Best TWAS P=4.72e-14 · Best GWAS P=5.13e-23 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADAMTSL3 | 0.10 | 0.04 | lasso | 4 | 0.04 | 8.7e-06 | -7.43 | -6.3 | 2.5e-10 | 0.56 | 0.24 | 0.05 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LOC388152 | 0.14 | 0.14 | enet | 20 | 0.18 | 6.7e-22 | 5.23 | -7.1 | 1.4e-12 | 0.52 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | AC103965.1 | 0.24 | 0.14 | lasso | 6 | 0.15 | 2.6e-12 | 5.24 | -6.5 | 7.5e-11 | 0.40 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | RP11-182J1.14 | 0.11 | 0.11 | lasso | 9 | 0.12 | 8.1e-10 | 5.19 | 5.2 | 2.1e-07 | -0.31 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Adipose Subcutaneous | CSPG4P11 | 0.19 | 0.17 | lasso | 5 | 0.20 | 7.9e-16 | 5.24 | -6.2 | 4.9e-10 | 0.38 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Adipose Visceral Omentum | GOLGA6L3 | 0.23 | 0.05 | lasso | 5 | 0.07 | 2.2e-04 | -5.76 | -5.2 | 2.0e-07 | 0.37 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Adipose Visceral Omentum | UBE2Q2P1 | 0.14 | 0.03 | enet | 34 | 0.06 | 4.0e-04 | 6.92 | 5.2 | 2.0e-07 | -0.17 | 0.04 | 0.67 | FALSE |
| 8 | GTEx | Adrenal Gland | AC103965.1 | 0.09 | 0.00 | enet | 5 | -0.01 | 7.7e-01 | 5.21 | -5.3 | 1.5e-07 | 0.32 | 0.09 | 0.09 | FALSE |
| 9 | GTEx | Adrenal Gland | CSPG4P11 | 0.14 | -0.01 | enet | 15 | 0.04 | 1.7e-02 | 5.24 | -5.2 | 1.7e-07 | 0.22 | 0.14 | 0.11 | FALSE |
| 10 | GTEx | Artery Aorta | UBE2Q2P1 | 0.15 | 0.00 | enet | 21 | 0.05 | 8.4e-04 | -3.90 | 6.2 | 5.8e-10 | -0.46 | 0.16 | 0.46 | FALSE |
| 11 | GTEx | Artery Aorta | AC103965.1 | 0.10 | 0.12 | lasso | 3 | 0.10 | 3.9e-06 | 5.23 | -5.2 | 1.6e-07 | 0.30 | 0.92 | 0.05 | FALSE |
| 12 | GTEx | Artery Aorta | RP11-182J1.16 | 0.11 | 0.12 | lasso | 3 | 0.11 | 1.6e-06 | 5.24 | -5.2 | 2.0e-07 | 0.28 | 0.94 | 0.01 | FALSE |
| 13 | GTEx | Artery Aorta | CSPG4P11 | 0.11 | 0.10 | lasso | 4 | 0.08 | 3.1e-05 | 5.24 | -5.2 | 1.7e-07 | 0.30 | 0.92 | 0.01 | FALSE |
| 14 | GTEx | Artery Tibial | SCAND2P | 0.12 | 0.05 | enet | 16 | 0.08 | 8.7e-07 | -3.81 | -6.7 | 2.3e-11 | 0.38 | 0.64 | 0.06 | FALSE |
| 15 | GTEx | Artery Tibial | AC103965.1 | 0.27 | 0.26 | enet | 31 | 0.30 | 1.8e-23 | 5.19 | -6.1 | 1.1e-09 | 0.41 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Artery Tibial | CSPG4P11 | 0.16 | 0.24 | lasso | 4 | 0.23 | 3.0e-18 | 5.19 | -6.5 | 6.8e-11 | 0.41 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Brain Caudate basal ganglia | AC103965.1 | 0.28 | 0.25 | lasso | 7 | 0.25 | 6.7e-08 | 4.95 | -6.0 | 2.7e-09 | 0.37 | 0.82 | 0.04 | FALSE |
| 18 | GTEx | Brain Cerebellar Hemisphere | UBE2Q2P1 | 0.18 | 0.08 | enet | 18 | 0.12 | 4.2e-04 | 5.60 | 5.5 | 4.9e-08 | -0.28 | 0.06 | 0.74 | FALSE |
| 19 | GTEx | Brain Cerebellar Hemisphere | CSPG4P11 | 0.30 | 0.21 | lasso | 3 | 0.16 | 7.6e-05 | 5.19 | 5.2 | 1.5e-07 | -0.34 | 0.39 | 0.08 | FALSE |
| 20 | GTEx | Brain Cerebellum | AC103965.1 | 0.13 | 0.02 | enet | 21 | 0.01 | 2.1e-01 | 5.24 | -7.5 | 4.7e-14 | 0.53 | 0.08 | 0.42 | TRUE |
| 21 | GTEx | Brain Cortex | GOLGA6L4 | 0.42 | 0.21 | lasso | 7 | 0.28 | 2.8e-08 | -6.38 | -7.0 | 2.0e-12 | 0.65 | 0.17 | 0.75 | FALSE |
| 22 | GTEx | Brain Cortex | AC103965.1 | 0.17 | 0.19 | lasso | 3 | 0.16 | 4.3e-05 | 4.95 | -6.1 | 1.4e-09 | 0.40 | 0.21 | 0.44 | FALSE |
| 23 | GTEx | Brain Nucleus accumbens basal ganglia | GOLGA6L4 | 0.21 | 0.04 | lasso | 5 | 0.09 | 2.3e-03 | -7.33 | -5.7 | 1.3e-08 | 0.55 | 0.06 | 0.18 | FALSE |
| 24 | GTEx | Brain Nucleus accumbens basal ganglia | AC103965.1 | 0.29 | 0.23 | enet | 21 | 0.27 | 6.9e-08 | 5.13 | -6.5 | 6.8e-11 | 0.45 | 0.84 | 0.10 | FALSE |
| 25 | GTEx | Breast Mammary Tissue | AC103965.1 | 0.13 | 0.11 | lasso | 1 | 0.13 | 2.9e-07 | 5.19 | -5.2 | 2.1e-07 | 0.31 | 0.92 | 0.02 | FALSE |
| 26 | GTEx | Breast Mammary Tissue (Male) | GOLGA6L4 | 0.23 | 0.07 | lasso | 2 | 0.12 | 8.3e-04 | -6.38 | -6.6 | 3.2e-11 | 0.57 | 0.07 | 0.34 | FALSE |
| 27 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 4.95 | -7.3 | 2.1e-13 | 0.55 | 0.07 | 0.59 | TRUE |
| 28 | GTEx | Breast Mammary Tissue (Male) | RN7SL417P | 0.20 | 0.12 | lasso | 3 | 0.10 | 3.1e-03 | 5.60 | 5.4 | 7.4e-08 | -0.40 | 0.06 | 0.14 | FALSE |
| 29 | GTEx | Breast Mammary Tissue (Male) | RP11-182J1.14 | 0.04 | -0.01 | enet | 1 | -0.01 | 5.9e-01 | 5.13 | 5.1 | 2.9e-07 | -0.33 | 0.03 | 0.06 | FALSE |
| 30 | GTEx | Cells Transformed fibroblasts | AC103965.1 | 0.15 | 0.09 | lasso | 7 | 0.11 | 1.3e-08 | 5.24 | -7.3 | 2.3e-13 | 0.56 | 0.68 | 0.32 | FALSE |
| 31 | GTEx | Colon Sigmoid | RP11-182J1.14 | 0.31 | 0.29 | lasso | 9 | 0.30 | 2.7e-11 | 5.21 | 5.5 | 3.1e-08 | -0.36 | 1.00 | 0.00 | FALSE |
| 32 | GTEx | Colon Transverse | AC103965.1 | 0.15 | 0.07 | enet | 33 | 0.06 | 7.1e-04 | -5.78 | -6.9 | 5.5e-12 | 0.50 | 0.09 | 0.54 | TRUE |
| 33 | GTEx | Colon Transverse | CSPG4P11 | 0.10 | 0.10 | lasso | 4 | 0.08 | 1.2e-04 | -5.78 | -5.8 | 6.7e-09 | 0.40 | 0.25 | 0.04 | TRUE |
| 34 | GTEx | Esophagus Mucosa | AC103965.1 | 0.20 | 0.19 | enet | 47 | 0.16 | 8.4e-11 | 5.19 | -6.1 | 1.1e-09 | 0.47 | 1.00 | 0.00 | FALSE |
| 35 | GTEx | Esophagus Mucosa | RP11-182J1.16 | 0.20 | 0.05 | lasso | 5 | 0.10 | 1.8e-07 | 5.21 | -6.8 | 1.5e-11 | 0.46 | 0.89 | 0.02 | FALSE |
| 36 | GTEx | Esophagus Mucosa | CSPG4P11 | 0.21 | 0.01 | enet | 28 | 0.08 | 3.7e-06 | -5.78 | -6.9 | 5.9e-12 | 0.56 | 0.60 | 0.33 | FALSE |
| 37 | GTEx | Esophagus Muscularis | UBE2Q2P1 | 0.34 | 0.03 | lasso | 7 | 0.15 | 1.9e-09 | 3.21 | 7.2 | 4.2e-13 | -0.42 | 0.15 | 0.67 | TRUE |
| 38 | GTEx | Esophagus Muscularis | AC103965.1 | 0.18 | 0.14 | enet | 16 | 0.14 | 7.6e-09 | 5.19 | -6.1 | 1.4e-09 | 0.40 | 1.00 | 0.00 | FALSE |
| 39 | GTEx | Heart Atrial Appendage | RP11-182J1.14 | 0.06 | 0.05 | lasso | 3 | 0.05 | 3.6e-03 | 5.21 | 5.2 | 1.9e-07 | -0.33 | 0.21 | 0.07 | FALSE |
| 40 | GTEx | Lung | AC103965.1 | 0.20 | 0.14 | lasso | 4 | 0.16 | 1.8e-12 | 5.19 | -6.5 | 9.1e-11 | 0.42 | 1.00 | 0.00 | FALSE |
| 41 | GTEx | Muscle Skeletal | SCAND2P | 0.05 | 0.00 | lasso | 4 | 0.00 | 1.3e-01 | -2.94 | -5.4 | 8.4e-08 | 0.34 | 0.11 | 0.29 | FALSE |
| 42 | GTEx | Muscle Skeletal | NMB | 0.07 | 0.00 | enet | 23 | 0.00 | 9.9e-02 | -3.98 | -5.9 | 4.0e-09 | 0.39 | 0.16 | 0.26 | FALSE |
| 43 | GTEx | Nerve Tibial | UBE2Q2P1 | 0.13 | 0.01 | enet | 37 | 0.04 | 1.3e-03 | 5.23 | 5.5 | 4.7e-08 | -0.20 | 0.07 | 0.54 | FALSE |
| 44 | GTEx | Nerve Tibial | AC103965.1 | 0.20 | 0.22 | enet | 17 | 0.27 | 5.1e-19 | 5.19 | -7.0 | 1.9e-12 | 0.49 | 1.00 | 0.00 | FALSE |
| 45 | GTEx | Nerve Tibial | CSPG4P11 | 0.23 | 0.23 | lasso | 9 | 0.27 | 3.0e-19 | 5.24 | -5.1 | 3.1e-07 | 0.31 | 1.00 | 0.00 | FALSE |
| 46 | GTEx | Ovary | AC103965.1 | 0.27 | 0.22 | lasso | 3 | 0.24 | 1.6e-06 | 5.24 | -6.9 | 4.4e-12 | 0.43 | 0.34 | 0.13 | FALSE |
| 47 | GTEx | Pancreas | AC103965.1 | 0.29 | 0.23 | lasso | 9 | 0.18 | 2.8e-08 | 5.24 | -5.7 | 1.0e-08 | 0.39 | 1.00 | 0.00 | FALSE |
| 48 | GTEx | Pancreas | RP11-182J1.16 | 0.08 | -0.01 | enet | 11 | -0.01 | 7.9e-01 | -5.78 | -7.1 | 1.6e-12 | 0.62 | 0.03 | 0.52 | FALSE |
| 49 | GTEx | Pituitary | UBE2Q2P1 | 0.32 | 0.00 | lasso | 20 | 0.06 | 1.1e-02 | -4.07 | 6.0 | 1.6e-09 | -0.50 | 0.04 | 0.70 | FALSE |
| 50 | GTEx | Pituitary | AC103965.1 | 0.30 | 0.16 | enet | 10 | 0.24 | 8.4e-07 | 5.20 | -6.3 | 2.9e-10 | 0.52 | 0.28 | 0.46 | FALSE |
| 51 | GTEx | Prostate | RP11-182J1.16 | 0.24 | 0.06 | enet | 27 | 0.08 | 6.2e-03 | -0.18 | -6.3 | 3.8e-10 | 0.48 | 0.06 | 0.32 | FALSE |
| 52 | GTEx | Prostate | CSPG4P11 | 0.34 | 0.07 | enet | 13 | 0.18 | 2.3e-05 | -2.23 | -6.5 | 8.6e-11 | 0.42 | 0.06 | 0.71 | FALSE |
| 53 | GTEx | Skin Not Sun Exposed Suprapubic | AC103965.1 | 0.23 | 0.15 | lasso | 8 | 0.19 | 1.9e-10 | 5.24 | -5.5 | 2.9e-08 | 0.37 | 0.96 | 0.02 | FALSE |
| 54 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-182J1.16 | 0.10 | 0.01 | enet | 13 | 0.04 | 3.1e-03 | 0.28 | -5.2 | 1.6e-07 | 0.40 | 0.37 | 0.07 | FALSE |
| 55 | GTEx | Skin Sun Exposed Lower leg | ZSCAN2 | 0.08 | 0.02 | enet | 13 | 0.03 | 1.4e-03 | -5.77 | 5.4 | 5.6e-08 | -0.34 | 0.39 | 0.07 | FALSE |
| 56 | GTEx | Skin Sun Exposed Lower leg | AC103965.1 | 0.33 | 0.17 | enet | 24 | 0.23 | 4.8e-19 | 5.19 | -7.2 | 4.5e-13 | 0.50 | 1.00 | 0.00 | FALSE |
| 57 | GTEx | Small Intestine Terminal Ileum | RP11-182J1.14 | 0.26 | 0.01 | enet | 27 | 0.12 | 1.3e-03 | -8.34 | 6.7 | 2.5e-11 | -0.37 | 0.06 | 0.13 | FALSE |
| 58 | GTEx | Spleen | GOLGA6L4 | 0.55 | 0.20 | enet | 19 | 0.40 | 2.6e-11 | -5.82 | -7.4 | 1.5e-13 | 0.54 | 0.87 | 0.04 | FALSE |
| 59 | GTEx | Testis | RP11-182J1.14 | 0.10 | 0.19 | lasso | 1 | 0.17 | 6.7e-08 | 5.19 | 5.2 | 2.1e-07 | -0.31 | 0.94 | 0.00 | FALSE |
| 60 | GTEx | Thyroid | AC103965.1 | 0.30 | 0.25 | lasso | 7 | 0.25 | 1.8e-19 | 5.24 | -6.1 | 8.7e-10 | 0.37 | 1.00 | 0.00 | FALSE |
| 61 | GTEx | Thyroid | RP11-182J1.16 | 0.10 | 0.02 | lasso | 7 | 0.05 | 1.3e-04 | -7.92 | -5.8 | 5.6e-09 | 0.56 | 0.37 | 0.33 | FALSE |
| 62 | GTEx | Whole Blood | GOLGA6L4 | 0.12 | 0.08 | enet | 16 | 0.11 | 2.1e-10 | -5.83 | -7.2 | 6.4e-13 | 0.58 | 0.80 | 0.20 | FALSE |
| 63 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GOLGA6L5 | 0.04 | 0.04 | enet | 5 | 0.05 | 4.6e-11 | -2.25 | -5.4 | 5.8e-08 | 0.42 | 0.24 | 0.67 | FALSE |
| 64 | The Cancer Genome Atlas | Esophageal Carcinoma | LOC388152 | 0.10 | 0.08 | enet | 2 | 0.08 | 1.8e-03 | 5.15 | -5.2 | 2.4e-07 | 0.30 | 0.00 | 0.69 | FALSE |
| 65 | The Cancer Genome Atlas | Glioblastoma Multiforme | LOC388152 | 0.12 | 0.08 | lasso | 3 | 0.08 | 1.9e-03 | 5.14 | -5.1 | 2.8e-07 | 0.29 | 0.00 | 0.61 | FALSE |
| 66 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZSCAN2 | 0.11 | 0.00 | blup | 46 | 0.03 | 1.2e-04 | 1.19 | 5.3 | 1.4e-07 | -0.23 | 0.02 | 0.04 | FALSE |
| 67 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GOLGA6L5 | 0.04 | 0.01 | blup | 7 | 0.03 | 4.9e-04 | 5.23 | -5.2 | 1.7e-07 | 0.28 | 0.00 | 0.92 | FALSE |
| 68 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UBE2Q2P1 | 0.07 | 0.04 | blup | 22 | 0.06 | 1.8e-07 | 5.24 | 5.6 | 2.2e-08 | -0.37 | 0.63 | 0.30 | FALSE |
| 69 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | UBE2Q2P1 | 0.10 | 0.00 | blup | 22 | 0.03 | 1.9e-02 | -5.35 | 6.1 | 9.7e-10 | -0.40 | 0.00 | 0.42 | FALSE |
| 70 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC388152 | 0.02 | 0.03 | lasso | 1 | 0.02 | 1.2e-03 | 5.15 | -5.2 | 2.6e-07 | 0.30 | 0.00 | 0.90 | FALSE |
| 71 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBE2Q2P1 | 0.03 | 0.03 | lasso | 3 | 0.02 | 9.2e-04 | 5.24 | 5.7 | 9.6e-09 | -0.36 | 0.04 | 0.21 | FALSE |
| 72 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOC388152 | 0.04 | 0.05 | enet | 2 | 0.05 | 4.2e-04 | 5.19 | -5.2 | 2.3e-07 | 0.30 | 0.00 | 0.86 | FALSE |
| 73 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LOC388152 | 0.08 | 0.11 | lasso | 3 | 0.11 | 2.4e-05 | 5.14 | -5.1 | 2.8e-07 | 0.29 | 0.00 | 0.97 | FALSE |
| 74 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GOLGA6L5 | 0.11 | 0.03 | blup | 7 | 0.09 | 5.5e-10 | -2.72 | -5.3 | 1.2e-07 | 0.43 | 0.08 | 0.90 | FALSE |
| 75 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GOLGA6L5 | 0.09 | 0.08 | enet | 4 | 0.09 | 5.2e-06 | -2.72 | -5.8 | 7.7e-09 | 0.44 | 0.02 | 0.80 | FALSE |