[Hub]/) : Traits : Whole body fat-free mass : ← →

chr5:136,723,696-141,087,689

Best TWAS P=7.04e-15 · Best GWAS P=1.95e-19 conditioned to 1.78e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBE2D2	0.05	0.02	enet	6	0.03	4.4e-04	5.2	7.8	7.0e-15	0.76	0.01	0.97	TRUE
19	ROSMAP	Brain Pre-frontal Cortex	WNT8A	0.05	0.01	blup	300	0.03	1.0e-04	-2.1	-7.0	3.7e-12	0.05	0.09	0.86	TRUE
15	GTEx	Nerve Tibial	HARS	0.07	0.01	enet	16	0.04	1.1e-03	-4.8	6.0	2.1e-09	-0.03	0.06	0.88	TRUE
11	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	4.4	7.4	1.2e-13	0.77	0.03	0.84	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BRD8	0.12	0.07	lasso	4	0.05	1.2e-03	7.2	-6.9	4.7e-12	0.03	0.00	0.98	FALSE
23	YFS	Blood	CXXC5	0.01	0.00	bslmm	244	0.01	2.6e-03	9.0	-6.8	1.2e-11	-0.67	0.00	0.95	FALSE
12	GTEx	Esophagus Mucosa	TMEM173	0.10	0.03	enet	20	0.10	1.8e-07	9.0	-6.4	1.4e-10	-0.60	0.01	0.97	FALSE
18	GTEx	Vagina	PURA	0.52	0.05	enet	51	0.09	3.6e-03	5.5	-6.2	6.3e-10	-0.44	0.06	0.10	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	DNAJC18	0.26	0.09	lasso	2	0.12	9.7e-05	4.4	6.2	6.8e-10	0.49	0.15	0.39	FALSE
13	GTEx	Esophagus Muscularis	DNAJC18	0.22	0.10	lasso	6	0.13	3.2e-08	4.4	6.1	9.7e-10	0.40	0.56	0.10	FALSE
10	GTEx	Colon Transverse	DNAJC18	0.37	-0.01	lasso	5	0.01	1.1e-01	4.4	6.0	1.6e-09	0.39	0.06	0.06	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	KDM3B	0.07	0.01	blup	307	0.03	1.0e-04	5.5	-6.0	1.9e-09	-0.03	0.11	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DNAJC18	0.09	0.10	bslmm	260	0.10	2.5e-12	3.8	5.8	4.9e-09	0.41	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM53C	0.05	0.02	bslmm	291	0.03	4.1e-04	7.7	5.8	6.5e-09	-0.06	0.03	0.92	FALSE
16	GTEx	Skin Sun Exposed Lower leg	WDR55	0.04	0.01	enet	10	0.01	2.8e-02	-4.8	-5.8	7.7e-09	-0.02	0.06	0.86	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM173	0.02	0.03	blup	7	0.03	4.6e-07	4.9	-5.8	8.8e-09	-0.40	0.07	0.92	FALSE
14	GTEx	Esophagus Muscularis	TMEM173	0.24	0.00	lasso	6	0.06	1.5e-04	4.4	-5.7	1.2e-08	-0.40	0.77	0.06	FALSE
17	GTEx	Spleen	DNAJC18	0.30	0.13	lasso	5	0.20	6.5e-06	4.4	5.7	1.6e-08	0.47	0.15	0.49	FALSE
9	GTEx	Colon Transverse	TMCO6	0.15	0.06	enet	16	0.05	1.4e-03	4.7	-5.6	2.1e-08	-0.07	0.13	0.62	FALSE
24	YFS	Blood	TMCO6	0.01	0.00	blup	329	0.01	4.1e-03	-4.7	-5.5	4.1e-08	-0.03	0.07	0.91	FALSE
5	GTEx	Artery Tibial	PROB1	0.06	0.09	enet	10	0.08	5.9e-07	4.4	-5.5	4.2e-08	-0.39	0.92	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PCDHA2	0.04	0.03	blup	478	0.03	5.0e-05	-4.9	-5.5	4.8e-08	-0.05	0.06	0.94	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	FAM53C	0.13	0.06	lasso	4	0.05	4.6e-07	5.5	5.4	7.3e-08	0.05	1.00	0.00	FALSE
4	GTEx	Artery Tibial	TMEM173	0.24	0.14	lasso	3	0.13	1.2e-10	4.9	-5.3	1.1e-07	-0.36	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	CD14	0.09	0.05	lasso	4	0.06	2.7e-05	-3.7	-5.2	1.7e-07	-0.05	0.24	0.67	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIF20A	0.01	0.00	blup	27	0.01	1.4e-02	-2.4	5.2	1.7e-07	-0.01	0.01	0.39	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR55	0.07	0.06	blup	44	0.06	1.7e-06	-4.9	-5.2	1.7e-07	-0.05	0.02	0.97	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	PROB1	0.12	0.09	lasso	6	0.10	7.7e-13	4.4	-5.2	2.0e-07	-0.39	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR55	0.10	0.03	enet	8	0.04	3.3e-09	-4.9	-5.2	2.5e-07	0.01	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	WDR55	0.09	0.08	enet	12	0.12	1.5e-07	-4.9	-5.2	2.5e-07	-0.05	0.02	0.97	FALSE
7	GTEx	Cells Transformed fibroblasts	ZMAT2	0.04	0.02	lasso	4	0.02	2.4e-02	-4.8	-5.1	3.1e-07	0.00	0.07	0.83	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD14	0.01	0.01	blup	38	0.00	3.5e-02	4.5	-5.1	3.1e-07	-0.07	0.01	0.37	FALSE