage (left) 1.8 7.2 15.7 -4.0 -1.7 -1.0 -3.6 -1.6 -2.8
Average weekly red wine intake 0.9 1.4 2.6 1.6 1.6 0.0 1.0 -0.3 1.4
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 -0.2 0.1 0.8 0.4 0.7 0.2
Mood swings 0.5 0.8 2.0 0.4 -0.1 -1.4 -1.3 -1.0 -0.5
Loneliness, isolation 0.3 0.5 1.4 0.2 -0.4 -0.7 -1.2 -0.6 -0.7
Long-standing illness, disability or infirmity 1.5 2.3 5.5 -0.4 -0.7 2.3 1.5 2.3 -0.2
Ever had bowel cancer screening 1.7 2.0 5.7 0.8 -0.6 1.4 1.8 2.4 0.4
Diabetes diagnosed by doctor 1.7 2.8 7.1 -1.0 -1.2 2.3 1.0 2.7 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 2.2 0.2 0.4 0.9 1.5 1.3 -0.2
Friendships satisfaction 1.4 1.7 4.0 -1.6 -0.8 -0.5 -2.0 -0.4 -1.6
Qualifications: nursing, teaching 2.0 3.1 6.4 0.9 1.8 0.8 2.5 1.2 2.4
Commuting to job workplace: Walk 0.9 1.0 3.8 2.0 0.4 -0.8 -0.4 -1.0 0.5
Eye problems/disorders: Cataract 0.8 1.0 2.0 1.4 1.1 -0.8 1.0 0.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.5 0.5 0.7 -0.7 0.2 0.5 -0.1
Medication for cholesterol 1.9 2.8 8.4 -1.8 -0.3 -0.2 -2.9 -1.8 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 3.6 -0.4 0.7 0.2 1.9 0.6 1.1
Back pain experienced in last month 1.6 2.4 3.8 -1.3 -1.7 1.9 0.2 1.8 -1.6
Mineral and other dietary supplements 1.2 1.6 5.0 2.2 1.3 -0.9 -0.0 -1.0 1.0
Breast cancer (self-reported) 1.1 1.3 3.4 -0.5 -1.4 0.7 -1.3 0.4 -1.8
Asthma (self-reported) 2.1 4.2 12.8 1.2 1.3 -3.6 -1.3 -2.6 0.8
Osteoporosis (self-reported) 0.8 0.9 2.3 0.5 0.6 -1.5 -0.8 -1.4 0.0
Osteoarthritis (self-reported) 0.4 0.5 1.3 -0.9 0.7 -1.1 -0.1 -0.7 0.1
Medication: Aspirin 1.7 2.2 4.6 0.9 0.4 1.9 2.0 2.1 0.3
Medication: Gliclazide 0.4 0.5 1.4 -0.1 -0.5 1.0 0.3 1.2 -0.6
Illnesses of father: None of the above (group 1) 1.1 1.4 3.6 -0.8 -1.3 0.3 -1.9 -0.4 -1.5
Smoking status: Current 6.1 9.7 17.4 -2.1 -4.2 3.0 -0.1 3.3 -4.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 7.1 -2.7 -1.9 1.1 -1.6 -0.7 -1.5
Whole body water mass 3.5 19.7 39.4 -6.3 -4.1 5.0 1.4 5.2 -2.8
Leg predicted mass (right) 2.7 14.4 39.7 -6.3 -3.5 3.5 0.3 3.8 -2.8
Arm fat mass (left) 1.9 7.9 25.4 -5.0 -2.6 0.7 -2.3 0.4 -3.0
Number of self-reported non-cancer illnesses 1.2 2.0 7.1 2.7 1.2 -1.3 0.5 -0.6 1.0
Average weekly champagne plus white wine intake 0.8 1.1 2.2 -0.9 0.1 -1.2 -1.5 -1.4 0.4
Miserableness 0.5 0.8 2.2 -0.5 -1.0 0.7 0.8 1.5 -0.3
Guilty feelings 1.1 1.7 4.2 -0.2 2.1 -1.5 -0.1 -1.3 1.4
Wears glasses or contact lenses 0.2 0.2 0.7 0.3 0.8 0.1 -0.1 0.5 -0.2
Ever taken oral contraceptive pill 0.8 0.9 4.0 -2.0 0.2 -0.1 0.6 -0.1 1.1
Hearing aid user 0.2 0.2 0.5 -0.5 -0.1 -0.3 -0.7 -0.5 -0.5
Mother’s age at death 0.3 0.4 1.5 0.2 -0.4 1.2 0.2 0.6 0.4
Financial situation satisfaction 3.9 4.8 8.5 -1.1 -2.8 1.9 0.4 2.7 -2.9
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.3 -0.4 -0.0 1.1 0.9 1.0 -0.1
Commuting to job workplace: Public transport 0.2 0.3 0.8 0.3 0.3 0.4 0.9 0.2 0.7
Eye problems/disorders: Glaucoma 0.3 0.3 1.1 -1.1 -0.4 0.7 -0.2 -0.1 0.2
Medication: Blood pressure 1.2 2.2 4.9 1.3 -0.3 1.3 2.2 2.2 -0.2
Pain type(s) experienced in last month: Hip pain 3.1 3.9 7.5 -1.6 -0.2 -2.3 -2.7 -2.4 -1.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.9 -0.9 -0.5 0.3 0.1 0.3 -0.6
High cholesterol (Self-reported) 0.2 0.4 1.0 0.2 -0.1 0.8 0.7 1.0 -0.2
Medication: Bendroflumethiazide 2.6 3.9 9.0 1.9 0.0 1.7 2.8 3.0 -0.2
Medication: Paracetamol 1.4 2.2 3.7 1.3 1.8 -1.1 1.7 -0.7 1.9
Medication: Lisinopril 1.6 2.0 4.0 2.0 0.6 1.1 1.9 1.6 0.3
Medication: Atorvastatin 0.4 0.5 1.1 0.7 0.3 0.3 0.9 0.7 1.0
Illnesses of father: High blood pressure 0.2 0.3 0.8 0.9 0.0 0.4 0.3 0.6 -0.6
Alcohol drinker status: Never 0.7 0.8 2.9 -1.7 -0.7 0.3 -1.1 -0.3 -0.4
Ever smoked 6.4 11.2 23.1 0.1 -4.2 4.8 1.6 4.3 -2.3
Basal metabolic rate 3.3 18.4 39.5 -6.3 -3.9 4.7 1.2 5.0 -2.8
Leg fat percentage (left) 1.6 5.8 16.8 -4.1 -1.8 0.2 -2.7 -0.3 -2.7
Arm fat-free mass (left) 3.6 18.2 36.1 -6.0 -3.9 4.8 1.3 5.1 -2.7
Number of operations (self-reported) 0.4 0.5 1.3 -1.1 0.6 -0.6 -0.1 -0.4 0.9
Average weekly beer plus cider intake 0.8 1.2 4.1 2.0 0.5 -0.3 1.2 0.3 1.0
Irritability 0.7 1.2 2.2 -0.6 -1.5 1.0 -0.4 1.1 -1.4
Risk taking 1.1 1.7 3.9 -2.0 -1.5 1.5 -0.0 1.0 -0.9
Ever had prostate specific antigen (PSA) test 1.7 2.0 3.8 1.0 1.0 -1.8 -1.6 -1.9 0.1
Fractured/broken bones in last 5 years 1.4 1.9 3.6 0.9 1.5 -1.9 -0.5 -1.9 0.8
Age started oral contraceptive pill 0.1 0.1 0.3 -0.5 0.1 0.1 0.2 0.4 0.5
Diastolic blood pressure, automated reading 1.5 4.6 9.7 1.6 0.2 2.4 3.1 3.1 0.1
Ever depressed for a whole week 1.7 2.1 6.6 1.4 0.3 0.7 2.6 1.8 0.4
Unable to work because of sickness or disability 0.5 0.6 1.1 -0.1 -0.7 0.9 0.4 1.0 -1.0
Commuting to job workplace: Cycle 0.6 0.8 1.9 -0.4 -0.4 1.4 0.8 1.1 -0.7
Myopia 0.1 0.2 0.3 0.3 0.1 -0.6 -0.5 0.2 -0.5
Vascular/heart problems diagnosed by doctor 1.5 4.1 9.0 -3.0 0.3 -2.1 -2.2 -2.5 0.6
Cholesterol lowering medication 0.2 0.3 0.9 0.4 0.6 0.0 0.9 0.1 0.7
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.8 0.9 0.1 0.1 0.7 0.3 0.4
Pain experienced in last month 0.2 0.3 0.9 0.7 0.3 0.9 0.3 0.6 -0.2
Supplements: Calcium 0.4 0.4 0.9 -0.7 -0.4 -0.6 -0.9 -0.5 -0.7
Basal cell carcinoma (self-reported) 1.3 1.6 3.1 1.6 0.2 1.2 1.8 1.4 0.7
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 0.6 0.7 0.2 0.7 -0.3 0.2
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 2.7 0.3 1.5 -1.5 0.2 -1.6 1.3
Heart disease (siblings) 1.3 1.6 4.0 1.2 0.5 1.2 2.0 1.1 1.1
Alcohol drinker status: Previous 0.6 0.7 1.2 0.9 -0.6 0.9 0.2 1.0 -1.1
Pack years of smoking 2.6 3.9 8.2 0.2 -2.6 2.0 -0.0 2.0 -2.9
Impedance of whole body 2.4 12.4 50.8 7.1 1.0 1.3 3.5 1.5 2.5
Leg fat mass (left) 2.3 8.9 27.8 -5.3 -2.8 1.7 -1.7 1.4 -3.2
Arm predicted mass (left) 3.7 18.8 37.5 -6.1 -3.9 4.9 1.4 5.1 -2.8