Best TWAS P=2.69e-10 · Best GWAS P=5.83e-08 conditioned to 1.17e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NT5C3B | 0.50 | 0.64 | enet | 25 | 0.66 | 1.9e-70 | -5.1 | -5.4 | 5.1e-08 | -0.07 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | FKBP10 | 0.09 | 0.03 | lasso | 5 | 0.04 | 1.6e-04 | -4.6 | -5.5 | 4.5e-08 | -0.07 | 0.06 | 0.93 | FALSE |
| 3 | GTEx | Colon Transverse | NT5C3B | 0.37 | 0.41 | lasso | 3 | 0.39 | 6.1e-20 | -5.2 | -5.2 | 2.6e-07 | -0.11 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | NT5C3B | 0.47 | 0.58 | enet | 16 | 0.62 | 3.8e-28 | -5.0 | -5.3 | 9.8e-08 | -0.11 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | FKBP10 | 0.11 | 0.08 | lasso | 2 | 0.04 | 1.2e-02 | -5.2 | -5.2 | 1.5e-07 | -0.12 | 0.04 | 0.83 | FALSE |
| 6 | GTEx | Esophagus Muscularis | FKBP10 | 0.20 | 0.13 | lasso | 5 | 0.11 | 2.1e-07 | -5.2 | -5.1 | 2.8e-07 | -0.12 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Lung | NAGLU | 0.16 | 0.06 | enet | 29 | 0.06 | 1.5e-05 | -3.4 | 5.4 | 7.3e-08 | -0.03 | 0.01 | 0.94 | TRUE |
| 8 | GTEx | Muscle Skeletal | NT5C3B | 0.35 | 0.48 | lasso | 8 | 0.48 | 5.5e-53 | -5.1 | -5.1 | 3.0e-07 | -0.10 | 0.04 | 0.96 | FALSE |
| 9 | GTEx | Muscle Skeletal | FKBP10 | 0.05 | 0.01 | lasso | 5 | 0.01 | 1.9e-02 | -4.7 | -5.5 | 3.5e-08 | -0.11 | 0.04 | 0.94 | FALSE |
| 10 | GTEx | Nerve Tibial | NT5C3B | 0.54 | 0.64 | enet | 18 | 0.66 | 7.9e-61 | -5.1 | -5.4 | 5.5e-08 | -0.10 | 0.04 | 0.96 | FALSE |
| 11 | GTEx | Nerve Tibial | FKBP10 | 0.21 | 0.24 | enet | 11 | 0.24 | 2.3e-17 | -5.0 | -5.3 | 1.0e-07 | -0.11 | 0.04 | 0.96 | FALSE |
| 12 | GTEx | Pancreas | NT5C3B | 0.37 | 0.36 | lasso | 10 | 0.39 | 1.2e-17 | -5.0 | -5.5 | 3.9e-08 | -0.11 | 0.04 | 0.96 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | NT5C3B | 0.44 | 0.60 | lasso | 7 | 0.62 | 1.3e-42 | -5.1 | -5.1 | 3.0e-07 | -0.11 | 0.04 | 0.96 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | AC019349.5 | 0.07 | 0.00 | enet | 16 | 0.02 | 2.5e-02 | -5.2 | -5.2 | 2.1e-07 | -0.12 | 0.06 | 0.85 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | FKBP10 | 0.07 | 0.03 | lasso | 3 | 0.02 | 6.9e-03 | -3.8 | -5.3 | 1.1e-07 | -0.07 | 0.05 | 0.94 | FALSE |
| 16 | GTEx | Thyroid | RAB5C | 0.05 | 0.01 | lasso | 4 | 0.01 | 5.8e-02 | -4.9 | -5.2 | 1.5e-07 | -0.09 | 0.04 | 0.83 | FALSE |
| 17 | METSIM | Adipose | CNP | 0.04 | 0.02 | blup | 367 | 0.03 | 8.7e-05 | -4.4 | 6.3 | 2.7e-10 | 0.01 | 0.07 | 0.89 | TRUE |
| 18 | METSIM | Adipose | NT5C3B | 0.16 | 0.24 | lasso | 10 | 0.24 | 4.0e-35 | -5.2 | -5.2 | 2.2e-07 | -0.11 | 0.04 | 0.96 | FALSE |
| 19 | NTR | Blood | KLHL11 | 0.03 | 0.02 | blup | 402 | 0.01 | 2.1e-05 | -4.4 | -5.4 | 5.0e-08 | 0.00 | 0.06 | 0.94 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NT5C3L | 0.12 | 0.15 | lasso | 4 | 0.15 | 1.9e-16 | -5.2 | -5.1 | 3.0e-07 | -0.11 | 0.01 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NT5C3L | 0.18 | 0.10 | lasso | 3 | 0.11 | 2.5e-12 | -5.2 | -5.5 | 3.9e-08 | -0.09 | 0.01 | 0.99 | FALSE |
| 22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NT5C3L | 0.09 | 0.10 | blup | 17 | 0.11 | 8.8e-08 | -4.9 | -5.2 | 2.2e-07 | -0.11 | 0.01 | 0.98 | FALSE |
| 23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NT5C3L | 0.16 | 0.22 | lasso | 9 | 0.21 | 3.6e-09 | -5.2 | -5.2 | 2.5e-07 | -0.12 | 0.01 | 0.99 | FALSE |
| 24 | The Cancer Genome Atlas | Rectum Adenocarcinoma | NT5C3L | 0.23 | 0.13 | lasso | 12 | 0.10 | 1.9e-03 | -5.2 | -5.2 | 1.9e-07 | -0.11 | 0.01 | 0.75 | FALSE |
| 25 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NT5C3L | 0.16 | 0.19 | lasso | 5 | 0.19 | 2.0e-11 | -5.0 | -5.2 | 2.0e-07 | -0.10 | 0.01 | 0.98 | FALSE |