[Hub]/) : Traits : Whole body water mass :

chr3:9,283,299-11,999,795

Best TWAS P=7.82e-13 · Best GWAS P=1.48e-14 conditioned to 1.97e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous CRELD1 0.46 0.16 enet 51 0.27 2.2e-22 -6.4 -6.6 4.2e-11 0.07 0.00 1.00 FALSE
2 GTEx Adipose Subcutaneous AC034193.5 0.08 0.07 lasso 4 0.07 2.2e-06 5.1 5.3 1.4e-07 0.00 0.72 0.24 FALSE
3 GTEx Adipose Visceral Omentum CRELD1 0.19 0.12 lasso 4 0.10 4.1e-06 -6.4 -6.1 1.1e-09 -0.02 0.00 0.98 FALSE
4 GTEx Artery Aorta CRELD1 0.30 0.07 lasso 7 0.12 2.4e-07 -6.4 -6.1 1.3e-09 0.03 0.00 1.00 FALSE
5 GTEx Artery Aorta AC034193.5 0.12 0.01 lasso 3 0.00 1.6e-01 5.3 5.3 1.1e-07 -0.01 0.20 0.28 FALSE
6 GTEx Artery Aorta RP11-1020A11.1 0.15 0.01 lasso 3 0.00 4.0e-01 -6.4 -7.1 1.4e-12 -0.03 0.02 0.69 FALSE
7 GTEx Artery Tibial CRELD1 0.43 0.15 enet 41 0.21 1.1e-16 -6.4 -5.8 5.8e-09 0.08 0.00 1.00 FALSE
8 GTEx Artery Tibial AC034193.5 0.10 0.08 lasso 1 0.06 1.2e-05 5.2 5.2 1.9e-07 -0.02 0.71 0.26 FALSE
9 GTEx Breast Mammary Tissue CRELD1 0.25 0.19 lasso 6 0.18 2.2e-09 -6.4 -6.1 7.9e-10 -0.02 0.00 1.00 FALSE
10 GTEx Cells EBV-transformed lymphocytes CYCSP10 0.19 0.01 lasso 5 -0.01 6.6e-01 5.2 -5.3 1.1e-07 0.01 0.07 0.13 FALSE
11 GTEx Cells Transformed fibroblasts CRELD1 0.39 0.19 enet 39 0.28 4.5e-21 -6.4 -7.1 1.7e-12 0.04 0.00 1.00 FALSE
12 GTEx Cells Transformed fibroblasts AC034193.5 0.12 0.05 lasso 3 0.05 1.2e-04 5.2 5.2 1.6e-07 -0.03 0.70 0.26 FALSE
13 GTEx Cells Transformed fibroblasts HRH1 0.20 0.00 lasso 3 0.01 1.1e-01 7.7 -6.5 1.0e-10 -0.77 0.00 0.94 TRUE
14 GTEx Cells Transformed fibroblasts RP11-1020A11.1 0.20 0.10 enet 67 0.09 1.9e-07 -6.4 -6.3 2.4e-10 0.01 0.00 1.00 FALSE
15 GTEx Esophagus Mucosa VHL 0.14 0.00 lasso 1 0.00 2.9e-01 5.2 -5.2 1.8e-07 0.02 0.08 0.37 FALSE
16 GTEx Esophagus Muscularis CRELD1 0.21 0.10 lasso 1 0.08 1.7e-05 -6.4 -6.4 1.9e-10 -0.02 0.00 0.99 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic AC034193.5 0.15 0.09 enet 11 0.08 3.3e-05 5.2 5.5 4.7e-08 0.02 0.62 0.22 FALSE
18 GTEx Skin Sun Exposed Lower leg CRELD1 0.29 0.15 enet 36 0.23 8.2e-19 -6.4 -5.9 3.1e-09 0.04 0.00 1.00 FALSE
19 GTEx Skin Sun Exposed Lower leg AC034193.5 0.09 0.11 lasso 2 0.09 8.7e-08 5.2 5.2 2.1e-07 -0.02 0.74 0.26 FALSE
20 GTEx Testis CRELD1 0.22 0.22 lasso 8 0.26 1.1e-11 5.2 -7.2 7.8e-13 0.00 0.14 0.86 TRUE
21 GTEx Thyroid CIDECP 0.11 0.12 lasso 2 0.11 1.1e-08 5.2 5.2 1.9e-07 0.00 0.75 0.25 FALSE
22 GTEx Thyroid BRK1 0.08 0.05 lasso 3 0.04 6.8e-04 5.2 -5.4 5.7e-08 0.01 0.43 0.55 FALSE
23 METSIM Adipose BRK1 0.04 0.02 bslmm 559 0.01 8.9e-03 4.9 -5.9 4.1e-09 -0.04 0.17 0.64 FALSE
24 METSIM Adipose CRELD1 0.23 0.16 bslmm 480 0.21 3.1e-30 -6.4 -5.4 6.1e-08 0.07 0.00 1.00 FALSE
25 ROSMAP Brain Pre-frontal Cortex AC022007.5 0.05 0.02 blup 515 0.03 2.8e-04 6.0 5.8 5.6e-09 0.02 0.05 0.95 FALSE
26 YFS Blood FANCD2 0.04 0.04 lasso 1 0.04 7.7e-13 6.0 -6.0 2.0e-09 -0.06 0.04 0.96 FALSE
27 YFS Blood PRRT3 0.08 0.02 bslmm 469 0.04 7.4e-13 -6.4 -5.2 1.9e-07 -0.03 0.00 1.00 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma C3orf10 0.01 0.01 blup 49 0.01 9.4e-03 4.8 -5.3 1.4e-07 0.02 0.10 0.06 FALSE
29 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C3orf10 0.03 0.05 lasso 5 0.04 3.4e-05 5.3 -5.3 1.1e-07 -0.01 0.42 0.50 FALSE
30 The Cancer Genome Atlas Prostate Adenocarcinoma CIDECP 0.04 0.02 blup 33 0.03 3.8e-04 5.2 5.8 6.8e-09 0.00 0.05 0.90 FALSE
31 The Cancer Genome Atlas Prostate Adenocarcinoma LOC401052 0.06 0.07 enet 6 0.06 3.5e-07 6.1 -6.0 1.6e-09 -0.05 0.01 0.99 FALSE
32 The Cancer Genome Atlas Soft Tissue Sarcoma CRELD1 0.12 0.01 enet 22 0.04 1.4e-03 -1.7 -5.4 5.4e-08 0.04 0.02 0.19 FALSE
33 The Cancer Genome Atlas Thyroid Carcinoma C3orf10 0.05 0.02 blup 49 0.04 9.3e-05 4.9 -5.2 2.0e-07 -0.03 0.49 0.43 FALSE