Best TWAS P=1.24e-16 · Best GWAS P=2.86e-16 conditioned to 0.00963
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CTPS1 | 0.10 | 0.00 | enet | 8 | 0.00 | 4.6e-01 | 6.23 | 7.1 | 1.6e-12 | 0.74 | 0.05 | 0.59 | FALSE |
2 | GTEx | Artery Coronary | CTPS1 | 0.25 | -0.01 | enet | 23 | 0.00 | 3.0e-01 | -0.81 | 5.8 | 5.7e-09 | 0.39 | 0.07 | 0.13 | FALSE |
3 | GTEx | Brain Cerebellum | HIVEP3 | 0.23 | 0.16 | lasso | 6 | 0.19 | 2.8e-06 | 4.51 | 5.8 | 8.5e-09 | 0.06 | 0.57 | 0.03 | TRUE |
4 | GTEx | Cells EBV-transformed lymphocytes | CTPS1 | 0.26 | 0.11 | lasso | 6 | 0.08 | 1.6e-03 | 7.02 | 6.7 | 2.6e-11 | 0.69 | 0.19 | 0.37 | FALSE |
5 | GTEx | Lung | CTPS1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.4e-04 | 7.41 | 7.3 | 3.1e-13 | 0.77 | 0.21 | 0.64 | FALSE |
6 | GTEx | Nerve Tibial | SCMH1 | 0.16 | 0.03 | enet | 24 | 0.07 | 1.6e-05 | 7.55 | -6.0 | 2.6e-09 | -0.69 | 0.03 | 0.96 | FALSE |
7 | GTEx | Testis | SLFNL1 | 0.30 | 0.17 | lasso | 14 | 0.28 | 5.3e-13 | 8.18 | 5.4 | 5.3e-08 | 0.86 | 0.01 | 0.99 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | RIMKLA | 0.06 | 0.06 | bslmm | 341 | 0.05 | 1.3e-07 | -4.30 | 6.1 | 1.2e-09 | 0.03 | 0.97 | 0.01 | TRUE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RIMKLA | 0.03 | 0.02 | blup | 53 | 0.01 | 2.8e-02 | 4.86 | 5.3 | 1.1e-07 | 0.06 | 0.00 | 0.86 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCMH1 | 0.03 | 0.03 | lasso | 2 | 0.02 | 6.2e-03 | 8.08 | -8.1 | 6.5e-16 | -0.98 | 0.01 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SCMH1 | 0.35 | 0.14 | blup | 96 | 0.14 | 1.5e-05 | -3.64 | 5.2 | 2.6e-07 | 0.47 | 0.17 | 0.29 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | SCMH1 | 0.07 | 0.08 | blup | 97 | 0.07 | 2.5e-07 | 7.62 | -8.3 | 1.2e-16 | -0.73 | 0.17 | 0.83 | TRUE |