Best TWAS P=4.74e-35 · Best GWAS P=4.36e-33 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 11.455 | 11.5 | 2.1e-30 | 0.89 | 0.17 | 0.83 | FALSE |
| 2 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 5.285 | -5.8 | 7.9e-09 | -0.57 | 0.60 | 0.18 | FALSE |
| 3 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | 0.054 | -5.2 | 1.8e-07 | -0.27 | 0.12 | 0.05 | FALSE |
| 4 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 5.285 | -5.3 | 1.2e-07 | -0.49 | 0.48 | 0.12 | FALSE |
| 5 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 5.678 | -5.7 | 1.2e-08 | -0.54 | 0.16 | 0.31 | FALSE |
| 6 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 4.788 | -6.5 | 9.5e-11 | -0.56 | 0.05 | 0.55 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | AC007566.10 | 0.04 | -0.01 | lasso | 2 | 0.01 | 2.0e-01 | 1.901 | -6.4 | 1.2e-10 | -0.32 | 0.03 | 0.13 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 5.285 | -7.2 | 5.0e-13 | -0.69 | 0.90 | 0.10 | FALSE |
| 9 | GTEx | Colon Transverse | GATAD1 | 0.13 | 0.00 | enet | 16 | 0.05 | 3.0e-03 | 5.285 | -5.6 | 2.6e-08 | -0.52 | 0.16 | 0.34 | FALSE |
| 10 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 5.285 | -5.4 | 5.9e-08 | -0.46 | 0.65 | 0.25 | FALSE |
| 11 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -7.748 | -7.8 | 5.2e-15 | -0.55 | 0.09 | 0.18 | FALSE |
| 12 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 5.285 | -5.2 | 1.9e-07 | -0.53 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Muscle Skeletal | PEX1 | 0.06 | 0.03 | lasso | 5 | 0.02 | 2.7e-03 | 5.001 | 5.4 | 7.7e-08 | 0.42 | 0.38 | 0.38 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 5.285 | -5.4 | 7.7e-08 | -0.53 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | PEX1 | 0.18 | 0.06 | enet | 41 | 0.03 | 1.5e-03 | -6.334 | -6.2 | 4.0e-10 | -0.44 | 0.21 | 0.13 | FALSE |
| 16 | GTEx | Spleen | PEX1 | 0.18 | 0.00 | enet | 38 | 0.05 | 2.4e-02 | 2.041 | -5.5 | 4.8e-08 | -0.38 | 0.08 | 0.14 | FALSE |
| 17 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 11.983 | -12.4 | 4.7e-35 | -0.96 | 0.00 | 0.99 | TRUE |
| 18 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 5.285 | -7.0 | 2.2e-12 | -0.53 | 0.74 | 0.09 | FALSE |