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chr1:31,402,148-34,592,020

Best TWAS P=1.83e-16 · Best GWAS P=6.42e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	CommonMind	Brain Pre-frontal Cortex	TMEM54	0.05	0.00	blup	281	0.02	4.5e-03	1.7	-8.2	1.8e-16	0.50	0.11	0.23	TRUE
4	CommonMind	Brain Pre-frontal Cortex	ZNF362	0.05	0.06	lasso	1	0.06	2.2e-07	-8.1	-8.1	6.4e-16	1.00	0.01	0.99	TRUE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	S100PBP	0.06	0.03	blup	48	0.06	6.8e-04	-6.3	7.2	6.1e-13	-0.08	0.01	0.82	TRUE
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PTP4A2	0.09	-0.01	blup	26	0.00	4.1e-01	6.0	6.3	2.4e-10	0.00	0.00	0.81	TRUE
5	GTEx	Artery Aorta	PEF1	0.15	0.05	lasso	5	0.04	2.2e-03	-5.2	5.9	4.4e-09	-0.06	0.10	0.80	TRUE
10	GTEx	Thyroid	BAI2	0.31	0.23	lasso	6	0.22	1.4e-16	5.7	5.7	1.2e-08	-0.01	0.09	0.91	TRUE
7	GTEx	Cells EBV-transformed lymphocytes	PHC2	0.58	0.34	lasso	7	0.28	7.3e-10	-8.0	7.9	2.6e-15	-0.97	0.01	0.99	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	PHC2	0.11	0.07	lasso	3	0.05	2.2e-07	-8.0	-7.6	3.6e-14	0.97	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	S100PBP	0.06	0.06	blup	47	0.05	5.2e-06	-6.8	6.8	1.0e-11	-0.08	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	S100PBP	0.04	0.04	lasso	4	0.04	2.3e-05	-6.8	6.8	1.2e-11	-0.08	0.00	0.99	FALSE
9	GTEx	Muscle Skeletal	FNDC5	0.15	0.16	enet	5	0.16	1.9e-15	-6.4	-6.4	1.6e-10	0.07	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	S100PBP	0.21	0.15	lasso	5	0.15	2.9e-05	-6.4	6.4	2.0e-10	-0.07	0.01	0.91	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	S100PBP	0.03	0.02	blup	46	0.02	6.6e-06	-6.8	6.4	2.1e-10	-0.08	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF362	0.03	0.01	blup	49	0.01	1.3e-03	3.3	-5.9	3.1e-09	0.70	0.01	0.32	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FNDC5	0.03	0.04	enet	6	0.03	2.9e-04	-6.3	-5.9	3.9e-09	0.09	0.03	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	S100PBP	0.05	0.04	enet	10	0.02	1.2e-03	-6.9	5.9	4.7e-09	-0.03	0.95	0.01	FALSE
8	GTEx	Colon Sigmoid	PEF1	0.16	0.09	lasso	3	0.09	4.3e-04	-5.8	5.8	5.8e-09	-0.04	0.08	0.66	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	FNDC5	0.02	0.01	blup	33	0.01	9.2e-03	-4.8	-5.7	1.2e-08	0.07	0.02	0.46	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	KPNA6	0.19	0.14	enet	18	0.10	4.9e-04	4.7	5.6	2.2e-08	-0.03	0.20	0.14	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	4	0.03	2.8e-04	-5.5	5.5	4.0e-08	-0.02	0.20	0.77	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	3	0.02	4.2e-04	-5.5	5.5	4.9e-08	-0.02	0.22	0.73	FALSE
13	METSIM	Adipose	ZNF362	0.09	0.02	enet	32	0.03	1.5e-05	-8.1	-5.4	5.3e-08	0.69	0.01	0.98	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HPCA	0.05	0.09	lasso	7	0.08	3.6e-09	-4.9	5.4	5.6e-08	-0.07	0.16	0.84	FALSE
11	GTEx	Thyroid	TMEM54	0.10	0.09	lasso	7	0.07	3.3e-06	-5.4	5.4	7.3e-08	-0.06	0.99	0.00	FALSE
12	METSIM	Adipose	PEF1	0.03	0.02	enet	17	0.02	7.9e-04	-5.5	5.4	7.9e-08	-0.01	0.09	0.79	FALSE