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chr4:1,785,025-3,943,984

Best TWAS P=3.31e-14 · Best GWAS P=3.34e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	GTEx	Vagina	GRK4	0.27	0.12	lasso	4	0.11	1.6e-03	-7.3	7.6	3.3e-14	-0.95	0.02	0.90	TRUE
21	GTEx	Esophagus Muscularis	GRK4	0.29	0.30	enet	7	0.30	2.5e-18	-6.8	7.1	1.8e-12	-0.80	0.10	0.90	TRUE
27	GTEx	Pancreas	GRK4	0.14	0.05	lasso	9	0.03	3.0e-02	-6.8	6.9	4.9e-12	-0.79	0.05	0.91	TRUE
62	The Cancer Genome Atlas	Thyroid Carcinoma	C4orf10	0.18	0.06	lasso	3	0.07	2.2e-07	-6.9	6.3	2.6e-10	-0.67	0.02	0.98	TRUE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GRK4	0.13	0.10	blup	76	0.11	8.4e-08	-6.9	5.9	3.5e-09	-0.73	0.02	0.98	TRUE
39	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	-6.9	5.2	1.9e-07	-0.71	0.06	0.84	TRUE
20	GTEx	Esophagus Muscularis	RNF4	0.15	0.07	enet	4	0.07	3.7e-05	5.0	5.1	3.0e-07	-0.14	0.80	0.01	TRUE
18	GTEx	Esophagus Gastroesophageal Junction	GRK4	0.37	0.23	lasso	9	0.22	2.2e-08	-6.9	7.6	3.9e-14	-0.74	0.05	0.95	FALSE
17	GTEx	Colon Transverse	GRK4	0.27	0.25	enet	18	0.25	2.4e-12	-6.9	7.4	1.9e-13	-0.79	0.06	0.94	FALSE
57	The Cancer Genome Atlas	Rectum Adenocarcinoma	GRK4	0.27	0.10	blup	76	0.13	7.3e-04	-6.9	7.3	2.5e-13	-0.81	0.03	0.81	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	GRK4	0.18	0.23	blup	76	0.21	3.8e-12	-6.9	7.2	4.8e-13	-0.85	0.04	0.96	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GRK4	0.09	0.12	blup	76	0.12	1.7e-06	-6.7	7.2	5.0e-13	-0.84	0.03	0.97	FALSE
5	GTEx	Artery Aorta	GRK4	0.29	0.38	enet	11	0.40	1.3e-23	-6.8	7.2	5.2e-13	-0.84	0.08	0.92	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRK4	0.12	0.13	lasso	6	0.14	6.0e-15	-6.9	7.2	5.5e-13	-0.83	0.02	0.98	FALSE
11	GTEx	Brain Cortex	GRK4	0.25	0.26	lasso	4	0.25	1.7e-07	-6.8	7.1	1.1e-12	-0.84	0.08	0.91	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRK4	0.11	0.17	lasso	7	0.18	6.7e-36	-6.9	7.1	1.5e-12	-0.80	0.03	0.97	FALSE
8	GTEx	Artery Tibial	GRK4	0.34	0.35	lasso	4	0.35	1.1e-28	-6.8	7.1	1.6e-12	-0.84	0.10	0.90	FALSE
1	GTEx	Adipose Subcutaneous	GRK4	0.30	0.39	lasso	6	0.41	1.2e-35	-6.8	7.1	1.7e-12	-0.81	0.08	0.92	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	GRK4	0.38	0.43	lasso	4	0.42	9.6e-25	-6.8	7.0	1.8e-12	-0.81	0.09	0.91	FALSE
15	GTEx	Cells Transformed fibroblasts	GRK4	0.32	0.35	lasso	7	0.37	3.1e-29	-6.9	7.0	1.9e-12	-0.79	0.05	0.95	FALSE
2	GTEx	Adipose Visceral Omentum	GRK4	0.32	0.38	lasso	4	0.40	5.5e-22	-6.9	7.0	2.0e-12	-0.80	0.07	0.93	FALSE
37	GTEx	Thyroid	GRK4	0.50	0.47	lasso	9	0.48	6.4e-41	-6.8	7.0	2.0e-12	-0.82	0.08	0.92	FALSE
13	GTEx	Breast Mammary Tissue (Female)	GRK4	0.23	0.24	lasso	3	0.24	1.1e-07	-6.9	7.0	2.1e-12	-0.79	0.06	0.94	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	GRK4	0.12	0.14	lasso	4	0.14	1.8e-17	-6.9	7.0	2.1e-12	-0.80	0.06	0.94	FALSE
23	GTEx	Lung	GRK4	0.26	0.36	lasso	4	0.36	3.3e-29	-6.8	7.0	2.3e-12	-0.80	0.09	0.91	FALSE
36	GTEx	Thyroid	MFSD10	0.15	0.11	lasso	8	0.13	3.6e-10	-7.2	7.0	2.4e-12	-0.88	0.03	0.97	FALSE
12	GTEx	Breast Mammary Tissue	GRK4	0.27	0.32	enet	11	0.32	5.3e-17	-6.8	7.0	2.6e-12	-0.80	0.09	0.91	FALSE
28	GTEx	Pituitary	GRK4	0.17	0.00	enet	6	-0.01	5.6e-01	-7.0	7.0	3.1e-12	-0.76	0.05	0.55	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GRK4	0.23	0.32	lasso	5	0.31	1.0e-13	-6.8	7.0	3.4e-12	-0.82	0.04	0.96	FALSE
25	GTEx	Nerve Tibial	GRK4	0.29	0.38	lasso	3	0.39	4.6e-29	-6.8	6.9	4.0e-12	-0.81	0.10	0.90	FALSE
7	GTEx	Artery Coronary	GRK4	0.27	0.24	lasso	3	0.22	6.7e-08	-6.8	6.9	5.1e-12	-0.80	0.06	0.94	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	GRK4	0.17	0.24	lasso	6	0.24	1.2e-17	-6.9	6.9	5.3e-12	-0.81	0.04	0.96	FALSE
33	GTEx	Stomach	GRK4	0.22	0.19	lasso	7	0.19	2.6e-09	-6.9	6.9	5.5e-12	-0.74	0.08	0.92	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRK4	0.19	0.23	blup	77	0.22	4.2e-24	-6.9	6.9	5.8e-12	-0.82	0.05	0.95	FALSE
19	GTEx	Esophagus Mucosa	GRK4	0.28	0.35	lasso	4	0.34	3.1e-23	-6.8	6.9	6.2e-12	-0.81	0.10	0.90	FALSE
42	METSIM	Adipose	GRK4	0.20	0.26	lasso	6	0.25	9.9e-38	-6.7	6.9	6.4e-12	-0.80	0.11	0.89	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GRK4	0.09	0.10	lasso	4	0.14	1.4e-11	-6.9	6.9	6.4e-12	-0.83	0.06	0.94	FALSE
61	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GRK4	0.08	0.09	lasso	1	0.06	4.2e-03	-6.9	6.9	6.8e-12	-0.80	0.03	0.70	FALSE
16	GTEx	Colon Sigmoid	GRK4	0.26	0.30	lasso	2	0.28	2.6e-10	-6.8	6.9	7.1e-12	-0.80	0.08	0.92	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	GRK4	0.22	0.39	lasso	6	0.38	4.1e-39	-6.9	6.9	7.3e-12	-0.81	0.04	0.96	FALSE
32	GTEx	Spleen	GRK4	0.24	0.16	lasso	5	0.12	4.8e-04	-6.9	6.8	8.6e-12	-0.79	0.06	0.78	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GRK4	0.16	0.18	lasso	6	0.20	1.9e-11	-5.9	6.8	1.2e-11	-0.89	0.04	0.96	FALSE
31	GTEx	Skin Sun Exposed Lower leg	GRK4	0.37	0.45	enet	30	0.46	1.3e-41	-6.8	6.8	1.3e-11	-0.78	0.10	0.90	FALSE
34	GTEx	Testis	GRK4	0.36	0.18	enet	22	0.28	1.3e-12	-6.8	6.7	1.7e-11	-0.68	0.06	0.94	FALSE
66	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	GRK4	0.11	0.12	lasso	1	0.10	8.4e-04	-6.7	6.7	1.7e-11	-0.75	0.02	0.85	FALSE
4	GTEx	Adrenal Gland	GRK4	0.38	0.25	lasso	5	0.29	5.1e-11	-6.8	6.7	1.9e-11	-0.78	0.10	0.90	FALSE
48	The Cancer Genome Atlas	Esophageal Carcinoma	GRK4	0.28	0.32	lasso	8	0.34	1.7e-11	-6.9	6.7	2.0e-11	-0.75	0.07	0.93	FALSE
38	GTEx	Thyroid	NOP14-AS1	0.18	0.09	lasso	8	0.11	1.3e-08	-6.9	6.7	2.6e-11	-0.79	0.08	0.92	FALSE
10	GTEx	Brain Cerebellum	GRK4	0.41	0.36	lasso	7	0.34	7.7e-11	-6.8	6.6	3.0e-11	-0.80	0.09	0.91	FALSE
22	GTEx	Lung	ADD1	0.09	0.02	enet	6	0.01	3.5e-02	4.7	6.6	4.2e-11	-0.75	0.07	0.87	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRK4	0.10	0.14	enet	16	0.14	4.6e-15	-6.9	6.6	4.2e-11	-0.75	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	GRK4	0.13	0.19	lasso	2	0.19	6.1e-22	-6.7	6.4	1.2e-10	-0.75	0.06	0.94	FALSE
24	GTEx	Lung	HTT	0.06	0.00	lasso	4	0.00	5.8e-01	-7.0	6.4	1.3e-10	-0.92	0.05	0.71	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	GRK4	0.08	0.07	blup	77	0.09	4.4e-06	-5.9	6.4	1.7e-10	-0.78	0.09	0.91	FALSE
41	GTEx	Whole Blood	GRK4	0.08	0.10	lasso	4	0.10	1.0e-09	-6.8	6.3	2.4e-10	-0.78	0.15	0.85	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GRK4	0.09	0.18	lasso	5	0.20	1.5e-22	-7.0	6.3	2.4e-10	-0.77	0.02	0.98	FALSE
35	GTEx	Thyroid	NOP14	0.09	0.04	lasso	5	0.03	4.5e-03	-5.9	6.3	2.6e-10	-0.79	0.18	0.77	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	MFSD10	0.07	0.02	enet	6	0.08	7.2e-08	-6.9	6.3	3.1e-10	-0.71	0.03	0.96	FALSE
26	GTEx	Ovary	GRK4	0.25	0.19	lasso	8	0.18	3.6e-05	-6.8	5.9	3.5e-09	-0.78	0.06	0.78	FALSE
29	GTEx	Prostate	GRK4	0.38	0.19	enet	27	0.25	5.3e-07	-6.8	5.9	3.8e-09	-0.57	0.06	0.86	FALSE
3	GTEx	Adrenal Gland	NOP14	0.35	0.15	enet	33	0.19	1.9e-07	-5.9	5.9	4.4e-09	-0.48	0.51	0.46	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	NOP14	0.09	0.12	blup	57	0.13	1.4e-12	-5.8	5.8	7.1e-09	-0.76	0.25	0.75	FALSE
14	GTEx	Cells Transformed fibroblasts	NOP14	0.12	0.06	enet	11	0.09	2.9e-07	-5.8	5.8	8.8e-09	-0.72	0.11	0.88	FALSE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3BP2	0.08	0.03	blup	53	0.02	2.8e-02	5.2	5.5	4.1e-08	-0.44	0.01	0.21	FALSE
6	GTEx	Artery Aorta	NOP14-AS1	0.11	0.01	lasso	5	0.07	1.7e-04	2.1	-5.5	4.9e-08	0.73	0.06	0.85	FALSE
9	GTEx	Brain Cerebellar Hemisphere	GRK4	0.33	0.30	enet	25	0.35	8.2e-10	-7.1	5.4	8.7e-08	-0.80	0.03	0.96	FALSE