Best TWAS P=2.14e-11 · Best GWAS P=3.74e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CCDC152 | 0.09 | 0.04 | lasso | 4 | 0.02 | 6.4e-03 | 6.6 | 6.7 | 3.0e-11 | 1.00 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CCDC152 | 0.09 | 0.06 | lasso | 9 | 0.05 | 1.9e-03 | 6.5 | 6.0 | 1.8e-09 | 0.98 | 0.01 | 0.92 | FALSE |
3 | GTEx | Artery Aorta | CCDC152 | 0.31 | 0.24 | lasso | 8 | 0.24 | 2.5e-13 | 6.5 | 6.2 | 6.9e-10 | 0.98 | 0.01 | 0.99 | FALSE |
4 | GTEx | Artery Coronary | CCDC152 | 0.20 | 0.13 | lasso | 2 | 0.12 | 7.7e-05 | 6.5 | 6.5 | 6.4e-11 | 1.00 | 0.01 | 0.98 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | NNT-AS1 | 0.12 | -0.01 | enet | 34 | 0.03 | 2.1e-02 | -4.3 | 5.3 | 1.4e-07 | -0.08 | 0.03 | 0.30 | TRUE |
6 | GTEx | Esophagus Muscularis | CCDC152 | 0.13 | 0.09 | lasso | 8 | 0.10 | 7.9e-07 | 5.8 | 5.7 | 1.2e-08 | 0.92 | 0.02 | 0.98 | FALSE |
7 | GTEx | Thyroid | CCDC152 | 0.10 | 0.07 | lasso | 4 | 0.04 | 4.2e-04 | 6.5 | 6.5 | 6.1e-11 | 1.00 | 0.01 | 0.99 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | 6.4 | -6.7 | 2.6e-11 | -0.98 | 0.01 | 0.99 | FALSE |
9 | YFS | Blood | CCDC152 | 0.07 | 0.06 | enet | 16 | 0.06 | 2.0e-19 | 6.6 | 6.7 | 2.1e-11 | 0.99 | 0.01 | 0.99 | TRUE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEPP1 | 0.01 | 0.00 | enet | 7 | 0.01 | 1.5e-03 | 6.1 | -5.2 | 1.6e-07 | -0.79 | 0.02 | 0.65 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC152 | 0.06 | 0.06 | blup | 40 | 0.07 | 1.6e-08 | 6.3 | -6.3 | 2.4e-10 | -0.95 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC152 | 0.15 | 0.12 | lasso | 6 | 0.12 | 1.0e-12 | 6.1 | -6.1 | 9.9e-10 | -0.92 | 0.11 | 0.89 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEPP1 | 0.06 | 0.02 | blup | 38 | 0.04 | 5.2e-05 | 5.8 | -5.9 | 3.7e-09 | -0.79 | 0.09 | 0.88 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | MGC42105 | 0.04 | 0.01 | blup | 63 | 0.01 | 4.3e-02 | -3.1 | -5.5 | 3.7e-08 | -0.11 | 0.02 | 0.21 | TRUE |