Best TWAS P=2.99e-12 · Best GWAS P=3.09e-11 conditioned to 0.228
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MED25 | 0.05 | 0.01 | blup | 361 | 0.02 | 2.2e-03 | 5.6 | 5.1 | 2.8e-07 | -0.69 | 0.03 | 0.88 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PNKP | 0.15 | 0.16 | enet | 23 | 0.16 | 7.0e-19 | 5.8 | 5.4 | 8.0e-08 | -0.78 | 0.15 | 0.85 | FALSE |
3 | GTEx | Brain Putamen basal ganglia | CTB-33G10.6 | 0.21 | 0.02 | enet | 7 | -0.01 | 4.5e-01 | 6.1 | 5.4 | 5.8e-08 | -0.73 | 0.03 | 0.36 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | TBC1D17 | 0.11 | 0.03 | enet | 23 | 0.04 | 6.5e-04 | 6.1 | -5.4 | 7.3e-08 | 0.78 | 0.02 | 0.97 | FALSE |
5 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | 5.1 | 6.7 | 2.8e-11 | -0.77 | 0.08 | 0.92 | FALSE |
6 | GTEx | Muscle Skeletal | ATF5 | 0.11 | 0.09 | lasso | 4 | 0.07 | 8.6e-08 | -4.9 | 5.6 | 2.1e-08 | -0.46 | 0.49 | 0.51 | FALSE |
7 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | 6.1 | -6.2 | 7.1e-10 | 0.81 | 0.03 | 0.97 | FALSE |
8 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | 5.8 | 7.0 | 3.0e-12 | -0.79 | 0.07 | 0.91 | TRUE |
9 | GTEx | Spleen | PPFIA3 | 0.25 | 0.23 | lasso | 4 | 0.21 | 3.9e-06 | -4.4 | 5.3 | 1.0e-07 | -0.04 | 0.03 | 0.90 | FALSE |
10 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | -5.4 | -6.5 | 5.6e-11 | 0.47 | 0.04 | 0.47 | FALSE |
11 | GTEx | Testis | NUP62 | 0.21 | 0.09 | lasso | 6 | 0.05 | 4.2e-03 | -4.9 | 5.6 | 2.8e-08 | -0.38 | 0.31 | 0.14 | FALSE |
12 | GTEx | Thyroid | FUZ | 0.08 | 0.00 | enet | 19 | 0.01 | 6.5e-02 | 6.1 | -5.5 | 3.2e-08 | 0.65 | 0.05 | 0.78 | FALSE |
13 | METSIM | Adipose | ATF5 | 0.12 | 0.05 | blup | 341 | 0.06 | 1.3e-09 | -5.4 | 5.6 | 1.8e-08 | -0.45 | 0.81 | 0.19 | FALSE |
14 | YFS | Blood | PNKP | 0.22 | 0.28 | enet | 47 | 0.30 | 3.9e-101 | 5.7 | 5.1 | 2.8e-07 | -0.71 | 0.48 | 0.52 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP2A1 | 0.04 | 0.03 | lasso | 4 | 0.04 | 1.8e-08 | 5.8 | -5.6 | 1.8e-08 | 0.82 | 0.05 | 0.95 | FALSE |
16 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | -5.1 | 5.8 | 7.1e-09 | -0.07 | 0.00 | 0.75 | TRUE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TBC1D17 | 0.06 | 0.03 | blup | 50 | 0.02 | 9.5e-04 | 5.7 | -5.2 | 1.8e-07 | 0.75 | 0.08 | 0.88 | FALSE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | NUP62 | 0.03 | 0.03 | lasso | 3 | 0.03 | 2.1e-04 | -5.4 | 5.4 | 8.3e-08 | -0.37 | 0.27 | 0.18 | FALSE |
19 | The Cancer Genome Atlas | Lung Adenocarcinoma | PNKP | 0.03 | 0.00 | blup | 46 | 0.02 | 4.0e-03 | 5.7 | 5.5 | 3.2e-08 | -0.63 | 0.01 | 0.16 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUP62 | 0.05 | 0.05 | blup | 54 | 0.05 | 9.5e-06 | -4.8 | 5.8 | 6.0e-09 | -0.45 | 0.28 | 0.23 | FALSE |
21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL4I1 | 0.15 | -0.01 | blup | 63 | 0.05 | 5.7e-03 | -5.4 | 5.4 | 8.3e-08 | -0.59 | 0.03 | 0.22 | FALSE |