Best TWAS P=1.82e-14 · Best GWAS P=2.54e-14 conditioned to 0.0978
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | ROSMAP | Brain Pre-frontal Cortex | HOXD-AS1 | 0.11 | 0.06 | lasso | 6 | 0.09 | 1.4e-11 | -6.4 | 7.7 | 1.8e-14 | -0.67 | 0.19 | 0.81 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXD11 | 0.03 | 0.02 | enet | 7 | 0.03 | 5.8e-04 | -5.5 | 6.0 | 1.5e-09 | -0.15 | 0.16 | 0.25 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ATP5G3 | 0.11 | 0.05 | enet | 8 | 0.07 | 1.2e-03 | -5.0 | -5.4 | 7.8e-08 | 0.07 | 0.02 | 0.86 | TRUE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HOXD9 | 0.05 | 0.02 | blup | 54 | 0.03 | 6.1e-03 | 5.2 | 6.5 | 9.1e-11 | -0.13 | 0.03 | 0.25 | FALSE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | HOXD12 | 0.21 | 0.05 | blup | 48 | 0.13 | 6.3e-05 | -4.2 | 5.7 | 1.1e-08 | -0.26 | 0.03 | 0.16 | FALSE |
| 1 | GTEx | Cells Transformed fibroblasts | ATP5G3 | 0.07 | 0.04 | lasso | 6 | 0.01 | 4.6e-02 | -5.0 | -5.1 | 2.8e-07 | 0.01 | 0.02 | 0.97 | FALSE |