Best TWAS P=6.44e-09 · Best GWAS P=5.99e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | OIP5-AS1 | 0.21 | 0.23 | lasso | 5 | 0.26 | 3.7e-21 | 4.9 | 5.3 | 1.1e-07 | 0.73 | 0.18 | 0.81 | FALSE |
2 | GTEx | Adrenal Gland | OIP5-AS1 | 0.17 | 0.16 | lasso | 3 | 0.16 | 2.6e-06 | 5.2 | 5.3 | 1.3e-07 | 0.77 | 0.11 | 0.86 | FALSE |
3 | GTEx | Artery Coronary | OIP5-AS1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.3e-05 | 5.3 | 5.3 | 9.2e-08 | 0.74 | 0.12 | 0.82 | FALSE |
4 | GTEx | Artery Tibial | OIP5-AS1 | 0.16 | 0.23 | lasso | 4 | 0.24 | 3.6e-19 | 4.8 | 5.2 | 2.0e-07 | 0.75 | 0.29 | 0.71 | FALSE |
5 | GTEx | Brain Caudate basal ganglia | NUSAP1 | 0.31 | 0.38 | lasso | 9 | 0.40 | 1.1e-12 | 5.2 | 5.5 | 4.2e-08 | 0.78 | 0.08 | 0.92 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | NDUFAF1 | 0.20 | 0.23 | lasso | 6 | 0.22 | 2.2e-06 | 5.3 | -5.5 | 4.2e-08 | -0.77 | 0.08 | 0.90 | FALSE |
7 | GTEx | Brain Cerebellum | NUSAP1 | 0.22 | 0.23 | enet | 18 | 0.22 | 3.7e-07 | 5.2 | 5.2 | 1.7e-07 | 0.78 | 0.09 | 0.90 | FALSE |
8 | GTEx | Brain Cerebellum | NDUFAF1 | 0.24 | 0.26 | lasso | 8 | 0.20 | 1.1e-06 | 5.4 | -5.3 | 1.1e-07 | -0.77 | 0.06 | 0.94 | FALSE |
9 | GTEx | Brain Cortex | NDUFAF1 | 0.40 | 0.37 | enet | 22 | 0.36 | 7.0e-11 | 5.0 | -5.4 | 7.1e-08 | -0.69 | 0.15 | 0.85 | FALSE |
10 | GTEx | Brain Frontal Cortex BA9 | NDUFAF1 | 0.55 | 0.37 | lasso | 8 | 0.40 | 1.6e-11 | 5.4 | -5.5 | 5.1e-08 | -0.74 | 0.08 | 0.92 | FALSE |
11 | GTEx | Brain Hypothalamus | NUSAP1 | 0.26 | 0.36 | lasso | 4 | 0.27 | 5.6e-07 | 5.2 | 5.5 | 3.4e-08 | 0.66 | 0.10 | 0.88 | FALSE |
12 | GTEx | Brain Nucleus accumbens basal ganglia | NUSAP1 | 0.36 | 0.32 | lasso | 6 | 0.26 | 1.5e-07 | 5.4 | 5.3 | 1.4e-07 | 0.76 | 0.08 | 0.91 | FALSE |
13 | GTEx | Brain Nucleus accumbens basal ganglia | NDUFAF1 | 0.12 | 0.11 | lasso | 6 | 0.10 | 9.7e-04 | 5.3 | -5.5 | 4.7e-08 | -0.73 | 0.08 | 0.78 | FALSE |
14 | GTEx | Brain Putamen basal ganglia | NUSAP1 | 0.38 | 0.30 | lasso | 20 | 0.34 | 9.1e-09 | 5.2 | 5.3 | 9.7e-08 | 0.75 | 0.11 | 0.89 | FALSE |
15 | GTEx | Cells EBV-transformed lymphocytes | OIP5-AS1 | 0.21 | 0.12 | lasso | 7 | 0.10 | 3.2e-04 | 5.4 | 5.4 | 5.2e-08 | 0.83 | 0.07 | 0.77 | FALSE |
16 | GTEx | Cells Transformed fibroblasts | CHP1 | 0.13 | 0.11 | lasso | 6 | 0.11 | 2.1e-08 | 5.5 | -5.7 | 1.2e-08 | -0.94 | 0.04 | 0.96 | FALSE |
17 | GTEx | Cells Transformed fibroblasts | OIP5-AS1 | 0.28 | 0.32 | lasso | 2 | 0.32 | 3.5e-24 | 5.4 | 5.4 | 7.9e-08 | 0.73 | 0.07 | 0.93 | FALSE |
18 | GTEx | Colon Sigmoid | OIP5-AS1 | 0.21 | 0.27 | lasso | 3 | 0.25 | 3.3e-09 | 5.4 | 5.4 | 5.2e-08 | 0.76 | 0.12 | 0.88 | FALSE |
19 | GTEx | Colon Transverse | OIP5-AS1 | 0.13 | 0.14 | lasso | 5 | 0.15 | 1.8e-07 | 5.4 | 5.3 | 9.7e-08 | 0.75 | 0.12 | 0.88 | FALSE |
20 | GTEx | Esophagus Gastroesophageal Junction | OIP5-AS1 | 0.18 | 0.10 | lasso | 7 | 0.11 | 8.9e-05 | 5.4 | 5.5 | 4.9e-08 | 0.85 | 0.09 | 0.88 | FALSE |
21 | GTEx | Esophagus Mucosa | OIP5-AS1 | 0.20 | 0.22 | lasso | 6 | 0.20 | 1.7e-13 | 5.2 | 5.3 | 1.3e-07 | 0.76 | 0.12 | 0.88 | FALSE |
22 | GTEx | Esophagus Muscularis | NDUFAF1 | 0.24 | 0.23 | lasso | 5 | 0.28 | 2.8e-17 | 5.3 | -5.1 | 2.9e-07 | -0.69 | 0.12 | 0.88 | FALSE |
23 | GTEx | Esophagus Muscularis | OIP5-AS1 | 0.24 | 0.24 | enet | 19 | 0.28 | 4.6e-17 | 5.4 | 5.2 | 1.5e-07 | 0.73 | 0.15 | 0.85 | FALSE |
24 | GTEx | Heart Atrial Appendage | NDUFAF1 | 0.36 | 0.28 | enet | 24 | 0.34 | 9.5e-16 | 5.4 | -5.6 | 2.4e-08 | -0.73 | 0.06 | 0.94 | FALSE |
25 | GTEx | Heart Atrial Appendage | RTF1 | 0.14 | 0.07 | lasso | 4 | 0.08 | 2.4e-04 | 5.7 | -5.8 | 6.4e-09 | -0.98 | 0.02 | 0.97 | TRUE |
26 | GTEx | Heart Left Ventricle | NDUFAF1 | 0.49 | 0.62 | lasso | 8 | 0.62 | 2.0e-41 | 5.4 | -5.5 | 3.1e-08 | -0.75 | 0.05 | 0.95 | FALSE |
27 | GTEx | Muscle Skeletal | NDUFAF1 | 0.44 | 0.56 | enet | 31 | 0.60 | 3.0e-73 | 5.3 | -5.3 | 1.5e-07 | -0.78 | 0.06 | 0.94 | FALSE |
28 | GTEx | Nerve Tibial | OIP5 | 0.07 | 0.08 | lasso | 2 | 0.05 | 1.6e-04 | 5.0 | 5.2 | 2.0e-07 | 0.91 | 0.02 | 0.98 | FALSE |
29 | GTEx | Nerve Tibial | NUSAP1 | 0.15 | 0.09 | enet | 10 | 0.15 | 9.8e-11 | 5.2 | 5.3 | 8.6e-08 | 0.84 | 0.10 | 0.90 | FALSE |
30 | GTEx | Nerve Tibial | NDUFAF1 | 0.36 | 0.43 | lasso | 6 | 0.43 | 8.0e-33 | 5.2 | 5.4 | 8.3e-08 | 0.74 | 0.07 | 0.93 | FALSE |
31 | GTEx | Nerve Tibial | OIP5-AS1 | 0.20 | 0.22 | enet | 21 | 0.26 | 1.3e-18 | 5.3 | 5.3 | 9.6e-08 | 0.73 | 0.12 | 0.88 | FALSE |
32 | GTEx | Pancreas | NDUFAF1 | 0.41 | 0.39 | enet | 20 | 0.42 | 2.7e-19 | 5.3 | 5.5 | 2.8e-08 | 0.75 | 0.06 | 0.94 | FALSE |
33 | GTEx | Prostate | NDUFAF1 | 0.30 | 0.12 | lasso | 2 | 0.14 | 2.7e-04 | 5.5 | 5.7 | 1.3e-08 | 0.88 | 0.04 | 0.85 | FALSE |
34 | GTEx | Skin Not Sun Exposed Suprapubic | OIP5-AS1 | 0.17 | 0.19 | enet | 17 | 0.22 | 4.3e-12 | 5.0 | 5.3 | 1.1e-07 | 0.80 | 0.13 | 0.87 | FALSE |
35 | GTEx | Skin Sun Exposed Lower leg | OIP5-AS1 | 0.13 | 0.17 | lasso | 3 | 0.23 | 5.0e-19 | 4.9 | 5.4 | 8.5e-08 | 0.80 | 0.28 | 0.72 | FALSE |
36 | GTEx | Thyroid | OIP5 | 0.06 | 0.03 | lasso | 5 | 0.02 | 1.1e-02 | 5.2 | 5.6 | 2.2e-08 | 0.76 | 0.10 | 0.80 | FALSE |
37 | GTEx | Thyroid | NDUFAF1 | 0.25 | 0.21 | lasso | 6 | 0.22 | 9.3e-17 | 5.3 | 5.5 | 3.2e-08 | 0.81 | 0.07 | 0.93 | FALSE |
38 | GTEx | Whole Blood | NDUFAF1 | 0.25 | 0.07 | lasso | 6 | 0.12 | 6.4e-11 | 5.0 | 5.2 | 2.5e-07 | 0.81 | 0.07 | 0.93 | FALSE |
39 | METSIM | Adipose | NUSAP1 | 0.03 | 0.03 | lasso | 6 | 0.02 | 4.2e-04 | 5.1 | 5.2 | 2.7e-07 | 0.77 | 0.13 | 0.81 | FALSE |
40 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NDUFAF1 | 0.03 | 0.04 | lasso | 3 | 0.04 | 3.2e-05 | 5.3 | -5.3 | 9.0e-08 | -0.77 | 0.02 | 0.98 | FALSE |
41 | The Cancer Genome Atlas | Lung Adenocarcinoma | NDUFAF1 | 0.14 | 0.17 | lasso | 5 | 0.18 | 9.6e-21 | 5.3 | 5.2 | 1.7e-07 | 0.74 | 0.01 | 0.99 | FALSE |
42 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC729082 | 0.15 | 0.05 | blup | 44 | 0.10 | 8.6e-05 | 5.4 | -5.6 | 2.4e-08 | -0.72 | 0.04 | 0.83 | FALSE |
43 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NDUFAF1 | 0.18 | 0.21 | blup | 28 | 0.22 | 5.4e-09 | 5.3 | 5.2 | 1.5e-07 | 0.76 | 0.01 | 0.99 | FALSE |
44 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NDUFAF1 | 0.13 | 0.16 | enet | 8 | 0.17 | 2.2e-17 | 5.3 | 5.2 | 2.2e-07 | 0.74 | 0.01 | 0.99 | FALSE |
45 | The Cancer Genome Atlas | Thyroid Carcinoma | NDUFAF1 | 0.32 | 0.38 | enet | 11 | 0.39 | 1.2e-39 | 5.3 | 5.3 | 1.3e-07 | 0.76 | 0.01 | 0.99 | FALSE |