[Hub]/) : Traits : Basal metabolic rate : ← →

chr4:121,982,122-124,538,705

Best TWAS P=4.21e-19 · Best GWAS P=4.39e-14 conditioned to 8.46e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNA2	0.03	0.01	blup	34	0.02	1.5e-03	-7.42	8.9	4.2e-19	-0.80	0.00	0.97	TRUE
5	GTEx	Artery Tibial	FGF2	0.18	0.05	lasso	3	0.02	1.3e-02	5.88	6.1	1.2e-09	-0.01	0.08	0.11	TRUE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FGF2	0.06	0.04	blup	65	0.05	4.4e-06	6.36	6.0	2.0e-09	-0.03	0.01	0.98	TRUE
9	GTEx	Breast Mammary Tissue	NUDT6	0.25	0.10	lasso	3	0.08	4.2e-05	5.77	5.8	7.0e-09	0.01	0.09	0.87	TRUE
10	GTEx	Breast Mammary Tissue (Male)	NUDT6	0.29	0.00	lasso	6	0.00	3.5e-01	5.56	5.7	1.2e-08	0.04	0.04	0.42	TRUE
14	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	0.68	5.6	1.8e-08	-0.07	0.04	0.58	TRUE
19	GTEx	Skin Sun Exposed Lower leg	NUDT6	0.11	0.08	lasso	3	0.08	6.2e-07	5.56	5.6	1.9e-08	0.03	0.94	0.02	TRUE
11	GTEx	Breast Mammary Tissue (Female)	NUDT6	0.30	-0.01	enet	30	0.00	2.6e-01	5.95	5.4	5.4e-08	-0.03	0.03	0.33	TRUE
18	GTEx	Skin Not Sun Exposed Suprapubic	NUDT6	0.07	0.02	lasso	6	0.03	1.5e-02	4.38	5.3	9.1e-08	0.04	0.19	0.60	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	enet	9	0.03	2.0e-04	5.73	5.3	1.2e-07	0.03	0.62	0.16	TRUE
34	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC9	0.04	0.05	lasso	2	0.04	7.1e-05	7.25	8.1	6.8e-16	-0.78	0.02	0.97	FALSE
13	GTEx	Cells Transformed fibroblasts	BBS7	0.16	0.09	lasso	7	0.16	2.9e-12	-7.55	-8.0	9.2e-16	0.91	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC9	0.03	0.04	enet	9	0.04	2.8e-08	7.25	8.0	1.6e-15	-0.70	0.05	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BBS7	0.19	0.21	bslmm	423	0.23	1.8e-27	-7.45	-7.8	5.2e-15	0.93	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EXOSC9	0.03	0.02	lasso	2	0.02	1.0e-03	7.02	7.6	3.4e-14	-0.66	0.05	0.58	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	EXOSC9	0.29	0.17	lasso	7	0.16	6.6e-06	6.91	7.5	4.3e-14	-0.68	0.13	0.85	FALSE
20	GTEx	Testis	EXOSC9	0.17	0.07	lasso	8	0.10	2.5e-05	-5.68	7.5	4.6e-14	-0.87	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BBS7	0.04	0.04	lasso	2	0.03	6.1e-04	-7.45	-7.5	9.0e-14	1.00	0.00	0.99	FALSE
23	YFS	Blood	EXOSC9	0.06	0.09	bslmm	401	0.09	7.0e-28	6.91	7.4	1.5e-13	-0.63	0.18	0.82	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	BBS7	0.05	0.00	blup	47	0.02	1.9e-02	7.29	-7.3	3.5e-13	0.56	0.02	0.29	FALSE
8	GTEx	Brain Cerebellum	BBS7	0.20	-0.01	enet	24	0.01	2.2e-01	-5.60	-6.0	2.3e-09	0.73	0.07	0.72	FALSE
15	GTEx	Muscle Skeletal	NUDT6	0.15	0.12	lasso	3	0.11	1.1e-10	5.80	5.8	4.9e-09	0.03	0.98	0.02	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	EXOSC9	0.05	0.02	lasso	7	0.02	5.3e-04	5.06	5.8	5.4e-09	-0.54	0.16	0.74	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	lasso	3	0.02	6.5e-04	5.80	5.8	6.2e-09	0.02	0.72	0.04	FALSE
6	GTEx	Artery Tibial	NUDT6	0.08	0.08	lasso	5	0.05	5.6e-05	5.66	5.8	8.2e-09	0.02	0.65	0.08	FALSE
16	GTEx	Muscle Skeletal	RP11-170N16.3	0.07	0.07	lasso	3	0.06	8.8e-07	4.99	5.7	1.0e-08	0.04	0.23	0.76	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUDT6	0.02	0.02	lasso	4	0.01	5.4e-03	5.65	5.7	1.6e-08	0.04	0.13	0.14	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMEM155	0.06	0.05	lasso	3	0.02	5.5e-04	-6.04	-5.5	3.5e-08	0.68	0.14	0.80	FALSE
26	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCNA2	0.11	-0.01	enet	14	0.02	4.4e-02	0.50	5.5	4.0e-08	-0.56	0.00	0.26	FALSE
17	GTEx	Nerve Tibial	NUDT6	0.11	0.08	lasso	3	0.05	2.1e-04	5.42	5.4	6.0e-08	0.02	0.80	0.02	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BBS7	0.04	0.02	blup	47	0.03	1.3e-04	-5.66	-5.4	6.1e-08	0.91	0.06	0.90	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDT6	0.10	0.07	lasso	6	0.07	1.0e-07	5.66	5.3	8.6e-08	0.02	0.96	0.04	FALSE
7	GTEx	Brain Cerebellar Hemisphere	BBS7	0.27	0.05	lasso	3	0.08	4.7e-03	-5.66	-5.3	8.7e-08	0.61	0.08	0.32	FALSE
4	GTEx	Adipose Subcutaneous	EXOSC9	0.07	0.00	lasso	2	0.00	4.5e-01	-5.68	5.3	1.1e-07	-0.83	0.05	0.31	FALSE