TWAS hub - MACF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0820	0.030	0.00015	0.076	NA	0.034	NA	0.064	6.9e-07	NA	0.00079	NA	5.3e-06
2	METSIM	Adipose	0.0514	0.024	0.00240	-0.002	0.008	0.002	0.009	-0.001	8.6e-01	0.019	0.15000	0.015	4.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
HDL Cholesterol	11.6	19.4	24.3	4.9	-3.8
Diabetes (mother)	11.0	14.1	17.3	-4.2	3.3
Ovarian Cancer	10.6	14.0	19.3	-2.9	4.4
Number of full brothers	10.6	13.3	16.7	-3.1	4.1
Type 2 Diabetes (T2D) (2018)	9.5	17.8	24.4	-4.9	3.4
Pain experienced in last month	9.2	15.3	16.9	4.1	-3.7
Alcohol intake versus 10 years previously	8.4	12.6	13.9	-3.7	3.4
Diabetes diagnosed by doctor	8.4	13.9	19.7	-4.4	2.8
Diabetes (self-reported)	7.1	10.9	14.9	-3.9	2.6
High blood pressure (mother)	6.6	9.3	9.6	-3.0	3.1
Neck or shoulder pain in last month	6.6	9.4	11.2	-3.3	2.7
Long-standing illness, disability or infirmity	6.6	10.0	12.0	-2.8	3.5
Headache pain in last month	5.9	10.1	15.8	-4.0	2.1
Triglycerides	5.8	9.4	14.5	-3.8	2.1
Ever highly irritable/argumentative for 2 days	5.8	7.0	13.9	3.7	-0.2
Financial difficulties in last 2 years	5.6	7.5	10.7	-2.1	3.3
Back pain experienced in last month	5.6	8.2	9.6	-2.6	3.1
Medication: Metformin	5.5	7.8	12.9	-3.6	1.6
Fasting Glucose	5.4	6.5	7.0	-2.6	2.4
Birth weight	5.3	11.6	13.0	3.2	-3.6
Leg fat-free mass (right)	5.0	26.6	39.3	-6.3	3.7
Schizophrenia vs Biploar Disorder	4.9	6.5	12.3	3.5	-0.9
Leg fat-free mass (left)	4.9	25.9	40.4	-6.4	3.4
Impedance of leg (left)	4.9	24.0	31.8	5.6	-4.0
Leg predicted mass (left)	4.9	25.8	40.4	-6.4	3.3
Pulse rate, automated reading	4.9	16.0	22.1	-4.7	3.1
Leg predicted mass (right)	4.9	26.0	38.3	-6.2	3.7
Prostate Cancer	4.7	6.6	12.0	-3.5	1.0
Heart disease (mother)	4.6	5.6	6.5	-2.2	2.5
Medication: Levothyroxine sodium	4.5	7.6	7.8	2.8	-2.7
Lung FEV1/FVC ratio	4.4	22.1	40.4	6.4	-1.9
Mother’s age at death	4.4	5.5	10.8	3.3	-0.4
Worrier / anxious feelings	4.3	8.2	10.6	3.2	-2.4
Osteoporosis (self-reported)	4.3	5.3	5.7	2.2	-2.4
Impedance of leg (right)	4.2	20.2	23.5	4.8	-4.1
Time employed in main current job	4.2	4.8	8.1	1.3	-2.8
Illnesses of siblings: Diabetes	4.2	5.1	5.6	-2.2	2.4
Illness, injury, bereavement, stress in last 2 years	4.1	5.0	7.1	1.7	-2.7
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.4	8.6	-2.0	2.9
Knee pain experienced in last month	3.9	6.1	6.5	-2.4	2.5
Hypothyroidism (self reported)	3.7	8.5	9.7	3.1	-2.7
Irritability	3.7	6.3	7.4	2.7	-2.3
Alcohol intake frequency.	3.6	8.5	13.2	-3.6	1.9
Illnesses of siblings	3.5	4.9	6.1	2.5	-1.9
Type 2 Diabetes (T2D) (2012)	3.4	4.0	5.0	-2.2	1.7
Medication: Ramipril	3.4	4.3	5.9	-2.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.1	7.9	2.8	-2.5
Waist circumference	3.3	12.2	20.1	-4.5	2.1
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	4.4	-2.1	1.6
Qualifications: CSEs or equivalent	3.2	4.2	5.0	-1.9	2.2
Basal metabolic rate	3.2	17.4	28.6	-5.3	2.5
Illnesses of mother	3.1	3.8	5.0	1.6	-2.2
Hair/balding pattern: Pattern 4	3.1	7.6	11.0	3.3	-2.0
Whole body fat-free mass	3.0	17.1	27.2	-5.2	2.6
Whole body water mass	3.0	17.2	27.4	-5.2	2.6
Coronary Artery Disease (CAD)	2.9	3.5	4.6	-2.1	1.5
HbA1C	2.9	3.2	4.8	-2.2	1.3
Medication: Blood pressure	2.9	5.1	8.4	-2.9	1.4
Medication: Omeprazole	2.9	3.4	4.1	-2.0	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	4.8	1.4	-2.2
Respiratory disease	2.8	6.1	8.5	-2.9	2.0
Neuroticism	2.8	6.7	8.3	2.9	-2.3
Neuroticism score	2.8	5.8	9.4	3.1	-1.5
Weight	2.8	13.8	24.5	-4.9	1.8
Angina	2.7	3.5	5.7	-2.4	1.2
Allergy	2.7	6.3	6.3	2.5	-2.5
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	3.5	-1.9	1.8
Heel T-Score	2.6	20.4	24.4	-4.1	4.9
Hip circumference	2.6	11.3	18.1	-4.2	2.1
Angina (self-reported)	2.5	3.3	5.3	-2.3	1.1
Mineral and other dietary supplements	2.5	3.4	6.3	2.5	-0.7
Neuroticism (Nagel 2018)	2.4	5.7	9.6	3.1	-1.3
Cardiovascular Disease	2.4	7.9	12.0	-3.5	2.0
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.4	8.5	-1.5	2.9
Heart attack	2.4	3.0	4.6	-2.2	1.2
Happiness	2.4	3.0	3.8	2.0	-1.4
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	5.5	2.4	-2.0
Medication: Gliclazide	2.4	2.7	4.5	-2.1	1.0
Age at First Birth	2.3	3.3	6.0	2.4	-0.8
BMI	2.3	13.6	22.6	-4.8	2.2
Trunk fat-free mass	2.3	12.9	21.4	-4.6	2.1
Medication for cholesterol	2.3	3.4	3.9	1.7	-2.0
Heart attack/myocardial infarction (self-reported)	2.3	3.0	4.7	-2.2	1.2
Trunk predicted mass	2.2	12.4	20.5	-4.5	2.0
Peak expiratory flow (PEF)	2.2	5.1	7.2	2.7	-1.7
Lung FVC	2.1	10.6	15.1	3.9	-2.5
Sitting height	2.1	14.7	26.3	-5.1	1.8
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	6.8	-1.7	2.6
High blood pressure (siblings)	2.1	3.0	4.5	-2.1	1.2
Average weekly champagne plus white wine intake	2.1	2.8	3.3	-1.8	1.6
Chronotype (morning person)	2.0	4.6	6.7	2.6	-1.6
Mouth/teeth dental problems: Dentures	2.0	3.4	5.3	1.2	-2.3
Arm fat mass (right)	2.0	8.1	14.8	-3.9	1.2
Arm predicted mass (right)	2.0	10.1	15.8	-4.0	2.1
Ever taken oral contraceptive pill	2.0	2.3	3.7	-0.9	1.9
Vascular/heart problems diagnosed by doctor	2.0	5.4	7.5	2.7	-1.8
Crohns Disease (2012)	1.9	3.0	3.3	-1.8	1.6
Sensitivity / hurt feelings	1.9	3.2	6.4	2.5	-0.1
Trunk fat mass	1.9	8.3	15.1	-3.9	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.5	-2.1	0.3
Arm fat mass (left)	1.9	7.6	14.0	-3.7	1.1
Average weekly beer plus cider intake	1.9	2.8	4.5	-2.1	1.0
Basal cell carcinoma (self-reported)	1.9	2.3	2.7	1.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.7	-0.3	2.2
Crohns Disease (2017)	1.8	3.9	4.1	-2.0	1.9
Maternal smoking around birth	1.8	2.6	3.7	1.2	-1.9
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	3.4	1.9	-0.9
Exposure to tobacco smoke outside home	1.8	2.5	3.5	-1.9	1.2
Medication for pain relief, constipation, heartburn	1.8	3.1	4.2	2.0	-1.4
Impedance of whole body	1.8	9.1	11.6	3.4	-2.6
Townsend deprivation index at recruitment	1.7	2.4	3.5	-1.9	1.1
High blood pressure	1.7	4.9	6.6	-2.6	1.8
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	5.0	2.2	-0.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	2.4	-1.6	1.3
Neuroticism (2016)	1.6	2.4	4.2	2.0	-0.8
Hearing difficulty/problems with background noise	1.6	2.5	4.7	2.2	-0.5
Father’s age at death	1.6	2.2	2.8	1.3	1.7
Pulse rate	1.6	2.7	3.5	-1.9	1.4
Arm fat-free mass (right)	1.6	8.4	13.6	-3.7	1.8
Medication: Blood pressure	1.6	3.1	3.9	-2.0	1.5
Arm fat-free mass (left)	1.6	7.9	14.3	-3.8	1.2
Arm predicted mass (left)	1.6	8.3	14.7	-3.8	1.4
Body mass index (BMI)	1.5	6.5	11.1	-3.3	1.4
Medication: Simvastatin	1.5	2.2	2.6	-1.4	1.6
Wheeze or whistling in the chest in last year	1.5	2.7	2.7	-1.6	1.6
Whole body fat mass	1.5	6.4	12.0	-3.5	0.8
Hypertension (Self-reported)	1.5	4.1	5.8	-2.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	4.8	-2.2	1.1
Diabetes (father)	1.4	1.7	3.2	-1.8	0.5
Fed-up feelings	1.4	2.6	5.2	2.3	-0.2
Hair/balding pattern: Pattern 2	1.4	1.8	2.3	-1.1	1.5
Had menopause	1.4	1.8	3.0	1.7	-0.8
Number of children fathered	1.4	1.6	2.5	-1.6	0.9
Supplements: Vitamin C	1.4	1.6	3.0	1.7	-0.4
Arm fat percentage (left)	1.4	5.5	9.7	-3.1	1.2
Friendships satisfaction	1.4	1.7	2.0	1.4	-1.2
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.0	1.4	-1.2
Arm fat percentage (right)	1.3	5.2	9.6	-3.1	0.9
Cholesterol lowering medication	1.3	1.9	3.0	-0.8	1.7
Schizophrenia (2014)	1.2	2.7	4.0	2.0	-1.2
Blood clot in the leg (DVT)	1.2	1.6	3.1	0.2	1.8
Medication: Ibuprofen	1.2	1.5	2.9	-0.2	1.7
Asthma (self-reported)	1.2	2.4	2.5	-1.6	1.5
Depressed Affect (Nagel 2018)	1.1	2.3	3.5	1.9	-1.0
Blood Red Count	1.1	11.1	13.2	-3.6	3.0
Number of treatments/medications taken	1.1	1.9	3.7	-1.9	0.4
Trunk fat percentage	1.1	4.3	8.2	-2.9	0.6
Medication: Seretide 50 evohaler	1.1	1.3	1.5	-1.2	-1.1
Leg fat mass (right)	1.1	4.3	8.3	-2.9	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.3	1.5	-1.0
Bipolar Disorder (2018)	1.0	1.5	2.8	-1.7	-0.5
Lupus	1.0	1.6	2.0	-1.1	1.4
Blood Eosinophil Count	1.0	7.3	7.5	-2.7	2.7
Multivitamins +/- minerals	1.0	1.3	1.9	-1.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.2	1.8	-0.1
Asthma	1.0	1.9	2.2	-1.3	1.5
Worry too long after embarrassment	1.0	1.7	2.4	1.6	-1.0
Emphysema/chronic bronchitis	1.0	1.1	1.9	-1.4	0.6
Overall health rating	1.0	2.2	4.0	-2.0	0.7
Medication: Aspirin	1.0	1.3	2.1	-1.5	0.7
Miserableness	1.0	1.7	3.1	1.8	-0.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.3	-1.5	0.2
Leg fat mass (left)	1.0	3.9	7.6	-2.8	0.5
Breast Cancer	0.9	2.1	4.0	2.0	-0.5
Rheumatoid Arthritis	0.9	1.2	1.2	1.1	-1.1
Blood Platelet Count	0.9	9.9	11.1	-3.3	-2.9
Falls in the last year	0.9	1.2	2.2	-1.5	-0.5
Smoking status: Previous	0.9	1.4	2.2	0.7	-1.5
Medication: Paracetamol	0.9	1.5	2.3	-1.5	0.8
Medication: Lisinopril	0.9	1.2	2.2	-1.5	0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.5	-1.2	-0.7
Ever depressed for a whole week	0.9	1.1	1.9	1.4	-0.6
Worry (Nagel 2018)	0.8	1.8	2.9	1.7	-0.8
Relative age voice broke	0.8	1.2	2.3	1.5	0.2
Age when periods started (menarche)	0.8	1.8	2.2	1.2	-1.5
Depression (self-reported)	0.8	1.0	1.1	-1.1	0.9
Pulse wave Arterial Stiffness index	0.8	0.9	1.5	-1.2	0.6
Standing height	0.8	7.7	14.7	-3.8	0.8
Tense / ‘highly strung’	0.8	1.3	1.8	0.9	-1.4
Migraine (self-reported)	0.8	0.9	1.7	-1.3	-0.5
Number of full sisters	0.8	1.0	1.8	0.3	1.4
Eye problems/disorders: Cataract	0.8	0.9	1.5	1.2	-0.5
Hearing aid user	0.8	0.9	1.0	1.0	-0.9
Supplements: Calcium	0.8	0.8	1.4	0.5	-1.2
Heart disease (siblings)	0.8	1.0	1.5	-1.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	0.7	-1.1
Serious illness, injury or assault to yourself	0.7	0.9	0.9	-0.9	1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.0	-1.0	0.8
Medication: Atenolol	0.7	0.9	1.4	-1.2	0.7
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	-1.3	-0.2
Mouth/teeth dental problems	0.7	1.1	1.4	-1.2	0.9
Noisy workplace	0.7	0.9	1.1	-0.8	1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.5	1.6	1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-0.4	1.3
Body fat percentage	0.7	2.9	5.8	-2.4	0.3
Age at first live birth	0.7	1.3	2.3	1.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	0.1	-1.2
Mean time to correctly identify matches	0.7	1.4	1.7	1.3	-1.1
Number of self-reported non-cancer illnesses	0.7	1.3	2.0	-1.4	0.7
Guilty feelings	0.7	1.1	1.6	1.3	0.7
Waist Hip Ratio (WHR)	0.6	2.7	5.2	-2.3	0.4
Pack years adult smoking proportion	0.6	0.9	1.1	-1.1	0.8
Supplements: Glucosamine	0.6	0.7	0.8	-0.8	0.9
Fluid intelligence score	0.6	1.2	2.4	-1.6	0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.4	-0.2	1.2
Comparative height size at age 10	0.6	3.5	6.7	-2.6	0.5
Average weekly red wine intake	0.6	0.9	1.1	1.0	-0.8
Alcohol drinker status: Never	0.6	0.8	1.4	-0.3	-1.2
Schizophrenia (2018)	0.5	0.9	1.6	1.3	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	1.1	0.0
Ulcerative Colitis (UC)	0.5	1.0	1.1	0.9	-1.0
Reaction Time	0.5	0.9	1.7	1.3	-0.3
Primary Biliary Cirrhosis	0.5	0.8	0.9	0.9	-0.8
Tanning	0.5	5.7	7.4	2.0	-2.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	1.1	-0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	0.1	1.1
Systolic blood pressure, automated reading	0.5	1.4	2.6	-0.4	-1.6
Supplements: Zinc	0.5	0.6	1.1	1.0	-0.3
Number of incorrect matches in round	0.5	0.9	1.1	1.0	-0.8
Nervous feelings	0.5	0.9	1.5	1.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.0	1.7	-0.7
Medication: Aspirin	0.5	0.6	1.1	-1.1	0.4
Breast cancer (self-reported)	0.5	0.6	1.1	-0.4	-1.0
Osteoarthritis (self-reported)	0.5	0.6	1.3	-0.1	1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	-1.0	0.5
Illnesses of father: High blood pressure	0.5	0.6	1.1	-1.0	0.2
Number of operations (self-reported)	0.5	0.8	1.3	-1.1	0.6
Commuting to job workplace: Cycle	0.5	0.6	0.7	0.8	-0.7
Depression (Nagel 2018)	0.4	0.6	1.2	0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.2	-1.5	0.1
Bipolar Disorder (2011)	0.4	0.4	0.5	-0.5	0.7
Mean Putamen Volume	0.4	0.4	0.4	-0.6	0.6
LDL Cholesterol	0.4	0.7	1.3	-1.1	-0.1
Ulcerative Colitis	0.4	0.6	1.1	0.3	-1.1
Blood White Count	0.4	3.1	5.1	-2.3	-1.0
Average weekly fortified wine intake	0.4	0.5	0.9	0.9	-0.4
Taking other prescription medications	0.4	0.7	1.3	-1.1	0.1
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.1	-1.1	0.9
Qualifications: None of the above	0.4	0.8	1.3	0.5	-1.2
Impedance of arm (right)	0.4	1.6	1.7	1.3	-1.3
Glaucoma (self-reported)	0.4	0.5	1.0	-1.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.6	-0.8	0.7
Pulse wave peak to peak time	0.4	0.4	0.6	0.8	-0.5
Medication: Allopurinol	0.4	0.5	0.9	0.9	-0.4
Chest pain or discomfort	0.4	0.6	1.1	-1.0	-0.4
Family relationship satisfaction	0.4	0.5	0.5	0.7	-0.7
Mood swings	0.4	0.7	1.3	1.1	-0.4
Ever had bowel cancer screening	0.4	0.5	1.0	0.1	-1.0
Financial situation satisfaction	0.4	0.6	0.7	-0.7	0.8
Age started oral contraceptive pill	0.4	0.5	0.6	0.8	-0.7
Diastolic blood pressure, automated reading	0.4	1.2	2.3	-1.5	0.3
Myopia	0.4	0.6	0.8	-0.7	0.9
Alzheimer’s Disease (in father)	0.3	0.4	0.4	0.6	-0.6
Major Depression (MDD)	0.3	0.4	0.7	0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	-1.1	-0.6
Body Mass Index (BMI) (2010)	0.3	0.3	0.6	-0.8	0.3
Height	0.3	6.3	12.6	-3.5	-0.1
Systolic Blood Pressure	0.3	1.3	1.9	-0.9	-1.4
Vitamin and mineral supplements	0.3	0.4	0.8	0.9	-0.2
Hand grip strength (right)	0.3	0.7	1.3	-1.1	0.5
Alcohol usually taken with meals	0.3	0.4	0.8	-0.2	-0.9
Length of working week for main job	0.3	0.3	0.6	-0.3	-0.8
Medication: Paracetamol	0.3	0.4	0.7	-0.8	0.5
Leg fat percentage (right)	0.3	1.0	1.4	-1.2	-0.7
Health satisfaction	0.3	0.4	0.4	-0.6	0.6
Age at last live birth	0.3	0.5	0.7	0.5	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	0.5	-0.8
Qualifications: nursing, teaching	0.3	0.4	0.5	0.6	-0.7
Wears glasses or contact lenses	0.3	0.4	0.6	-0.8	-0.4
High cholesterol (Self-reported)	0.3	0.5	0.6	-0.8	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	0.7	-0.8	0.6
Hair Pigment	0.2	6.6	10.9	-3.3	1.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	-0.6	0.5
Medication: Co-codamol	0.2	0.3	0.5	-0.2	0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	0.0	0.7
Pain all over the body in last month	0.2	0.2	0.4	0.6	-0.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	1.0	-0.6
Impedance of arm (left)	0.2	1.0	1.2	1.1	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.3	-0.5	0.5
Birth weight of first child	0.2	0.4	0.6	0.5	-0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.2	-0.4	-0.5
Comparative body size at age 10	0.2	0.5	1.0	-1.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.2	-0.6
Qualifications: College or University degree	0.2	0.5	0.9	0.9	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.3	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.2	0.5	0.4
Leg fat percentage (left)	0.2	0.6	0.8	-0.9	-0.6
Risk taking	0.2	0.2	0.4	-0.6	-0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.6	0.1
Alcohol drinker status: Previous	0.2	0.2	0.4	0.0	0.6
Pack years of smoking	0.2	0.3	0.6	-0.8	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.1	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	0.3	0.3
Allergy or Eczema	0.1	0.3	0.5	-0.7	0.4
Hand grip strength (left)	0.1	0.2	0.2	-0.5	0.4
Severe depression (siblings)	0.1	0.1	0.1	-0.1	0.4
Current tobacco smoking	0.1	0.2	0.4	-0.1	0.6
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	0.5
Past tobacco smoking	0.1	0.2	0.4	-0.3	0.6
Had other major operations	0.1	0.2	0.3	-0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.4	0.1
Number of live births	0.1	0.2	0.3	-0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.2	-0.4	0.3
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.6	-0.2
Prospective memory result	0.1	0.1	0.2	0.4	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.4	0.1
Pulse wave reflection index	0.1	0.1	0.1	-0.4	0.3
Loud music exposure frequency	0.1	0.1	0.3	-0.5	0.1
Gout (self-reported)	0.1	0.2	0.4	0.6	0.0
Medication: Amlodipine	0.1	0.1	0.1	-0.1	0.4
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	-0.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.2	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.2	-0.3
Suffer from ‘nerves’	0.1	0.2	0.4	0.6	0.1
Had major operations	0.1	0.1	0.1	-0.1	-0.4
Leg pain on walking	0.1	0.1	0.2	-0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.3	0.4
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.6	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.1	-0.3
Smoking status: Current	0.1	0.2	0.3	0.1	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.4	0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	-0.3	0.3
Unable to work because of sickness or disability	0.1	0.1	0.2	0.3	0.4
Smoking Status	0.0	0.0	0.0	-0.1	0.2
Average weekly spirits intake	0.0	0.1	0.1	0.3	0.1
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.0	-0.2
Relative age of first facial hair	0.0	0.0	0.0	0.1	-0.1
Medication for hormone replacement therapy	0.0	0.0	0.1	0.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	0.1	0.2
Forced vital capacity (FVC)	0.0	0.0	0.0	0.1	-0.2
Medication: Lansoprazole	0.0	0.0	0.1	0.1	-0.3
Lung cancer (father)	0.0	0.1	0.1	-0.3	-0.1
Breastfed as a baby	0.0	0.1	0.1	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.2	-0.4
Shortness of breath walking on level ground	0.0	0.0	0.0	-0.1	0.1
Loneliness, isolation	0.0	0.0	0.0	0.2	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	0.0
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.2	-0.2
Medication: Atorvastatin	0.0	0.0	0.1	-0.3	0.1
Ever smoked	0.0	0.1	0.1	-0.2	0.3

Hub : Genes

MACF1

Models

Trait associations