Best TWAS P=2.46e-14 · Best GWAS P=3.96e-19 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | RPRD2 | 0.08 | -0.01 | enet | 19 | 0.00 | 4.2e-01 | -3.9 | 7.3 | 3.1e-13 | 0.30 | 0.08 | 0.32 | TRUE |
2 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 8.9 | 6.2 | 5.0e-10 | 0.70 | 0.00 | 1.00 | FALSE |
3 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 5.5 | 7.4 | 1.6e-13 | 0.78 | 0.00 | 0.99 | TRUE |
4 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 8.9 | 5.9 | 3.5e-09 | 0.72 | 0.00 | 1.00 | FALSE |
5 | GTEx | Brain Cerebellum | ECM1 | 0.34 | 0.21 | lasso | 6 | 0.19 | 3.2e-06 | 4.4 | 5.2 | 1.6e-07 | 0.17 | 0.56 | 0.12 | TRUE |
6 | GTEx | Brain Hypothalamus | RP11-316M1.12 | 0.14 | 0.03 | lasso | 6 | 0.02 | 9.9e-02 | -5.1 | 5.2 | 2.5e-07 | 0.09 | 0.09 | 0.25 | TRUE |
7 | GTEx | Breast Mammary Tissue (Male) | RP11-54A4.2 | 0.07 | 0.01 | enet | 2 | 0.03 | 7.4e-02 | 6.2 | 6.2 | 4.4e-10 | 0.08 | 0.02 | 0.57 | TRUE |
8 | GTEx | Esophagus Gastroesophageal Junction | ARNT | 0.11 | 0.03 | enet | 18 | 0.02 | 8.8e-02 | -3.3 | -5.2 | 2.5e-07 | -0.14 | 0.23 | 0.05 | TRUE |
9 | GTEx | Spleen | RP11-54A4.2 | 0.29 | 0.10 | lasso | 9 | 0.04 | 3.8e-02 | -5.1 | 5.2 | 2.5e-07 | 0.04 | 0.06 | 0.80 | FALSE |
10 | GTEx | Testis | CTSK | 0.07 | 0.01 | enet | 19 | 0.01 | 1.2e-01 | -3.3 | -5.4 | 8.4e-08 | -0.03 | 0.05 | 0.87 | FALSE |
11 | GTEx | Thyroid | ANP32E | 0.08 | 0.00 | enet | 15 | 0.01 | 8.6e-02 | -4.2 | 7.6 | 2.5e-14 | 0.37 | 0.04 | 0.17 | TRUE |
12 | METSIM | Adipose | BNIPL | 0.05 | 0.01 | blup | 313 | 0.03 | 9.7e-05 | 3.5 | 5.2 | 2.0e-07 | 0.01 | 0.58 | 0.17 | FALSE |
13 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RPRD2 | 0.14 | 0.13 | enet | 8 | 0.13 | 1.5e-04 | 4.9 | 5.5 | 4.5e-08 | 0.04 | 0.00 | 0.63 | TRUE |