Best TWAS P=2.07e-12 · Best GWAS P=9.34e-15 conditioned to 1.07e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CRELD1 | 0.46 | 0.16 | enet | 51 | 0.27 | 2.2e-22 | -6.2 | -6.5 | 6.2e-11 | 0.07 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | AC034193.5 | 0.08 | 0.07 | lasso | 4 | 0.07 | 2.2e-06 | 5.1 | 5.2 | 1.7e-07 | 0.00 | 0.70 | 0.26 | FALSE |
3 | GTEx | Adipose Visceral Omentum | CRELD1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 4.1e-06 | -6.2 | -5.9 | 3.4e-09 | -0.02 | 0.01 | 0.96 | FALSE |
4 | GTEx | Artery Aorta | CRELD1 | 0.30 | 0.07 | lasso | 7 | 0.12 | 2.4e-07 | -6.2 | -5.9 | 3.1e-09 | 0.03 | 0.01 | 0.99 | FALSE |
5 | GTEx | Artery Aorta | AC034193.5 | 0.12 | 0.01 | lasso | 3 | 0.00 | 1.6e-01 | 5.2 | 5.3 | 1.4e-07 | -0.01 | 0.19 | 0.32 | FALSE |
6 | GTEx | Artery Aorta | RP11-1020A11.1 | 0.15 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -6.2 | -6.9 | 4.2e-12 | -0.03 | 0.02 | 0.62 | FALSE |
7 | GTEx | Artery Tibial | CRELD1 | 0.43 | 0.15 | enet | 41 | 0.21 | 1.1e-16 | -6.2 | -5.7 | 9.6e-09 | 0.08 | 0.01 | 0.99 | FALSE |
8 | GTEx | Artery Tibial | AC034193.5 | 0.10 | 0.08 | lasso | 1 | 0.06 | 1.2e-05 | 5.2 | 5.2 | 2.3e-07 | -0.02 | 0.68 | 0.29 | FALSE |
9 | GTEx | Breast Mammary Tissue | CRELD1 | 0.25 | 0.19 | lasso | 6 | 0.18 | 2.2e-09 | -6.2 | -6.0 | 2.6e-09 | -0.02 | 0.01 | 0.99 | FALSE |
10 | GTEx | Cells EBV-transformed lymphocytes | CYCSP10 | 0.19 | 0.01 | lasso | 5 | -0.01 | 6.6e-01 | 5.2 | -5.3 | 1.5e-07 | 0.01 | 0.07 | 0.14 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | CRELD1 | 0.39 | 0.19 | enet | 39 | 0.28 | 4.5e-21 | -6.2 | -7.0 | 3.4e-12 | 0.04 | 0.01 | 0.99 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | AC034193.5 | 0.12 | 0.05 | lasso | 3 | 0.05 | 1.2e-04 | 5.2 | 5.2 | 2.0e-07 | -0.03 | 0.68 | 0.28 | FALSE |
13 | GTEx | Cells Transformed fibroblasts | HRH1 | 0.20 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | 7.7 | -6.4 | 1.3e-10 | -0.77 | 0.00 | 0.95 | TRUE |
14 | GTEx | Cells Transformed fibroblasts | RP11-1020A11.1 | 0.20 | 0.10 | enet | 67 | 0.09 | 1.9e-07 | -6.2 | -6.2 | 4.0e-10 | 0.01 | 0.01 | 0.99 | FALSE |
15 | GTEx | Esophagus Mucosa | VHL | 0.14 | 0.00 | lasso | 1 | 0.00 | 2.9e-01 | 5.2 | -5.2 | 2.2e-07 | 0.02 | 0.08 | 0.33 | FALSE |
16 | GTEx | Esophagus Muscularis | CRELD1 | 0.21 | 0.10 | lasso | 1 | 0.08 | 1.7e-05 | -6.2 | -6.2 | 7.0e-10 | -0.02 | 0.01 | 0.98 | FALSE |
17 | GTEx | Skin Not Sun Exposed Suprapubic | AC034193.5 | 0.15 | 0.09 | enet | 11 | 0.08 | 3.3e-05 | 5.2 | 5.4 | 6.5e-08 | 0.02 | 0.60 | 0.24 | FALSE |
18 | GTEx | Skin Sun Exposed Lower leg | CRELD1 | 0.29 | 0.15 | enet | 36 | 0.23 | 8.2e-19 | -6.2 | -5.8 | 5.0e-09 | 0.04 | 0.01 | 0.99 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | AC034193.5 | 0.09 | 0.11 | lasso | 2 | 0.09 | 8.7e-08 | 5.2 | 5.2 | 2.6e-07 | -0.02 | 0.72 | 0.28 | FALSE |
20 | GTEx | Testis | CRELD1 | 0.22 | 0.22 | lasso | 8 | 0.26 | 1.1e-11 | 5.2 | -7.0 | 2.1e-12 | 0.00 | 0.15 | 0.85 | TRUE |
21 | GTEx | Thyroid | CIDECP | 0.11 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 5.1 | 5.2 | 2.5e-07 | 0.00 | 0.72 | 0.28 | FALSE |
22 | GTEx | Thyroid | BRK1 | 0.08 | 0.05 | lasso | 3 | 0.04 | 6.8e-04 | 5.2 | -5.4 | 8.5e-08 | 0.01 | 0.39 | 0.60 | FALSE |
23 | METSIM | Adipose | BRK1 | 0.04 | 0.02 | bslmm | 559 | 0.01 | 8.9e-03 | 4.7 | -5.8 | 8.7e-09 | -0.04 | 0.16 | 0.67 | FALSE |
24 | METSIM | Adipose | CRELD1 | 0.23 | 0.16 | bslmm | 480 | 0.21 | 3.1e-30 | -6.2 | -5.3 | 1.1e-07 | 0.07 | 0.01 | 0.99 | FALSE |
25 | ROSMAP | Brain Pre-frontal Cortex | AC022007.5 | 0.05 | 0.02 | blup | 515 | 0.03 | 2.8e-04 | 6.0 | 5.8 | 7.0e-09 | 0.02 | 0.04 | 0.96 | FALSE |
26 | YFS | Blood | FANCD2 | 0.04 | 0.04 | lasso | 1 | 0.04 | 7.7e-13 | 6.0 | -6.0 | 2.5e-09 | -0.06 | 0.03 | 0.97 | FALSE |
27 | YFS | Blood | PRRT3 | 0.08 | 0.02 | bslmm | 469 | 0.04 | 7.4e-13 | -6.2 | -5.2 | 2.0e-07 | -0.03 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf10 | 0.01 | 0.01 | blup | 49 | 0.01 | 9.4e-03 | 4.7 | -5.2 | 1.9e-07 | 0.02 | 0.10 | 0.12 | FALSE |
29 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C3orf10 | 0.03 | 0.05 | lasso | 5 | 0.04 | 3.4e-05 | 5.2 | -5.3 | 1.4e-07 | -0.01 | 0.24 | 0.72 | FALSE |
30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CIDECP | 0.04 | 0.02 | blup | 33 | 0.03 | 3.8e-04 | 5.2 | 5.8 | 9.0e-09 | 0.00 | 0.05 | 0.90 | FALSE |
31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC401052 | 0.06 | 0.07 | enet | 6 | 0.06 | 3.5e-07 | 6.1 | -6.0 | 1.9e-09 | -0.05 | 0.01 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CRELD1 | 0.12 | 0.01 | enet | 22 | 0.04 | 1.4e-03 | -1.7 | -5.4 | 8.5e-08 | 0.04 | 0.02 | 0.19 | FALSE |