Best TWAS P=5.11e-18 · Best GWAS P=1.99e-37 conditioned to 3.97e-21
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | 6.86 | 8.7 | 5.1e-18 | 0.77 | 0.06 | 0.67 | TRUE |
| 2 | GTEx | Nerve Tibial | FOSB | 0.28 | 0.00 | lasso | 4 | 0.00 | 4.1e-01 | 4.69 | 5.3 | 1.3e-07 | -0.03 | 0.52 | 0.47 | TRUE |
| 3 | GTEx | Small Intestine Terminal Ileum | PNMAL1 | 0.40 | 0.00 | enet | 11 | 0.15 | 2.7e-04 | -5.01 | -5.7 | 1.2e-08 | -0.01 | 0.02 | 0.57 | TRUE |
| 4 | METSIM | Adipose | PNMAL1 | 0.24 | 0.27 | bslmm | 380 | 0.28 | 2.9e-41 | -5.01 | -5.2 | 2.0e-07 | -0.01 | 0.00 | 0.99 | FALSE |
| 5 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | 5.86 | 8.3 | 1.1e-16 | 0.61 | 0.61 | 0.39 | FALSE |
| 6 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | 8.50 | 7.2 | 5.7e-13 | 0.56 | 0.99 | 0.01 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM160 | 0.04 | 0.00 | blup | 26 | 0.01 | 2.3e-03 | 0.63 | 5.5 | 4.7e-08 | 0.46 | 0.00 | 0.05 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | PNMAL1 | 0.28 | 0.33 | lasso | 3 | 0.35 | 4.1e-21 | -5.01 | -5.1 | 3.1e-07 | -0.01 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRLF1 | 0.04 | 0.04 | blup | 51 | 0.03 | 7.0e-05 | -4.40 | -6.2 | 4.8e-10 | -0.04 | 0.46 | 0.03 | TRUE |
| 10 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PNMAL1 | 0.37 | 0.32 | lasso | 4 | 0.21 | 9.4e-06 | -5.01 | -5.2 | 2.7e-07 | -0.01 | 0.00 | 0.99 | FALSE |