Hub : Genes

ZDHHC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pituitary	0.2290	0.1020	4.2e-03	0.128	NA	-0.002	NA	0.084	4.2e-04	NA	3.7e-01	NA	4.0e-03
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1030	0.0550	5.1e-03	0.001	NA	-0.005	NA	-0.003	2.6e-01	NA	8.6e-01	NA	5.1e-01
3	GTEx	Thyroid	0.0740	0.0440	4.7e-03	0.030	NA	0.006	NA	0.017	2.2e-03	NA	1.1e-01	NA	1.6e-02
4	YFS	Blood	0.0506	0.0189	6.6e-14	0.047	0.050	0.052	0.051	0.051	4.2e-15	5.3e-16	1.8e-16	2.3e-16	3.1e-16
5	TCGA	Breast Invasive Carcinoma	0.0180	0.0158	7.5e-03	0.014	0.006	0.004	NA	0.010	6.0e-04	1.8e-02	3.5e-02	NA	2.4e-03
6	TCGA	Thyroid Carcinoma	0.0710	0.0410	1.6e-06	0.062	0.068	0.069	NA	0.059	1.2e-06	3.7e-07	2.8e-07	NA	2.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.6	4.2	6.6	0.0	-1.5	2.4	2.6	-2.3	2.3
Bipolar Disorder or Schizophrenia	3.7	9.1	13.7	0.0	-2.2	3.5	3.5	-3.4	3.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.8	1.1	-0.5	0.0	0.6	-0.4
Depression (Nagel 2018)	0.4	0.6	0.8	-0.8	0.4	-0.8	-0.7	0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.1	-0.5	-0.4	-0.7	0.2	-0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.2	0.4	0.0	0.2	0.1	0.3
Schizophrenia (2018)	2.4	5.0	8.1	0.0	-1.6	2.6	2.5	-2.5	2.8
Schizophrenia vs Biploar Disorder	0.2	0.2	1.1	0.0	1.0	-0.3	0.2	0.5	-0.0
Worry (Nagel 2018)	0.4	0.9	1.3	0.9	-1.1	0.9	0.6	-0.9	1.1
Alzheimer’s Disease (in mother)	1.4	1.7	3.9	-1.5	0.8	-1.1	-2.0	1.1	-0.9
Alzheimer’s Disease (in father)	3.8	4.2	6.1	1.3	-1.3	2.5	2.1	-2.4	2.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.5	-0.0	0.4	-0.7	-0.3	0.3
Crohns Disease (2017)	0.0	0.1	0.5	0.7	0.0	-0.3	-0.0	0.1	-0.2
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.1	0.0	0.1
Ulcerative Colitis (UC)	0.1	0.3	0.8	-0.9	-0.0	0.4	0.5	-0.4	0.6
Major Depression (MDD)	0.6	0.8	2.9	1.7	-0.4	0.7	0.4	-0.7	0.7
Reaction Time	1.0	1.9	3.6	-0.5	1.0	-1.5	-1.9	1.5	-1.5
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.5	0.3	-0.7	-0.0	-0.5	-0.1	0.3
Breast Cancer	0.7	1.6	3.0	-1.3	0.8	-1.2	-1.2	1.2	-1.7
Ovarian Cancer	4.1	5.4	9.0	-2.6	1.4	-2.2	-3.0	2.1	-2.4
Prostate Cancer	1.9	2.7	5.1	-1.0	0.8	-1.7	-2.3	1.6	-2.0
Age at First Birth	0.2	0.3	1.3	0.0	-1.1	-0.0	0.7	-0.1	0.3
Bipolar Disorder (2011)	3.8	3.7	12.0	0.0	0.0	0.0	0.0	-3.2	3.5
Body Mass Index (BMI) (2010)	2.4	3.3	4.4	0.0	-1.6	2.0	2.1	-2.1	2.0
Coronary Artery Disease (CAD)	1.6	1.9	2.7	0.0	1.6	-1.5	-1.4	1.5	-1.4
Crohns Disease (2012)	0.2	0.3	0.5	0.0	0.3	-0.7	-0.4	0.6	-0.7
Mean Putamen Volume	1.4	1.6	2.4	0.0	-1.5	1.5	0.7	-1.6	1.4
Fasting Glucose	2.1	2.5	3.8	0.0	1.1	-1.9	-1.8	1.8	-2.0
HbA1C	0.1	0.2	0.3	0.0	-0.5	0.4	0.4	-0.5	0.4
HDL Cholesterol	0.9	1.5	4.0	0.0	0.5	1.5	2.0	-1.1	0.9
LDL Cholesterol	0.2	0.3	0.5	0.0	-0.7	0.6	0.1	-0.6	0.6
Lupus	0.0	0.0	0.1	0.2	0.0	-0.1	-0.3	0.1	-0.0
Neuroticism (2016)	0.1	0.1	0.6	0.8	0.2	-0.1	0.0	0.2	0.4
Primary Biliary Cirrhosis	0.4	0.5	0.8	0.0	0.8	-0.9	-0.7	0.9	-0.6
Rheumatoid Arthritis	0.3	0.4	0.6	0.0	-0.2	0.8	0.5	-0.8	0.8
Schizophrenia (2014)	1.5	3.4	5.7	0.0	-0.9	2.2	2.2	-2.1	2.4
Triglycerides	0.0	0.0	0.1	0.0	0.1	-0.1	0.3	-0.0	0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.0	0.0	-1.7	0.9	1.3	-1.0	1.1
Ulcerative Colitis	0.1	0.2	1.0	0.0	1.0	0.0	-0.2	-0.0	-0.0
Blood Eosinophil Count	1.7	12.8	17.1	-4.1	4.1	-3.3	-3.3	3.6	-2.9
Blood Platelet Count	0.8	9.5	10.8	-3.2	2.7	-3.1	-2.8	3.3	-3.3
Blood Red Count	5.4	51.9	59.0	6.1	-6.8	7.7	7.6	-7.4	7.5
Blood White Count	1.6	11.5	12.7	-3.5	3.2	-3.4	-3.6	3.4	-3.4
Heel T-Score	3.4	27.2	62.7	4.9	-3.8	4.9	7.9	-5.0	3.6
BMI	0.9	5.3	10.0	3.2	-0.0	2.4	2.4	-2.4	2.3
Height	4.1	79.3	106.1	-7.3	9.0	-9.7	-6.8	9.8	-10.3
Waist Hip Ratio (WHR)	8.5	38.2	45.6	-6.2	4.5	-6.4	-6.8	6.4	-6.6
Systolic Blood Pressure	0.0	0.2	0.5	0.6	-0.3	-0.1	0.7	0.1	0.2
Smoking Status	0.1	0.3	0.8	-0.0	0.9	-0.5	-0.2	0.6	-0.5
Allergy or Eczema	0.0	0.1	0.2	-0.5	-0.2	-0.5	-0.0	0.4	-0.1
Cardiovascular Disease	0.4	1.3	2.9	-0.5	1.7	-1.1	-1.2	1.2	-0.8
Hypothyroidism (self reported)	14.2	32.6	38.5	5.2	-4.6	6.0	6.2	-5.9	6.1
Respiratory disease	0.0	0.1	0.2	0.5	-0.2	0.2	0.2	-0.3	0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.4	-1.7	0.6	-0.7	-1.9	0.7	-1.1
Lung FEV1/FVC ratio	8.4	42.9	55.4	7.4	-2.4	6.9	7.4	-6.5	7.2
Lung FVC	0.2	1.1	3.4	0.5	-1.1	-1.0	-1.9	0.7	-0.6
Neuroticism	0.1	0.1	0.5	0.2	0.2	0.3	0.4	-0.1	0.7
Chronotype (morning person)	2.3	5.3	12.0	-1.4	3.5	-2.4	-1.2	2.3	-2.3
Hair Pigment	0.4	11.0	12.8	3.5	-2.5	3.5	3.6	-3.4	3.3
Tanning	0.1	0.9	2.7	-1.3	1.6	-0.3	0.3	0.3	-0.6
Hand grip strength (left)	0.3	0.7	1.4	0.1	-0.2	0.9	1.2	-0.9	0.9
Number of treatments/medications taken	0.4	0.6	2.1	-0.8	1.4	-0.6	-0.6	0.7	-0.2
Average weekly spirits intake	1.7	2.1	3.5	-1.8	1.0	-1.3	-1.2	1.3	-1.9
Sensitivity / hurt feelings	0.6	1.0	1.8	-1.0	1.3	-0.9	-1.0	0.9	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.1	-0.6	0.6	0.6	-0.6	0.6
Hearing difficulty/problems: Yes	1.0	1.6	2.6	0.7	-1.4	1.5	0.4	-1.6	1.3
Relative age of first facial hair	0.1	0.1	0.2	-0.1	-0.5	-0.4	-0.1	0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.2	0.2	-0.5	-1.0	0.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.8	0.4	-0.7	-0.1	0.7	-0.8
Ever had hysterectomy (womb removed)	1.1	1.3	2.1	0.1	1.4	-1.4	-0.6	1.4	-1.1
Systolic blood pressure, automated reading	0.0	0.1	0.3	0.4	-0.4	0.2	0.2	-0.2	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.5	0.0	-0.3	-0.6	0.4	-0.5
Angina	0.0	0.0	0.1	0.2	0.3	0.1	0.1	-0.1	0.0
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	0.1	-0.7	-0.4	0.7	-0.6
Vitamin and mineral supplements	0.1	0.2	0.5	0.2	0.5	-0.3	-0.7	0.2	-0.3
Supplements: Zinc	0.9	1.0	3.1	0.4	-0.6	0.9	1.8	-0.9	1.0
Medication: Co-codamol	0.6	0.7	2.0	1.4	-0.2	0.8	0.6	-0.8	0.5
Medication: Metformin	0.2	0.3	0.5	0.3	-0.3	0.7	0.4	-0.7	0.5
Diabetes (father)	0.4	0.5	1.4	-0.9	-1.2	0.2	0.4	-0.2	0.7
Diabetes (mother)	0.3	0.3	1.0	-0.8	1.0	-0.2	-0.2	0.3	-0.4
Severe depression (siblings)	0.5	0.5	2.2	-0.0	1.5	-0.6	0.1	0.7	-0.4
Pack years adult smoking proportion	2.5	3.8	4.9	-1.7	1.6	-2.1	-2.0	2.0	-2.2
Impedance of leg (right)	5.6	26.9	30.6	-5.3	3.9	-5.4	-5.4	5.5	-5.3
Leg fat-free mass (left)	0.2	0.9	3.2	0.9	1.8	-0.5	0.5	0.5	-1.0
Trunk fat percentage	1.2	4.6	9.2	-2.1	3.0	-1.8	-1.8	1.9	-2.0
Hand grip strength (right)	0.4	1.0	2.1	0.4	-0.6	1.1	1.5	-1.1	0.8
Townsend deprivation index at recruitment	0.1	0.1	0.5	0.7	-0.0	0.1	-0.2	-0.1	-0.1
Current tobacco smoking	4.5	7.4	11.1	-2.5	3.3	-2.8	-2.0	2.9	-2.6
Average weekly fortified wine intake	0.2	0.2	1.0	1.0	0.2	-0.3	-0.3	0.3	-0.4
Maternal smoking around birth	1.0	1.5	1.9	-1.4	1.2	-1.1	-1.2	1.1	-1.3
Fed-up feelings	0.1	0.1	0.3	0.1	0.4	0.4	-0.0	-0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.2	-0.5	0.1	-0.4	-0.1	-0.0
Relative age voice broke	0.6	0.9	2.9	0.9	-0.7	0.6	1.7	-0.7	0.7
Taking other prescription medications	0.2	0.3	1.6	1.3	0.6	-0.0	-0.2	0.0	-0.1
Age when periods started (menarche)	0.1	0.3	1.7	1.3	-0.0	-0.1	0.3	0.1	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.6	0.7	-1.0	1.1	0.7	-1.0	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	10.3	0.9	-1.1	1.8	3.2	-1.8	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	3.0	0.0	-1.7	0.2	0.8	-0.2	0.5
Qualifications: CSEs or equivalent	8.2	10.8	14.6	2.4	-2.6	3.6	3.8	-3.5	3.5
Serious illness, injury or assault to yourself	5.3	6.4	8.8	-2.6	1.4	-2.9	-2.1	2.8	-3.0
High blood pressure	0.2	0.6	2.3	-0.8	0.2	-0.5	-1.5	0.6	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.7	-0.7	0.4	0.9	-0.4	0.7
Multivitamins +/- minerals	0.4	0.5	1.8	0.1	-0.4	0.7	1.3	-0.6	0.6
Stomach or abdominal pain in last month	0.5	0.7	1.2	-0.6	-0.6	0.9	0.7	-0.9	1.1
Supplements: Glucosamine	0.9	1.2	3.2	-1.8	0.3	-1.2	0.1	1.1	-1.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	0.2	-0.2	-0.5	0.2	-0.2
Medication: Atenolol	0.2	0.3	0.5	-0.7	0.6	-0.6	-0.6	0.6	-0.0
Medication: Levothyroxine sodium	9.7	16.4	20.1	3.8	-2.7	4.4	4.5	-4.3	4.4
Sitting height	0.5	3.8	8.4	-0.2	1.4	-2.5	-0.2	2.5	-2.9
Chronic bronchitis/emphysema (father)	0.3	0.3	1.5	-1.2	-0.2	-0.5	-0.1	0.5	-0.2
High blood pressure (mother)	1.1	1.6	3.1	0.7	-1.1	1.4	0.7	-1.5	1.8
Body mass index (BMI)	0.4	1.9	2.5	1.5	0.1	1.6	1.4	-1.6	1.4
Impedance of leg (left)	5.6	27.0	30.8	-5.5	4.0	-5.5	-5.2	5.5	-5.3
Leg predicted mass (left)	0.2	1.0	3.3	0.7	1.8	-0.6	0.4	0.5	-1.0
Trunk fat mass	1.7	7.1	14.6	-2.1	3.8	-2.4	-2.0	2.5	-2.7
Waist circumference	2.6	9.6	12.6	-2.3	3.5	-3.2	-3.0	3.2	-3.3
Number of incorrect matches in round	2.3	3.8	4.8	-2.1	1.6	-1.9	-2.2	2.0	-1.8
Past tobacco smoking	0.4	0.7	1.5	-1.2	0.7	-0.4	-1.2	0.4	-0.6
Alcohol usually taken with meals	4.1	6.6	9.1	2.3	-1.9	2.7	2.8	-2.6	3.0
Nervous feelings	2.4	4.5	7.4	1.5	-2.7	2.1	1.4	-2.2	2.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.6	-0.4	0.1	0.1	0.0	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.3	-0.5	0.4	-0.6	-0.5	0.3
Hair/balding pattern: Pattern 2	0.2	0.2	1.2	0.0	-0.1	-0.0	1.1	-0.0	-0.3
Had menopause	0.9	1.1	1.7	-0.7	1.3	-1.3	-0.9	1.3	-0.7
Had other major operations	0.5	0.6	0.9	0.7	-0.1	1.0	0.5	-0.9	0.9
Forced vital capacity (FVC)	2.0	7.9	11.5	-1.5	2.0	-3.2	-3.4	3.1	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	9.2	0.9	-1.4	1.7	3.0	-1.7	0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.8	0.1	-0.4	-0.5	0.4	-0.6
Qualifications: None of the above	0.8	1.8	6.0	-2.4	0.8	-0.9	-1.4	0.9	-0.8
Financial difficulties in last 2 years	3.1	4.1	6.9	-1.7	2.6	-2.0	-1.9	2.1	-1.7
Mouth/teeth dental problems	0.3	0.4	1.4	-1.2	-0.9	-0.1	-0.3	0.1	0.4
Heart attack	0.2	0.2	0.7	0.4	-0.2	0.3	0.8	-0.2	0.5
Allergy	0.3	0.7	1.0	-0.9	0.9	-0.7	-0.7	0.7	-1.0
Pain all over the body in last month	0.2	0.3	1.0	0.2	1.0	-0.3	-0.6	0.3	-0.0
Diabetes (self-reported)	0.5	0.8	2.7	-0.8	0.5	-0.6	-1.6	0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.7	-1.4	1.0	-1.5	-1.0	1.5	-1.6
Medication: Ramipril	0.1	0.2	0.4	-0.1	0.4	-0.3	-0.6	0.3	-0.4
Medication: Simvastatin	0.3	0.4	1.2	-1.1	0.7	-0.5	-0.3	0.5	-0.4
Fluid intelligence score	0.4	0.9	1.2	-1.1	0.2	-1.1	-1.1	0.9	-0.9
Illnesses of siblings	1.0	1.4	2.7	0.8	-0.4	1.4	1.7	-1.3	1.0
Neuroticism score	0.2	0.3	0.8	-0.1	-0.0	0.7	0.5	-0.6	0.9
Weight	0.9	4.6	11.2	-1.0	3.3	-2.0	-1.2	2.0	-2.4
Impedance of arm (right)	2.2	10.3	17.3	-4.2	1.8	-3.0	-3.8	3.1	-2.9
Arm fat percentage (right)	0.1	0.3	1.8	0.0	1.3	0.3	-0.3	-0.2	0.1
Trunk fat-free mass	0.9	5.2	11.6	0.2	3.4	-2.4	-0.7	2.3	-2.9
Hip circumference	0.1	0.6	2.4	0.6	1.6	-0.5	0.0	0.5	-0.6
Time employed in main current job	3.2	3.6	4.3	1.8	-2.1	2.0	2.0	-2.0	1.6
Alcohol intake versus 10 years previously	5.4	8.1	9.4	-2.5	2.4	-3.0	-3.1	3.0	-3.0
Father’s age at death	1.2	1.6	2.2	1.1	-1.4	1.2	1.1	-1.2	1.5
Worrier / anxious feelings	0.0	0.1	0.2	0.5	0.1	0.0	-0.5	-0.0	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.2	-1.1	0.5	-0.7	-0.8	0.7	-0.6
Falls in the last year	2.4	3.3	5.8	-1.6	-0.0	-2.0	-2.0	1.9	-2.4
Hair/balding pattern: Pattern 3	2.8	4.1	5.2	2.3	-1.8	2.0	1.9	-2.0	2.2
Number of live births	0.4	0.6	1.0	-0.5	0.8	0.7	1.0	-0.6	0.9
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	0.9	0.3	-0.2	-0.3	0.2	-0.1
Pulse rate	1.4	2.4	4.1	-1.9	0.4	-1.4	-2.0	1.4	-1.7
Happiness	4.6	5.6	7.8	-1.9	2.1	-2.6	-2.0	2.6	-2.8
Noisy workplace	0.2	0.2	0.4	-0.0	-0.6	-0.6	-0.1	0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.6	-0.4	0.2	-1.4	-1.4	1.3	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.4	-1.5	1.0	-1.0	-0.7	0.9	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	1.7	-1.3	-0.0	0.1	-0.5	-0.1	-0.5
Asthma	0.2	0.5	0.9	0.9	-0.9	0.6	0.6	-0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	-0.8	0.5	0.1	0.0	-0.1	-0.1
Medication: Cholesterol lowering	0.5	0.7	1.3	0.6	-1.0	0.8	0.7	-0.8	1.1
Depression (self-reported)	0.1	0.1	0.5	-0.2	0.7	-0.2	-0.2	0.2	-0.3
Medication: Lansoprazole	0.5	0.5	1.2	-0.4	1.1	-0.8	-0.5	0.9	-0.4
Prospective memory result	0.3	0.4	1.9	0.2	1.4	0.0	0.6	0.1	0.1
Lung cancer (father)	0.0	0.0	0.1	0.0	0.4	-0.2	-0.2	0.2	0.0
Illnesses of mother	0.2	0.2	0.7	0.8	-0.0	0.2	0.8	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.0	1.0	0.4	0.0	-0.3	-0.1	-0.0
Pulse wave Arterial Stiffness index	1.3	1.5	4.6	1.1	2.1	-0.7	-1.2	0.8	-0.8
Impedance of arm (left)	1.8	8.4	16.2	-4.0	1.4	-2.6	-3.5	2.7	-2.5
Arm fat mass (right)	0.3	1.2	5.1	-0.4	2.3	-0.7	-0.5	0.7	-0.9
Trunk predicted mass	0.9	5.3	11.7	0.2	3.4	-2.4	-0.8	2.3	-3.0
Standing height	5.2	51.7	70.2	-5.4	7.4	-7.9	-5.6	7.9	-8.4
Length of working week for main job	0.9	1.0	2.5	-0.2	1.3	-0.7	-1.6	0.8	-0.8
Exposure to tobacco smoke at home	0.2	0.3	1.0	-0.3	1.0	-0.2	-0.5	0.2	-0.4
Breastfed as a baby	1.7	2.2	4.7	1.1	-1.6	1.5	0.8	-1.4	2.2
Tense / ‘highly strung’	0.1	0.2	0.5	-0.5	-0.7	0.3	0.1	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.4	0.3	-0.4	-0.5	0.4	-0.6
Hair/balding pattern: Pattern 4	20.0	48.4	60.3	-5.7	5.8	-7.8	-7.5	7.7	-7.0
Birth weight of first child	1.0	1.9	2.6	1.2	-1.1	1.6	1.5	-1.6	1.0
Peak expiratory flow (PEF)	1.2	2.9	7.0	2.6	-1.2	1.4	1.3	-1.4	1.8
Pulse wave reflection index	0.9	1.1	4.4	2.1	0.9	0.5	0.8	-0.5	0.5
Ever highly irritable/argumentative for 2 days	6.8	8.2	10.4	-2.9	2.8	-2.7	-3.2	2.8	-2.7
Loud music exposure frequency	0.1	0.2	0.6	0.5	0.8	-0.0	-0.3	-0.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	1.0	-0.6	0.3	0.8	-0.4	0.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.1	0.0	2.3	-1.2	-0.3	1.3	-1.1
Blood clot in the leg (DVT)	0.4	0.5	1.3	0.5	-0.1	0.9	0.5	-0.8	1.1
Medication: Paracetamol	4.1	6.8	9.0	-1.9	3.0	-2.6	-2.6	2.6	-2.8
Headache pain in last month	0.9	1.5	3.5	-0.9	1.9	-1.1	-1.3	1.2	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.8	0.1	-0.5	0.0	0.5	-0.6
Glaucoma (self-reported)	0.9	1.1	1.5	-1.1	0.2	-1.2	-1.2	1.2	-0.9
Gout (self-reported)	1.2	1.6	3.2	0.8	-1.8	1.3	0.9	-1.2	1.4
Hypothyroidism/myxoedema (self-reported)	11.0	21.5	25.3	4.1	-3.7	5.0	4.9	-4.9	5.0
Medication: Amlodipine	2.1	3.0	6.7	2.6	-2.0	1.5	-0.2	-1.6	1.6
Medication: Ventolin 100micrograms inhaler	1.6	2.0	2.6	1.2	-1.1	1.6	1.5	-1.6	1.4
Birth weight	1.4	3.1	5.3	-1.8	0.9	-1.7	-1.9	1.7	-2.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	2.8	1.0	-0.8	1.7	1.1	-1.6	1.7
High blood pressure (siblings)	0.1	0.2	0.6	0.2	-0.7	-0.2	-0.8	0.2	0.1
Forced vital capacity (FVC), Best measure	1.2	4.3	6.9	-1.1	1.4	-2.4	-2.6	2.2	-2.2
Body fat percentage	0.9	3.7	8.8	-1.8	3.0	-1.6	-1.6	1.6	-1.7
Leg fat percentage (right)	1.0	3.6	8.0	-1.5	2.8	-1.6	-1.7	1.7	-1.6
Arm fat-free mass (right)	0.7	3.6	9.5	0.3	3.1	-1.8	-0.2	1.8	-2.3
Exposure to tobacco smoke outside home	0.9	1.2	1.8	-0.6	1.3	-1.1	-0.9	1.1	-1.3
Comparative body size at age 10	1.1	3.0	13.8	-1.0	3.7	-0.9	0.8	1.1	-0.9
Number of full brothers	0.1	0.2	0.9	-0.9	0.3	-0.1	-0.1	0.0	-0.1
Worry too long after embarrassment	0.1	0.2	0.6	-0.4	-0.8	0.2	0.1	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	0.1	0.6	-0.9	-0.2	0.9	-1.2
Wheeze or whistling in the chest in last year	0.5	0.8	2.1	-0.8	1.4	-0.9	-0.7	0.8	-0.5
Number of children fathered	0.2	0.3	0.8	0.4	-0.9	0.4	0.5	-0.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.5	0.8	-0.5	0.3	0.6	0.1
Age at first live birth	1.1	2.0	5.9	0.6	-2.4	1.1	1.2	-1.2	1.1
Pulse wave peak to peak time	0.7	0.8	2.8	-1.7	-1.3	-0.1	0.6	0.1	-0.0
Health satisfaction	1.6	2.1	4.2	-1.1	1.0	-1.4	-2.0	1.4	-1.4
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.5	0.8	-0.6	-1.2	0.5	-0.8
Qualifications: College or University degree	1.3	4.0	6.8	-1.2	1.4	-2.6	-1.2	2.5	-2.5
Eye problems/disorders: None of the above	0.1	0.2	0.4	-0.6	0.5	-0.3	-0.0	0.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.7	0.9	-0.7	0.3	0.8	-0.5
Emphysema/chronic bronchitis	1.2	1.4	4.4	-2.1	0.1	-0.9	-1.2	0.7	-1.1
Medication for pain relief, constipation, heartburn	2.7	4.7	5.7	2.0	-2.4	2.0	2.3	-2.1	2.1
Neck or shoulder pain in last month	0.4	0.6	1.6	0.4	0.8	0.7	1.3	-0.6	0.6
Medication: Blood pressure	0.2	0.4	2.0	0.1	-0.2	-0.2	-1.4	0.2	-0.1
Angina (self-reported)	0.1	0.2	0.4	0.6	0.2	0.4	0.5	-0.4	0.3
Migraine (self-reported)	0.4	0.5	1.5	1.2	0.6	0.6	0.5	-0.6	0.5
Medication: Ibuprofen	0.4	0.4	0.7	0.2	-0.0	0.8	0.9	-0.8	0.7
Medication: Allopurinol	0.2	0.3	0.8	0.3	-0.9	0.5	0.1	-0.5	0.6
Medication: Omeprazole	4.4	5.2	6.9	-1.4	2.6	-2.3	-2.5	2.4	-2.3
Medication: Seretide 50 evohaler	3.1	3.6	5.0	-1.8	1.3	-2.0	-2.0	1.9	-2.2
Mean time to correctly identify matches	0.4	0.9	2.2	0.4	0.9	-0.8	-1.5	0.8	-0.8
Heart disease (mother)	0.3	0.3	0.6	-0.3	0.8	-0.5	-0.8	0.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	4.3	1.9	-0.7	0.9	2.1	-0.8	0.7
Whole body fat mass	1.2	5.0	12.4	-1.6	3.5	-1.9	-1.6	2.0	-2.2
Leg fat mass (right)	1.2	4.5	11.2	-1.3	3.4	-1.9	-1.5	2.0	-2.1
Arm predicted mass (right)	0.7	3.6	9.5	0.5	3.1	-1.8	-0.0	1.8	-2.3
Pulse rate, automated reading	1.3	4.3	13.4	-1.9	-0.4	-1.6	-3.7	1.6	-1.7
Alcohol intake frequency.	0.4	0.8	1.2	1.1	-0.3	1.1	0.5	-1.0	1.0
Comparative height size at age 10	7.2	39.8	45.0	-5.2	6.6	-6.6	-5.9	6.7	-6.7
Number of full sisters	1.6	2.0	2.9	-1.7	1.3	-1.4	-1.6	1.4	-1.0
Suffer from ‘nerves’	3.3	5.3	7.0	1.7	-2.1	2.6	1.9	-2.6	2.6
Overall health rating	1.0	2.2	5.4	-1.3	0.6	-1.4	-2.3	1.3	-1.4
Chest pain or discomfort	0.2	0.3	0.9	-1.0	-0.4	0.5	-0.0	-0.5	0.3
Had major operations	0.7	0.8	1.6	-1.1	1.2	-0.7	-0.9	0.7	-0.6
Age at last live birth	0.2	0.3	1.3	-1.2	-0.8	-0.2	-0.1	0.2	0.1
Family relationship satisfaction	5.6	6.9	9.7	-1.7	2.4	-3.1	-2.1	3.1	-3.0
Leg pain on walking	2.7	3.3	5.1	-1.3	1.4	-1.9	-1.9	1.9	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.4	-0.7	2.3	-1.3	-0.6	1.3	-1.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	-0.3	-0.8	0.7	-0.0	-0.7	0.5
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	2.6	1.6	-1.5	1.3	1.0	-1.4	1.1
Medication: Aspirin	0.6	0.8	2.2	-1.5	0.3	-0.7	-1.1	0.8	-0.7
Supplements: Vitamin C	0.7	0.9	1.5	0.6	-1.2	0.7	1.0	-0.7	1.1
Knee pain experienced in last month	0.2	0.4	1.0	-0.5	1.0	0.1	1.0	-0.0	-0.1
Hypertension (Self-reported)	0.1	0.2	1.2	-0.4	-0.1	-0.2	-1.1	0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.4	-1.1	1.1	-1.4	-1.5	1.4	-1.3
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.7	-0.7	-0.3	-0.5	0.2	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.3	-0.6	0.9	-0.1	-0.9	0.9
Smoking status: Previous	3.1	4.6	5.8	2.4	-2.4	1.9	2.3	-1.9	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.5	-0.7	1.9	-1.3	-0.1	1.4	-1.7
Whole body fat-free mass	0.5	3.0	7.9	0.5	2.8	-1.6	-0.1	1.6	-2.2
Leg fat-free mass (right)	0.1	0.8	2.4	1.0	1.6	-0.3	0.8	0.2	-0.8
Arm fat percentage (left)	0.1	0.4	2.1	-0.2	1.4	0.3	-0.2	-0.2	0.1
Average weekly red wine intake	0.8	1.2	3.4	-0.8	1.8	-0.9	0.3	1.0	-1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.1	-0.6	0.6	-0.9	-1.5	0.9	-0.6
Mood swings	0.4	0.7	1.6	0.2	-0.3	0.9	1.3	-0.8	0.9
Loneliness, isolation	0.2	0.2	1.1	-0.2	1.1	-0.1	-0.1	0.2	-0.2
Long-standing illness, disability or infirmity	0.9	1.4	2.3	0.7	0.6	-1.4	-1.5	1.4	-1.3
Ever had bowel cancer screening	0.4	0.4	1.1	0.2	0.7	-0.6	-1.1	0.6	-0.3
Diabetes diagnosed by doctor	0.6	1.0	2.6	-1.2	0.6	-0.7	-1.6	0.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	1.9	-1.3	1.2	-1.4	-0.5	1.4	-1.2
Friendships satisfaction	3.6	4.5	7.4	-0.6	1.9	-2.7	-1.4	2.7	-2.5
Qualifications: nursing, teaching	1.6	2.4	4.1	1.6	-1.7	1.2	2.0	-1.2	1.5
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.6	-0.3	-0.0	0.5	0.0	0.1
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.5	-0.5	0.6	0.3	-0.6	0.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.1	2.0	-0.6	1.4	1.2	-1.4	1.0
Medication for cholesterol	1.2	1.8	2.2	1.2	-1.5	1.4	1.5	-1.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.7	5.7	-1.9	2.0	-2.2	-2.4	2.3	-2.2
Back pain experienced in last month	0.2	0.4	1.1	-0.6	1.0	-0.5	0.5	0.5	-0.1
Mineral and other dietary supplements	0.6	0.8	1.3	1.1	-1.0	0.8	-0.9	-0.8	0.8
Breast cancer (self-reported)	0.6	0.8	1.5	0.9	-1.2	0.7	0.0	-0.7	1.1
Asthma (self-reported)	0.1	0.1	0.3	0.5	-0.6	0.1	0.1	-0.1	0.0
Osteoporosis (self-reported)	1.5	1.8	6.7	-0.9	0.1	-1.0	-2.6	1.0	-1.2
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.8	-0.7	0.6	0.5	-0.5	0.6
Medication: Aspirin	0.6	0.8	2.2	-1.5	0.5	-0.7	-1.1	0.8	-0.6
Medication: Gliclazide	0.7	0.7	1.6	1.3	-0.1	0.8	1.0	-0.7	0.9
Illnesses of father: None of the above (group 1)	0.3	0.3	1.8	0.5	1.3	0.1	-0.3	-0.1	-0.1
Smoking status: Current	4.4	6.9	9.4	-2.5	3.1	-2.7	-2.1	2.8	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.7	1.3	-1.7	2.1	0.9	-2.2	1.7
Whole body water mass	0.5	2.6	7.3	0.7	2.7	-1.4	0.0	1.4	-2.0
Leg predicted mass (right)	0.2	0.8	2.5	1.0	1.6	-0.3	0.7	0.3	-0.8
Arm fat mass (left)	0.3	1.4	5.3	-0.5	2.3	-0.8	-0.6	0.8	-1.0
Number of self-reported non-cancer illnesses	0.4	0.8	2.7	-0.7	-0.3	-0.7	-1.6	0.6	-0.6
Average weekly champagne plus white wine intake	0.8	1.1	1.7	1.3	0.3	1.0	1.3	-0.9	1.2
Miserableness	0.0	0.0	0.1	0.1	0.1	-0.3	-0.0	0.4	0.0
Guilty feelings	0.7	1.0	3.3	-1.2	1.8	-0.7	-0.2	0.8	-0.6
Wears glasses or contact lenses	0.0	0.0	0.1	0.2	0.0	0.0	-0.3	-0.0	-0.1
Ever taken oral contraceptive pill	0.9	1.0	2.2	0.8	-1.0	0.9	1.5	-0.9	0.7
Hearing aid user	0.2	0.2	0.5	-0.7	0.5	-0.5	0.4	0.5	-0.3
Mother’s age at death	0.2	0.2	0.9	-0.9	0.1	-0.4	-0.4	0.4	-0.2
Financial situation satisfaction	2.4	2.9	4.0	-2.0	1.7	-1.7	-1.2	1.7	-2.0
Tinnitus: Yes, now most or all of the time	2.8	3.3	4.2	1.0	-2.0	2.0	1.5	-2.0	2.1
Commuting to job workplace: Public transport	0.8	1.0	1.8	0.1	0.7	-1.1	-1.4	1.0	-1.1
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	-0.6	-0.1	-0.8	-0.8	0.7	-0.5
Medication: Blood pressure	0.2	0.3	1.0	-0.4	0.2	-0.6	-1.0	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	1.0	-0.5	0.8	1.2	-0.7	1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.7	0.1	0.0	0.2	1.6	-0.2	0.4
High cholesterol (Self-reported)	0.1	0.1	0.4	-0.1	0.7	-0.2	-0.5	0.2	0.1
Medication: Bendroflumethiazide	2.0	3.0	5.4	-1.2	1.3	-1.8	-2.3	1.8	-1.7
Medication: Paracetamol	2.0	3.1	5.0	-1.1	2.2	-1.8	-1.6	1.8	-1.9
Medication: Lisinopril	2.2	2.8	4.9	-1.5	1.5	-1.7	-2.2	1.7	-1.3
Medication: Atorvastatin	1.0	1.3	3.0	-0.2	1.3	-1.1	-1.7	1.1	-0.7
Illnesses of father: High blood pressure	2.1	2.6	3.4	1.6	-1.6	1.7	1.2	-1.7	1.9
Alcohol drinker status: Never	0.0	0.1	0.2	0.5	0.0	-0.0	-0.3	0.1	0.2
Ever smoked	0.4	0.7	2.0	1.3	0.0	0.4	1.4	-0.3	0.5
Basal metabolic rate	0.7	3.7	9.5	0.1	3.1	-1.9	-0.5	1.8	-2.4
Leg fat percentage (left)	0.9	3.1	7.6	-1.6	2.8	-1.5	-1.4	1.5	-1.5
Arm fat-free mass (left)	0.9	4.5	10.7	0.2	3.3	-2.1	-0.6	2.1	-2.6
Number of operations (self-reported)	1.4	2.1	3.6	0.9	-0.8	1.9	1.2	-1.9	1.6
Average weekly beer plus cider intake	0.9	1.4	4.0	-2.0	0.2	-0.9	-0.6	0.9	-1.4
Irritability	0.3	0.5	1.4	0.3	-0.3	0.8	0.7	-0.7	1.2
Risk taking	2.1	3.1	4.0	-1.4	1.8	-2.0	-1.5	2.0	-1.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.6	-1.1	0.7	0.6	-0.7	0.4
Fractured/broken bones in last 5 years	2.4	3.0	4.5	-0.9	1.4	-1.9	-2.1	2.0	-1.8
Age started oral contraceptive pill	0.2	0.2	0.6	0.8	0.1	0.3	0.1	-0.3	0.6
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.5	-0.3	0.2	0.0	-0.1	0.4
Ever depressed for a whole week	0.2	0.3	0.7	-0.3	0.8	-0.5	-0.4	0.5	-0.7
Unable to work because of sickness or disability	0.6	0.7	1.7	0.6	1.3	-0.8	-0.7	0.8	-0.7
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.4	-0.3	0.0	0.9	0.0	-0.1
Myopia	3.7	5.3	10.2	3.2	-2.0	2.1	1.9	-2.0	2.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.2	0.7	-0.6	0.8	1.5	-0.8	0.2
Cholesterol lowering medication	1.3	2.0	4.3	-1.0	2.1	-1.3	-1.4	1.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	4.6	5.6	7.9	-1.5	2.8	-2.4	-2.5	2.5	-2.2
Pain experienced in last month	1.3	2.1	5.5	1.0	-2.3	1.5	0.5	-1.6	1.1
Supplements: Calcium	0.6	0.6	1.1	1.1	-0.6	0.8	0.5	-0.8	0.9
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.4	-0.2	0.3	0.8	-0.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.5	0.2	-0.0	0.2	0.7	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.8	0.2	1.0	0.6	-0.9	1.3
Heart disease (siblings)	1.0	1.2	1.8	-0.9	0.4	-1.3	-1.2	1.3	-1.2
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.0	-0.8	0.3	-0.6	-0.3	0.1
Pack years of smoking	2.4	3.5	4.6	-1.7	1.5	-2.0	-1.8	2.0	-2.1
Impedance of whole body	3.9	19.8	28.2	-5.3	2.8	-4.4	-4.9	4.5	-4.3
Leg fat mass (left)	1.0	3.9	10.7	-1.2	3.3	-1.7	-1.3	1.8	-1.9
Arm predicted mass (left)	0.9	4.5	10.4	0.1	3.2	-2.2	-0.5	2.1	-2.6