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chr1:39,182,130-40,737,589

Best TWAS P=4.65e-14 · Best GWAS P=1.05e-14 conditioned to 0.00263

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adrenal Gland	PABPC4	0.20	0.09	lasso	8	0.06	3.0e-03	6.2	-7.5	4.6e-14	-0.77	0.06	0.79	TRUE
33	NTR	Blood	PABPC4	0.01	0.00	blup	383	0.00	2.8e-02	6.2	-7.5	8.0e-14	-0.68	0.04	0.54	FALSE
9	GTEx	Breast Mammary Tissue (Female)	PABPC4	0.10	0.00	enet	9	0.01	1.5e-01	7.2	-7.5	8.5e-14	-0.83	0.03	0.46	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	PABPC4	0.09	0.07	enet	5	0.08	4.1e-08	6.2	-6.8	1.3e-11	-0.62	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	BMP8A	0.05	0.01	blup	48	0.04	6.8e-05	6.8	6.7	1.7e-11	0.68	0.00	0.98	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BMP8A	0.04	0.03	blup	48	0.04	3.5e-05	5.1	6.7	2.3e-11	0.68	0.02	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BMP8A	0.05	0.03	lasso	3	0.02	8.8e-04	6.4	6.6	3.7e-11	0.71	0.07	0.87	FALSE
21	GTEx	Nerve Tibial	RP11-69E11.8	0.05	0.00	lasso	3	0.01	6.9e-02	6.2	-6.6	4.1e-11	-0.75	0.03	0.86	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	PABPC4	0.12	0.10	lasso	3	0.05	1.0e-03	6.4	-6.5	7.5e-11	-0.71	0.28	0.43	FALSE
12	GTEx	Esophagus Mucosa	PABPC4	0.06	0.06	lasso	3	0.08	7.3e-06	6.4	-6.4	1.3e-10	-0.73	0.39	0.54	FALSE
8	GTEx	Breast Mammary Tissue	PABPC4	0.13	0.02	enet	14	0.04	3.4e-03	6.4	-6.3	2.5e-10	-0.70	0.08	0.80	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RP11-69E11.4	0.13	0.12	lasso	6	0.15	1.3e-12	6.3	6.3	2.6e-10	0.72	0.97	0.03	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC4	0.03	0.03	lasso	2	0.04	1.3e-08	6.2	-6.3	3.9e-10	-0.62	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	PABPC4	0.04	0.03	enet	8	0.04	4.5e-05	6.4	-6.3	3.9e-10	-0.62	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	PABPC4	0.07	0.09	lasso	1	0.06	2.7e-05	6.2	-6.2	4.2e-10	-0.68	0.20	0.75	FALSE
26	GTEx	Spleen	RP11-69E11.4	0.25	0.12	lasso	4	0.15	9.3e-05	5.1	6.2	4.9e-10	0.70	0.22	0.52	FALSE
5	GTEx	Adrenal Gland	RP11-69E11.4	0.11	0.05	lasso	3	0.00	2.4e-01	5.4	6.2	5.4e-10	0.52	0.08	0.37	FALSE
19	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	6.2	-6.2	5.4e-10	-0.73	0.07	0.93	FALSE
24	GTEx	Skin Sun Exposed Lower leg	PABPC4	0.11	0.09	lasso	7	0.08	2.7e-07	6.4	-6.2	6.3e-10	-0.71	0.30	0.69	FALSE
6	GTEx	Artery Tibial	PABPC4	0.10	0.10	lasso	4	0.10	3.4e-08	6.2	-6.2	7.3e-10	-0.72	0.50	0.50	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPC4	0.03	0.01	enet	4	0.02	4.3e-03	6.2	-6.0	1.7e-09	-0.68	0.00	0.99	FALSE
32	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	-1.1	6.0	1.8e-09	0.62	0.10	0.72	FALSE
22	GTEx	Ovary	RP11-69E11.4	0.25	0.05	enet	11	0.03	6.7e-02	5.1	6.0	2.1e-09	0.68	0.05	0.42	FALSE
27	GTEx	Spleen	BMP8A	0.16	0.08	lasso	3	0.05	1.6e-02	6.3	5.9	3.3e-09	0.75	0.07	0.29	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PABPC4	0.04	0.05	blup	31	0.04	1.2e-05	5.3	-5.9	3.3e-09	-0.57	0.03	0.96	FALSE
13	GTEx	Esophagus Mucosa	RP11-69E11.4	0.18	0.06	lasso	9	0.07	2.2e-05	5.1	5.8	5.4e-09	0.64	0.84	0.14	FALSE
31	METSIM	Adipose	PABPC4	0.05	0.02	lasso	6	0.03	6.0e-05	6.4	-5.8	6.0e-09	-0.71	0.06	0.94	FALSE
14	GTEx	Esophagus Mucosa	BMP8A	0.08	0.02	lasso	2	0.01	1.4e-01	-2.3	5.7	9.2e-09	0.69	0.11	0.82	FALSE
17	GTEx	Lung	PABPC4	0.05	0.03	lasso	3	0.02	1.3e-02	6.2	-5.7	9.3e-09	-0.64	0.12	0.72	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	BMP8A	0.05	0.01	lasso	6	0.02	5.5e-05	6.4	5.7	1.1e-08	0.55	0.14	0.76	FALSE
20	GTEx	Nerve Tibial	RP11-69E11.4	0.18	0.08	lasso	5	0.18	1.3e-12	5.0	5.7	1.2e-08	0.66	0.67	0.33	FALSE
2	GTEx	Adipose Subcutaneous	PABPC4	0.15	0.04	lasso	8	0.04	3.3e-04	3.2	-5.6	2.7e-08	-0.77	0.08	0.92	FALSE
28	GTEx	Stomach	RP11-69E11.4	0.31	0.20	lasso	4	0.20	4.0e-10	5.1	5.5	3.0e-08	0.54	0.89	0.10	FALSE
11	GTEx	Colon Transverse	RP11-69E11.4	0.23	0.12	lasso	4	0.15	1.8e-07	6.4	5.5	3.3e-08	0.67	0.40	0.58	FALSE
29	GTEx	Thyroid	PABPC4	0.08	0.03	lasso	6	0.05	1.3e-04	7.0	-5.5	4.2e-08	-0.78	0.10	0.88	FALSE
3	GTEx	Adipose Subcutaneous	BMP8A	0.06	0.05	lasso	1	0.04	3.5e-04	5.4	5.4	6.3e-08	0.46	0.14	0.28	FALSE
15	GTEx	Esophagus Mucosa	PPIEL	0.11	0.02	lasso	3	0.02	9.4e-03	6.1	5.4	6.4e-08	0.76	0.16	0.49	FALSE
30	GTEx	Thyroid	RP11-69E11.4	0.17	0.04	lasso	9	0.06	4.4e-05	5.1	5.4	6.4e-08	0.55	0.31	0.42	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPIEL	0.04	0.02	lasso	4	0.02	1.7e-03	5.1	5.4	8.0e-08	0.55	0.05	0.41	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PABPC4	0.05	0.05	enet	4	0.05	5.5e-04	6.4	-5.3	1.1e-07	-0.64	0.00	0.97	FALSE
7	GTEx	Brain Frontal Cortex BA9	RP11-69E11.4	0.23	0.10	lasso	6	0.11	7.2e-04	5.3	5.3	1.4e-07	0.47	0.14	0.13	FALSE
16	GTEx	Esophagus Muscularis	BMP8A	0.08	0.05	enet	10	0.05	3.5e-04	2.9	5.1	2.7e-07	0.69	0.31	0.59	FALSE
18	GTEx	Lung	RP11-69E11.4	0.26	0.09	lasso	9	0.20	3.8e-15	-2.3	5.1	2.7e-07	0.49	0.96	0.04	FALSE