Hub : Genes

TMEM160

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.278	0.0900	0.0038	-0.007	NA	0.019	NA	-0.010	5.7e-01	NA	9.1e-02	NA	8.3e-01
2	YFS	Blood	0.248	0.0387	0.0000	0.110	0.090	0.111	0.12	0.112	4.7e-34	5.6e-28	2.2e-34	3.5e-37	9.1e-35
3	TCGA	Breast Invasive Carcinoma	0.037	0.0184	0.0022	-0.001	0.011	0.005	NA	-0.001	9.5e-01	2.3e-03	2.9e-02	NA	5.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.5	2.3	6.5	-2.5	-0.7	0.0
Bipolar Disorder or Schizophrenia	1.9	4.7	12.3	-3.5	-1.3	0.0
Depressed Affect (Nagel 2018)	0.8	1.7	4.1	-0.9	-2.0	0.3
Depression (Nagel 2018)	0.7	1.1	1.7	-0.4	-1.3	1.2
Intelligence (Savage-Jansen 2018)	3.0	9.3	19.1	2.9	-0.4	-4.4
Neuroticism (Nagel 2018)	0.9	2.2	3.7	-1.6	-1.9	0.6
Schizophrenia (2018)	1.0	2.1	6.3	-2.5	-0.3	0.0
Schizophrenia vs Biploar Disorder	0.7	0.9	2.4	1.6	0.5	0.0
Worry (Nagel 2018)	1.2	2.5	3.4	-1.1	-1.8	1.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.0	0.6	0.0
Alzheimer’s Disease (in father)	0.6	0.6	1.6	0.5	-0.4	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	1.1	0.4	0.1
Crohns Disease (2017)	0.2	0.4	0.8	0.5	-0.5	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	0.5	-1.1	0.3
Ulcerative Colitis (UC)	0.7	1.3	2.8	0.1	-1.0	1.7
Major Depression (MDD)	2.4	3.0	4.6	-2.1	-2.1	0.0
Reaction Time	0.5	0.9	1.3	-1.1	1.1	0.6
Verbal and Numeric Reasoning (VNR)	2.9	7.0	15.8	2.3	-0.3	-4.0
Breast Cancer	2.1	5.1	10.4	-0.1	3.2	-2.2
Ovarian Cancer	0.2	0.2	0.4	-0.7	0.4	-0.3
Prostate Cancer	0.6	0.8	1.3	0.9	0.4	1.2
Age at First Birth	0.6	0.9	2.4	1.5	0.1	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	1.5	-0.5	0.0
Coronary Artery Disease (CAD)	1.2	1.4	4.2	0.0	2.0	0.0
Crohns Disease (2012)	1.0	1.6	4.0	-0.8	-2.0	0.0
Mean Putamen Volume	0.2	0.2	0.7	0.1	-0.8	0.0
Fasting Glucose	0.7	0.8	1.4	1.2	1.1	-0.1
HbA1C	0.3	0.3	0.6	0.4	0.2	-0.8
HDL Cholesterol	0.4	0.7	1.7	-1.3	-0.7	0.0
LDL Cholesterol	0.0	0.0	0.1	0.3	-0.1	0.0
Lupus	0.3	0.5	1.0	1.0	-0.0	0.7
Neuroticism (2016)	1.9	2.7	6.2	-2.5	-1.3	0.5
Primary Biliary Cirrhosis	3.8	5.4	9.4	-2.2	-1.4	3.1
Rheumatoid Arthritis	1.3	1.7	2.9	-1.5	-1.7	0.0
Schizophrenia (2014)	0.6	1.2	3.6	-1.9	-0.0	0.0
Triglycerides	3.8	6.3	14.4	2.1	3.8	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	-1.3	0.2	0.0
Ulcerative Colitis	0.2	0.2	0.5	0.5	-0.7	0.0
Blood Eosinophil Count	0.3	2.0	3.6	-0.9	-1.3	1.9
Blood Platelet Count	0.2	2.9	4.6	-2.0	-2.1	0.4
Blood Red Count	1.9	18.2	48.2	-2.5	-0.4	6.9
Blood White Count	0.4	3.1	5.2	-2.3	-1.3	1.5
Heel T-Score	0.1	0.9	2.3	-0.2	-0.6	-1.5
BMI	1.7	10.0	28.6	1.1	-0.2	-5.3
Height	0.2	3.0	7.0	-0.6	-2.6	1.3
Waist Hip Ratio (WHR)	0.3	1.5	2.5	-1.3	-0.4	1.6
Systolic Blood Pressure	1.1	5.7	12.3	-3.5	-1.7	1.4
Smoking Status	0.9	2.1	5.8	-0.6	-0.5	-2.4
Allergy or Eczema	0.1	0.4	0.7	-0.0	0.7	0.9
Cardiovascular Disease	0.9	2.9	4.2	-1.0	-2.0	-1.8
Hypothyroidism (self reported)	2.6	6.0	13.2	3.6	1.0	-1.9
Respiratory disease	1.5	3.3	6.2	-2.5	0.0	-1.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	0.7	1.0	-0.4
Lung FEV1/FVC ratio	0.6	3.3	5.3	2.3	2.1	-0.3
Lung FVC	0.4	1.8	4.1	-2.0	-0.6	-1.0
Neuroticism	1.1	2.6	4.8	-1.8	-2.2	-0.2
Chronotype (morning person)	2.0	4.7	7.4	-0.7	2.7	-2.5
Hair Pigment	0.1	2.2	5.3	-2.3	0.5	1.0
Tanning	0.3	3.2	3.5	-1.9	-1.8	1.7
Hand grip strength (left)	1.6	4.3	7.2	-0.1	-2.7	-2.4
Number of treatments/medications taken	0.3	0.5	0.8	0.6	-0.4	-0.9
Average weekly spirits intake	1.2	1.4	3.2	1.8	-0.2	1.0
Sensitivity / hurt feelings	0.7	1.1	2.2	-1.5	0.1	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	-0.7	0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.1	-0.3	0.3
Relative age of first facial hair	1.0	2.0	3.2	-1.3	1.0	1.8
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.0	-0.7	-1.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.7	1.6	0.8	0.5
Ever had hysterectomy (womb removed)	1.6	1.8	4.8	0.6	0.2	2.2
Systolic blood pressure, automated reading	0.5	1.6	2.3	-1.5	-1.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.2	0.0	0.0
Angina	1.4	1.9	4.0	-1.3	0.3	-2.0
Medication for hormone replacement therapy	0.3	0.4	0.5	0.6	0.4	0.7
Vitamin and mineral supplements	0.2	0.3	0.6	-0.3	-0.8	-0.6
Supplements: Zinc	2.5	2.7	5.2	2.3	0.6	-1.6
Medication: Co-codamol	0.5	0.6	1.0	0.4	-0.8	-1.0
Medication: Metformin	1.4	1.9	3.3	0.6	1.4	-1.8
Diabetes (father)	0.6	0.7	1.2	-0.2	-1.0	-1.1
Diabetes (mother)	0.6	0.8	1.1	-1.0	-0.9	-0.6
Severe depression (siblings)	1.9	2.2	3.1	-0.5	-1.8	1.8
Pack years adult smoking proportion	0.3	0.5	1.3	-1.1	-0.4	0.2
Impedance of leg (right)	1.6	7.7	20.4	-0.2	1.6	4.5
Leg fat-free mass (left)	1.3	7.0	17.8	-0.1	-1.8	-4.2
Trunk fat percentage	0.5	2.0	5.1	-0.6	-0.7	-2.3
Hand grip strength (right)	0.9	2.5	7.2	-0.5	-2.7	-0.4
Townsend deprivation index at recruitment	1.7	2.4	5.1	-1.5	2.2	0.2
Current tobacco smoking	0.5	0.8	2.2	-0.2	0.5	-1.5
Average weekly fortified wine intake	1.4	1.7	2.2	1.5	-1.2	1.2
Maternal smoking around birth	0.6	0.9	2.4	-0.4	1.5	-0.5
Fed-up feelings	0.8	1.5	2.6	-1.6	-1.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.0	-1.0	-0.4	0.4
Relative age voice broke	3.7	5.6	8.7	-3.0	0.6	2.8
Taking other prescription medications	1.6	2.4	4.2	1.7	-0.1	-2.1
Age when periods started (menarche)	2.9	7.0	9.6	-1.9	-3.1	2.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.7	-0.1	-1.6	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	0.6	0.5	-1.0
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	3.6	-1.5	0.9	1.9
Qualifications: CSEs or equivalent	1.0	1.3	2.9	0.3	-1.0	1.7
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-0.7	1.2	-0.3
High blood pressure	1.3	3.7	5.6	-1.8	-1.5	-2.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.3	0.2	1.5	0.4
Multivitamins +/- minerals	0.5	0.6	0.9	0.9	0.9	-0.4
Stomach or abdominal pain in last month	0.4	0.5	0.6	-0.8	-0.8	-0.5
Supplements: Glucosamine	0.5	0.7	0.7	-0.8	0.7	0.9
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.0	1.6	-0.8	-2.0
Medication: Atenolol	0.6	0.7	1.8	0.4	0.2	-1.4
Medication: Levothyroxine sodium	2.9	4.9	11.7	3.4	1.0	-1.4
Sitting height	0.1	0.9	1.2	-1.0	-0.8	-1.1
Chronic bronchitis/emphysema (father)	1.2	1.4	4.0	0.3	-0.3	-2.0
High blood pressure (mother)	3.3	4.6	7.8	-2.4	-2.8	-0.7
Body mass index (BMI)	2.1	8.9	24.9	0.8	-1.1	-5.0
Impedance of leg (left)	1.6	8.0	21.3	-0.3	1.6	4.6
Leg predicted mass (left)	1.3	6.7	16.9	-0.1	-1.8	-4.1
Trunk fat mass	0.9	4.1	10.8	-0.4	-1.1	-3.3
Waist circumference	1.6	5.8	14.7	-0.2	-1.6	-3.8
Number of incorrect matches in round	2.4	4.1	5.4	-1.5	2.3	2.1
Past tobacco smoking	1.8	3.3	8.2	-0.2	1.3	2.9
Alcohol usually taken with meals	1.1	1.9	4.6	-0.0	2.1	1.0
Nervous feelings	0.4	0.8	1.2	-1.1	-1.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	6.5	-2.2	-2.6	1.7
Hearing difficulty/problems with background noise	0.9	1.4	2.9	-0.5	-1.7	-1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.4	-0.7	0.1
Had menopause	0.3	0.4	0.7	0.8	-0.3	0.6
Had other major operations	0.9	1.1	2.2	-1.5	0.5	1.0
Forced vital capacity (FVC)	0.8	3.1	5.8	-2.4	-1.7	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.5	0.8	-0.4	-1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-0.7	-0.1	1.2
Qualifications: None of the above	0.3	0.6	1.6	-0.2	-0.4	1.3
Financial difficulties in last 2 years	0.4	0.6	1.4	-0.2	1.2	0.5
Mouth/teeth dental problems	0.8	1.3	2.7	-0.8	-1.6	0.7
Heart attack	1.0	1.3	3.3	0.2	0.7	-1.8
Allergy	0.6	1.3	3.5	-0.0	-1.9	0.6
Pain all over the body in last month	0.5	0.6	1.2	1.1	-0.4	-0.6
Diabetes (self-reported)	1.2	1.9	5.1	0.5	2.3	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.5	0.7	-0.1
Medication: Ramipril	0.2	0.3	0.8	-0.0	-0.9	-0.4
Medication: Simvastatin	0.3	0.4	0.8	-0.7	0.1	-0.9
Fluid intelligence score	2.0	4.3	10.5	1.5	-0.1	-3.2
Illnesses of siblings	0.5	0.8	1.6	-0.7	0.5	-1.2
Neuroticism score	1.3	2.7	6.4	-2.5	-1.3	0.1
Weight	1.6	8.0	21.4	0.1	-1.6	-4.6
Impedance of arm (right)	2.4	11.4	22.3	-3.4	-0.1	4.7
Arm fat percentage (right)	0.9	3.7	8.9	-0.6	-1.4	-3.0
Trunk fat-free mass	1.1	6.4	15.9	0.7	-1.7	-4.0
Hip circumference	1.6	6.8	15.8	0.0	-2.1	-4.0
Time employed in main current job	1.0	1.2	2.2	1.5	1.1	-0.4
Alcohol intake versus 10 years previously	0.7	1.0	1.6	0.7	1.0	1.3
Father’s age at death	0.3	0.5	0.7	-0.8	-0.6	-0.6
Worrier / anxious feelings	0.7	1.3	1.8	-0.9	-1.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	1.0	-0.2	-0.6
Falls in the last year	0.3	0.4	1.0	0.2	0.2	-1.0
Hair/balding pattern: Pattern 3	1.2	1.9	3.3	0.1	1.5	-1.8
Number of live births	3.8	5.3	10.4	-2.3	-0.7	3.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.3	-1.8	-0.8	-1.0
Pulse rate	0.3	0.5	1.4	0.4	1.2	0.2
Happiness	2.0	2.4	3.9	-2.0	-0.6	1.7
Noisy workplace	3.2	4.0	6.2	-2.5	0.6	2.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.9	0.0	0.2	-1.4
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	4.4	1.5	1.0	-2.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.5	0.4	-0.1	-1.6
Asthma	0.9	1.8	4.0	-1.1	0.5	-2.0
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	8.4	0.2	2.9	1.1
Medication: Cholesterol lowering	0.7	1.1	2.9	-0.6	0.3	-1.7
Depression (self-reported)	0.5	0.6	1.4	-0.0	-1.2	0.6
Medication: Lansoprazole	0.9	1.0	1.4	-1.2	-0.9	0.9
Prospective memory result	1.5	1.9	4.7	0.4	2.2	0.9
Lung cancer (father)	0.5	0.6	1.0	-0.7	0.6	1.0
Illnesses of mother	4.6	5.7	11.2	3.3	2.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.5	-1.6	-0.8	-1.2
Pulse wave Arterial Stiffness index	4.3	5.1	10.4	-3.2	-0.6	2.1
Impedance of arm (left)	2.5	11.4	25.0	-3.0	-0.1	5.0
Arm fat mass (right)	1.4	5.7	15.0	-0.2	-1.4	-3.9
Trunk predicted mass	1.1	6.4	15.8	0.8	-1.7	-4.0
Standing height	0.1	1.0	1.5	-1.2	-1.2	0.3
Length of working week for main job	0.5	0.6	1.0	-0.7	1.0	-0.4
Exposure to tobacco smoke at home	1.0	1.2	3.2	-0.5	-1.8	-0.0
Breastfed as a baby	1.4	1.8	2.7	-1.6	-1.6	0.2
Tense / ‘highly strung’	0.8	1.3	1.9	-1.1	-0.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.6	0.2	-1.8	-2.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.7	-0.7	-1.3	-0.5
Birth weight of first child	1.7	3.1	6.8	1.1	-1.2	-2.6
Peak expiratory flow (PEF)	0.8	1.8	5.0	-2.2	0.0	0.6
Pulse wave reflection index	1.0	1.3	1.6	-1.3	-1.1	1.0
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.4	-1.8	-0.3	0.8
Loud music exposure frequency	1.8	1.9	5.5	-0.6	-0.2	2.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.2	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	3.8	-2.0	-1.1	1.1
Blood clot in the leg (DVT)	1.7	2.2	5.0	0.6	2.2	1.1
Medication: Paracetamol	1.0	1.6	3.3	1.2	0.1	1.8
Headache pain in last month	1.2	2.1	5.5	0.8	-0.3	2.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.1	1.5	1.1	0.7
Glaucoma (self-reported)	0.6	0.7	1.7	0.6	-1.3	-0.3
Gout (self-reported)	2.5	3.4	5.2	-1.9	-1.2	2.3
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	17.1	4.1	0.9	-1.8
Medication: Amlodipine	0.6	0.9	2.1	0.4	0.5	-1.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.8	-0.7	0.1	-1.7
Birth weight	2.3	4.9	13.6	-1.0	-3.7	0.2
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.5	0.2	-0.5	2.1
High blood pressure (siblings)	1.4	2.0	4.1	-0.9	-2.0	1.2
Forced vital capacity (FVC), Best measure	0.6	2.3	5.1	-2.3	-1.1	-0.6
Body fat percentage	0.6	2.5	7.0	-0.1	-0.8	-2.6
Leg fat percentage (right)	1.1	3.9	10.8	0.8	-0.3	-3.3
Arm fat-free mass (right)	1.4	7.0	17.1	1.7	-1.1	-4.1
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.2	0.0	-0.0
Comparative body size at age 10	4.2	11.5	33.4	0.5	-0.9	-5.8
Number of full brothers	0.3	0.4	0.6	-0.8	-0.2	0.8
Worry too long after embarrassment	0.2	0.4	0.7	-0.9	0.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	-0.5	-0.5
Wheeze or whistling in the chest in last year	1.8	3.2	6.9	0.2	1.7	-2.6
Number of children fathered	0.9	1.0	1.7	-1.3	-0.9	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.1	-1.5	-1.0	0.4
Age at first live birth	0.1	0.2	0.5	-0.7	-0.3	-0.0
Pulse wave peak to peak time	3.9	4.6	9.1	3.0	0.4	-2.1
Health satisfaction	0.4	0.6	1.6	0.3	0.3	1.3
Shortness of breath walking on level ground	0.5	0.6	1.1	1.1	-0.7	0.2
Qualifications: College or University degree	1.0	3.1	4.0	1.9	1.3	-2.0
Eye problems/disorders: None of the above	1.1	1.3	2.5	0.0	-1.6	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	-0.6	0.9	-0.1
Emphysema/chronic bronchitis	0.2	0.3	0.7	0.2	0.3	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	-0.8	-0.7	-0.0
Neck or shoulder pain in last month	1.0	1.4	2.1	-1.5	0.7	1.3
Medication: Blood pressure	1.4	2.5	4.8	-1.5	-2.2	-0.7
Angina (self-reported)	1.4	1.9	3.5	-1.3	0.5	-1.9
Migraine (self-reported)	0.4	0.5	1.2	0.5	0.1	-1.1
Medication: Ibuprofen	1.6	1.9	5.7	0.1	2.4	0.3
Medication: Allopurinol	2.6	3.4	6.8	-1.7	-0.8	2.6
Medication: Omeprazole	1.3	1.6	4.1	0.7	-0.4	-2.0
Medication: Seretide 50 evohaler	0.7	0.8	1.4	0.3	-0.9	1.2
Mean time to correctly identify matches	0.5	0.9	1.5	-1.2	1.0	-0.4
Heart disease (mother)	2.1	2.5	6.1	-2.5	-1.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	0.5	0.8	1.0
Whole body fat mass	1.1	4.6	12.2	0.0	-1.2	-3.5
Leg fat mass (right)	1.6	6.2	17.5	0.8	-0.7	-4.2
Arm predicted mass (right)	1.3	6.6	16.8	1.3	-1.2	-4.1
Pulse rate, automated reading	1.3	4.2	11.8	-0.1	0.9	3.4
Alcohol intake frequency.	1.0	2.2	4.6	1.2	2.1	0.8
Comparative height size at age 10	0.1	0.5	0.8	-0.7	-0.9	0.3
Number of full sisters	2.4	2.9	6.1	-2.5	-1.4	0.8
Suffer from ‘nerves’	0.6	0.9	1.2	-0.9	-0.8	-1.1
Overall health rating	0.1	0.3	0.7	0.1	-0.8	-0.4
Chest pain or discomfort	0.6	0.8	2.2	-1.5	0.3	-0.5
Had major operations	0.1	0.1	0.2	-0.3	-0.4	-0.1
Age at last live birth	0.5	0.7	1.5	-0.4	-1.2	0.6
Family relationship satisfaction	0.7	0.9	1.6	0.1	1.0	1.3
Leg pain on walking	0.4	0.5	1.4	0.4	1.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	-0.9	-0.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	0.8	0.3	-1.1
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.2	0.3	-2.1	1.1
Medication: Aspirin	1.4	1.8	2.3	1.3	1.5	-1.2
Supplements: Vitamin C	0.1	0.1	0.3	0.6	0.1	-0.1
Knee pain experienced in last month	0.3	0.4	0.7	-0.8	0.0	-0.8
Hypertension (Self-reported)	1.2	3.2	4.5	-1.4	-1.8	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.9	-0.4	0.3	-1.4
Illnesses of father: Heart disease	0.6	0.9	2.2	-0.6	1.5	0.2
Illnesses of siblings: Diabetes	0.8	1.0	1.5	1.2	-0.8	-0.9
Smoking status: Previous	1.6	2.4	3.7	0.3	-1.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.8	-0.6	0.5	1.4
Whole body fat-free mass	1.3	7.2	18.4	0.4	-1.8	-4.3
Leg fat-free mass (right)	1.3	6.9	16.5	-0.3	-2.0	-4.1
Arm fat percentage (left)	0.9	3.7	9.0	-0.4	-1.4	-3.0
Average weekly red wine intake	1.5	2.2	4.7	1.2	2.2	-0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.9	-1.7	-0.1	0.7
Mood swings	0.4	0.8	1.1	-0.9	-1.1	-0.6
Loneliness, isolation	0.5	0.7	1.2	-1.1	-0.5	-0.8
Long-standing illness, disability or infirmity	2.8	4.3	11.6	-0.3	1.1	-3.4
Ever had bowel cancer screening	0.4	0.5	1.4	-1.2	-0.3	-0.1
Diabetes diagnosed by doctor	1.2	2.0	3.8	0.9	1.9	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	-1.1	-0.6	0.2
Friendships satisfaction	0.0	0.1	0.1	-0.2	-0.3	0.2
Qualifications: nursing, teaching	0.4	0.6	1.5	0.5	-1.2	0.0
Commuting to job workplace: Walk	1.9	2.1	3.2	-1.7	0.3	1.8
Eye problems/disorders: Cataract	2.5	2.9	5.3	0.4	1.8	-2.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.8	1.2	1.7	-0.7
Medication for cholesterol	0.5	0.7	1.7	-0.7	0.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.0	1.0	0.6	1.7
Back pain experienced in last month	0.3	0.4	1.1	0.2	0.4	-1.0
Mineral and other dietary supplements	0.6	0.8	1.9	-0.5	-1.4	-0.4
Breast cancer (self-reported)	0.5	0.6	0.8	0.9	0.6	-0.8
Asthma (self-reported)	1.0	2.0	4.7	-1.0	0.4	-2.2
Osteoporosis (self-reported)	0.5	0.6	1.1	-1.1	-0.5	0.8
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.0	-0.2	-0.6
Medication: Aspirin	1.4	1.8	2.8	1.3	0.9	-1.7
Medication: Gliclazide	2.2	2.5	2.5	1.6	1.6	-1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.6	0.6	1.0
Smoking status: Current	0.4	0.6	1.2	-0.3	0.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.5	-1.2	-0.9	-0.8
Whole body water mass	1.3	7.3	19.0	0.5	-1.6	-4.4
Leg predicted mass (right)	1.3	6.7	16.0	-0.3	-2.0	-4.0
Arm fat mass (left)	1.5	6.4	17.1	0.1	-1.4	-4.1
Number of self-reported non-cancer illnesses	1.4	2.4	5.6	-1.1	-0.5	-2.4
Average weekly champagne plus white wine intake	0.3	0.4	1.1	1.1	0.4	-0.1
Miserableness	0.7	1.3	3.2	-1.8	-0.8	0.0
Guilty feelings	1.6	2.4	5.5	-2.4	-1.1	0.7
Wears glasses or contact lenses	1.5	1.7	4.5	2.1	0.2	-0.8
Ever taken oral contraceptive pill	0.7	0.8	0.8	0.9	0.8	0.9
Hearing aid user	1.4	1.5	2.0	1.1	1.4	-1.2
Mother’s age at death	0.6	0.8	1.6	-0.8	0.1	1.3
Financial situation satisfaction	1.0	1.2	2.9	0.2	0.9	1.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.2	-0.5	-0.2	2.0
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.1	-0.5	-0.1
Eye problems/disorders: Glaucoma	1.1	1.3	2.3	0.8	-1.0	-1.5
Medication: Blood pressure	2.4	4.6	6.9	-0.5	-2.6	-2.6
Pain type(s) experienced in last month: Hip pain	2.3	2.9	4.4	-2.1	1.3	1.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.3	0.4	0.6
High cholesterol (Self-reported)	1.2	2.1	3.1	-0.6	-1.7	-1.8
Medication: Bendroflumethiazide	2.4	3.6	6.8	-1.9	-2.6	-0.7
Medication: Paracetamol	0.5	0.7	1.4	1.2	0.1	0.9
Medication: Lisinopril	0.1	0.2	0.3	-0.4	0.5	0.2
Medication: Atorvastatin	0.5	0.6	0.8	-0.8	0.9	-0.6
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.4	-0.8	0.4
Alcohol drinker status: Never	1.7	2.0	3.1	0.8	1.5	-1.8
Ever smoked	1.5	2.6	7.3	-0.4	-0.6	-2.7
Basal metabolic rate	1.3	7.4	19.2	0.3	-1.7	-4.4
Leg fat percentage (left)	1.0	3.7	10.2	0.7	-0.5	-3.2
Arm fat-free mass (left)	1.5	7.4	18.8	1.4	-1.2	-4.3
Number of operations (self-reported)	0.1	0.2	0.6	-0.1	-0.2	0.8
Average weekly beer plus cider intake	0.1	0.1	0.4	0.0	-0.6	-0.3
Irritability	1.0	1.7	4.3	-2.1	0.9	0.1
Risk taking	1.3	1.8	4.0	1.0	2.0	-0.7
Ever had prostate specific antigen (PSA) test	2.3	2.6	4.5	-1.3	-1.3	2.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.0	0.2	-0.2
Age started oral contraceptive pill	0.4	0.5	1.4	-0.0	1.2	0.1
Diastolic blood pressure, automated reading	0.9	2.9	4.4	-1.4	-1.6	2.1
Ever depressed for a whole week	0.3	0.4	0.7	-0.8	0.0	0.7
Unable to work because of sickness or disability	0.2	0.3	0.8	-0.1	0.9	0.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.1	0.2	0.2
Myopia	1.1	1.6	3.8	1.9	0.7	-0.7
Vascular/heart problems diagnosed by doctor	1.2	3.2	7.2	0.9	1.2	2.7
Cholesterol lowering medication	0.3	0.5	0.8	0.7	-0.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.4	-0.7	-0.4
Pain experienced in last month	0.7	1.1	2.7	1.6	-0.5	-0.6
Supplements: Calcium	0.6	0.7	1.3	0.8	-0.3	1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.4	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.8	0.4	0.3	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.6	0.6	2.1	1.2
Heart disease (siblings)	0.8	1.0	2.5	-0.3	0.7	1.6
Alcohol drinker status: Previous	0.3	0.4	0.9	0.3	1.0	0.3
Pack years of smoking	0.3	0.4	1.1	-1.1	-0.3	-0.1
Impedance of whole body	2.2	11.4	29.8	-1.8	1.0	5.5
Leg fat mass (left)	1.5	6.0	16.9	0.7	-0.7	-4.1
Arm predicted mass (left)	1.5	7.4	19.4	1.5	-0.8	-4.4