Best TWAS P=1.49e-16 · Best GWAS P=1.81e-13 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DTX2P1-UPK3BP1-PMS2P11 | 0.18 | 0.09 | enet | 21 | 0.12 | 6.1e-15 | 6.61 | 8.3 | 1.5e-16 | 0.82 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RP11-467H10.2 | 0.12 | 0.00 | lasso | 6 | 0.01 | 2.1e-02 | 2.96 | 6.0 | 2.4e-09 | 0.05 | 0.13 | 0.04 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | TMEM60 | 0.20 | 0.13 | lasso | 8 | 0.11 | 2.3e-06 | -5.01 | -5.3 | 1.0e-07 | -0.01 | 0.27 | 0.73 | TRUE |
| 4 | GTEx | Artery Aorta | GSAP | 0.19 | 0.07 | lasso | 2 | 0.04 | 2.8e-03 | 5.80 | -6.2 | 5.3e-10 | -0.03 | 0.26 | 0.04 | TRUE |
| 5 | GTEx | Brain Cerebellum | GSAP | 0.38 | 0.30 | lasso | 4 | 0.31 | 6.4e-10 | 5.67 | -5.9 | 3.9e-09 | -0.01 | 0.91 | 0.03 | TRUE |
| 6 | GTEx | Brain Frontal Cortex BA9 | GSAP | 0.38 | 0.22 | lasso | 6 | 0.21 | 3.0e-06 | 5.77 | -6.8 | 9.9e-12 | -0.13 | 0.14 | 0.20 | FALSE |
| 7 | GTEx | Esophagus Muscularis | RSBN1L | 0.07 | 0.03 | lasso | 3 | 0.01 | 4.3e-02 | -5.09 | -5.1 | 3.0e-07 | -0.01 | 0.15 | 0.66 | FALSE |
| 8 | GTEx | Heart Left Ventricle | GSAP | 0.21 | 0.02 | lasso | 5 | 0.03 | 9.3e-03 | 4.72 | -5.7 | 1.2e-08 | -0.01 | 0.12 | 0.04 | FALSE |
| 9 | GTEx | Muscle Skeletal | GSAP | 0.20 | 0.12 | lasso | 2 | 0.12 | 1.8e-11 | 5.77 | -5.9 | 4.0e-09 | -0.04 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Ovary | TMEM60 | 0.23 | 0.19 | enet | 7 | 0.13 | 5.2e-04 | -5.20 | -5.3 | 1.1e-07 | 0.01 | 0.09 | 0.55 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | DTX2P1 | 0.16 | 0.03 | enet | 22 | 0.05 | 4.8e-05 | 7.36 | 5.7 | 1.3e-08 | 0.70 | 0.00 | 0.99 | FALSE |
| 12 | GTEx | Thyroid | TMEM60 | 0.06 | 0.04 | lasso | 8 | 0.04 | 8.2e-04 | -5.03 | -5.1 | 2.8e-07 | -0.01 | 0.22 | 0.74 | FALSE |
| 13 | GTEx | Thyroid | GSAP | 0.19 | 0.08 | lasso | 3 | 0.07 | 3.3e-06 | 5.80 | -5.9 | 3.7e-09 | -0.02 | 0.87 | 0.03 | FALSE |
| 14 | GTEx | Thyroid | AC007000.12 | 0.13 | 0.08 | enet | 24 | 0.07 | 2.6e-06 | -4.71 | -5.8 | 7.4e-09 | -0.18 | 0.66 | 0.02 | FALSE |
| 15 | GTEx | Whole Blood | TMEM60 | 0.05 | 0.04 | enet | 7 | 0.03 | 5.4e-04 | -4.74 | -5.2 | 2.7e-07 | -0.02 | 0.32 | 0.67 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | GSAP | 0.36 | 0.27 | lasso | 7 | 0.28 | 1.5e-35 | 5.77 | -5.7 | 1.4e-08 | -0.02 | 0.97 | 0.03 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | RSBN1L | 0.09 | 0.07 | enet | 42 | 0.08 | 9.9e-11 | -4.03 | -5.3 | 1.2e-07 | -0.03 | 0.61 | 0.38 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM60 | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.3e-05 | 5.29 | -5.3 | 1.2e-07 | 0.00 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PMS2L11 | 0.05 | 0.02 | enet | 3 | 0.06 | 2.5e-07 | -0.20 | 5.3 | 9.1e-08 | 0.71 | 0.01 | 0.97 | TRUE |
| 20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PMS2L11 | 0.05 | 0.01 | blup | 6 | 0.03 | 1.1e-02 | -0.61 | 5.1 | 2.8e-07 | 0.81 | 0.00 | 0.67 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PION | 0.08 | 0.05 | lasso | 3 | 0.05 | 8.5e-07 | 5.80 | -5.8 | 6.2e-09 | -0.06 | 0.00 | 1.00 | TRUE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PMS2L11 | 0.02 | 0.01 | blup | 6 | 0.02 | 9.7e-04 | -0.61 | 5.1 | 2.9e-07 | 0.76 | 0.00 | 0.70 | TRUE |
| 23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM60 | 0.02 | 0.03 | blup | 29 | 0.02 | 6.8e-03 | 5.29 | -5.2 | 1.6e-07 | -0.01 | 0.00 | 0.91 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PION | 0.13 | 0.07 | enet | 9 | 0.08 | 3.4e-09 | 5.80 | -5.6 | 2.0e-08 | -0.03 | 0.00 | 1.00 | TRUE |