TWAS hub - CNP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1320	0.0590	0.0050	0.035	NA	0.013	NA	0.036	0.00500	NA	6.0e-02	NA	0.00440
2	METSIM	Adipose	0.0428	0.0162	0.0001	0.020	0.025	0.013	0.023	0.017	0.00051	8.7e-05	3.5e-03	1.6e-04	0.00100
3	NTR	Blood	0.0146	0.0056	0.0001	0.008	0.013	0.013	0.013	0.009	0.00130	3.0e-05	3.3e-05	3.3e-05	0.00035
4	TCGA	Liver Hepatocellular Carcinoma	0.0700	0.0410	0.0015	0.072	0.070	0.066	NA	0.066	0.00028	3.5e-04	5.1e-04	NA	0.00049

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Impedance of leg (left)	6.7	32.5	46.1	-0.9	6.8	6.2	-6.7
Impedance of leg (right)	6.5	31.7	43.8	-1.5	6.6	6.1	-6.6
Eye problems/disorders: Cataract	6.5	7.5	12.5	-2.0	3.5	2.8	-2.3
Osteoarthritis (self-reported)	5.3	6.9	12.5	0.8	-2.8	-2.6	3.5
Heel bone mineral density (BMD) T-score, automated (left)	4.8	10.8	24.8	3.3	-5.0	-1.7	2.0
Eye problems/disorders: None of the above	4.5	5.2	11.7	1.2	-3.4	-1.7	2.2
Impedance of whole body	4.2	21.3	39.9	-2.0	6.3	4.3	-4.8
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.5	20.2	2.6	-4.5	-0.4	1.8
Friendships satisfaction	3.3	4.1	7.5	-1.4	-2.3	-1.4	2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	4.7	2.2	2.0	0.8	-2.1
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	6.5	0.0	-1.4	-2.5	2.0
Hearing difficulty/problems with background noise	2.8	4.5	10.1	-1.7	0.0	-2.2	3.2
Noisy workplace	2.7	3.3	7.1	-1.0	-1.7	-1.4	2.7
Mouth/teeth dental problems: Loose teeth	2.6	3.0	5.9	1.6	-2.4	-1.1	1.5
Mean Putamen Volume	2.5	2.9	4.6	0.1	1.8	2.0	-2.1
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	8.8	-2.4	-0.1	-3.0	2.2
Impedance of arm (left)	2.4	10.9	23.8	-2.4	4.9	2.4	-2.9
Waist Hip Ratio (WHR)	2.3	10.2	16.7	4.1	-0.9	3.2	-3.6
Forced vital capacity (FVC)	2.3	9.0	14.4	-3.8	-2.7	-1.9	3.3
Forced expiratory volume in 1-second (FEV1)	2.3	7.6	9.8	-2.5	-3.0	-2.3	3.1
Leg fat-free mass (right)	2.3	12.3	27.6	-0.6	-5.2	-2.8	3.7
Leg predicted mass (right)	2.3	12.4	27.4	-0.6	-5.2	-2.9	3.7
Leg fat-free mass (left)	2.1	10.9	25.6	-1.0	-5.1	-2.5	3.3
Breastfed as a baby	2.1	2.5	4.4	1.1	0.6	2.1	-2.1
Mood swings	2.1	3.8	11.3	3.4	-1.5	-1.3	-0.1
Fractured/broken bones in last 5 years	2.1	2.7	7.2	-2.7	1.8	-0.5	0.4
Hypothyroidism (self reported)	2.0	4.6	7.2	-2.7	-0.3	-2.7	2.0
Medication: Levothyroxine sodium	2.0	3.3	8.0	-1.0	-0.5	-2.8	2.0
Leg predicted mass (left)	2.0	10.8	25.7	-1.0	-5.1	-2.4	3.3
Medication: Lisinopril	2.0	2.6	6.9	-0.0	0.1	2.6	-1.8
Blood Eosinophil Count	1.9	14.5	27.8	-2.8	-3.0	-3.6	5.3
Heel T-Score	1.8	14.1	35.4	4.4	-6.0	-0.0	1.1
Diabetes (father)	1.8	2.2	4.7	0.7	1.2	1.4	-2.2
Impedance of arm (right)	1.8	8.4	20.5	-2.3	4.5	1.6	-2.2
Illnesses of mother	1.8	2.2	6.6	2.6	-0.6	-0.1	-1.3
Gout (self-reported)	1.8	2.5	4.8	1.6	-1.4	-2.2	0.7
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.4	-1.3	-1.0	-1.4	2.1
Leg fat percentage (right)	1.8	6.5	14.1	-0.2	0.9	3.8	-3.3
Pain type(s) experienced in last month: Hip pain	1.8	2.3	3.4	1.6	-1.3	-1.9	1.2
Unable to work because of sickness or disability	1.8	2.3	4.2	0.5	-2.0	-1.6	1.5
Whole body water mass	1.7	9.4	25.1	-0.4	-5.0	-2.0	2.9
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.0	-0.9	-1.4	-1.5	1.7
Leg fat percentage (left)	1.7	6.0	13.2	0.1	0.9	3.6	-3.2
Fasting Glucose	1.6	1.9	5.1	-2.3	-0.3	0.3	1.6
Systolic Blood Pressure	1.6	8.1	28.4	-5.3	1.2	1.0	1.2
Average weekly fortified wine intake	1.6	1.9	6.5	-2.6	0.6	-0.2	0.8
Fed-up feelings	1.6	3.0	5.5	2.3	-1.7	-1.5	1.1
Number of full brothers	1.6	2.0	3.5	0.7	1.2	1.6	-1.9
Whole body fat-free mass	1.6	9.3	24.9	-0.5	-5.0	-1.9	2.9
Alzheimer’s Disease (including proxy)	1.5	2.2	3.8	-1.2	1.9	1.3	-1.3
Body Mass Index (BMI) (2010)	1.5	2.1	5.6	-0.1	-2.4	-0.8	1.5
Chronotype (morning person)	1.5	3.5	7.3	1.8	1.2	1.4	-2.7
Taking other prescription medications	1.5	2.4	5.0	-1.0	-0.7	-2.2	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	7.0	-1.8	-2.6	-2.1	2.1
Pulse wave reflection index	1.5	1.8	2.2	1.0	-1.4	-1.5	1.4
High blood pressure (siblings)	1.5	2.2	3.5	-1.9	1.4	1.6	-0.7
Suffer from ‘nerves’	1.5	2.3	5.2	0.9	-1.4	-2.3	1.2
Ever depressed for a whole week	1.5	1.9	4.9	-0.7	0.0	-1.4	2.2
Irritable Bowel Disease (IBD)	1.4	3.2	6.8	-2.6	2.1	-0.3	1.3
Relative age of first facial hair	1.4	2.9	4.3	1.7	1.9	0.8	-2.1
Chronic bronchitis/emphysema (father)	1.4	1.6	3.0	-1.7	1.6	-0.5	0.8
Trunk fat-free mass	1.4	7.9	21.9	-0.3	-4.7	-1.7	2.6
Depression (self-reported)	1.4	1.6	2.6	1.1	1.6	0.6	-1.5
Trunk predicted mass	1.4	8.0	22.5	-0.2	-4.7	-1.7	2.6
Forced vital capacity (FVC), Best measure	1.4	5.2	7.3	-2.7	-2.5	-1.7	2.1
Health satisfaction	1.4	1.9	4.3	-1.3	-0.2	-2.1	1.2
Average weekly champagne plus white wine intake	1.4	1.9	2.5	-1.5	0.8	1.6	-1.5
High cholesterol (Self-reported)	1.4	2.5	6.3	1.5	1.1	0.7	-2.5
Alcohol drinker status: Never	1.4	1.7	4.1	-0.2	2.0	1.2	-1.0
Alzheimer’s Disease (in mother)	1.3	1.5	2.6	-0.8	1.6	0.9	-1.4
Crohns Disease (2017)	1.3	2.9	5.5	-2.3	2.2	-0.0	1.1
Respiratory disease	1.3	3.0	6.7	0.4	-0.4	-2.6	2.2
Qualifications: CSEs or equivalent	1.3	1.7	3.1	-0.4	-1.8	-1.0	1.6
Medication: Lansoprazole	1.3	1.5	3.1	-0.2	1.7	0.1	-1.8
Prospective memory result	1.3	1.6	3.5	-0.7	-0.9	-1.9	1.2
Medication: Seretide 50 evohaler	1.3	1.5	2.9	-0.2	-1.7	-0.9	1.5
Breast cancer (self-reported)	1.3	1.6	3.4	-1.9	-1.4	-0.3	0.9
Medication: Bendroflumethiazide	1.3	2.0	3.9	-0.4	0.8	2.0	-1.9
Basal metabolic rate	1.3	7.4	21.3	-0.6	-4.6	-1.4	2.5
Arm fat-free mass (left)	1.3	6.7	20.8	-0.4	-4.6	-0.9	2.2
Average weekly beer plus cider intake	1.3	1.8	5.8	-0.2	-2.4	-0.5	1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.7	-0.5	-1.5	-1.1	1.6
Age when periods started (menarche)	1.2	3.0	5.4	2.0	2.3	-0.1	-1.5
Age at last live birth	1.2	1.7	4.8	2.2	-1.2	-0.3	-0.6
Illnesses of siblings: Diabetes	1.2	1.4	3.5	-0.5	0.8	1.2	-1.9
Asthma (self-reported)	1.2	2.4	4.5	-0.8	0.4	-2.1	2.0
Bipolar Disorder (2018)	1.1	1.7	2.4	-0.5	1.5	1.3	-1.5
Hand grip strength (left)	1.1	3.0	3.7	-1.8	-1.5	-1.7	1.9
Neuroticism score	1.1	2.3	8.3	2.9	-0.1	-0.9	-0.4
Asthma	1.1	2.2	4.2	-0.8	0.5	-2.1	1.9
Peak expiratory flow (PEF)	1.1	2.7	4.6	-0.5	-1.2	-2.1	2.1
Shortness of breath walking on level ground	1.1	1.3	3.5	-1.9	0.8	-0.4	1.0
Long-standing illness, disability or infirmity	1.1	1.6	3.2	-1.8	0.0	-1.1	1.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.6	-1.6	-0.4	-1.3	1.6
Arm predicted mass (left)	1.1	5.7	18.0	-0.5	-4.2	-0.7	2.0
LDL Cholesterol	1.0	1.6	3.5	1.9	-0.6	0.4	-1.5
Lung FVC	1.0	5.2	9.4	-3.1	-2.1	-0.9	2.5
Systolic blood pressure, automated reading	1.0	2.8	8.9	-3.0	-0.2	0.6	1.4
Serious illness, injury or assault to yourself	1.0	1.2	1.3	1.1	-1.1	-1.1	1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.2	-2.1	-0.2	-0.3	0.9
Headache pain in last month	1.0	1.6	4.4	0.3	2.1	0.7	-1.3
Arm fat-free mass (right)	1.0	4.9	17.0	-0.2	-4.1	-0.4	1.5
Number of children fathered	1.0	1.1	2.7	0.5	-1.6	-0.4	1.1
Arm predicted mass (right)	1.0	4.9	17.1	-0.2	-4.1	-0.2	1.6
Leg pain on walking	1.0	1.3	2.8	0.1	-0.9	-1.7	1.2
Osteoporosis (self-reported)	1.0	1.2	2.4	-1.5	1.4	0.7	0.1
Miserableness	1.0	1.7	6.0	2.5	-0.4	-0.5	-0.6
Major Depression (MDD)	0.9	1.1	2.4	-1.4	-0.1	-0.3	1.5
Crohns Disease (2012)	0.9	1.4	2.9	-1.7	0.7	-0.1	1.5
Angina	0.9	1.2	2.2	0.7	0.8	1.1	-1.5
Nervous feelings	0.9	1.7	1.8	1.1	-1.3	-1.3	1.3
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.4	-0.8	1.8	1.2	-1.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.1	-1.5	0.4	1.3	0.5
Wheeze or whistling in the chest in last year	0.9	1.6	3.1	-1.5	1.8	-1.0	0.2
Supplements: Vitamin C	0.9	1.1	2.7	-0.8	0.0	-1.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	4.1	0.4	-1.5	-2.0	1.2
Mother’s age at death	0.9	1.2	1.9	-1.2	-0.2	-1.1	1.4
Alcohol drinker status: Previous	0.9	1.0	2.6	0.0	-1.6	0.9	-0.7
HDL Cholesterol	0.8	1.3	2.2	0.4	1.1	1.3	-1.5
Blood Red Count	0.8	7.9	12.3	-2.0	3.2	3.5	-2.3
Hearing difficulty/problems: Yes	0.8	1.2	2.7	0.1	-0.1	-1.4	1.6
Trunk fat percentage	0.8	3.1	6.9	-1.1	0.5	2.6	-2.0
Maternal smoking around birth	0.8	1.2	2.3	-0.3	-1.5	-0.3	1.5
Heart attack	0.8	1.1	3.1	1.8	-0.7	-0.2	-0.8
Allergy	0.8	1.8	4.1	0.1	-0.2	1.7	-2.0
Diabetes (self-reported)	0.8	1.2	1.7	1.3	-1.3	-1.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.0	-1.1	0.8	-0.7	1.4
Medication: Simvastatin	0.8	1.2	3.3	1.2	0.4	-0.1	-1.8
Pulse rate	0.8	1.4	3.1	0.2	1.5	0.3	-1.8
Exposure to tobacco smoke at home	0.8	0.9	1.7	-0.9	0.6	1.3	-1.0
Tense / ‘highly strung’	0.8	1.3	3.7	1.9	-1.0	-0.5	-0.5
Age at first live birth	0.8	1.4	2.9	0.5	-1.7	-1.4	0.9
Pulse wave peak to peak time	0.8	0.9	2.8	-1.7	-0.6	-0.2	0.7
Medication: Blood pressure	0.8	1.4	2.2	-1.0	0.4	1.5	-1.5
Angina (self-reported)	0.8	1.0	2.0	0.6	0.6	1.1	-1.4
Medication: Ibuprofen	0.8	0.9	2.6	1.6	-0.0	-0.8	0.6
Alcohol intake frequency.	0.8	1.9	3.7	0.9	1.1	1.9	-1.5
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.4	-1.2	-0.5	-0.8	1.2
Ever taken oral contraceptive pill	0.8	0.9	2.8	0.0	-1.7	-0.1	1.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.4	0.4	1.1	2.1	-1.8
Ulcerative Colitis (UC)	0.7	1.3	2.7	-1.7	0.8	-0.5	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.7	-0.1	0.2	2.2	-1.4
Ovarian Cancer	0.7	1.0	3.7	-1.9	-0.2	0.1	0.2
HbA1C	0.7	0.8	1.4	-1.0	1.2	0.4	-0.8
Blood Platelet Count	0.7	8.4	15.2	-2.2	2.4	3.9	-2.8
Allergy or Eczema	0.7	1.9	4.0	-0.6	0.8	-2.0	1.7
Lung FEV1/FVC ratio	0.7	3.4	7.1	2.7	-2.4	-0.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	1.0	0.4	1.3	-0.6
Stomach or abdominal pain in last month	0.7	0.9	2.8	0.1	1.7	0.8	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.0	-0.4	-0.2	-1.4	1.1
Mouth/teeth dental problems	0.7	1.1	2.2	1.5	0.2	1.1	-1.1
Illnesses of siblings	0.7	0.9	1.9	1.2	-0.2	-1.4	0.6
Number of live births	0.7	1.0	2.2	0.1	0.7	1.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	-1.2	1.2	-0.2	0.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	1.5	0.6	0.3	-0.7
Length of working week for main job	0.7	0.8	2.1	-0.4	-0.2	1.4	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.3	0.8	-0.8	-0.9	1.5
Body fat percentage	0.7	2.9	7.0	-0.7	0.3	2.6	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	1.3	0.1	-1.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.2	1.5	0.3	-0.9	-0.4
Migraine (self-reported)	0.7	0.9	2.8	0.6	1.7	-0.7	-0.1
Pulse rate, automated reading	0.7	2.3	6.2	0.5	1.3	1.1	-2.5
Medication: Gliclazide	0.7	0.8	1.8	0.2	-1.3	-0.8	0.8
Pack years of smoking	0.7	1.0	3.0	1.7	-0.4	-0.6	-0.6
Lupus	0.6	0.9	2.1	1.4	1.0	-0.0	-0.8
Blood White Count	0.6	4.5	8.9	3.0	-0.7	-2.6	1.3
Type 2 Diabetes (T2D) (2018)	0.6	1.0	2.0	1.4	-0.8	-1.2	0.4
Neuroticism	0.6	1.6	5.8	2.4	-0.0	-0.5	-0.4
Supplements: Zinc	0.6	0.7	1.5	0.2	0.0	-1.0	1.2
Diabetes (mother)	0.6	0.7	1.6	1.2	0.0	-1.1	0.1
Pack years adult smoking proportion	0.6	0.9	2.7	1.6	-0.5	-0.6	-0.3
Hand grip strength (right)	0.6	1.6	5.7	-2.4	-0.1	-0.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.7	0.2	-0.3	-1.3	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.0	-0.2	0.3	-1.5	1.7
Waist circumference	0.6	2.3	7.4	0.5	-2.7	1.2	-0.4
Alcohol usually taken with meals	0.6	1.0	1.3	-0.8	0.9	1.1	-1.0
Weight	0.6	3.1	10.8	-0.7	-3.3	-0.1	1.1
Worrier / anxious feelings	0.6	1.2	3.6	0.6	-0.5	-1.9	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.5	0.9	-0.9	-0.8	1.2
Hair/balding pattern: Pattern 4	0.6	1.5	3.1	-1.8	-0.4	1.6	0.3
Exposure to tobacco smoke outside home	0.6	0.7	2.7	0.0	-1.6	-0.2	0.6
Worry too long after embarrassment	0.6	1.1	1.8	0.8	1.3	0.6	-1.2
Leg fat mass (right)	0.6	2.2	4.9	-0.4	-1.2	2.2	-1.5
Knee pain experienced in last month	0.6	1.0	2.7	1.7	-0.9	-0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	0.6	1.5	0.3	-0.5
Loneliness, isolation	0.6	0.9	1.4	-1.2	0.5	1.1	-0.8
Diabetes diagnosed by doctor	0.6	1.0	1.5	1.1	-1.0	-1.2	0.3
Qualifications: nursing, teaching	0.6	0.9	2.1	1.0	1.4	-0.1	-0.6
Back pain experienced in last month	0.6	0.9	1.7	-0.7	-0.8	1.3	-0.8
Hearing aid user	0.6	0.7	1.2	1.1	-1.0	-0.6	0.6
Irritability	0.6	0.9	3.1	1.8	-0.3	-0.3	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	2.0	-0.9	1.4	1.2	-0.9
Alzheimer’s Disease (in father)	0.5	0.5	1.1	-1.0	1.1	-0.2	-0.1
Reaction Time	0.5	0.9	2.2	1.5	-0.6	0.2	-0.9
Rheumatoid Arthritis	0.5	0.7	2.2	0.7	1.5	-0.5	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.5	0.9	0.8	-0.3	-0.8	1.0
BMI	0.5	2.8	10.0	1.0	-3.2	0.1	0.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-1.1	-0.5	0.8	0.3
Medication: Metformin	0.5	0.7	2.5	0.4	-1.6	-0.1	0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.0	0.2	1.4	0.5	-0.0
Medication: Atenolol	0.5	0.7	1.4	0.3	1.2	-0.0	-1.1
Sitting height	0.5	3.6	10.4	-3.2	-0.4	-0.9	1.8
Body mass index (BMI)	0.5	2.1	7.3	0.4	-2.7	-0.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.3	-0.5	-1.0	1.3
Pain all over the body in last month	0.5	0.5	1.0	-0.4	1.0	-0.8	-0.4
Happiness	0.5	0.6	0.9	0.2	-0.9	-0.8	0.9
Lung cancer (father)	0.5	0.6	1.4	1.2	-0.7	0.3	0.4
Comparative height size at age 10	0.5	2.5	5.0	-1.8	-2.2	0.2	1.3
Had major operations	0.5	0.6	1.7	0.2	1.3	-0.3	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	1.3	-0.8	0.3	-0.2
Medication: Atorvastatin	0.5	0.6	1.3	-1.1	1.0	-0.3	0.0
Ever smoked	0.5	0.8	2.2	-1.5	0.7	0.8	-0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.7	1.3	-0.4	-0.1	-0.7
Leg fat mass (left)	0.5	2.0	4.5	-0.3	-1.2	2.1	-1.4
Depressed Affect (Nagel 2018)	0.4	0.9	3.0	1.7	-0.4	-0.3	-0.6
Depression (Nagel 2018)	0.4	0.6	1.1	-0.8	0.2	-1.0	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	0.8	-0.6	-0.9	0.7
Prostate Cancer	0.4	0.5	1.0	1.0	0.8	-0.3	-0.6
Neuroticism (2016)	0.4	0.5	1.2	0.0	-0.8	-0.4	1.1
Primary Biliary Cirrhosis	0.4	0.6	1.3	-0.1	-0.0	1.1	-1.0
Ulcerative Colitis	0.4	0.6	1.0	-0.4	-0.6	-1.0	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.8	-0.2	-0.2	1.1
Townsend deprivation index at recruitment	0.4	0.5	1.3	-0.5	0.2	1.2	-0.7
Trunk fat mass	0.4	1.6	3.4	-0.9	-0.9	1.8	-1.1
Number of incorrect matches in round	0.4	0.6	2.3	-1.5	0.3	-0.0	0.4
Hair/balding pattern: Pattern 2	0.4	0.4	1.5	-1.2	0.5	-0.1	0.2
Financial difficulties in last 2 years	0.4	0.5	1.2	-0.3	-1.1	-0.2	0.8
Time employed in main current job	0.4	0.4	0.8	0.8	-0.9	-0.6	0.0
Alcohol intake versus 10 years previously	0.4	0.6	1.3	1.2	-0.7	0.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	1.2	0.5	-0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	1.0	-0.5	-0.8	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-1.1	0.1	-0.4	0.7
Medication: Amlodipine	0.4	0.6	0.9	-0.9	-0.4	-0.6	0.9
Heart disease (mother)	0.4	0.5	1.9	0.4	1.4	-0.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.2	-0.7	0.1	-0.2	1.1
Medication: Aspirin	0.4	0.5	0.6	-0.5	0.7	0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	-1.5	-0.9	-0.1	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.6	1.3	0.2	-0.3	-0.6
Commuting to job workplace: Walk	0.4	0.4	1.0	0.2	0.6	1.0	-0.5
Arm fat mass (left)	0.4	1.6	5.9	-0.6	-2.4	0.4	0.3
Financial situation satisfaction	0.4	0.6	1.6	0.7	-1.2	0.1	0.4
Commuting to job workplace: Public transport	0.4	0.5	1.8	1.4	0.3	0.4	0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	1.2	-0.6	0.2	0.3
Number of operations (self-reported)	0.4	0.7	1.6	0.1	1.3	0.8	-0.6
Myopia	0.4	0.6	1.4	0.6	-0.8	-0.2	1.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	0.4	1.2	0.0	-0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.9	1.4	0.1	-0.9	-0.4
Sensitivity / hurt feelings	0.3	0.5	1.1	1.0	0.8	-0.6	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.7	0.5	-0.6	0.7
Medication for hormone replacement therapy	0.3	0.3	0.8	0.9	-0.3	-0.4	0.6
Medication: Co-codamol	0.3	0.3	0.9	-1.0	0.3	-0.5	0.1
Relative age voice broke	0.3	0.5	1.5	0.7	1.2	-0.3	-0.3
Supplements: Glucosamine	0.3	0.3	0.6	-0.0	-0.7	-0.5	0.8
High blood pressure (mother)	0.3	0.4	1.3	-1.1	0.0	0.5	0.3
Had other major operations	0.3	0.3	0.8	-0.0	-0.9	0.3	0.6
Hip circumference	0.3	1.5	3.0	-1.7	-1.4	-0.5	0.7
Falls in the last year	0.3	0.4	0.8	-0.3	-0.9	-0.6	0.6
Arm fat mass (right)	0.3	1.4	5.2	-0.4	-2.3	0.0	0.5
Birth weight of first child	0.3	0.6	1.4	0.1	-0.6	-1.2	0.9
Blood clot in the leg (DVT)	0.3	0.4	0.9	-1.0	-0.8	-0.4	0.1
Comparative body size at age 10	0.3	0.8	1.6	0.3	-1.2	-0.5	1.3
Neck or shoulder pain in last month	0.3	0.4	0.7	0.6	0.6	0.9	-0.5
Medication: Allopurinol	0.3	0.5	1.7	0.1	-0.2	-1.3	0.2
Mean time to correctly identify matches	0.3	0.5	1.4	1.2	-0.8	-0.1	-0.2
Whole body fat mass	0.3	1.4	2.7	-0.8	-1.2	1.6	-0.9
Number of full sisters	0.3	0.4	1.2	-0.2	0.6	1.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.6	0.0	-0.4
Number of self-reported non-cancer illnesses	0.3	0.6	0.7	-0.7	0.8	0.7	-0.8
Guilty feelings	0.3	0.5	1.0	1.0	0.8	-0.5	-0.1
Wears glasses or contact lenses	0.3	0.3	0.9	0.3	1.0	0.2	-0.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	0.0	0.3	1.0	-0.7
Medication: Blood pressure	0.3	0.7	2.2	-0.6	0.2	1.5	-0.2
Illnesses of father: High blood pressure	0.3	0.4	0.8	-0.4	0.2	0.9	-0.8
Age started oral contraceptive pill	0.3	0.4	1.4	0.3	-1.2	0.2	-0.2
Supplements: Calcium	0.3	0.3	1.3	0.0	0.2	-1.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-0.9	-0.6	-0.5	0.1
Heart disease (siblings)	0.3	0.4	1.0	-0.1	-1.0	-0.6	0.2
Worry (Nagel 2018)	0.2	0.5	1.2	0.9	0.1	-1.1	-0.1
Breast Cancer	0.2	0.5	1.4	-1.2	0.7	0.1	-0.4
Age at First Birth	0.2	0.3	0.7	0.7	-0.4	0.2	-0.8
Triglycerides	0.2	0.3	0.8	0.4	-0.9	0.3	-0.4
Smoking Status	0.2	0.4	1.3	-0.5	0.1	-0.3	1.1
Hair Pigment	0.2	4.4	10.2	0.2	-1.8	-3.2	2.1
Number of treatments/medications taken	0.2	0.4	0.6	-0.7	0.8	-0.2	-0.5
Average weekly spirits intake	0.2	0.2	0.5	0.3	0.4	-0.7	0.3
Severe depression (siblings)	0.2	0.2	0.5	0.7	0.3	-0.3	-0.0
Current tobacco smoking	0.2	0.3	0.7	-0.8	-0.0	-0.5	0.6
High blood pressure	0.2	0.6	1.4	-0.4	0.0	1.2	-0.9
Past tobacco smoking	0.2	0.4	0.9	0.6	-0.2	-0.9	0.4
Medication: Ramipril	0.2	0.3	0.8	0.9	-0.2	-0.5	0.1
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	0.7	-0.3	-0.4	0.5
Medication: Cholesterol lowering	0.2	0.3	1.0	0.5	-0.1	-0.0	-1.0
Standing height	0.2	2.4	5.9	-2.4	-1.7	0.2	0.8
Loud music exposure frequency	0.2	0.2	0.7	-0.3	0.1	0.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.2	0.1	0.5	-0.9
Medication: Paracetamol	0.2	0.4	1.5	0.1	1.2	-0.1	-0.2
Glaucoma (self-reported)	0.2	0.2	0.4	-0.6	0.6	0.5	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.8	-0.0	-0.5	0.0
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	-0.4	-1.2	0.3	0.2
Family relationship satisfaction	0.2	0.2	0.4	0.6	-0.5	-0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.1	-0.0	0.3	-0.9
Hypertension (Self-reported)	0.2	0.6	1.3	-0.3	-0.0	1.1	-1.0
Average weekly red wine intake	0.2	0.2	0.4	-0.6	-0.4	-0.3	0.6
Smoking status: Current	0.2	0.4	1.1	-1.1	-0.1	-0.3	0.6
Medication: Paracetamol	0.2	0.4	0.9	-0.4	1.0	-0.6	-0.1
Risk taking	0.2	0.3	0.8	-0.3	0.9	0.6	-0.3
Diastolic blood pressure, automated reading	0.2	0.7	1.4	-0.8	0.4	0.7	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.0	0.1	0.9	-0.6
Schizophrenia (2018)	0.1	0.3	0.5	-0.7	0.7	0.4	-0.0
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.3	-0.2	-0.4	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.2	-0.2	0.3	-0.4
Height	0.1	2.8	6.6	-2.6	-1.7	-0.5	1.1
Cardiovascular Disease	0.1	0.4	1.0	-0.3	-0.3	0.6	-1.0
Multivitamins +/- minerals	0.1	0.1	0.2	0.2	-0.3	-0.1	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.0	-0.3	-0.4	-0.2
Qualifications: None of the above	0.1	0.2	0.4	-0.7	-0.1	0.5	0.3
Fluid intelligence score	0.1	0.2	0.7	0.1	-0.3	0.8	-0.3
Arm fat percentage (right)	0.1	0.5	1.4	-0.8	-1.2	0.2	0.1
Father’s age at death	0.1	0.1	0.1	0.4	-0.1	-0.2	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.4	0.6	-0.2	-0.5
Birth weight	0.1	0.1	0.4	0.1	-0.0	0.7	-0.0
Qualifications: College or University degree	0.1	0.3	0.9	-0.9	0.5	-0.1	-0.3
Medication: Omeprazole	0.1	0.1	0.5	0.1	0.0	0.7	-0.3
Overall health rating	0.1	0.3	0.5	0.0	0.7	0.4	-0.7
Chest pain or discomfort	0.1	0.2	0.5	0.2	-0.2	-0.6	0.7
Illnesses of father: Heart disease	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.1
Arm fat percentage (left)	0.1	0.6	0.8	-0.7	-0.9	0.9	-0.5
Ever had bowel cancer screening	0.1	0.2	0.4	-0.2	0.1	-0.6	0.5
Medication for cholesterol	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.3
Mineral and other dietary supplements	0.1	0.2	0.4	-0.7	0.3	-0.2	-0.3
Medication: Aspirin	0.1	0.1	0.4	-0.6	0.4	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.4	-0.2	-0.2	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	0.2	0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.0	0.4	-0.7	0.6
Cholesterol lowering medication	0.1	0.2	0.6	0.8	0.2	-0.4	-0.2
Pain experienced in last month	0.1	0.2	0.6	0.3	-0.7	-0.3	0.5
Schizophrenia (2014)	0.0	0.1	0.2	-0.1	0.4	0.2	-0.5
Tanning	0.0	0.5	2.1	-1.4	0.0	0.2	0.3
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	-0.1	-0.0	0.1
Had menopause	0.0	0.0	0.1	-0.1	0.3	0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.2
Smoking status: Previous	0.0	0.1	0.2	0.2	-0.3	0.4	0.0

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Trait associations