TWAS hub - KLHL11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.0880	0.0340	2.4e-03	0.006	NA	0.001	NA	-0.001	7.7e-02	NA	2.5e-01	NA	4.2e-01
2	NTR	Blood	0.0255	0.0102	3.3e-05	0.016	0.014	0.014	0.013	0.014	3.8e-06	2.1e-05	2.3e-05	2.5e-05	2.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of leg (right)	4.9	23.8	45.7	-1.4	-6.8
Impedance of leg (left)	4.8	23.5	45.4	-1.3	-6.7
Length of working week for main job	4.4	4.8	8.7	-2.9	-1.0
Medication: Levothyroxine sodium	3.5	6.0	10.9	3.3	1.0
Medication: Lisinopril	3.5	4.6	8.6	-0.7	-2.9
Breastfed as a baby	3.3	4.0	5.0	-2.2	-1.7
Osteoarthritis (self-reported)	3.2	4.2	7.7	0.8	2.8
Alzheimer’s Disease (in mother)	3.0	3.5	5.5	1.2	-2.4
Eye problems/disorders: Cataract	2.9	3.3	6.6	0.2	-2.6
Impedance of whole body	2.9	14.9	29.7	-0.3	-5.4
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	5.2	0.7	2.3
Eye problems/disorders: None of the above	2.4	2.8	5.4	0.3	2.3
Diabetes (mother)	2.3	2.9	5.6	2.4	0.4
Noisy workplace	2.3	2.8	3.1	-1.6	1.8
Diabetes (father)	2.2	2.7	4.4	1.0	-2.1
Alzheimer’s Disease (including proxy)	2.1	3.0	5.8	0.4	-2.4
Medication: Blood pressure	2.1	3.8	4.0	-1.9	-2.0
Heart disease (mother)	2.0	2.5	4.4	2.1	-0.8
Body Mass Index (BMI) (2010)	1.9	2.6	4.1	-2.0	1.1
Hypothyroidism (self reported)	1.9	4.4	8.6	2.9	0.4
Leg fat percentage (right)	1.9	6.8	6.9	-2.6	-2.6
Had major operations	1.9	2.2	4.2	2.0	-0.5
Illnesses of father: High blood pressure	1.9	2.3	3.5	-1.9	-1.1
Alcohol drinker status: Never	1.9	2.3	3.7	0.9	-1.9
Asthma	1.8	3.6	5.4	2.3	1.3
Impedance of arm (left)	1.8	8.1	15.9	0.6	-4.0
Asthma (self-reported)	1.8	3.5	4.9	2.2	1.5
Had other major operations	1.7	2.1	4.2	-2.0	0.2
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	5.4	2.3	1.2
Leg fat percentage (left)	1.7	6.2	6.4	-2.5	-2.4
Medication: Bendroflumethiazide	1.6	2.5	3.9	-1.0	-2.0
Ulcerative Colitis	1.5	2.2	4.2	0.5	2.1
Allergy or Eczema	1.5	3.8	6.1	2.5	1.3
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.8	2.0	0.3
Angina (self-reported)	1.5	2.0	3.5	-1.9	-0.7
Respiratory disease	1.4	3.2	3.9	1.6	2.0
Ever had hysterectomy (womb removed)	1.4	1.6	1.8	-1.2	-1.4
Worrier / anxious feelings	1.4	2.7	4.7	2.2	0.9
Medication: Lansoprazole	1.4	1.6	1.6	1.3	-1.3
Loud music exposure frequency	1.4	1.5	2.7	-1.7	0.5
Leg fat-free mass (right)	1.4	7.2	13.1	-1.2	3.6
Commuting to job workplace: Walk	1.4	1.5	2.9	0.4	-1.7
Leg predicted mass (right)	1.4	7.6	13.8	-1.2	3.7
Pain type(s) experienced in last month: Hip pain	1.4	1.7	1.7	1.3	1.3
Bipolar Disorder (2011)	1.3	1.3	1.4	1.2	1.1
Fasting Glucose	1.3	1.6	3.0	-1.7	0.3
Average weekly spirits intake	1.3	1.6	2.9	1.7	0.4
Trunk fat percentage	1.3	5.2	6.7	-2.6	-1.9
Alcohol usually taken with meals	1.3	2.1	2.1	1.5	-1.4
Hair/balding pattern: Pattern 4	1.3	3.1	5.7	-0.8	-2.4
Average weekly red wine intake	1.3	1.8	3.6	1.9	0.3
Friendships satisfaction	1.3	1.6	2.5	0.8	1.6
Average weekly champagne plus white wine intake	1.3	1.8	2.9	-0.8	-1.7
Blood White Count	1.2	8.7	16.1	4.0	1.2
Hand grip strength (left)	1.2	3.1	4.1	-1.5	2.0
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.3	1.8	-0.4
Angina	1.2	1.6	2.6	-1.6	-0.8
Severe depression (siblings)	1.2	1.3	2.0	0.8	1.4
Leg fat-free mass (left)	1.2	6.5	10.9	-1.5	3.3
Leg predicted mass (left)	1.2	6.4	10.6	-1.5	3.2
Number of live births	1.2	1.7	2.8	-1.7	-0.8
Prospective memory result	1.2	1.5	2.5	-0.7	1.6
Body fat percentage	1.2	4.7	6.5	-2.5	-1.7
Number of full brothers	1.2	1.5	2.5	0.6	-1.6
Leg pain on walking	1.2	1.5	2.9	0.4	1.7
High cholesterol (Self-reported)	1.2	2.2	3.3	1.8	-1.1
Systolic blood pressure, automated reading	1.1	3.1	6.1	-2.5	-0.2
Age when periods started (menarche)	1.1	2.6	3.8	1.9	-1.2
Serious illness, injury or assault to yourself	1.1	1.4	2.8	-0.1	1.7
Allergy	1.1	2.5	3.1	-1.8	-1.4
Pulse wave reflection index	1.1	1.4	2.5	0.5	1.6
Headache pain in last month	1.1	1.9	2.8	1.0	-1.7
Birth weight	1.1	2.4	4.5	-2.1	0.6
Health satisfaction	1.1	1.4	2.1	1.4	0.8
Medication: Omeprazole	1.1	1.4	2.4	-1.6	-0.5
Leg fat mass (right)	1.1	4.1	7.5	-2.7	-0.9
Ever taken oral contraceptive pill	1.1	1.2	1.6	-1.3	0.9
HbA1C	1.0	1.1	2.2	-0.1	-1.5
Impedance of arm (right)	1.0	4.7	9.3	0.4	-3.0
Gout (self-reported)	1.0	1.3	1.6	1.3	1.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.5	-1.2	-1.0
Worry too long after embarrassment	1.0	1.7	2.1	1.1	-1.4
Diabetes diagnosed by doctor	1.0	1.7	1.9	1.2	1.4
Whole body water mass	1.0	5.5	8.9	-1.4	3.0
Diastolic blood pressure, automated reading	1.0	3.0	5.9	-2.4	-0.4
Leg fat mass (left)	1.0	3.7	6.9	-2.6	-0.8
Worry (Nagel 2018)	0.9	1.8	3.6	1.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.0	-1.2	-1.7
Mean Putamen Volume	0.9	1.1	1.5	-0.8	-1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.4	1.2	0.8
Waist Hip Ratio (WHR)	0.9	4.0	8.1	0.1	-2.8
Systolic Blood Pressure	0.9	4.5	4.9	-2.2	-2.0
Maternal smoking around birth	0.9	1.3	1.6	-1.0	1.3
Taking other prescription medications	0.9	1.3	2.1	1.4	0.8
Trunk fat mass	0.9	3.9	7.0	-2.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.7	1.3	-0.6
Neck or shoulder pain in last month	0.9	1.3	2.2	0.6	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.1	0.2	1.4
Whole body fat mass	0.9	3.9	7.5	-2.7	-0.6
Number of full sisters	0.9	1.0	1.8	-1.3	0.6
Whole body fat-free mass	0.9	5.3	8.5	-1.4	2.9
Ever had bowel cancer screening	0.9	1.0	2.0	1.4	-0.1
Arm fat-free mass (left)	0.9	4.6	4.8	-2.1	2.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.3	-1.1	-0.9
Blood Eosinophil Count	0.8	6.2	9.2	1.8	3.0
Sensitivity / hurt feelings	0.8	1.3	2.5	1.6	-0.3
Relative age voice broke	0.8	1.1	2.0	1.4	-0.6
Qualifications: CSEs or equivalent	0.8	1.0	2.0	-0.3	1.4
Supplements: Glucosamine	0.8	1.0	1.5	-1.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.9	-0.3	1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.0	0.8	1.4
Migraine (self-reported)	0.8	1.0	2.0	1.4	-0.2
Medication: Allopurinol	0.8	1.1	1.8	1.4	0.6
Age at last live birth	0.8	1.1	1.7	1.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.5	-0.4	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.5	1.2	-0.6
Number of self-reported non-cancer illnesses	0.8	1.3	1.3	1.2	-1.1
Basal metabolic rate	0.8	4.6	6.2	-1.8	2.5
Risk taking	0.8	1.2	2.2	-1.5	0.3
Unable to work because of sickness or disability	0.8	1.1	1.6	0.7	1.3
Arm predicted mass (left)	0.8	3.9	4.2	-2.0	1.9
Coronary Artery Disease (CAD)	0.7	0.8	1.6	1.3	0.1
LDL Cholesterol	0.7	1.1	2.3	-1.5	-0.0
Lupus	0.7	1.0	1.9	1.4	0.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.3	0.6	1.5
Hayfever, allergic rhinitis or eczema	0.7	1.6	1.6	1.3	1.2
Medication: Atenolol	0.7	0.9	1.3	-1.1	-0.7
Waist circumference	0.7	2.5	4.9	-2.2	0.2
Nervous feelings	0.7	1.2	2.1	1.4	0.6
Weight	0.7	3.5	5.7	-2.4	1.2
Trunk fat-free mass	0.7	4.0	6.7	-1.1	2.6
Hip circumference	0.7	2.9	3.9	-2.0	1.4
Alcohol intake versus 10 years previously	0.7	1.0	1.3	1.1	-0.9
Trunk predicted mass	0.7	4.1	6.8	-1.2	2.6
Medication: Seretide 50 evohaler	0.7	0.8	1.0	-1.0	0.8
Mood swings	0.7	1.4	2.7	-0.0	1.6
Hearing aid user	0.7	0.8	1.6	0.4	1.2
Eye problems/disorders: Glaucoma	0.7	0.9	0.9	-0.9	-1.0
Intelligence (Savage-Jansen 2018)	0.6	2.0	3.6	-0.6	-1.9
Blood Platelet Count	0.6	6.6	10.6	-1.6	-3.2
Blood Red Count	0.6	5.6	9.2	-1.4	-3.0
BMI	0.6	3.3	3.7	-1.7	1.9
Townsend deprivation index at recruitment	0.6	0.8	1.5	0.3	-1.2
Body mass index (BMI)	0.6	2.4	2.9	-1.7	1.4
Diabetes (self-reported)	0.6	1.0	1.7	0.5	1.3
Time employed in main current job	0.6	0.7	1.1	-0.6	1.0
Falls in the last year	0.6	0.8	0.9	-1.0	0.8
Depression (self-reported)	0.6	0.7	1.5	0.1	-1.2
Arm fat mass (right)	0.6	2.5	4.2	-2.1	0.9
Birth weight of first child	0.6	1.2	1.3	-1.1	1.0
High blood pressure (siblings)	0.6	0.9	1.6	-0.5	-1.2
Arm fat-free mass (right)	0.6	3.1	3.6	-1.9	1.6
Number of children fathered	0.6	0.7	1.4	0.1	1.2
Age at first live birth	0.6	1.1	1.8	1.3	0.7
Arm predicted mass (right)	0.6	3.0	3.9	-2.0	1.4
Long-standing illness, disability or infirmity	0.6	1.0	1.7	1.3	-0.5
Medication: Gliclazide	0.6	0.6	1.2	-0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.5	-0.4	1.6
Arm fat mass (left)	0.6	2.5	4.6	-2.1	0.6
Guilty feelings	0.6	1.0	1.9	1.4	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.1	-0.5	1.1
Ever depressed for a whole week	0.6	0.8	1.2	0.6	1.1
Pack years of smoking	0.6	0.9	0.9	-0.9	0.9
Depression (Nagel 2018)	0.5	0.8	1.6	1.2	0.1
Neuroticism (Nagel 2018)	0.5	1.3	2.2	1.5	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	1.1	-0.4
Breast Cancer	0.5	1.3	2.1	-1.4	0.7
Chronotype (morning person)	0.5	1.1	1.4	0.9	-1.2
Hearing difficulty/problems: Yes	0.5	0.8	1.0	0.8	1.0
Pack years adult smoking proportion	0.5	0.7	1.0	-0.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	-0.5	1.4
Hearing difficulty/problems with background noise	0.5	0.8	1.1	0.7	1.1
Mouth/teeth dental problems	0.5	0.7	1.5	1.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	1.2	0.1
Father’s age at death	0.5	0.7	1.0	0.7	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.3	-0.2	-1.5
Lung cancer (father)	0.5	0.5	1.1	0.0	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-1.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	0.8	0.9	0.7
Comparative height size at age 10	0.5	2.7	5.0	-2.2	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	-0.9	0.6
Breast cancer (self-reported)	0.5	0.6	0.9	-0.6	0.9
Number of operations (self-reported)	0.5	0.8	1.3	0.5	-1.2
Average weekly beer plus cider intake	0.5	0.7	0.8	0.9	0.7
Cholesterol lowering medication	0.5	0.7	1.4	1.2	0.4
Pain experienced in last month	0.5	0.8	1.6	0.0	1.3
Supplements: Calcium	0.5	0.5	1.0	1.0	0.1
Alzheimer’s Disease (in father)	0.4	0.5	0.6	-0.8	-0.5
Ovarian Cancer	0.4	0.5	1.0	-1.0	-0.2
Prostate Cancer	0.4	0.5	0.9	0.4	0.9
HDL Cholesterol	0.4	0.7	1.3	-1.1	0.1
Primary Biliary Cirrhosis	0.4	0.6	1.1	-0.4	-1.1
Hair Pigment	0.4	10.3	20.1	4.5	0.7
Number of treatments/medications taken	0.4	0.7	1.1	1.0	-0.6
Medication: Co-codamol	0.4	0.5	0.7	0.8	-0.5
Medication: Metformin	0.4	0.5	0.9	1.0	-0.3
Hand grip strength (right)	0.4	1.2	1.6	-1.3	0.9
Fed-up feelings	0.4	0.8	1.2	0.6	1.1
Illnesses of siblings	0.4	0.6	0.6	0.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	1.7	-1.1	1.3
Happiness	0.4	0.5	0.9	0.4	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.8	-0.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	-0.3	1.1
Peak expiratory flow (PEF)	0.4	0.8	1.5	0.4	1.2
Medication: Paracetamol	0.4	0.7	1.2	1.1	-0.3
Medication: Amlodipine	0.4	0.5	0.5	-0.7	0.7
Comparative body size at age 10	0.4	1.2	2.5	-0.0	1.6
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	0.2	0.9
Alcohol intake frequency.	0.4	1.0	1.9	0.2	-1.4
Suffer from ‘nerves’	0.4	0.7	0.7	0.8	0.9
Illnesses of father: Heart disease	0.4	0.6	0.9	1.0	0.5
Loneliness, isolation	0.4	0.6	0.7	-0.6	-0.9
Qualifications: nursing, teaching	0.4	0.5	1.0	1.0	-0.3
Medication: Paracetamol	0.4	0.6	1.2	1.1	-0.1
Medication: Atorvastatin	0.4	0.4	0.5	0.6	-0.7
Ever smoked	0.4	0.7	1.4	0.1	-1.2
Ulcerative Colitis (UC)	0.3	0.6	0.8	0.6	0.9
Major Depression (MDD)	0.3	0.4	0.7	-0.4	0.8
Rheumatoid Arthritis	0.3	0.4	0.8	-0.9	0.0
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.8	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	-0.6	-0.7
Past tobacco smoking	0.3	0.6	1.2	0.0	1.1
Forced vital capacity (FVC)	0.3	1.0	1.1	-1.0	1.0
Neuroticism score	0.3	0.6	1.1	1.1	0.4
Arm fat percentage (right)	0.3	1.4	2.7	-1.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.9	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	1.1	-1.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.8	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.7	0.8	-0.4
Family relationship satisfaction	0.3	0.3	0.6	0.8	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.1	-0.8
Supplements: Vitamin C	0.3	0.4	0.7	0.1	0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.6	0.3	-0.8
Smoking status: Previous	0.3	0.4	0.8	0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.9	-1.0	0.6
Arm fat percentage (left)	0.3	1.3	2.4	-1.6	-0.3
Medication: Blood pressure	0.3	0.5	0.5	-0.7	-0.7
Heel T-Score	0.2	1.7	1.8	-1.3	1.3
Lung FEV1/FVC ratio	0.2	1.2	2.4	-0.3	1.5
Current tobacco smoking	0.2	0.3	0.3	0.6	0.6
High blood pressure	0.2	0.6	0.7	-0.8	-0.6
Multivitamins +/- minerals	0.2	0.2	0.4	0.6	0.2
Sitting height	0.2	1.5	1.6	-1.3	1.1
Pain all over the body in last month	0.2	0.2	0.2	0.4	-0.5
Medication: Ramipril	0.2	0.2	0.4	0.6	0.3
Fluid intelligence score	0.2	0.4	0.8	0.2	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	-0.6	-0.5
Illnesses of mother	0.2	0.2	0.3	-0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.2	0.7
Medication: Ibuprofen	0.2	0.3	0.5	0.7	0.3
Mean time to correctly identify matches	0.2	0.4	0.4	0.7	0.6
Overall health rating	0.2	0.5	0.7	0.8	-0.6
Chest pain or discomfort	0.2	0.4	0.6	0.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.3	-0.5	0.6
Hypertension (Self-reported)	0.2	0.6	0.6	-0.8	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	0.3	0.8
Miserableness	0.2	0.3	0.4	0.7	0.3
Wears glasses or contact lenses	0.2	0.2	0.4	-0.0	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.6	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.6	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.4	-0.7
Depressed Affect (Nagel 2018)	0.1	0.1	0.1	0.4	-0.4
Schizophrenia (2018)	0.1	0.3	0.4	-0.4	-0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	0.6	0.3
Age at First Birth	0.1	0.1	0.2	-0.1	-0.5
Schizophrenia (2014)	0.1	0.1	0.2	-0.3	-0.4
Triglycerides	0.1	0.2	0.4	-0.2	-0.6
Height	0.1	1.7	3.3	-1.8	0.1
Smoking Status	0.1	0.1	0.3	0.5	-0.1
Cardiovascular Disease	0.1	0.4	0.7	0.4	-0.8
Lung FVC	0.1	0.7	1.3	-1.1	0.4
Neuroticism	0.1	0.3	0.6	0.8	-0.3
Tanning	0.1	0.7	1.4	0.2	-1.2
Relative age of first facial hair	0.1	0.1	0.2	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	-0.3	0.5
Supplements: Zinc	0.1	0.1	0.1	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.1	0.4
High blood pressure (mother)	0.1	0.1	0.2	-0.4	-0.1
Number of incorrect matches in round	0.1	0.1	0.1	-0.4	-0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.3	0.6
Qualifications: None of the above	0.1	0.2	0.3	-0.2	-0.5
Medication: Simvastatin	0.1	0.1	0.1	0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	0.4	-0.3
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.6	0.0
Standing height	0.1	1.2	2.5	-1.6	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.5	-0.1
Tense / ‘highly strung’	0.1	0.1	0.1	-0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.2	-0.6
Blood clot in the leg (DVT)	0.1	0.1	0.1	-0.4	0.2
Glaucoma (self-reported)	0.1	0.1	0.2	0.0	-0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.3	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.5	0.3
Qualifications: College or University degree	0.1	0.2	0.4	0.1	-0.6
Emphysema/chronic bronchitis	0.1	0.2	0.2	0.5	0.3
Pulse rate, automated reading	0.1	0.5	0.5	0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.0	0.6
Medication: Aspirin	0.1	0.2	0.3	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.0	-0.4
Back pain experienced in last month	0.1	0.1	0.2	-0.4	-0.3
Smoking status: Current	0.1	0.2	0.3	0.2	0.5
Mother’s age at death	0.1	0.1	0.2	-0.1	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.3	-0.2
Irritability	0.1	0.2	0.3	0.1	-0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.5	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.1	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.7	0.8	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.2	-0.5
Bipolar Disorder (2018)	0.0	0.1	0.1	0.2	-0.3
Crohns Disease (2017)	0.0	0.0	0.0	0.1	-0.1
Reaction Time	0.0	0.1	0.1	-0.4	0.2
Crohns Disease (2012)	0.0	0.0	0.0	-0.0	-0.1
Neuroticism (2016)	0.0	0.0	0.0	-0.1	-0.1
Vitamin and mineral supplements	0.0	0.1	0.1	0.1	0.3
Average weekly fortified wine intake	0.0	0.0	0.0	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.2	-0.2
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.3	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	-0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.2	0.2
Had menopause	0.0	0.0	0.0	0.1	0.1
Financial difficulties in last 2 years	0.0	0.1	0.1	-0.3	0.2
Heart attack	0.0	0.0	0.0	-0.0	-0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.0	0.1
Pulse rate	0.0	0.1	0.1	-0.3	0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.2	-0.1
Pulse wave peak to peak time	0.0	0.0	0.1	-0.3	0.0
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.0	0.0
Knee pain experienced in last month	0.0	0.1	0.1	0.3	0.2
Medication for cholesterol	0.0	0.0	0.0	-0.1	-0.2
Mineral and other dietary supplements	0.0	0.0	0.1	-0.0	0.3
Osteoporosis (self-reported)	0.0	0.0	0.1	-0.1	-0.3
Medication: Aspirin	0.0	0.1	0.1	-0.3	0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.2	0.2
Financial situation satisfaction	0.0	0.0	0.0	0.2	0.1
Commuting to job workplace: Public transport	0.0	0.1	0.1	-0.3	0.2
Age started oral contraceptive pill	0.0	0.0	0.1	-0.2	0.1
Myopia	0.0	0.0	0.1	-0.3	0.2
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.1	0.2
Heart disease (siblings)	0.0	0.1	0.1	-0.2	0.3

Hub : Genes

KLHL11

Models

Trait associations