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chr5:73,626,450-75,704,085

Best TWAS P=2.34e-35 · Best GWAS P=1.46e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	-12.3	12.4	2.3e-35	-0.90	0.18	0.82	TRUE
21	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	-8.9	-10.9	1.7e-27	0.72	0.17	0.37	TRUE
19	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	-4.9	-10.5	1.4e-25	0.59	0.17	0.20	TRUE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	-8.0	-8.3	1.4e-16	0.57	0.03	0.49	TRUE
25	GTEx	Thyroid	POC5	0.26	0.23	enet	15	0.23	1.8e-17	-8.6	-7.5	4.6e-14	0.49	1.00	0.00	TRUE
16	GTEx	Lung	POC5	0.18	0.09	enet	46	0.09	2.5e-07	-8.9	-5.5	3.6e-08	0.24	0.98	0.00	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	-9.9	-11.0	3.3e-28	0.81	0.27	0.63	FALSE
8	GTEx	Brain Cerebellar Hemisphere	POC5	0.31	0.15	enet	18	0.30	1.6e-08	-8.9	-10.5	1.3e-25	0.61	0.60	0.24	FALSE
7	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	-8.8	-10.3	6.5e-25	0.64	0.35	0.15	FALSE
28	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	-9.7	-10.1	5.0e-24	0.58	0.97	0.02	FALSE
5	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	-8.5	-9.9	6.2e-23	0.49	0.20	0.47	FALSE
11	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	-9.3	9.6	5.4e-22	-0.61	0.25	0.47	FALSE
26	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	-9.7	-9.6	1.1e-21	0.62	0.31	0.14	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	-6.3	9.5	2.5e-21	-0.63	0.08	0.54	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	POC5	0.05	0.00	blup	384	0.02	8.6e-04	-8.6	-9.3	1.6e-20	0.57	0.30	0.13	FALSE
24	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	-7.7	-9.2	3.5e-20	0.50	1.00	0.00	FALSE
20	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	-8.9	-9.1	1.4e-19	0.57	0.94	0.03	FALSE
9	GTEx	Brain Hypothalamus	CTC-366B18.4	0.26	0.12	lasso	8	0.07	9.0e-03	-8.9	9.0	1.8e-19	-0.56	0.10	0.09	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	-12.3	9.0	2.2e-19	-0.77	0.02	0.57	FALSE
3	GTEx	Adipose Subcutaneous	POC5	0.08	0.07	lasso	7	0.07	3.2e-06	-8.9	-8.9	4.1e-19	0.56	0.96	0.00	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	POC5	0.47	0.36	lasso	4	0.39	1.3e-13	-8.9	-8.8	1.6e-18	0.57	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	-6.4	8.8	1.7e-18	-0.57	0.12	0.78	FALSE
37	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	-9.1	-8.8	2.1e-18	0.73	0.05	0.80	FALSE
18	GTEx	Pancreas	POC5	0.32	0.23	lasso	3	0.21	3.5e-09	-8.6	-8.8	2.2e-18	0.57	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	-8.6	-8.7	3.4e-18	0.60	0.82	0.07	FALSE
12	GTEx	Cells Transformed fibroblasts	POC5	0.15	0.17	lasso	6	0.16	3.4e-12	-8.6	-8.6	6.1e-18	0.57	1.00	0.00	FALSE
15	GTEx	Esophagus Mucosa	POC5	0.18	0.16	lasso	1	0.15	4.8e-10	-8.6	-8.6	6.1e-18	0.57	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	POC5	0.16	0.12	lasso	5	0.10	7.6e-08	-8.6	-8.6	7.1e-18	0.57	0.99	0.00	FALSE
6	GTEx	Artery Tibial	GCNT4	0.08	0.07	lasso	2	0.04	3.9e-04	-8.5	8.6	9.2e-18	-0.44	0.56	0.24	FALSE
23	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	-9.4	8.4	3.7e-17	-0.65	0.59	0.20	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	GCNT4	0.10	0.06	enet	6	0.05	8.7e-04	-5.3	7.8	5.4e-15	-0.41	0.03	0.82	FALSE
27	METSIM	Adipose	POC5	0.11	0.09	enet	29	0.10	7.5e-15	-8.6	-7.6	2.7e-14	0.48	1.00	0.00	FALSE
22	GTEx	Stomach	POC5	0.10	0.06	enet	12	0.08	8.3e-05	-9.3	-7.3	3.2e-13	0.43	0.56	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANKRD31	0.10	0.13	lasso	9	0.13	3.9e-15	-7.8	7.1	1.3e-12	-0.33	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	COL4A3BP	0.09	0.06	lasso	5	0.05	4.2e-04	-4.8	7.0	3.6e-12	-0.51	0.79	0.06	FALSE
13	GTEx	Colon Transverse	POC5	0.23	0.16	lasso	4	0.18	6.0e-09	-8.6	-6.9	6.4e-12	0.39	0.96	0.00	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GCNT4	0.17	0.00	blup	50	0.05	1.5e-06	-6.1	-5.5	5.1e-08	0.27	0.00	0.24	FALSE