[Hub]/) : Traits : Whole body fat-free mass : ← →

chr5:129,797,129-132,839,137

Best TWAS P=7.49e-27 · Best GWAS P=1.46e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	HINT1	0.10	0.07	enet	16	0.06	8.8e-06	-8.79	-10.7	7.5e-27	-0.40	0.05	0.93	TRUE
57	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	9.30	-9.4	7.6e-21	-0.92	0.02	0.98	TRUE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-7.50	-7.9	2.9e-15	-0.76	0.06	0.94	TRUE
32	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-6.89	7.5	6.5e-14	0.61	0.36	0.47	TRUE
23	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	9.21	-6.8	1.5e-11	-0.71	0.10	0.86	TRUE
2	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-6.03	-6.4	2.0e-10	-0.67	1.00	0.00	TRUE
51	GTEx	Pancreas	P4HA2-AS1	0.16	0.16	lasso	5	0.16	3.2e-07	-5.04	5.9	2.9e-09	0.52	0.58	0.32	TRUE
13	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-8.33	-10.6	2.0e-26	-0.58	0.06	0.90	FALSE
87	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	9.21	-10.0	1.2e-23	-0.88	0.01	0.99	FALSE
9	GTEx	Artery Aorta	HINT1	0.07	0.07	enet	8	0.06	4.7e-04	-8.46	-9.7	2.3e-22	-0.37	0.09	0.54	FALSE
12	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	9.28	9.7	2.3e-22	0.96	0.01	0.99	FALSE
62	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	9.30	9.5	1.8e-21	0.98	0.01	0.99	FALSE
59	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	9.21	9.4	6.3e-21	0.88	0.02	0.94	FALSE
8	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	9.30	9.3	1.3e-20	1.00	0.01	0.99	FALSE
34	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	9.21	-9.3	1.7e-20	-0.95	0.01	0.99	FALSE
33	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	9.30	9.3	2.1e-20	0.95	0.01	0.99	FALSE
11	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	9.10	9.2	2.7e-20	0.96	0.02	0.96	FALSE
79	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	9.21	-9.2	3.3e-20	-0.90	0.02	0.98	FALSE
73	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	9.21	-9.2	3.4e-20	-0.90	0.01	0.99	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-8.73	-9.1	6.3e-20	-0.72	0.37	0.57	FALSE
27	GTEx	Cells Transformed fibroblasts	HINT1	0.10	0.06	lasso	2	0.05	2.1e-04	-8.33	-9.1	8.7e-20	-0.37	0.06	0.92	FALSE
16	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	9.26	9.1	9.6e-20	0.93	0.01	0.99	FALSE
47	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	8.19	9.1	1.0e-19	0.88	0.03	0.97	FALSE
58	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	8.98	-9.1	1.1e-19	-0.90	0.04	0.96	FALSE
102	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-6.28	9.0	2.0e-19	0.40	0.01	0.90	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	9.26	9.0	2.3e-19	0.95	0.00	1.00	FALSE
76	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	9.26	8.9	4.5e-19	0.86	0.01	0.99	FALSE
41	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	9.21	-8.9	6.4e-19	-0.93	0.02	0.98	FALSE
36	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	9.30	8.9	6.7e-19	0.97	0.02	0.98	FALSE
74	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	8.99	-8.8	1.2e-18	-0.79	0.06	0.93	FALSE
10	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-7.53	8.7	4.8e-18	0.74	0.42	0.37	FALSE
64	GTEx	Testis	RAPGEF6	0.50	0.35	lasso	4	0.32	6.5e-15	-8.23	-8.7	4.8e-18	-0.33	0.51	0.49	FALSE
20	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-7.75	8.6	8.8e-18	0.84	0.07	0.86	FALSE
28	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-7.47	-8.5	2.5e-17	-0.84	0.23	0.77	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-7.56	-8.4	3.6e-17	-0.82	0.14	0.86	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	9.21	-8.4	3.9e-17	-0.83	0.04	0.93	FALSE
72	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-7.47	-8.4	4.1e-17	-0.72	0.11	0.81	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-4.73	8.4	5.8e-17	0.54	0.80	0.11	FALSE
109	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-7.49	-8.4	6.3e-17	-0.79	0.11	0.89	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	9.26	8.3	6.7e-17	0.85	0.00	0.99	FALSE
70	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	9.28	8.3	6.8e-17	0.89	0.01	0.99	FALSE
44	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-7.49	8.3	8.2e-17	0.85	0.02	0.98	FALSE
66	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	9.28	8.3	8.2e-17	0.95	0.01	0.99	FALSE
39	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-7.53	8.2	1.8e-16	0.70	0.97	0.03	FALSE
67	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	8.19	-8.2	2.3e-16	-0.88	0.05	0.89	FALSE
77	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	8.22	-8.1	3.9e-16	-0.83	0.79	0.15	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	9.21	-8.1	4.8e-16	-0.78	0.04	0.91	FALSE
63	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-7.75	8.1	5.9e-16	0.71	0.24	0.15	FALSE
38	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-7.49	8.0	9.0e-16	0.77	0.54	0.46	FALSE
103	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-7.47	-8.0	9.1e-16	-0.69	0.06	0.71	FALSE
31	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-7.53	8.0	1.1e-15	0.73	0.92	0.04	FALSE
15	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	8.98	-8.0	1.9e-15	-0.83	0.03	0.97	FALSE
43	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-6.21	7.9	2.6e-15	0.82	0.09	0.64	FALSE
92	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-6.65	-7.9	2.7e-15	-0.68	1.00	0.00	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	HINT1	0.07	0.04	lasso	2	0.01	1.8e-02	-7.90	-7.9	2.7e-15	-0.35	0.00	0.98	FALSE
106	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-6.64	-7.9	2.9e-15	-0.74	0.04	0.96	FALSE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-7.47	-7.9	3.8e-15	-0.76	0.03	0.91	FALSE
17	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-7.42	7.8	4.9e-15	0.73	0.98	0.02	FALSE
61	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-6.65	7.8	5.7e-15	0.68	0.99	0.01	FALSE
60	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-6.96	-7.8	7.1e-15	-0.71	0.07	0.59	FALSE
30	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	9.21	-7.7	1.1e-14	-0.81	0.06	0.89	FALSE
42	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-7.42	7.7	1.1e-14	0.77	1.00	0.00	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	6.29	7.7	1.3e-14	0.80	0.06	0.09	FALSE
46	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-7.48	7.7	1.7e-14	0.71	0.99	0.01	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-7.56	7.6	2.3e-14	0.71	0.83	0.11	FALSE
35	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-7.75	7.6	2.9e-14	0.71	0.94	0.04	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-7.56	-7.6	4.1e-14	-0.71	0.35	0.26	FALSE
7	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-7.48	7.5	7.4e-14	0.71	0.65	0.15	FALSE
49	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	-5.61	7.5	7.6e-14	0.62	0.06	0.27	FALSE
5	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-7.47	7.5	7.7e-14	0.71	0.99	0.01	FALSE
116	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-7.47	-7.5	8.0e-14	-0.72	0.02	0.71	FALSE
6	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-7.42	7.4	1.2e-13	0.71	0.40	0.34	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	HINT1	0.06	0.03	enet	5	0.03	5.2e-04	-6.18	-7.4	1.2e-13	-0.27	0.08	0.41	FALSE
65	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-7.42	7.4	1.3e-13	0.71	0.86	0.05	FALSE
4	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	8.98	-7.4	1.6e-13	-0.83	0.04	0.94	FALSE
80	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	4.48	-7.3	2.0e-13	-0.67	0.15	0.82	FALSE
29	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-7.73	7.3	3.4e-13	0.70	0.24	0.16	FALSE
52	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-6.58	7.3	3.4e-13	0.66	0.66	0.09	FALSE
18	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-7.42	7.2	5.4e-13	0.70	0.92	0.07	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-5.61	-7.2	8.2e-13	-0.67	0.14	0.74	FALSE
108	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-5.61	-7.0	1.8e-12	-0.74	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	9.21	-7.0	2.5e-12	-0.82	0.01	0.98	FALSE
37	GTEx	Esophagus Muscularis	AC034220.3	0.12	0.08	enet	20	0.07	3.8e-05	-7.53	7.0	3.2e-12	0.63	0.82	0.08	FALSE
53	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-7.53	6.9	4.1e-12	0.69	0.89	0.10	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-6.89	-6.9	5.4e-12	-0.58	0.12	0.52	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-6.17	-6.9	6.5e-12	-0.73	1.00	0.00	FALSE
50	GTEx	Pancreas	P4HA2	0.22	0.21	lasso	13	0.20	5.3e-09	-5.04	6.8	1.5e-11	0.60	0.73	0.25	FALSE
99	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-6.64	-6.7	2.0e-11	-0.62	0.12	0.15	FALSE
24	GTEx	Breast Mammary Tissue (Female)	SLC22A5	0.04	-0.01	lasso	3	0.01	1.3e-01	-4.21	-6.6	3.2e-11	-0.55	0.05	0.16	FALSE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-4.94	-6.4	1.2e-10	-0.45	0.96	0.00	FALSE
84	YFS	Blood	CDC42SE2	0.14	0.05	lasso	9	0.07	3.1e-22	-8.34	6.4	1.6e-10	0.20	0.04	0.96	FALSE
75	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-4.55	6.2	4.2e-10	0.49	0.35	0.39	FALSE
26	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-6.21	-6.2	5.4e-10	-0.67	0.80	0.06	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-6.17	-6.2	5.6e-10	-0.69	0.99	0.01	FALSE
111	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-6.33	-6.2	7.1e-10	-0.51	0.09	0.13	FALSE
19	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-7.75	6.0	1.5e-09	0.64	0.63	0.23	FALSE
86	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-7.46	-6.0	1.5e-09	-0.71	1.00	0.00	FALSE
40	GTEx	Liver	AC034220.3	0.30	0.16	lasso	6	0.16	3.9e-05	-7.49	6.0	2.2e-09	0.56	0.59	0.05	FALSE
69	GTEx	Thyroid	AC034220.3	0.29	0.29	lasso	5	0.31	4.8e-24	-6.61	5.9	2.8e-09	0.46	1.00	0.00	FALSE
85	YFS	Blood	LYRM7	0.03	0.01	bslmm	243	0.01	7.0e-05	-6.49	-5.9	4.1e-09	-0.12	0.45	0.15	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-2.55	-5.8	8.8e-09	-0.65	0.15	0.09	FALSE
14	GTEx	Artery Tibial	LYRM7	0.10	0.03	lasso	3	0.04	3.1e-04	-6.38	5.7	1.2e-08	0.23	0.51	0.09	FALSE
105	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-1.53	-5.7	1.4e-08	-0.64	0.05	0.76	FALSE
45	GTEx	Nerve Tibial	LYRM7	0.05	0.02	enet	11	0.04	7.0e-04	-5.89	5.6	1.7e-08	0.25	0.36	0.35	FALSE
71	GTEx	Uterus	P4HA2	0.58	-0.01	lasso	5	0.02	1.6e-01	-3.61	5.6	2.4e-08	0.41	0.05	0.37	FALSE
78	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	4.48	-5.5	2.9e-08	-0.50	0.93	0.02	FALSE
98	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC42SE2	0.10	0.07	lasso	1	0.06	2.6e-04	-5.55	5.5	2.9e-08	0.16	0.04	0.73	FALSE
88	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDLIM4	0.05	0.01	enet	4	0.02	1.2e-02	-5.61	-5.5	3.1e-08	-0.53	0.08	0.07	FALSE
48	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-4.29	5.4	6.5e-08	0.58	0.29	0.34	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	AC034220.3	0.04	0.02	blup	415	0.04	1.3e-05	-3.32	5.3	8.7e-08	0.62	0.94	0.04	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	SLC22A5	0.15	0.00	enet	24	0.05	1.4e-02	-7.59	5.3	9.0e-08	0.45	0.10	0.19	FALSE
68	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-0.24	-5.3	1.3e-07	-0.68	0.06	0.93	FALSE
101	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-6.58	-5.3	1.3e-07	-0.61	0.04	0.36	FALSE
104	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C5orf56	0.07	0.01	blup	98	0.03	3.2e-04	-4.71	5.2	1.6e-07	0.36	0.25	0.08	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	P4HA2	0.04	0.01	blup	47	0.03	4.4e-04	-4.22	5.2	1.7e-07	0.50	0.05	0.18	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC553103	0.05	0.02	bslmm	433	0.03	3.2e-04	-6.51	5.2	1.8e-07	0.42	0.81	0.01	FALSE