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chr7:75,913,086-78,122,616

Best TWAS P=5.94e-17 · Best GWAS P=8.99e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DTX2P1-UPK3BP1-PMS2P11	0.18	0.09	enet	21	0.12	6.1e-15	6.73	8.4	5.9e-17	0.82	0.00	1.00	TRUE
6	GTEx	Artery Aorta	GSAP	0.19	0.07	lasso	2	0.04	2.8e-03	5.93	-6.4	2.0e-10	-0.03	0.26	0.04	TRUE
35	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	-4.52	-6.0	1.9e-09	-0.03	0.21	0.79	TRUE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	PION	0.08	0.05	lasso	3	0.05	8.5e-07	5.93	-5.9	3.5e-09	-0.06	0.00	1.00	TRUE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	PMS2L11	0.02	0.01	blup	6	0.02	9.7e-04	-0.84	5.3	1.2e-07	0.76	0.00	0.70	TRUE
8	GTEx	Artery Tibial	FAM185BP	0.11	0.02	enet	22	0.02	1.1e-02	5.65	5.2	2.5e-07	0.44	0.06	0.41	TRUE
11	GTEx	Brain Frontal Cortex BA9	GSAP	0.38	0.22	lasso	6	0.21	3.0e-06	5.94	-6.9	4.2e-12	-0.13	0.14	0.20	FALSE
20	GTEx	Muscle Skeletal	GSAP	0.20	0.12	lasso	2	0.12	1.8e-11	5.94	-6.0	1.5e-09	-0.04	0.96	0.04	FALSE
9	GTEx	Brain Cerebellum	GSAP	0.38	0.30	lasso	4	0.31	6.4e-10	5.84	-6.0	1.8e-09	-0.01	0.90	0.03	FALSE
30	GTEx	Thyroid	GSAP	0.19	0.08	lasso	3	0.07	3.3e-06	5.93	-6.0	1.8e-09	-0.02	0.87	0.04	FALSE
31	GTEx	Thyroid	AC007000.12	0.13	0.08	enet	24	0.07	2.6e-06	-4.82	-5.9	2.8e-09	-0.18	0.66	0.02	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	5.88	-5.9	4.2e-09	0.00	0.00	1.00	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	GSAP	0.36	0.27	lasso	7	0.28	1.5e-35	5.94	-5.8	5.6e-09	-0.02	0.96	0.04	FALSE
4	GTEx	Adipose Subcutaneous	RP11-467H10.2	0.12	0.00	lasso	6	0.01	2.1e-02	2.88	5.8	6.7e-09	0.05	0.13	0.04	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	5.88	-5.8	8.4e-09	-0.01	0.00	0.93	FALSE
5	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	-5.61	-5.8	8.9e-09	-0.01	0.15	0.85	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	PION	0.13	0.07	enet	9	0.08	3.4e-09	5.93	-5.7	1.2e-08	-0.03	0.00	1.00	FALSE
18	GTEx	Heart Left Ventricle	GSAP	0.21	0.02	lasso	5	0.03	9.3e-03	4.34	-5.7	1.4e-08	-0.01	0.12	0.04	FALSE
19	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-5.47	5.6	1.9e-08	0.02	0.05	0.95	FALSE
27	GTEx	Skin Sun Exposed Lower leg	DTX2P1	0.16	0.03	enet	22	0.05	4.8e-05	7.46	5.6	2.0e-08	0.70	0.00	0.99	FALSE
32	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	-5.29	-5.6	2.0e-08	-0.02	0.09	0.90	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-5.47	5.6	2.0e-08	0.01	0.02	0.82	FALSE
22	GTEx	Ovary	TMEM60	0.23	0.19	enet	7	0.13	5.2e-04	-5.35	-5.5	3.6e-08	0.01	0.10	0.52	FALSE
33	METSIM	Adipose	TMEM60	0.10	0.07	enet	9	0.08	2.1e-12	5.38	-5.5	4.1e-08	-0.02	0.04	0.96	FALSE
26	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-5.47	-5.5	4.6e-08	-0.01	0.06	0.94	FALSE
21	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-5.47	-5.5	4.8e-08	-0.02	0.11	0.89	FALSE
28	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-5.04	-5.4	6.2e-08	0.00	0.23	0.77	FALSE
13	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-5.47	-5.4	6.3e-08	-0.02	0.07	0.93	FALSE
7	GTEx	Artery Tibial	TMEM60	0.07	0.05	enet	12	0.02	6.6e-03	-5.47	-5.4	6.5e-08	0.00	0.06	0.87	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMS2L11	0.05	0.02	enet	3	0.06	2.5e-07	-0.20	5.4	7.3e-08	0.71	0.01	0.97	FALSE
16	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-5.47	-5.4	7.7e-08	-0.02	0.07	0.92	FALSE
29	GTEx	Thyroid	TMEM60	0.06	0.04	lasso	8	0.04	8.2e-04	-5.17	-5.4	8.4e-08	-0.01	0.15	0.82	FALSE
12	GTEx	Brain Putamen basal ganglia	GSAP	0.48	0.20	lasso	12	0.15	2.2e-04	5.93	-5.3	1.0e-07	-0.11	0.15	0.10	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-5.61	-5.3	1.1e-07	-0.03	0.14	0.86	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PMS2L11	0.05	0.01	blup	6	0.03	1.1e-02	-0.84	5.3	1.3e-07	0.81	0.00	0.67	FALSE
14	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-5.17	-5.3	1.4e-07	-0.03	0.13	0.53	FALSE
17	GTEx	Esophagus Muscularis	RSBN1L	0.07	0.03	lasso	3	0.01	4.3e-02	-5.24	-5.3	1.4e-07	-0.01	0.15	0.65	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	-5.29	-5.2	1.6e-07	-0.03	0.18	0.82	FALSE
10	GTEx	Brain Cerebellum	RSBN1L	0.14	0.12	lasso	2	0.13	1.3e-04	4.88	5.2	2.0e-07	0.05	0.15	0.70	FALSE
24	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	4.59	-5.2	2.3e-07	-0.02	0.14	0.64	FALSE
23	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	-4.52	-5.2	2.4e-07	0.00	0.10	0.69	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	GSAP	0.18	0.01	lasso	6	0.08	2.5e-05	-1.88	-5.2	2.5e-07	-0.05	0.22	0.06	FALSE
3	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	-5.29	-5.1	2.9e-07	-0.03	0.09	0.90	FALSE
44	The Cancer Genome Atlas	Soft Tissue Sarcoma	PHTF2	0.06	0.04	blup	72	0.04	2.0e-03	4.97	-5.1	3.0e-07	-0.01	0.05	0.61	FALSE