Hub : Genes

MACF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.0820 0.030 0.00015 0.076 NA 0.034 NA 0.064 6.9e-07 NA 0.00079 NA 5.3e-06
2 METSIM Adipose 0.0514 0.024 0.00240 -0.002 0.008 0.002 0.009 -0.001 8.6e-01 0.019 0.15000 0.015 4.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.5 2.8 -1.7 -0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.4 -0.1 -0.6
Depressed Affect (Nagel 2018) 1.1 2.3 3.5 1.9 -1.0
Depression (Nagel 2018) 0.4 0.6 1.2 0.1 -1.1
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.2 -1.5 0.1
Neuroticism (Nagel 2018) 2.4 5.7 9.6 3.1 -1.3
Schizophrenia (2018) 0.5 0.9 1.6 1.3 -0.5
Schizophrenia vs Biploar Disorder 4.9 6.5 12.3 3.5 -0.9
Worry (Nagel 2018) 0.8 1.8 2.9 1.7 -0.8
Alzheimer’s Disease (in mother) 0.5 0.6 1.2 1.1 0.0
Alzheimer’s Disease (in father) 0.3 0.4 0.4 0.6 -0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 0.3 0.3
Crohns Disease (2017) 1.8 3.9 4.1 -2.0 1.9
Irritable Bowel Disease (IBD) 0.2 0.5 0.7 -0.8 0.6
Ulcerative Colitis (UC) 0.5 1.0 1.1 0.9 -1.0
Major Depression (MDD) 0.3 0.4 0.7 0.8 0.2
Reaction Time 0.5 0.9 1.7 1.3 -0.3
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.1 -1.1 -0.6
Breast Cancer 0.9 2.1 4.0 2.0 -0.5
Ovarian Cancer 10.6 14.0 19.3 -2.9 4.4
Prostate Cancer 4.7 6.6 12.0 -3.5 1.0
Age at First Birth 2.3 3.3 6.0 2.4 -0.8
Bipolar Disorder (2011) 0.4 0.4 0.5 -0.5 0.7
Body Mass Index (BMI) (2010) 0.3 0.3 0.6 -0.8 0.3
Coronary Artery Disease (CAD) 2.9 3.5 4.6 -2.1 1.5
Crohns Disease (2012) 1.9 3.0 3.3 -1.8 1.6
Mean Putamen Volume 0.4 0.4 0.4 -0.6 0.6
Fasting Glucose 5.4 6.5 7.0 -2.6 2.4
HbA1C 2.9 3.2 4.8 -2.2 1.3
HDL Cholesterol 11.6 19.4 24.3 4.9 -3.8
LDL Cholesterol 0.4 0.7 1.3 -1.1 -0.1
Lupus 1.0 1.6 2.0 -1.1 1.4
Neuroticism (2016) 1.6 2.4 4.2 2.0 -0.8
Primary Biliary Cirrhosis 0.5 0.8 0.9 0.9 -0.8
Rheumatoid Arthritis 0.9 1.2 1.2 1.1 -1.1
Schizophrenia (2014) 1.2 2.7 4.0 2.0 -1.2
Triglycerides 5.8 9.4 14.5 -3.8 2.1
Type 2 Diabetes (T2D) (2012) 3.4 4.0 5.0 -2.2 1.7
Ulcerative Colitis 0.4 0.6 1.1 0.3 -1.1
Blood Eosinophil Count 1.0 7.3 7.5 -2.7 2.7
Blood Platelet Count 0.9 9.9 11.1 -3.3 -2.9
Blood Red Count 1.1 11.1 13.2 -3.6 3.0
Blood White Count 0.4 3.1 5.1 -2.3 -1.0
Heel T-Score 2.6 20.4 24.4 -4.1 4.9
BMI 2.3 13.6 22.6 -4.8 2.2
Height 0.3 6.3 12.6 -3.5 -0.1
Waist Hip Ratio (WHR) 0.6 2.7 5.2 -2.3 0.4
Systolic Blood Pressure 0.3 1.3 1.9 -0.9 -1.4
Smoking Status 0.0 0.0 0.0 -0.1 0.2
Allergy or Eczema 0.1 0.3 0.5 -0.7 0.4
Cardiovascular Disease 2.4 7.9 12.0 -3.5 2.0
Hypothyroidism (self reported) 3.7 8.5 9.7 3.1 -2.7
Respiratory disease 2.8 6.1 8.5 -2.9 2.0
Type 2 Diabetes (T2D) (2018) 9.5 17.8 24.4 -4.9 3.4
Lung FEV1/FVC ratio 4.4 22.1 40.4 6.4 -1.9
Lung FVC 2.1 10.6 15.1 3.9 -2.5
Neuroticism 2.8 6.7 8.3 2.9 -2.3
Chronotype (morning person) 2.0 4.6 6.7 2.6 -1.6
Hair Pigment 0.2 6.6 10.9 -3.3 1.6
Tanning 0.5 5.7 7.4 2.0 -2.7
Hand grip strength (left) 0.1 0.2 0.2 -0.5 0.4
Number of treatments/medications taken 1.1 1.9 3.7 -1.9 0.4
Average weekly spirits intake 0.0 0.1 0.1 0.3 0.1
Sensitivity / hurt feelings 1.9 3.2 6.4 2.5 -0.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.3 -0.6 0.5
Hearing difficulty/problems: Yes 0.0 0.0 0.0 0.0 -0.2
Relative age of first facial hair 0.0 0.0 0.0 0.1 -0.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.2 1.1 -0.1
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.0 1.4 -1.2
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 0.1 1.1
Systolic blood pressure, automated reading 0.5 1.4 2.6 -0.4 -1.6
Eye problems/disorders: Diabetes related eye disease 3.2 3.5 4.4 -2.1 1.6
Angina 2.7 3.5 5.7 -2.4 1.2
Medication for hormone replacement therapy 0.0 0.0 0.1 0.0 -0.2
Vitamin and mineral supplements 0.3 0.4 0.8 0.9 -0.2
Supplements: Zinc 0.5 0.6 1.1 1.0 -0.3
Medication: Co-codamol 0.2 0.3 0.5 -0.2 0.7
Medication: Metformin 5.5 7.8 12.9 -3.6 1.6
Diabetes (father) 1.4 1.7 3.2 -1.8 0.5
Diabetes (mother) 11.0 14.1 17.3 -4.2 3.3
Severe depression (siblings) 0.1 0.1 0.1 -0.1 0.4
Pack years adult smoking proportion 0.6 0.9 1.1 -1.1 0.8
Impedance of leg (right) 4.2 20.2 23.5 4.8 -4.1
Leg fat-free mass (left) 4.9 25.9 40.4 -6.4 3.4
Trunk fat percentage 1.1 4.3 8.2 -2.9 0.6
Hand grip strength (right) 0.3 0.7 1.3 -1.1 0.5
Townsend deprivation index at recruitment 1.7 2.4 3.5 -1.9 1.1
Current tobacco smoking 0.1 0.2 0.4 -0.1 0.6
Average weekly fortified wine intake 0.4 0.5 0.9 0.9 -0.4
Maternal smoking around birth 1.8 2.6 3.7 1.2 -1.9
Fed-up feelings 1.4 2.6 5.2 2.3 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.3 0.7 -1.1
Relative age voice broke 0.8 1.2 2.3 1.5 0.2
Taking other prescription medications 0.4 0.7 1.3 -1.1 0.1
Age when periods started (menarche) 0.8 1.8 2.2 1.2 -1.5
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 0.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.4 8.5 -1.5 2.9
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.5 0.0 0.7
Qualifications: CSEs or equivalent 3.2 4.2 5.0 -1.9 2.2
Serious illness, injury or assault to yourself 0.7 0.9 0.9 -0.9 1.0
High blood pressure 1.7 4.9 6.6 -2.6 1.8
Hayfever, allergic rhinitis or eczema 0.4 1.0 1.1 -1.1 0.9
Multivitamins +/- minerals 1.0 1.3 1.9 -1.4 0.9
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.2 0.5
Supplements: Glucosamine 0.6 0.7 0.8 -0.8 0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.0 -1.0 0.8
Medication: Atenolol 0.7 0.9 1.4 -1.2 0.7
Medication: Levothyroxine sodium 4.5 7.6 7.8 2.8 -2.7
Sitting height 2.1 14.7 26.3 -5.1 1.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.6 -1.3 -0.2
High blood pressure (mother) 6.6 9.3 9.6 -3.0 3.1
Body mass index (BMI) 1.5 6.5 11.1 -3.3 1.4
Impedance of leg (left) 4.9 24.0 31.8 5.6 -4.0
Leg predicted mass (left) 4.9 25.8 40.4 -6.4 3.3
Trunk fat mass 1.9 8.3 15.1 -3.9 1.2
Waist circumference 3.3 12.2 20.1 -4.5 2.1
Number of incorrect matches in round 0.5 0.9 1.1 1.0 -0.8
Past tobacco smoking 0.1 0.2 0.4 -0.3 0.6
Alcohol usually taken with meals 0.3 0.4 0.8 -0.2 -0.9
Nervous feelings 0.5 0.9 1.5 1.2 -0.5
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.2 1.8 -0.1
Hearing difficulty/problems with background noise 1.6 2.5 4.7 2.2 -0.5
Hair/balding pattern: Pattern 2 1.4 1.8 2.3 -1.1 1.5
Had menopause 1.4 1.8 3.0 1.7 -0.8
Had other major operations 0.1 0.2 0.3 -0.5 0.2
Forced vital capacity (FVC) 0.0 0.0 0.0 0.1 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.9 6.8 -1.7 2.6
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 3.4 1.9 -0.9
Qualifications: None of the above 0.4 0.8 1.3 0.5 -1.2
Financial difficulties in last 2 years 5.6 7.5 10.7 -2.1 3.3
Mouth/teeth dental problems 0.7 1.1 1.4 -1.2 0.9
Heart attack 2.4 3.0 4.6 -2.2 1.2
Allergy 2.7 6.3 6.3 2.5 -2.5
Pain all over the body in last month 0.2 0.2 0.4 0.6 -0.0
Diabetes (self-reported) 7.1 10.9 14.9 -3.9 2.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 0.4 0.1
Medication: Ramipril 3.4 4.3 5.9 -2.4 1.7
Medication: Simvastatin 1.5 2.2 2.6 -1.4 1.6
Fluid intelligence score 0.6 1.2 2.4 -1.6 0.0
Illnesses of siblings 3.5 4.9 6.1 2.5 -1.9
Neuroticism score 2.8 5.8 9.4 3.1 -1.5
Weight 2.8 13.8 24.5 -4.9 1.8
Impedance of arm (right) 0.4 1.6 1.7 1.3 -1.3
Arm fat percentage (right) 1.3 5.2 9.6 -3.1 0.9
Trunk fat-free mass 2.3 12.9 21.4 -4.6 2.1
Hip circumference 2.6 11.3 18.1 -4.2 2.1
Time employed in main current job 4.2 4.8 8.1 1.3 -2.8
Alcohol intake versus 10 years previously 8.4 12.6 13.9 -3.7 3.4
Father’s age at death 1.6 2.2 2.8 1.3 1.7
Worrier / anxious feelings 4.3 8.2 10.6 3.2 -2.4
Frequency of tiredness / lethargy in last 2 weeks 4.0 6.4 8.6 -2.0 2.9
Falls in the last year 0.9 1.2 2.2 -1.5 -0.5
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 0.4 -0.6
Number of live births 0.1 0.2 0.3 -0.4 0.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.0 1.7 -0.7
Pulse rate 1.6 2.7 3.5 -1.9 1.4
Happiness 2.4 3.0 3.8 2.0 -1.4
Noisy workplace 0.7 0.9 1.1 -0.8 1.0
Qualifications: A levels/AS levels or equivalent 0.7 1.5 1.6 1.2 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.2 -0.4 0.3
Mouth/teeth dental problems: Dentures 2.0 3.4 5.3 1.2 -2.3
Asthma 1.0 1.9 2.2 -1.3 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.6 -0.4 1.3
Medication: Cholesterol lowering 0.1 0.2 0.4 -0.6 -0.2
Depression (self-reported) 0.8 1.0 1.1 -1.1 0.9
Medication: Lansoprazole 0.0 0.0 0.1 0.1 -0.3
Prospective memory result 0.1 0.1 0.2 0.4 -0.3
Lung cancer (father) 0.0 0.1 0.1 -0.3 -0.1
Illnesses of mother 3.1 3.8 5.0 1.6 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.0 1.0 -0.6
Pulse wave Arterial Stiffness index 0.8 0.9 1.5 -1.2 0.6
Impedance of arm (left) 0.2 1.0 1.2 1.1 -0.9
Arm fat mass (right) 2.0 8.1 14.8 -3.9 1.2
Trunk predicted mass 2.2 12.4 20.5 -4.5 2.0
Standing height 0.8 7.7 14.7 -3.8 0.8
Length of working week for main job 0.3 0.3 0.6 -0.3 -0.8
Exposure to tobacco smoke at home 0.1 0.1 0.1 0.4 0.1
Breastfed as a baby 0.0 0.1 0.1 0.2 0.3
Tense / ‘highly strung’ 0.8 1.3 1.8 0.9 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.3 -0.5 0.5
Hair/balding pattern: Pattern 4 3.1 7.6 11.0 3.3 -2.0
Birth weight of first child 0.2 0.4 0.6 0.5 -0.8
Peak expiratory flow (PEF) 2.2 5.1 7.2 2.7 -1.7
Pulse wave reflection index 0.1 0.1 0.1 -0.4 0.3
Ever highly irritable/argumentative for 2 days 5.8 7.0 13.9 3.7 -0.2
Loud music exposure frequency 0.1 0.1 0.3 -0.5 0.1
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.1 0.2 -0.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.4 -0.2 1.2
Blood clot in the leg (DVT) 1.2 1.6 3.1 0.2 1.8
Medication: Paracetamol 0.3 0.4 0.7 -0.8 0.5
Headache pain in last month 5.9 10.1 15.8 -4.0 2.1
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 5.0 2.2 -0.8
Glaucoma (self-reported) 0.4 0.5 1.0 -1.0 -0.1
Gout (self-reported) 0.1 0.2 0.4 0.6 0.0
Hypothyroidism/myxoedema (self-reported) 2.4 4.7 5.5 2.4 -2.0
Medication: Amlodipine 0.1 0.1 0.1 -0.1 0.4
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.6 -0.8 0.7
Birth weight 5.3 11.6 13.0 3.2 -3.6
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.2 -0.4 -0.5
High blood pressure (siblings) 2.1 3.0 4.5 -2.1 1.2
Forced vital capacity (FVC), Best measure 0.1 0.2 0.4 -0.6 0.0
Body fat percentage 0.7 2.9 5.8 -2.4 0.3
Leg fat percentage (right) 0.3 1.0 1.4 -1.2 -0.7
Arm fat-free mass (right) 1.6 8.4 13.6 -3.7 1.8
Exposure to tobacco smoke outside home 1.8 2.5 3.5 -1.9 1.2
Comparative body size at age 10 0.2 0.5 1.0 -1.0 0.1
Number of full brothers 10.6 13.3 16.7 -3.1 4.1
Worry too long after embarrassment 1.0 1.7 2.4 1.6 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.2 -0.4
Wheeze or whistling in the chest in last year 1.5 2.7 2.7 -1.6 1.6
Number of children fathered 1.4 1.6 2.5 -1.6 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.2 -0.6
Age at first live birth 0.7 1.3 2.3 1.5 -0.4
Pulse wave peak to peak time 0.4 0.4 0.6 0.8 -0.5
Health satisfaction 0.3 0.4 0.4 -0.6 0.6
Shortness of breath walking on level ground 0.0 0.0 0.0 -0.1 0.1
Qualifications: College or University degree 0.2 0.5 0.9 0.9 -0.3
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.2 -0.3
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.5 0.1 -1.2
Emphysema/chronic bronchitis 1.0 1.1 1.9 -1.4 0.6
Medication for pain relief, constipation, heartburn 1.8 3.1 4.2 2.0 -1.4
Neck or shoulder pain in last month 6.6 9.4 11.2 -3.3 2.7
Medication: Blood pressure 2.9 5.1 8.4 -2.9 1.4
Angina (self-reported) 2.5 3.3 5.3 -2.3 1.1
Migraine (self-reported) 0.8 0.9 1.7 -1.3 -0.5
Medication: Ibuprofen 1.2 1.5 2.9 -0.2 1.7
Medication: Allopurinol 0.4 0.5 0.9 0.9 -0.4
Medication: Omeprazole 2.9 3.4 4.1 -2.0 1.6
Medication: Seretide 50 evohaler 1.1 1.3 1.5 -1.2 -1.1
Mean time to correctly identify matches 0.7 1.4 1.7 1.3 -1.1
Heart disease (mother) 4.6 5.6 6.5 -2.2 2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.9 3.5 4.8 1.4 -2.2
Whole body fat mass 1.5 6.4 12.0 -3.5 0.8
Leg fat mass (right) 1.1 4.3 8.3 -2.9 0.5
Arm predicted mass (right) 2.0 10.1 15.8 -4.0 2.1
Pulse rate, automated reading 4.9 16.0 22.1 -4.7 3.1
Alcohol intake frequency. 3.6 8.5 13.2 -3.6 1.9
Comparative height size at age 10 0.6 3.5 6.7 -2.6 0.5
Number of full sisters 0.8 1.0 1.8 0.3 1.4
Suffer from ‘nerves’ 0.1 0.2 0.4 0.6 0.1
Overall health rating 1.0 2.2 4.0 -2.0 0.7
Chest pain or discomfort 0.4 0.6 1.1 -1.0 -0.4
Had major operations 0.1 0.1 0.1 -0.1 -0.4
Age at last live birth 0.3 0.5 0.7 0.5 -0.9
Family relationship satisfaction 0.4 0.5 0.5 0.7 -0.7
Leg pain on walking 0.1 0.1 0.2 -0.3 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 4.5 -2.1 0.3
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 -0.3 0.3
Illness, injury, bereavement, stress in last 2 years 4.1 5.0 7.1 1.7 -2.7
Medication: Aspirin 0.5 0.6 1.1 -1.1 0.4
Supplements: Vitamin C 1.4 1.6 3.0 1.7 -0.4
Knee pain experienced in last month 3.9 6.1 6.5 -2.4 2.5
Hypertension (Self-reported) 1.5 4.1 5.8 -2.4 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.3 0.4
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.6 -0.0
Illnesses of siblings: Diabetes 4.2 5.1 5.6 -2.2 2.4
Smoking status: Previous 0.9 1.4 2.2 0.7 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 4.8 -2.2 1.1
Whole body fat-free mass 3.0 17.1 27.2 -5.2 2.6
Leg fat-free mass (right) 5.0 26.6 39.3 -6.3 3.7
Arm fat percentage (left) 1.4 5.5 9.7 -3.1 1.2
Average weekly red wine intake 0.6 0.9 1.1 1.0 -0.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 0.5 -0.8
Mood swings 0.4 0.7 1.3 1.1 -0.4
Loneliness, isolation 0.0 0.0 0.0 0.2 -0.2
Long-standing illness, disability or infirmity 6.6 10.0 12.0 -2.8 3.5
Ever had bowel cancer screening 0.4 0.5 1.0 0.1 -1.0
Diabetes diagnosed by doctor 8.4 13.9 19.7 -4.4 2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 0.3 -0.6
Friendships satisfaction 1.4 1.7 2.0 1.4 -1.2
Qualifications: nursing, teaching 0.3 0.4 0.5 0.6 -0.7
Commuting to job workplace: Walk 0.0 0.0 0.0 0.1 0.0
Eye problems/disorders: Cataract 0.8 0.9 1.5 1.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 2.3 1.5 -1.0
Medication for cholesterol 2.3 3.4 3.9 1.7 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.1 -0.1 -0.3
Back pain experienced in last month 5.6 8.2 9.6 -2.6 3.1
Mineral and other dietary supplements 2.5 3.4 6.3 2.5 -0.7
Breast cancer (self-reported) 0.5 0.6 1.1 -0.4 -1.0
Asthma (self-reported) 1.2 2.4 2.5 -1.6 1.5
Osteoporosis (self-reported) 4.3 5.3 5.7 2.2 -2.4
Osteoarthritis (self-reported) 0.5 0.6 1.3 -0.1 1.1
Medication: Aspirin 1.0 1.3 2.1 -1.5 0.7
Medication: Gliclazide 2.4 2.7 4.5 -2.1 1.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.2 0.5 0.4
Smoking status: Current 0.1 0.2 0.3 0.1 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.4 7.1 7.9 2.8 -2.5
Whole body water mass 3.0 17.2 27.4 -5.2 2.6
Leg predicted mass (right) 4.9 26.0 38.3 -6.2 3.7
Arm fat mass (left) 1.9 7.6 14.0 -3.7 1.1
Number of self-reported non-cancer illnesses 0.7 1.3 2.0 -1.4 0.7
Average weekly champagne plus white wine intake 2.1 2.8 3.3 -1.8 1.6
Miserableness 1.0 1.7 3.1 1.8 -0.5
Guilty feelings 0.7 1.1 1.6 1.3 0.7
Wears glasses or contact lenses 0.3 0.4 0.6 -0.8 -0.4
Ever taken oral contraceptive pill 2.0 2.3 3.7 -0.9 1.9
Hearing aid user 0.8 0.9 1.0 1.0 -0.9
Mother’s age at death 4.4 5.5 10.8 3.3 -0.4
Financial situation satisfaction 0.4 0.6 0.7 -0.7 0.8
Tinnitus: Yes, now most or all of the time 1.0 1.2 2.3 -1.5 0.2
Commuting to job workplace: Public transport 0.1 0.1 0.1 -0.4 0.3
Eye problems/disorders: Glaucoma 0.1 0.1 0.1 -0.3 0.3
Medication: Blood pressure 1.6 3.1 3.9 -2.0 1.5
Pain type(s) experienced in last month: Hip pain 1.7 2.1 2.4 -1.6 1.3
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.1 -1.0 0.5
High cholesterol (Self-reported) 0.3 0.5 0.6 -0.8 0.7
Medication: Bendroflumethiazide 0.0 0.0 0.1 -0.2 -0.2
Medication: Paracetamol 0.9 1.5 2.3 -1.5 0.8
Medication: Lisinopril 0.9 1.2 2.2 -1.5 0.4
Medication: Atorvastatin 0.0 0.0 0.1 -0.3 0.1
Illnesses of father: High blood pressure 0.5 0.6 1.1 -1.0 0.2
Alcohol drinker status: Never 0.6 0.8 1.4 -0.3 -1.2
Ever smoked 0.0 0.1 0.1 -0.2 0.3
Basal metabolic rate 3.2 17.4 28.6 -5.3 2.5
Leg fat percentage (left) 0.2 0.6 0.8 -0.9 -0.6
Arm fat-free mass (left) 1.6 7.9 14.3 -3.8 1.2
Number of operations (self-reported) 0.5 0.8 1.3 -1.1 0.6
Average weekly beer plus cider intake 1.9 2.8 4.5 -2.1 1.0
Irritability 3.7 6.3 7.4 2.7 -2.3
Risk taking 0.2 0.2 0.4 -0.6 -0.4
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.5 -1.2 -0.7
Fractured/broken bones in last 5 years 0.2 0.2 0.4 -0.6 0.1
Age started oral contraceptive pill 0.4 0.5 0.6 0.8 -0.7
Diastolic blood pressure, automated reading 0.4 1.2 2.3 -1.5 0.3
Ever depressed for a whole week 0.9 1.1 1.9 1.4 -0.6
Unable to work because of sickness or disability 0.1 0.1 0.2 0.3 0.4
Commuting to job workplace: Cycle 0.5 0.6 0.7 0.8 -0.7
Myopia 0.4 0.6 0.8 -0.7 0.9
Vascular/heart problems diagnosed by doctor 2.0 5.4 7.5 2.7 -1.8
Cholesterol lowering medication 1.3 1.9 3.0 -0.8 1.7
Medication: Omeprazole (e.g. Zanprol) 2.7 3.3 3.5 -1.9 1.8
Pain experienced in last month 9.2 15.3 16.9 4.1 -3.7
Supplements: Calcium 0.8 0.8 1.4 0.5 -1.2
Basal cell carcinoma (self-reported) 1.9 2.3 2.7 1.4 -1.6
Heart attack/myocardial infarction (self-reported) 2.3 3.0 4.7 -2.2 1.2
Deep venous thrombosis (DVT) (self-reported) 1.9 2.4 4.7 -0.3 2.2
Heart disease (siblings) 0.8 1.0 1.5 -1.2 0.7
Alcohol drinker status: Previous 0.2 0.2 0.4 0.0 0.6
Pack years of smoking 0.2 0.3 0.6 -0.8 0.2
Impedance of whole body 1.8 9.1 11.6 3.4 -2.6
Leg fat mass (left) 1.0 3.9 7.6 -2.8 0.5
Arm predicted mass (left) 1.6 8.3 14.7 -3.8 1.4