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chr7:91,142,400-93,160,671

Best TWAS P=4.74e-35 · Best GWAS P=4.36e-33 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Testis	CDK6	0.10	0.10	lasso	3	0.09	8.0e-05	11.983	-12.4	4.7e-35	-0.96	0.00	0.99	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CDK6	0.12	0.10	lasso	2	0.10	1.9e-12	11.455	11.5	2.1e-30	0.89	0.17	0.83	FALSE
11	GTEx	Esophagus Muscularis	FAM133B	0.07	0.01	enet	2	0.01	1.2e-01	-7.748	-7.8	5.2e-15	-0.55	0.09	0.18	FALSE
8	GTEx	Cells Transformed fibroblasts	GATAD1	0.23	0.20	lasso	4	0.22	1.4e-16	5.285	-7.2	5.0e-13	-0.69	0.90	0.10	FALSE
18	YFS	Blood	GATAD1	0.01	0.01	blup	297	0.01	5.1e-04	5.285	-7.0	2.2e-12	-0.53	0.74	0.09	FALSE
6	GTEx	Brain Caudate basal ganglia	GATAD1	0.21	0.09	lasso	4	0.08	2.3e-03	4.788	-6.5	9.5e-11	-0.56	0.05	0.55	FALSE
7	GTEx	Breast Mammary Tissue (Female)	AC007566.10	0.04	-0.01	lasso	2	0.01	2.0e-01	1.901	-6.4	1.2e-10	-0.32	0.03	0.13	FALSE
15	GTEx	Skin Sun Exposed Lower leg	PEX1	0.18	0.06	enet	41	0.03	1.5e-03	-6.334	-6.2	4.0e-10	-0.44	0.21	0.13	FALSE
2	GTEx	Adrenal Gland	GATAD1	0.40	0.22	lasso	7	0.25	2.0e-09	5.285	-5.8	7.9e-09	-0.57	0.60	0.18	FALSE
5	GTEx	Artery Coronary	GATAD1	0.12	0.15	lasso	3	0.12	8.0e-05	5.678	-5.7	1.2e-08	-0.54	0.16	0.31	FALSE
9	GTEx	Colon Transverse	GATAD1	0.13	0.00	enet	16	0.05	3.0e-03	5.285	-5.6	2.6e-08	-0.52	0.16	0.34	FALSE
16	GTEx	Spleen	PEX1	0.18	0.00	enet	38	0.05	2.4e-02	2.041	-5.5	4.8e-08	-0.38	0.08	0.14	FALSE
10	GTEx	Esophagus Mucosa	GATAD1	0.16	0.05	enet	16	0.08	7.3e-06	5.285	-5.4	5.9e-08	-0.46	0.65	0.25	FALSE
13	GTEx	Muscle Skeletal	PEX1	0.06	0.03	lasso	5	0.02	2.7e-03	5.001	5.4	7.7e-08	0.42	0.38	0.38	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	GATAD1	0.22	0.27	lasso	4	0.26	1.1e-14	5.285	-5.4	7.7e-08	-0.53	1.00	0.00	FALSE
4	GTEx	Artery Aorta	GATAD1	0.09	0.08	enet	4	0.07	7.4e-05	5.285	-5.3	1.2e-07	-0.49	0.48	0.12	FALSE
3	GTEx	Artery Aorta	KRIT1	0.15	0.00	enet	24	0.03	1.3e-02	0.054	-5.2	1.8e-07	-0.27	0.12	0.05	FALSE
12	GTEx	Lung	GATAD1	0.15	0.12	lasso	2	0.11	1.1e-08	5.285	-5.2	1.9e-07	-0.53	0.99	0.00	FALSE