Best TWAS P=2.98e-10 · Best GWAS P=5.24e-11 conditioned to 0.577
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HR | 0.06 | 0.01 | bslmm | 452 | 0.03 | 3.8e-05 | -2.6 | 5.3 | 1.2e-07 | -0.01 | 0.03 | 0.90 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -6.6 | 6.3 | 3.0e-10 | -0.86 | 0.00 | 1.00 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | FAM160B2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 4.0e-08 | -5.5 | 5.1 | 3.0e-07 | -0.06 | 0.01 | 0.99 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | NUDT18 | 0.10 | 0.04 | enet | 6 | 0.03 | 4.7e-03 | 5.0 | 5.4 | 7.0e-08 | -0.05 | 0.02 | 0.89 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | AC091171.1 | 0.15 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -5.5 | 5.5 | 5.0e-08 | -0.05 | 0.01 | 0.98 | FALSE |
6 | GTEx | Esophagus Mucosa | FAM160B2 | 0.15 | 0.05 | enet | 19 | 0.09 | 1.7e-06 | 5.3 | 5.3 | 1.0e-07 | 0.01 | 0.01 | 0.98 | FALSE |
7 | GTEx | Esophagus Mucosa | AC091171.1 | 0.14 | 0.07 | lasso | 4 | 0.05 | 2.2e-04 | 5.4 | 5.6 | 2.5e-08 | -0.06 | 0.01 | 0.98 | TRUE |
8 | GTEx | Thyroid | NUDT18 | 0.17 | 0.19 | lasso | 3 | 0.19 | 3.2e-14 | -5.2 | -5.2 | 1.8e-07 | 0.05 | 0.03 | 0.97 | FALSE |
9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NUDT18 | 0.09 | 0.03 | blup | 45 | 0.08 | 1.3e-04 | -5.3 | -5.3 | 1.1e-07 | 0.06 | 0.02 | 0.96 | FALSE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160B2 | 0.06 | 0.07 | lasso | 1 | 0.06 | 2.3e-04 | 5.3 | 5.3 | 1.2e-07 | -0.05 | 0.01 | 0.89 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A37 | 0.11 | 0.09 | lasso | 5 | 0.09 | 7.8e-10 | -5.1 | -5.6 | 2.2e-08 | 0.59 | 0.87 | 0.13 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -4.9 | 5.9 | 3.2e-09 | -0.59 | 0.01 | 0.79 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NUDT18 | 0.10 | 0.16 | lasso | 2 | 0.16 | 2.3e-09 | -5.3 | -5.3 | 1.1e-07 | 0.05 | 0.02 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUDT18 | 0.11 | 0.22 | lasso | 6 | 0.22 | 3.6e-24 | -5.5 | -5.4 | 7.3e-08 | 0.06 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FAM160B2 | 0.02 | 0.02 | blup | 53 | 0.02 | 1.8e-03 | -5.5 | 5.2 | 2.2e-07 | -0.05 | 0.02 | 0.92 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NUDT18 | 0.06 | 0.08 | lasso | 3 | 0.07 | 1.6e-08 | -5.3 | -5.2 | 2.2e-07 | 0.05 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHMP7 | 0.03 | 0.03 | blup | 89 | 0.01 | 3.8e-02 | 3.8 | -5.3 | 1.4e-07 | 0.10 | 0.02 | 0.23 | TRUE |
18 | The Cancer Genome Atlas | Rectum Adenocarcinoma | NUDT18 | 0.24 | 0.08 | lasso | 6 | 0.06 | 1.7e-02 | -5.4 | -5.1 | 3.0e-07 | 0.05 | 0.01 | 0.69 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM160B2 | 0.08 | 0.06 | lasso | 4 | 0.05 | 1.4e-05 | -5.5 | 5.2 | 2.2e-07 | -0.05 | 0.01 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT18 | 0.15 | 0.17 | lasso | 4 | 0.12 | 2.3e-04 | -5.4 | -5.5 | 3.3e-08 | 0.05 | 0.01 | 0.96 | FALSE |