Best TWAS P=2.81e-09 · Best GWAS P=7.21e-09 conditioned to 0.455
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | TRIM4 | 0.40 | 0.39 | lasso | 5 | 0.40 | 4.5e-22 | -5.0 | 5.4 | 8.3e-08 | 0.75 | 0.12 | 0.88 | FALSE |
2 | GTEx | Adrenal Gland | TRIM4 | 0.51 | 0.37 | lasso | 7 | 0.48 | 1.6e-19 | -5.0 | 5.2 | 2.2e-07 | 0.77 | 0.14 | 0.86 | FALSE |
3 | GTEx | Adrenal Gland | STAG3L5P-PVRIG2P-PILRB | 0.32 | 0.25 | enet | 43 | 0.20 | 7.0e-08 | -3.5 | -5.2 | 1.7e-07 | -0.39 | 0.94 | 0.03 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | TRIM4 | 0.14 | 0.11 | lasso | 7 | 0.06 | 1.1e-02 | -5.0 | 5.3 | 1.2e-07 | 0.75 | 0.06 | 0.58 | FALSE |
5 | GTEx | Breast Mammary Tissue | TRIM4 | 0.35 | 0.35 | enet | 22 | 0.37 | 6.1e-20 | -5.0 | 5.2 | 2.2e-07 | 0.77 | 0.12 | 0.88 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | TRIM4 | 0.49 | 0.47 | lasso | 7 | 0.47 | 4.3e-17 | -5.0 | 5.2 | 2.2e-07 | 0.76 | 0.12 | 0.88 | FALSE |
7 | GTEx | Cells EBV-transformed lymphocytes | LAMTOR4 | 0.40 | 0.19 | enet | 39 | 0.21 | 2.2e-07 | -3.9 | 5.5 | 4.7e-08 | 0.29 | 0.50 | 0.11 | TRUE |
8 | GTEx | Cells Transformed fibroblasts | ZKSCAN1 | 0.23 | 0.18 | lasso | 5 | 0.19 | 4.9e-14 | -5.4 | 5.3 | 1.1e-07 | 0.46 | 0.01 | 0.99 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | TRIM4 | 0.35 | 0.24 | lasso | 10 | 0.23 | 7.6e-09 | -4.8 | 5.3 | 1.5e-07 | 0.76 | 0.12 | 0.88 | FALSE |
10 | GTEx | Esophagus Muscularis | TRIM4 | 0.30 | 0.30 | lasso | 9 | 0.29 | 6.8e-18 | -5.0 | 5.2 | 2.2e-07 | 0.74 | 0.11 | 0.88 | FALSE |
11 | GTEx | Lung | TRIM4 | 0.35 | 0.35 | lasso | 3 | 0.35 | 5.4e-28 | -5.0 | 5.1 | 3.0e-07 | 0.76 | 0.12 | 0.88 | FALSE |
12 | GTEx | Ovary | TRIM4 | 0.20 | 0.04 | enet | 11 | 0.07 | 1.1e-02 | 4.8 | 5.2 | 1.9e-07 | 0.82 | 0.06 | 0.76 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | TRIM4 | 0.18 | 0.09 | enet | 17 | 0.13 | 1.8e-07 | -5.0 | 5.7 | 1.5e-08 | 0.81 | 0.07 | 0.93 | TRUE |
14 | GTEx | Skin Sun Exposed Lower leg | TRIM4 | 0.39 | 0.26 | lasso | 11 | 0.25 | 5.5e-21 | -5.0 | 5.4 | 7.8e-08 | 0.78 | 0.10 | 0.90 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | ZNF3 | 0.05 | 0.01 | lasso | 4 | 0.01 | 7.9e-02 | 5.2 | 5.2 | 2.0e-07 | 0.77 | 0.05 | 0.77 | FALSE |
16 | GTEx | Stomach | TRIM4 | 0.34 | 0.27 | enet | 35 | 0.28 | 6.1e-14 | -5.0 | 5.6 | 1.8e-08 | 0.75 | 0.12 | 0.88 | FALSE |
17 | GTEx | Testis | PILRB | 0.23 | 0.13 | enet | 31 | 0.12 | 5.4e-06 | -3.4 | -5.3 | 1.4e-07 | -0.32 | 0.86 | 0.07 | FALSE |
18 | GTEx | Testis | TRIM4 | 0.42 | 0.35 | lasso | 17 | 0.36 | 8.6e-17 | -5.0 | 5.3 | 1.3e-07 | 0.80 | 0.10 | 0.89 | FALSE |
19 | GTEx | Vagina | TRIM4 | 0.32 | 0.19 | lasso | 7 | 0.27 | 6.0e-07 | -5.0 | 5.5 | 4.9e-08 | 0.70 | 0.11 | 0.74 | FALSE |
20 | GTEx | Whole Blood | TRIM4 | 0.12 | 0.05 | lasso | 5 | 0.06 | 5.9e-06 | -4.8 | 5.6 | 2.8e-08 | 0.78 | 0.06 | 0.93 | FALSE |
21 | METSIM | Adipose | TRIM4 | 0.17 | 0.22 | lasso | 13 | 0.22 | 3.9e-32 | -4.8 | 5.2 | 2.3e-07 | 0.76 | 0.14 | 0.86 | FALSE |
22 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM4 | 0.08 | 0.18 | lasso | 6 | 0.16 | 8.3e-14 | -4.8 | 5.1 | 2.8e-07 | 0.78 | 0.06 | 0.94 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRIM4 | 0.09 | 0.15 | lasso | 7 | 0.15 | 6.3e-30 | -5.0 | 5.2 | 1.7e-07 | 0.77 | 0.06 | 0.94 | FALSE |
24 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TRIM4 | 0.12 | 0.10 | blup | 52 | 0.09 | 3.7e-05 | -4.8 | 5.1 | 3.0e-07 | 0.79 | 0.02 | 0.98 | FALSE |
25 | The Cancer Genome Atlas | Colon Adenocarcinoma | TRIM4 | 0.22 | 0.28 | lasso | 10 | 0.29 | 5.5e-17 | -5.3 | 5.3 | 1.3e-07 | 0.77 | 0.02 | 0.98 | FALSE |
26 | The Cancer Genome Atlas | Glioblastoma Multiforme | TRIM4 | 0.23 | 0.13 | blup | 52 | 0.20 | 1.4e-06 | -5.0 | 5.4 | 8.6e-08 | 0.77 | 0.03 | 0.96 | FALSE |
27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AP1S1 | 0.16 | 0.05 | lasso | 3 | 0.09 | 7.7e-10 | -4.3 | -5.2 | 2.0e-07 | -0.18 | 0.00 | 0.90 | FALSE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | VGF | 0.09 | 0.03 | enet | 13 | 0.04 | 7.1e-05 | -4.3 | -5.9 | 2.8e-09 | -0.19 | 0.00 | 0.27 | TRUE |
29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TRIM4 | 0.12 | 0.16 | blup | 52 | 0.20 | 2.0e-11 | -4.8 | 5.3 | 1.4e-07 | 0.79 | 0.06 | 0.94 | FALSE |
30 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TRIM4 | 0.12 | 0.14 | blup | 52 | 0.16 | 7.2e-08 | 5.2 | 5.6 | 2.8e-08 | 0.82 | 0.06 | 0.94 | FALSE |
31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TRIM4 | 0.09 | 0.20 | lasso | 4 | 0.19 | 1.7e-21 | -5.0 | 5.2 | 1.8e-07 | 0.76 | 0.06 | 0.94 | FALSE |
32 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TRIM4 | 0.05 | 0.04 | blup | 52 | 0.03 | 2.5e-03 | -5.0 | 5.3 | 1.3e-07 | 0.78 | 0.05 | 0.84 | FALSE |
33 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | OR2AE1 | 0.18 | 0.12 | lasso | 4 | 0.11 | 2.7e-05 | -5.0 | -5.2 | 2.0e-07 | -0.78 | 0.02 | 0.97 | FALSE |
34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GJC3 | 0.03 | 0.05 | lasso | 6 | 0.05 | 1.5e-05 | -5.3 | -5.4 | 8.7e-08 | -0.77 | 0.03 | 0.96 | FALSE |
35 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | TRIM4 | 0.16 | 0.04 | enet | 12 | 0.02 | 9.1e-02 | 5.2 | 5.2 | 1.6e-07 | 0.79 | 0.03 | 0.48 | FALSE |
36 | The Cancer Genome Atlas | Stomach Adenocarcinoma | OR2AE1 | 0.05 | 0.04 | enet | 10 | 0.05 | 1.9e-04 | -5.0 | -5.3 | 1.4e-07 | -0.67 | 0.02 | 0.85 | FALSE |
37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TRIM4 | 0.12 | 0.06 | blup | 52 | 0.09 | 5.6e-07 | -5.3 | 5.3 | 1.1e-07 | 0.77 | 0.01 | 0.99 | FALSE |
38 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM4 | 0.16 | 0.30 | lasso | 9 | 0.30 | 9.9e-30 | -5.0 | 5.2 | 1.9e-07 | 0.77 | 0.06 | 0.94 | FALSE |