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chr18:20,082,830-21,863,589

Best TWAS P=3.65e-31 · Best GWAS P=1.41e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-9.7	-11.6	3.7e-31	0.43	0.18	0.42	TRUE
24	GTEx	Esophagus Mucosa	NPC1	0.09	0.04	lasso	3	0.05	1.5e-04	-9.4	-10.0	1.2e-23	0.30	0.57	0.02	TRUE
29	GTEx	Nerve Tibial	TMEM241	0.16	0.04	enet	10	0.07	1.8e-05	-8.0	-8.7	2.7e-18	0.48	0.70	0.02	TRUE
9	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	8.4	-8.3	9.4e-17	0.14	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	NPC1	0.08	0.07	lasso	3	0.08	5.2e-10	8.5	-7.7	1.3e-14	0.12	1.00	0.00	TRUE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPC1	0.06	0.01	enet	6	0.05	2.2e-04	-6.7	-6.2	7.8e-10	0.29	0.07	0.36	TRUE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	CABLES1	0.06	0.02	enet	12	0.04	6.8e-05	2.6	-5.7	9.9e-09	0.26	0.07	0.03	TRUE
26	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-10.0	-10.2	1.9e-24	0.25	0.72	0.07	FALSE
5	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-9.6	-10.2	2.5e-24	0.23	0.97	0.03	FALSE
13	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-9.6	-10.2	3.0e-24	0.26	0.80	0.05	FALSE
12	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-9.7	-10.1	8.0e-24	0.24	0.94	0.03	FALSE
11	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-9.8	-10.0	1.3e-23	0.22	0.43	0.05	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-9.7	-10.0	1.3e-23	0.23	0.98	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-9.7	-10.0	1.4e-23	0.22	0.98	0.02	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	8.4	-10.0	2.0e-23	0.20	0.03	0.97	FALSE
35	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-9.8	-9.9	3.9e-23	0.24	0.98	0.02	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPC1	0.03	0.04	lasso	2	0.05	4.2e-06	-9.5	-9.9	5.0e-23	0.27	0.02	0.98	FALSE
16	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-9.8	-9.8	7.4e-23	0.23	0.47	0.04	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-9.6	-9.8	9.9e-23	0.24	0.98	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RIOK3	0.02	0.01	bslmm	348	0.00	1.8e-01	-8.0	-9.8	1.1e-22	0.44	0.14	0.05	FALSE
19	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	-9.4	-9.8	1.4e-22	0.22	0.98	0.02	FALSE
36	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-9.4	-9.8	1.4e-22	0.23	1.00	0.00	FALSE
31	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	8.5	-9.8	1.9e-22	0.21	0.99	0.01	FALSE
27	GTEx	Heart Left Ventricle	NPC1	0.19	0.15	enet	12	0.17	1.6e-09	-9.6	-9.7	3.6e-22	0.26	0.99	0.01	FALSE
7	GTEx	Adipose Visceral Omentum	C18orf8	0.18	0.11	enet	10	0.04	4.5e-03	-10.0	-9.5	1.8e-21	0.30	0.78	0.09	FALSE
21	GTEx	Breast Mammary Tissue (Female)	NPC1	0.43	0.24	lasso	3	0.27	1.1e-08	-9.0	-9.5	2.0e-21	0.26	0.96	0.02	FALSE
8	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	-9.4	-9.5	2.2e-21	0.24	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	NPC1	0.27	0.27	enet	12	0.30	2.4e-25	-9.4	-9.4	3.6e-21	0.25	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	8.5	-9.4	5.2e-21	0.19	0.05	0.64	FALSE
32	GTEx	Pancreas	NPC1	0.33	0.14	lasso	7	0.12	1.1e-05	-9.7	-9.4	5.5e-21	0.24	0.79	0.03	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	-9.7	-9.3	8.5e-21	0.24	0.03	0.97	FALSE
25	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	8.5	-9.3	9.5e-21	0.17	0.95	0.01	FALSE
28	GTEx	Lung	NPC1	0.11	0.06	enet	11	0.04	2.3e-04	-9.8	-9.2	2.7e-20	0.21	0.95	0.04	FALSE
17	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-9.6	-9.1	9.7e-20	0.22	0.88	0.03	FALSE
30	GTEx	Nerve Tibial	C18orf8	0.16	0.07	enet	21	0.09	3.9e-07	-9.0	-9.0	3.4e-19	0.12	0.98	0.02	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPC1	0.05	0.02	blup	65	0.03	9.9e-04	-9.5	-8.9	7.5e-19	0.25	0.02	0.75	FALSE
41	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	-9.8	-8.9	7.7e-19	0.22	0.96	0.03	FALSE
14	GTEx	Brain Cerebellum	NPC1	0.20	0.10	enet	9	0.12	1.9e-04	-9.7	-8.8	1.3e-18	0.23	0.42	0.06	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	NPC1	0.04	0.03	blup	70	0.05	9.4e-06	-9.7	-8.7	3.8e-18	0.21	0.03	0.96	FALSE
38	GTEx	Thyroid	NPC1	0.20	0.10	enet	25	0.13	2.3e-10	-9.6	-8.5	1.8e-17	0.10	0.96	0.04	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	8.4	-8.4	3.0e-17	0.15	0.27	0.71	FALSE
10	GTEx	Artery Tibial	NPC1	0.26	0.07	enet	31	0.11	3.7e-09	8.4	-8.0	1.7e-15	0.02	0.99	0.01	FALSE
40	METSIM	Adipose	C18orf8	0.08	0.02	enet	23	0.04	1.0e-06	8.4	-7.8	8.7e-15	0.26	0.79	0.01	FALSE
39	GTEx	Vagina	NPC1	0.27	0.09	lasso	7	0.14	4.9e-04	-7.0	-7.7	9.9e-15	0.37	0.23	0.10	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NPC1	0.05	0.02	blup	66	0.03	1.4e-04	-9.5	-7.7	1.1e-14	0.24	0.17	0.60	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	TMEM241	0.17	0.02	lasso	6	-0.01	5.6e-01	-9.6	-7.4	1.1e-13	0.24	0.10	0.06	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf45	0.04	0.02	lasso	3	0.03	2.7e-04	6.4	-7.2	4.0e-13	0.34	0.70	0.02	FALSE
15	GTEx	Brain Cortex	TMEM241	0.37	0.12	enet	19	0.22	1.3e-06	2.4	-6.8	7.5e-12	0.26	0.67	0.04	FALSE
4	GTEx	Adipose Subcutaneous	TMEM241	0.07	0.00	enet	12	0.01	4.1e-02	-7.5	-6.7	1.6e-11	0.33	0.32	0.10	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NPC1	0.14	0.01	enet	14	0.08	3.3e-04	-9.5	-6.4	1.7e-10	0.16	0.02	0.83	FALSE
20	GTEx	Breast Mammary Tissue (Male)	NPC1	0.15	0.12	lasso	7	0.16	2.0e-04	-2.6	-6.2	5.0e-10	0.07	0.10	0.05	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	NPC1	0.19	0.13	lasso	5	0.11	1.1e-04	-4.8	-6.1	8.8e-10	0.13	0.44	0.10	FALSE
52	The Cancer Genome Atlas	Soft Tissue Sarcoma	C18orf45	0.08	0.06	blup	114	0.06	1.7e-04	-7.8	-6.0	2.7e-09	0.21	0.59	0.02	FALSE
22	GTEx	Cells Transformed fibroblasts	NPC1	0.26	0.24	lasso	8	0.24	5.7e-18	-4.8	-5.6	2.4e-08	0.13	1.00	0.00	FALSE