TWAS hub - FOSB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.2823	0.0976	0.00260	0.001	NA	-0.002	NA	-0.001	2.5e-01	NA	4.6e-01	NA	4.1e-01
2	YFS	Blood	0.0254	0.0088	0.00029	0.019	0.013	0.017	0.013	0.016	4.2e-07	3.9e-05	1.8e-06	2.8e-05	3.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	8.8	13.9	25.4	-5.0	1.5
Severe depression (siblings)	7.3	8.2	16.4	0.1	-4.0
Diabetes (mother)	6.0	7.6	8.6	-2.6	-2.9
BMI	5.5	31.9	61.3	-7.8	-1.6
Alzheimer’s Disease (including proxy)	5.1	7.4	8.5	-2.5	2.9
Angina	5.0	6.5	9.0	-3.0	2.0
Comparative body size at age 10	4.6	12.6	24.8	-5.0	0.7
Knee pain experienced in last month	4.4	6.8	11.7	-1.4	-3.4
High cholesterol (Self-reported)	4.4	7.8	10.1	-3.2	2.3
Body mass index (BMI)	4.3	18.5	36.8	-6.1	-0.4
Angina (self-reported)	4.3	5.6	7.5	-2.7	1.9
Number of children fathered	4.2	4.7	8.5	-1.0	2.9
Medication: Cholesterol lowering	4.1	6.3	12.1	-3.5	0.7
Asthma (self-reported)	3.9	7.7	15.3	3.9	0.2
Exposure to tobacco smoke at home	3.8	4.3	6.9	1.3	-2.6
Ulcerative Colitis	3.7	5.4	7.4	-1.8	-2.7
Medication: Ramipril	3.7	4.8	7.3	-1.5	2.7
Leg fat mass (right)	3.7	14.2	28.4	-5.3	0.1
Alzheimer’s Disease (in mother)	3.6	4.3	5.2	-1.8	2.3
Lung FEV1/FVC ratio	3.6	18.1	31.1	-5.6	2.2
Leg fat mass (left)	3.6	14.2	28.3	-5.3	-0.1
Waist circumference	3.3	12.0	23.9	-4.9	0.0
Leg fat percentage (right)	3.3	12.0	24.0	-4.9	0.2
Blood Platelet Count	3.2	37.1	59.8	3.8	7.7
Asthma	3.2	6.3	12.4	3.5	0.4
Breastfed as a baby	3.2	4.0	5.8	1.5	-2.4
Leg fat percentage (left)	3.2	11.7	23.4	-4.8	-0.0
Smoking status: Current	3.0	4.8	9.6	-0.0	-3.1
Cholesterol lowering medication	3.0	4.4	7.2	-2.7	1.2
Current tobacco smoking	2.9	4.8	9.6	-0.1	-3.1
Arm fat mass (right)	2.9	11.9	23.7	-4.9	-0.1
Arm fat mass (left)	2.9	11.7	23.4	-4.8	0.1
Fasting Glucose	2.8	3.3	6.3	-2.5	-0.5
Medication: Simvastatin	2.8	4.2	4.8	-2.2	1.9
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	6.2	0.8	2.5
Schizophrenia vs Biploar Disorder	2.7	3.5	6.8	2.6	0.5
Weight	2.7	13.3	26.6	-5.2	0.0
Impedance of arm (right)	2.7	12.5	24.9	5.0	-0.2
Whole body fat mass	2.7	11.2	22.3	-4.7	-0.2
Illnesses of father: None of the above (group 1)	2.7	3.3	4.8	2.2	-1.4
Impedance of whole body	2.7	13.9	27.8	5.3	0.3
Impedance of arm (left)	2.6	12.2	24.5	4.9	0.1
Illnesses of father: Heart disease	2.5	3.4	6.7	-2.6	-0.5
Father’s age at death	2.4	3.2	6.4	2.5	0.1
Mouth/teeth dental problems: Loose teeth	2.4	2.9	5.4	0.7	-2.3
Mother’s age at death	2.4	3.0	5.8	2.4	-0.4
Hand grip strength (left)	2.3	6.1	6.9	-2.6	2.3
Arm fat percentage (right)	2.3	9.0	17.5	-4.2	-0.7
Emphysema/chronic bronchitis	2.3	2.6	4.8	0.6	-2.2
Arm fat percentage (left)	2.3	9.0	17.6	-4.2	-0.6
Respiratory disease	2.2	4.8	8.4	2.9	-1.1
Mouth/teeth dental problems	2.2	3.4	6.3	-0.8	2.5
Number of live births	2.2	3.1	4.5	2.1	-1.3
Hair/balding pattern: Pattern 4	2.2	5.3	8.2	-1.6	2.9
Medication: Allopurinol	2.2	2.9	3.4	-1.5	1.8
Supplements: Calcium	2.2	2.4	4.6	0.4	-2.1
Impedance of leg (left)	2.1	10.1	18.6	4.3	1.3
Heart attack	2.1	2.7	4.6	-2.2	0.8
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	5.2	2.3	-1.4
Migraine (self-reported)	2.1	2.6	2.6	1.6	1.6
Body Mass Index (BMI) (2010)	2.0	2.7	5.2	-2.3	0.5
Trunk fat mass	2.0	8.5	17.0	-4.1	-0.1
Body fat percentage	2.0	7.8	15.5	-3.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	4.3	-0.7	2.1
Medication: Atorvastatin	2.0	2.5	4.2	-2.0	0.9
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.0	-2.0	1.1
Impedance of leg (right)	1.9	9.3	16.3	4.0	1.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	4.1	0.3	-2.0
Number of full sisters	1.9	2.4	4.4	2.1	-0.5
Crohns Disease (2017)	1.8	4.0	4.4	-2.1	1.9
Ulcerative Colitis (UC)	1.8	3.4	4.5	-2.1	-1.5
Vitamin and mineral supplements	1.8	2.4	3.1	-1.8	1.3
Mouth/teeth dental problems: Dentures	1.8	3.1	4.8	1.2	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.4	0.1	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.7	-2.8	-0.1
Pack years of smoking	1.8	2.7	4.5	-2.1	-0.9
Neuroticism (2016)	1.7	2.5	3.5	-1.9	-1.2
Illnesses of mother	1.7	2.1	2.7	1.2	-1.6
Arm fat-free mass (right)	1.7	8.6	17.0	-4.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	2.9	1.7	-1.2
Arm predicted mass (right)	1.7	8.5	16.7	-4.1	0.6
Arm fat-free mass (left)	1.7	8.7	16.9	-4.1	0.6
Vascular/heart problems diagnosed by doctor	1.7	4.6	5.1	2.3	-2.0
Irritable Bowel Disease (IBD)	1.6	3.9	7.8	-2.8	0.2
Qualifications: CSEs or equivalent	1.6	2.2	4.1	0.5	-2.0
Medication: Atenolol	1.6	2.0	2.8	-1.7	1.1
Heart disease (mother)	1.6	2.0	4.0	-2.0	-0.2
Supplements: Fish oil (including cod liver oil)	1.6	2.0	2.8	1.7	-1.1
Basal metabolic rate	1.6	8.7	17.2	-4.2	0.3
Fractured/broken bones in last 5 years	1.6	2.0	3.2	1.0	-1.8
Arm predicted mass (left)	1.6	8.0	15.7	-4.0	0.6
Pack years adult smoking proportion	1.5	2.3	3.9	-2.0	-0.9
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.1	-1.8	-0.7
Alcohol usually taken with meals	1.5	2.4	4.0	0.9	2.0
Family relationship satisfaction	1.5	1.8	3.6	0.1	-1.9
Smoking status: Previous	1.5	2.2	3.8	0.7	2.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.3	-0.5	1.8
Basal cell carcinoma (self-reported)	1.5	1.8	2.5	1.6	-1.1
HDL Cholesterol	1.4	2.4	4.8	-2.2	0.1
Leg fat-free mass (left)	1.4	7.5	14.8	-3.9	-0.4
Trunk fat percentage	1.4	5.7	11.3	-3.4	-0.3
Leg predicted mass (left)	1.4	7.5	14.9	-3.9	-0.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.4	1.9	0.4
Hip circumference	1.4	6.0	11.7	-3.4	-0.6
Blood clot in the leg (DVT)	1.4	1.8	3.3	-1.8	-0.4
Medication for pain relief, constipation, heartburn	1.4	2.3	3.3	1.2	-1.8
Medication: Aspirin	1.4	1.8	3.3	-1.8	-0.6
Osteoporosis (self-reported)	1.4	1.7	2.9	0.8	-1.7
Medication: Blood pressure	1.4	2.8	3.7	-1.9	1.4
Myopia	1.4	2.0	4.0	2.0	0.1
Heel T-Score	1.3	10.4	16.6	-2.1	4.1
Multivitamins +/- minerals	1.3	1.7	2.9	1.7	-0.7
Lung cancer (father)	1.3	1.5	2.2	-0.9	-1.5
Loneliness, isolation	1.3	1.8	3.6	-0.2	-1.9
Medication for cholesterol	1.3	2.0	2.1	1.4	-1.4
Leg predicted mass (right)	1.3	6.8	13.3	-3.6	-0.5
Alzheimer’s Disease (in father)	1.2	1.3	2.0	-1.4	0.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.1	1.8	0.0
Whole body fat-free mass	1.2	6.9	13.8	-3.7	0.2
Leg fat-free mass (right)	1.2	6.7	13.0	-3.6	-0.5
Qualifications: nursing, teaching	1.2	1.9	2.8	1.0	-1.7
Mineral and other dietary supplements	1.2	1.6	2.2	-1.5	1.0
Whole body water mass	1.2	7.0	13.9	-3.7	0.3
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.7	-1.6	0.3
Ovarian Cancer	1.1	1.5	1.8	1.0	1.4
Waist Hip Ratio (WHR)	1.1	4.8	8.6	-0.9	2.9
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.1	0.1	-1.8
Trunk predicted mass	1.1	6.0	11.4	-3.4	0.8
Headache pain in last month	1.1	2.0	2.9	1.7	1.0
Financial situation satisfaction	1.1	1.3	2.6	1.6	-0.3
Cardiovascular Disease	1.0	3.2	4.1	-2.0	1.5
Trunk fat-free mass	1.0	5.9	11.4	-3.4	0.7
Birth weight of first child	1.0	1.9	3.1	-0.8	-1.8
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	0.6	-1.5
Medication: Paracetamol	1.0	1.7	2.1	1.5	1.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.7	-0.8	1.3
Shortness of breath walking on level ground	1.0	1.1	1.4	-1.2	-0.9
Medication: Omeprazole	1.0	1.2	2.3	-0.0	1.5
Pulse rate, automated reading	1.0	3.3	4.6	1.4	-2.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.3	-1.5	-0.5
Mean Putamen Volume	0.9	1.0	1.1	0.9	-1.1
Blood White Count	0.9	6.9	6.9	2.6	2.6
Average weekly spirits intake	0.9	1.1	1.9	0.6	-1.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.0	-1.4	-0.6
Townsend deprivation index at recruitment	0.9	1.3	2.6	0.2	-1.6
High blood pressure	0.9	2.5	2.6	-1.5	1.6
Supplements: Glucosamine	0.9	1.2	2.3	0.3	-1.5
Medication: Levothyroxine sodium	0.9	1.5	3.1	1.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.8	-1.4	-0.6
Alcohol intake versus 10 years previously	0.9	1.4	2.0	-0.9	-1.4
Length of working week for main job	0.9	0.9	1.5	1.2	-0.6
Birth weight	0.9	1.9	3.8	-0.2	-1.9
Age at first live birth	0.9	1.5	2.6	-0.6	1.6
Qualifications: College or University degree	0.9	2.9	5.6	2.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.1	-0.1	1.4
Average weekly red wine intake	0.9	1.3	2.3	0.5	1.5
Medication: Paracetamol	0.9	1.4	1.8	1.3	1.0
Heart disease (siblings)	0.9	1.1	2.2	-1.5	-0.1
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.2	2.0	0.7
Primary Biliary Cirrhosis	0.8	1.1	1.5	-1.2	-0.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	1.4	0.2
Taking other prescription medications	0.8	1.3	2.5	1.6	0.3
Noisy workplace	0.8	1.0	1.9	-0.5	-1.4
Pulse wave reflection index	0.8	0.9	1.9	-1.4	-0.2
Guilty feelings	0.8	1.3	2.5	0.1	1.6
Ever taken oral contraceptive pill	0.8	0.9	1.9	-0.1	-1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.3	-0.8	1.1
Major Depression (MDD)	0.7	0.9	1.8	-0.0	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.3	0.9	1.5
Hand grip strength (right)	0.7	2.0	3.2	-1.8	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	0.4	-1.2
Glaucoma (self-reported)	0.7	0.8	1.7	-0.1	-1.3
Gout (self-reported)	0.7	1.0	1.4	-1.2	0.8
High blood pressure (siblings)	0.7	1.0	1.7	-0.5	-1.3
Supplements: Vitamin C	0.7	0.8	1.3	-0.6	-1.1
Medication: Aspirin	0.7	0.9	1.8	-1.3	-0.3
Number of self-reported non-cancer illnesses	0.7	1.2	1.3	-1.1	1.1
Hearing aid user	0.7	0.8	1.5	-0.2	1.2
Ever depressed for a whole week	0.7	0.9	1.3	-1.1	-0.7
Prostate Cancer	0.6	0.9	1.7	-0.3	-1.3
Schizophrenia (2014)	0.6	1.4	2.7	1.6	0.2
Blood Red Count	0.6	6.2	8.9	-1.9	-3.0
Systolic Blood Pressure	0.6	3.0	5.0	2.2	1.0
Average weekly fortified wine intake	0.6	0.8	1.3	-1.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.5	2.7	-0.5	1.6
Serious illness, injury or assault to yourself	0.6	0.7	1.4	-0.3	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	1.7	-1.0	1.3
Qualifications: None of the above	0.6	1.4	2.3	-1.5	0.7
Falls in the last year	0.6	0.9	1.7	1.3	-0.0
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	-0.1	-1.4
Exposure to tobacco smoke outside home	0.6	0.8	1.4	0.4	-1.2
Eye problems/disorders: None of the above	0.6	0.6	1.3	1.1	0.2
Leg pain on walking	0.6	0.8	1.6	-0.1	-1.3
Hypertension (Self-reported)	0.6	1.6	1.8	-1.2	1.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	-1.1	0.4
Breast cancer (self-reported)	0.6	0.7	1.1	0.5	1.1
Average weekly champagne plus white wine intake	0.6	0.8	1.5	-0.4	1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	0.9	-0.9	-0.9
Illnesses of father: High blood pressure	0.6	0.8	1.5	-0.2	1.2
Commuting to job workplace: Cycle	0.6	0.7	1.3	-1.1	-0.3
Depression (Nagel 2018)	0.5	0.7	1.0	-0.7	-1.0
Diabetes (father)	0.5	0.6	1.0	-0.5	-1.0
Maternal smoking around birth	0.5	0.8	1.3	-1.1	0.5
Illnesses of siblings	0.5	0.7	0.8	0.7	0.9
Hair/balding pattern: Pattern 3	0.5	0.8	0.9	-0.9	0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	2.6	-1.6	-1.0
Happiness	0.5	0.7	1.1	0.4	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.3	1.5	0.1
Medication: Blood pressure	0.5	0.9	1.0	-0.9	1.0
Alcohol intake frequency.	0.5	1.1	2.2	0.1	-1.5
Chest pain or discomfort	0.5	0.7	1.5	0.1	-1.2
Age at last live birth	0.5	0.8	1.6	-0.1	1.2
Miserableness	0.5	0.8	1.6	1.3	0.2
Risk taking	0.5	0.7	0.9	-0.7	-1.0
HbA1C	0.4	0.5	0.5	-0.6	-0.7
Hair Pigment	0.4	10.3	20.5	0.0	-4.5
Relative age of first facial hair	0.4	0.8	1.5	0.3	-1.2
Ever had hysterectomy (womb removed)	0.4	0.5	0.5	-0.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.9	0.3
Medication for hormone replacement therapy	0.4	0.5	0.8	0.9	0.3
Medication: Co-codamol	0.4	0.4	0.8	0.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.0	-0.4	-1.0
Age when periods started (menarche)	0.4	0.9	1.7	-0.3	-1.3
Nervous feelings	0.4	0.8	1.5	0.4	-1.2
Pain all over the body in last month	0.4	0.4	0.9	-0.9	-0.0
Prospective memory result	0.4	0.5	1.0	-1.0	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	0.9	-0.3
Loud music exposure frequency	0.4	0.5	1.0	-0.1	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	0.0	-1.2
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-0.1	-1.0
Long-standing illness, disability or infirmity	0.4	0.6	0.9	-0.9	-0.5
Friendships satisfaction	0.4	0.5	0.8	0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	0.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	-1.0	0.1
Osteoarthritis (self-reported)	0.4	0.5	1.0	-0.3	-1.0
Eye problems/disorders: Glaucoma	0.4	0.4	0.5	-0.6	-0.7
Medication: Bendroflumethiazide	0.4	0.6	0.6	-0.7	-0.8
Ever smoked	0.4	0.7	1.4	-0.2	-1.2
Alcohol drinker status: Previous	0.4	0.5	0.7	-0.8	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	1.2	0.2
Schizophrenia (2018)	0.3	0.7	1.1	1.0	0.5
Reaction Time	0.3	0.5	0.9	0.4	0.9
Lupus	0.3	0.4	0.9	0.1	-0.9
Rheumatoid Arthritis	0.3	0.3	0.4	0.6	-0.6
Hypothyroidism (self reported)	0.3	0.7	1.1	0.5	1.1
Lung FVC	0.3	1.3	2.5	0.2	-1.6
Supplements: Zinc	0.3	0.4	0.6	-0.3	-0.8
Relative age voice broke	0.3	0.4	0.8	-0.9	-0.2
Stomach or abdominal pain in last month	0.3	0.3	0.5	-0.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.3	-0.8
Sitting height	0.3	1.9	3.8	1.9	0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	0.2	-0.8
High blood pressure (mother)	0.3	0.5	0.9	1.0	0.1
Forced vital capacity (FVC)	0.3	1.0	1.9	-0.2	-1.4
Financial difficulties in last 2 years	0.3	0.4	0.7	0.9	0.3
Allergy	0.3	0.6	1.0	-1.0	0.4
Fluid intelligence score	0.3	0.7	1.4	0.2	1.2
Depression (self-reported)	0.3	0.4	0.7	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.7	-1.3	-0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.8	0.1
Peak expiratory flow (PEF)	0.3	0.7	1.4	-1.2	-0.3
Pulse wave peak to peak time	0.3	0.4	0.7	0.9	0.0
Suffer from ‘nerves’	0.3	0.5	0.6	-0.8	-0.5
Overall health rating	0.3	0.6	1.0	-1.0	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.7	0.2
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.8	0.1
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.8	0.1
Bipolar Disorder (2018)	0.2	0.3	0.4	0.6	-0.4
Crohns Disease (2012)	0.2	0.3	0.6	-0.2	0.8
Number of treatments/medications taken	0.2	0.3	0.5	0.4	0.7
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.3	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.4	-0.7	-0.3
Fed-up feelings	0.2	0.4	0.4	0.6	-0.6
Worrier / anxious feelings	0.2	0.4	0.7	0.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	0.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.4	0.6
Medication: Lansoprazole	0.2	0.2	0.4	-0.6	0.0
Standing height	0.2	1.8	2.5	1.6	1.1
Tense / ‘highly strung’	0.2	0.3	0.6	0.3	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.6	1.2	0.2	-1.1
Health satisfaction	0.2	0.3	0.5	0.0	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.7	0.3
Had major operations	0.2	0.3	0.3	0.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.3	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	-0.4	-0.4
Back pain experienced in last month	0.2	0.3	0.5	-0.7	0.3
Medication: Lisinopril	0.2	0.2	0.4	0.6	0.0
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.2
Unable to work because of sickness or disability	0.2	0.2	0.2	-0.5	-0.4
Pain experienced in last month	0.2	0.4	0.7	0.8	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.2	-0.4	-0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.7	0.0
Worry (Nagel 2018)	0.1	0.2	0.4	-0.7	-0.2
Breast Cancer	0.1	0.3	0.4	-0.6	0.5
Blood Eosinophil Count	0.1	1.1	2.2	0.0	-1.5
Height	0.1	2.2	4.0	0.6	2.0
Smoking Status	0.1	0.1	0.3	0.0	-0.5
Allergy or Eczema	0.1	0.2	0.3	0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.1	-0.7
Neuroticism	0.1	0.3	0.4	-0.4	-0.6
Chronotype (morning person)	0.1	0.3	0.5	0.7	0.4
Tanning	0.1	1.6	1.7	-1.3	-1.2
Systolic blood pressure, automated reading	0.1	0.3	0.4	0.5	0.6
Number of incorrect matches in round	0.1	0.2	0.3	0.6	0.2
Past tobacco smoking	0.1	0.2	0.3	-0.1	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.6	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.0	0.4
Had menopause	0.1	0.2	0.2	-0.4	0.3
Had other major operations	0.1	0.1	0.2	0.2	-0.5
Diabetes (self-reported)	0.1	0.1	0.1	0.3	-0.3
Neuroticism score	0.1	0.1	0.3	-0.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.4	0.6
Number of full brothers	0.1	0.1	0.3	0.5	-0.1
Worry too long after embarrassment	0.1	0.1	0.3	-0.5	0.0
Mean time to correctly identify matches	0.1	0.1	0.2	-0.2	0.4
Comparative height size at age 10	0.1	0.7	1.3	0.1	1.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.3	0.3
Mood swings	0.1	0.2	0.3	0.3	-0.5
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.3	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.3	-0.3
Wears glasses or contact lenses	0.1	0.1	0.2	0.0	0.4
Average weekly beer plus cider intake	0.1	0.1	0.1	-0.3	0.3
Irritability	0.1	0.1	0.1	-0.3	-0.3
Age started oral contraceptive pill	0.1	0.1	0.1	0.0	-0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.3	-0.5	-0.5
Age at First Birth	0.0	0.0	0.0	0.1	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.1	0.4	0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Medication: Metformin	0.0	0.0	0.0	0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.1	0.1
Time employed in main current job	0.0	0.0	0.1	-0.2	0.2
Pulse rate	0.0	0.0	0.0	-0.0	-0.0
Medication: Amlodipine	0.0	0.1	0.1	-0.1	0.3
Medication: Ibuprofen	0.0	0.0	0.0	-0.0	-0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.1	0.3
Ever had bowel cancer screening	0.0	0.0	0.0	0.2	-0.1
Medication: Gliclazide	0.0	0.0	0.0	-0.1	0.0
Alcohol drinker status: Never	0.0	0.1	0.1	-0.1	-0.3

Hub : Genes

FOSB

Models

Trait associations