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chr17:39,993,748-41,538,783

Best TWAS P=5.99e-11 · Best GWAS P=3.09e-09 conditioned to 0.113

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
49	NTR	Blood	TUBG2	0.01	0.00	blup	247	0.01	4.0e-03	-5.0	6.5	6.0e-11	-0.74	0.09	0.83	TRUE
8	GTEx	Brain Caudate basal ganglia	TUBG2	0.39	0.24	enet	45	0.25	7.7e-08	-5.4	-6.3	3.6e-10	0.80	0.08	0.92	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	CNTNAP1	0.06	0.05	blup	27	0.03	7.3e-03	-5.7	6.2	5.6e-10	-0.95	0.01	0.94	FALSE
44	GTEx	Thyroid	HSD17B1P1	0.04	0.00	enet	9	0.00	2.2e-01	-5.5	-6.1	9.5e-10	0.85	0.07	0.72	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MLX	0.03	0.03	enet	12	0.02	6.5e-04	-5.9	-6.1	1.1e-09	0.94	0.02	0.97	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	CNTNAP1	0.04	0.03	blup	27	0.05	2.7e-05	-5.7	6.1	1.3e-09	-0.89	0.01	0.98	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B1	0.30	0.05	enet	14	0.06	2.8e-07	-5.9	-6.0	1.4e-09	0.87	0.01	0.99	FALSE
15	GTEx	Breast Mammary Tissue	TUBG2	0.15	0.06	enet	18	0.08	4.5e-05	-5.6	-6.0	1.8e-09	0.94	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD17B1	0.02	0.03	blup	30	0.03	4.0e-04	-5.8	-6.0	2.0e-09	0.97	0.01	0.97	FALSE
11	GTEx	Brain Cerebellum	HSD17B1P1	0.17	0.16	lasso	4	0.20	1.7e-06	-5.8	-6.0	2.1e-09	0.94	0.04	0.94	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	TUBG2	0.04	0.02	blup	29	0.02	1.5e-03	-5.4	-6.0	2.7e-09	0.90	0.01	0.81	FALSE
3	GTEx	Adipose Subcutaneous	TUBG2	0.21	0.18	enet	17	0.26	2.1e-21	-5.6	-5.9	2.8e-09	0.94	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMC3IP	0.02	0.02	blup	33	0.02	9.8e-04	-5.4	-5.9	2.9e-09	0.89	0.04	0.76	FALSE
19	GTEx	Colon Sigmoid	TUBG2	0.16	0.04	lasso	5	0.05	6.7e-03	-5.9	-5.9	3.1e-09	1.00	0.03	0.90	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B1	0.05	0.07	blup	29	0.07	2.3e-07	-5.6	-5.9	4.0e-09	0.94	0.02	0.98	FALSE
23	GTEx	Esophagus Mucosa	TUBG2	0.09	0.09	lasso	4	0.11	5.5e-08	-5.5	-5.9	4.2e-09	0.86	0.12	0.88	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	CNTNAP1	0.06	0.04	blup	27	0.04	8.9e-05	-5.6	5.9	4.4e-09	-0.92	0.01	0.99	FALSE
32	GTEx	Nerve Tibial	TUBG2	0.26	0.28	enet	39	0.28	2.2e-20	-5.8	-5.8	4.9e-09	0.92	0.01	0.99	FALSE
29	GTEx	Heart Atrial Appendage	TUBG2	0.07	0.05	lasso	2	0.02	2.9e-02	-5.9	-5.8	5.3e-09	0.98	0.03	0.89	FALSE
43	GTEx	Thyroid	TUBG2	0.19	0.21	lasso	7	0.20	3.5e-15	-5.8	-5.8	5.4e-09	0.98	0.02	0.98	FALSE
12	GTEx	Brain Cortex	TUBG2	0.36	0.36	enet	15	0.32	1.1e-09	-5.4	-5.8	6.6e-09	0.94	0.08	0.92	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TUBG2	0.02	0.01	blup	29	0.02	4.5e-03	4.1	-5.8	8.4e-09	0.94	0.01	0.59	FALSE
30	GTEx	Lung	TUBG2	0.08	0.02	enet	8	0.04	7.8e-04	-5.5	-5.7	9.3e-09	0.88	0.04	0.88	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	HSD17B1	0.03	0.01	blup	30	0.01	1.5e-01	-5.5	-5.7	9.6e-09	0.97	0.02	0.68	FALSE
48	METSIM	Adipose	TUBG2	0.08	0.09	lasso	6	0.09	5.2e-13	4.6	-5.7	9.7e-09	0.87	0.04	0.96	FALSE
17	GTEx	Cells Transformed fibroblasts	TUBG2	0.16	0.18	lasso	4	0.17	6.5e-13	-5.4	-5.7	9.8e-09	0.93	0.09	0.91	FALSE
5	GTEx	Adipose Subcutaneous	HSD17B1	0.06	0.07	enet	5	0.06	6.8e-06	-5.5	-5.7	1.0e-08	0.94	0.08	0.92	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TUBG2	0.08	0.05	blup	29	0.07	3.5e-08	-5.4	-5.7	1.0e-08	0.96	0.01	0.98	FALSE
20	GTEx	Colon Transverse	HSD17B1P1	0.14	0.11	lasso	4	0.09	3.8e-05	-5.6	-5.7	1.1e-08	0.98	0.04	0.95	FALSE
13	GTEx	Brain Frontal Cortex BA9	TUBG2	0.33	0.26	lasso	4	0.18	1.9e-05	-5.4	-5.7	1.2e-08	0.90	0.06	0.92	FALSE
16	GTEx	Breast Mammary Tissue	CNTNAP1	0.06	0.03	lasso	2	0.05	9.9e-04	-5.6	5.7	1.2e-08	-0.99	0.02	0.94	FALSE
18	GTEx	Cells Transformed fibroblasts	MLX	0.04	0.03	enet	8	0.00	3.3e-01	-5.3	-5.7	1.3e-08	0.89	0.09	0.75	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	TUBG1	0.11	0.01	lasso	6	0.00	1.7e-01	4.6	-5.7	1.3e-08	0.88	0.03	0.75	FALSE
14	GTEx	Brain Putamen basal ganglia	TUBG2	0.17	0.12	lasso	5	0.09	3.7e-03	-5.5	-5.7	1.5e-08	0.95	0.05	0.78	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	TUBG2	0.07	0.12	enet	14	0.12	5.9e-13	-5.5	-5.7	1.5e-08	0.95	0.02	0.98	FALSE
27	GTEx	Esophagus Muscularis	HSD17B1	0.08	0.04	lasso	4	0.06	2.2e-04	-5.5	5.6	1.7e-08	-0.95	0.10	0.86	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	CNTNAP1	0.06	0.05	lasso	1	0.04	6.8e-06	-5.6	5.6	1.7e-08	-0.97	0.01	0.99	FALSE
33	GTEx	Pancreas	CNTNAP1	0.13	0.09	lasso	7	0.09	9.1e-05	4.2	5.6	1.9e-08	-0.71	0.06	0.86	FALSE
41	GTEx	Stomach	HSD17B1P1	0.10	0.04	lasso	3	0.04	6.9e-03	3.9	-5.6	1.9e-08	0.72	0.06	0.59	FALSE
42	GTEx	Testis	TUBG1	0.12	0.09	enet	18	0.08	1.8e-04	-5.6	-5.6	1.9e-08	0.98	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TUBG2	0.14	0.25	lasso	3	0.25	1.1e-29	-5.5	-5.6	2.1e-08	0.91	0.08	0.92	FALSE
4	GTEx	Adipose Subcutaneous	HSD17B1P1	0.06	0.09	enet	6	0.09	4.0e-08	-5.6	-5.6	2.1e-08	0.92	0.04	0.96	FALSE
25	GTEx	Esophagus Muscularis	TUBG2	0.14	0.16	enet	17	0.06	2.1e-04	-5.4	-5.6	2.3e-08	0.94	0.04	0.96	FALSE
39	GTEx	Skin Sun Exposed Lower leg	NAGLU	0.08	0.06	enet	9	0.09	5.8e-08	4.1	-5.6	2.5e-08	0.83	0.03	0.97	FALSE
26	GTEx	Esophagus Muscularis	HSD17B1P1	0.08	0.03	lasso	3	0.01	6.8e-02	-5.6	-5.5	3.3e-08	0.97	0.04	0.86	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSD17B1	0.06	0.04	lasso	5	0.06	4.0e-07	-5.5	-5.5	3.6e-08	0.87	0.02	0.98	FALSE
40	GTEx	Skin Sun Exposed Lower leg	TUBG1	0.04	0.06	lasso	1	0.05	8.3e-05	-5.5	5.5	3.7e-08	-0.91	0.11	0.81	FALSE
21	GTEx	Colon Transverse	HSD17B1	0.15	0.14	lasso	11	0.12	1.7e-06	-5.5	-5.5	4.0e-08	0.92	0.09	0.91	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	TUBG2	0.15	0.10	enet	18	0.12	3.7e-05	-5.7	-5.5	4.0e-08	0.86	0.02	0.95	FALSE
38	GTEx	Skin Sun Exposed Lower leg	TUBG2	0.14	0.10	enet	25	0.12	4.9e-10	-5.4	-5.5	4.5e-08	0.86	0.10	0.90	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3IP	0.02	0.02	blup	33	0.02	5.4e-03	-5.9	-5.5	4.5e-08	0.97	0.01	0.84	FALSE
34	GTEx	Pancreas	FAM134C	0.08	0.04	enet	9	0.03	2.0e-02	4.1	5.4	5.5e-08	-0.70	0.08	0.70	FALSE
35	GTEx	Pancreas	CTD-3193K9.3	0.12	0.07	lasso	5	0.07	5.7e-04	4.2	5.4	5.6e-08	-0.66	0.05	0.79	FALSE
24	GTEx	Esophagus Mucosa	HSD17B1P1	0.04	0.06	lasso	5	0.05	1.9e-04	-5.5	-5.4	5.9e-08	0.91	0.09	0.87	FALSE
7	GTEx	Artery Tibial	HSD17B1	0.12	0.07	lasso	9	0.07	4.4e-06	-5.5	-5.4	6.0e-08	0.87	0.09	0.91	FALSE
10	GTEx	Brain Cerebellum	TUBG2	0.18	0.11	enet	10	0.07	4.0e-03	-5.4	-5.4	6.5e-08	0.78	0.10	0.83	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	RND2	0.08	0.00	enet	16	0.02	3.5e-03	-3.4	5.4	6.6e-08	-0.18	0.00	0.00	FALSE
6	GTEx	Artery Tibial	TUBG2	0.25	0.22	enet	23	0.23	3.0e-18	-5.5	-5.4	7.2e-08	0.94	0.05	0.95	FALSE
45	GTEx	Thyroid	CNTNAP1	0.06	0.06	enet	12	0.06	3.5e-05	-5.4	5.3	8.6e-08	-0.89	0.10	0.88	FALSE
47	METSIM	Adipose	HSD17B1	0.08	0.08	lasso	6	0.06	3.1e-09	-5.4	-5.3	8.7e-08	0.90	0.11	0.89	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	TUBG2	0.07	0.01	enet	7	0.02	2.2e-03	4.0	-5.3	1.1e-07	0.69	0.01	0.48	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	TUBG2	0.15	0.13	lasso	5	0.12	4.0e-07	4.9	-5.3	1.3e-07	0.64	0.47	0.52	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	TUBG2	0.02	0.01	lasso	2	0.01	1.7e-02	4.0	-5.3	1.3e-07	0.83	0.01	0.63	FALSE
28	GTEx	Esophagus Muscularis	RP11-400F19.8	0.17	0.05	lasso	4	0.02	3.9e-02	4.9	-5.2	1.6e-07	0.48	0.08	0.05	FALSE
9	GTEx	Brain Cerebellar Hemisphere	HSD17B1P1	0.21	0.19	enet	23	0.12	4.7e-04	-5.4	-5.2	1.7e-07	0.92	0.06	0.93	FALSE
31	GTEx	Muscle Skeletal	HSD17B1	0.04	0.03	enet	5	0.03	3.9e-04	-5.5	-5.2	1.9e-07	0.84	0.10	0.86	FALSE
46	GTEx	Thyroid	CTD-3193K9.3	0.05	0.02	enet	8	0.02	5.1e-03	-5.4	5.2	2.3e-07	-0.82	0.09	0.82	FALSE