[Hub]/) : Traits : Impedance of whole body :

chr2:197,134,790-200,117,777

Best TWAS P=1.89e-32 · Best GWAS P=1.82e-32 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PLCL1 0.06 0.01 blup 397 0.02 4.9e-04 0.44 5.9 3.5e-09 0.51 0.06 0.56 FALSE
2 CommonMind Brain Pre-frontal Cortex SF3B1 0.06 0.07 enet 10 0.07 2.5e-09 7.50 7.5 6.4e-14 0.56 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous RFTN2 0.14 0.10 enet 11 0.13 5.3e-11 11.29 10.2 1.5e-24 0.87 0.12 0.88 FALSE
4 GTEx Adrenal Gland ANKRD44 0.15 0.05 lasso 5 0.15 3.9e-06 -1.29 -5.7 1.6e-08 -0.46 0.22 0.43 FALSE
5 GTEx Brain Frontal Cortex BA9 MARS2 0.18 0.12 lasso 2 0.07 5.1e-03 5.30 -5.3 1.1e-07 -0.53 0.14 0.10 FALSE
6 GTEx Breast Mammary Tissue SF3B1 0.06 0.06 lasso 4 0.03 6.6e-03 7.43 9.1 1.1e-19 0.70 0.18 0.66 FALSE
7 GTEx Breast Mammary Tissue (Female) SF3B1 0.05 -0.01 lasso 3 -0.01 8.1e-01 7.49 9.8 8.9e-23 0.75 0.05 0.09 FALSE
8 GTEx Cells EBV-transformed lymphocytes HSPD1 0.15 0.04 lasso 7 0.04 2.0e-02 5.78 -8.1 3.9e-16 -0.73 0.11 0.58 FALSE
9 GTEx Cells EBV-transformed lymphocytes MARS2 0.15 0.14 lasso 4 0.07 2.6e-03 -8.51 -8.6 5.5e-18 -0.76 0.05 0.75 FALSE
10 GTEx Colon Transverse MARS2 0.17 0.12 lasso 4 0.13 7.4e-07 -8.51 -7.9 3.8e-15 -0.69 0.21 0.49 FALSE
11 GTEx Esophagus Mucosa SF3B1 0.04 0.02 lasso 4 0.01 5.7e-02 7.66 7.5 8.4e-14 0.56 0.32 0.07 FALSE
12 GTEx Esophagus Muscularis SF3B1 0.06 0.02 lasso 4 0.03 1.0e-02 8.00 7.6 2.3e-14 0.49 0.18 0.16 FALSE
13 GTEx Lung SF3B1 0.06 0.04 enet 23 0.02 2.2e-02 7.66 6.0 2.0e-09 0.53 0.45 0.25 FALSE
14 GTEx Lung RFTN2 0.06 0.08 lasso 8 0.06 2.7e-05 11.84 11.8 6.1e-32 0.99 0.04 0.96 FALSE
15 GTEx Nerve Tibial SF3B1 0.06 0.09 lasso 8 0.08 3.3e-06 7.49 7.9 3.5e-15 0.61 0.97 0.02 FALSE
16 GTEx Pituitary HSPD1 0.10 0.03 enet 12 0.06 1.3e-02 0.78 5.5 3.8e-08 0.50 0.08 0.33 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic SF3B1 0.08 0.00 enet 19 0.01 1.6e-01 7.49 5.7 1.4e-08 0.38 0.31 0.05 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic MARS2 0.22 0.02 enet 30 0.02 3.6e-02 11.70 -5.3 1.2e-07 -0.56 0.06 0.53 FALSE
19 GTEx Skin Sun Exposed Lower leg MARS2 0.04 0.05 enet 8 0.03 1.2e-03 11.76 -11.9 1.9e-32 -0.98 0.06 0.94 TRUE
20 GTEx Spleen RFTN2 0.11 0.03 enet 26 0.05 2.4e-02 11.69 11.7 2.3e-31 0.96 0.05 0.65 FALSE
21 GTEx Spleen MARS2 0.12 0.04 lasso 5 0.00 3.4e-01 11.73 -11.5 1.1e-30 -0.94 0.05 0.50 FALSE
22 GTEx Testis ANKRD44 0.33 0.35 enet 15 0.36 6.2e-17 6.01 5.8 6.2e-09 0.45 1.00 0.00 FALSE
23 GTEx Testis SF3B1 0.10 0.07 enet 17 0.08 2.6e-04 7.50 8.2 1.9e-16 0.63 0.42 0.53 FALSE
24 GTEx Thyroid SF3B1 0.04 0.02 enet 14 0.02 2.0e-02 7.74 10.1 5.7e-24 0.83 0.07 0.86 FALSE
25 GTEx Thyroid PLCL1 0.04 0.01 lasso 4 0.00 2.6e-01 11.49 11.0 5.2e-28 0.89 0.16 0.60 FALSE
26 GTEx Thyroid RFTN2 0.04 0.01 enet 11 0.01 9.5e-02 11.73 10.3 1.2e-24 0.87 0.07 0.80 FALSE
27 GTEx Whole Blood PLCL1 0.08 0.08 enet 15 0.05 4.1e-05 11.31 11.0 2.8e-28 0.89 0.31 0.69 FALSE
28 METSIM Adipose PLCL1 0.06 0.01 blup 517 0.05 3.6e-08 -3.55 8.1 7.3e-16 0.76 0.12 0.88 FALSE
29 NTR Blood ANKRD44 0.03 0.00 bslmm 417 0.02 2.7e-06 7.04 -7.3 3.4e-13 -0.54 0.18 0.69 FALSE
30 NTR Blood PLCL1 0.02 0.01 enet 14 0.02 1.9e-06 11.29 8.5 2.1e-17 0.71 0.22 0.72 FALSE
31 ROSMAP Brain Pre-frontal Cortex SF3B1 0.02 0.01 blup 336 0.01 6.2e-03 7.62 7.1 1.0e-12 0.55 0.56 0.10 FALSE
32 ROSMAP Brain Pre-frontal Cortex MARS2 0.05 0.03 enet 14 0.05 2.2e-07 -8.07 -9.4 5.5e-21 -0.86 0.06 0.94 FALSE
33 YFS Blood ANKRD44 0.02 0.00 blup 416 0.01 6.3e-04 -1.18 -5.5 2.8e-08 -0.46 0.14 0.46 FALSE
34 YFS Blood PLCL1 0.10 0.10 lasso 9 0.14 1.5e-43 11.42 9.7 3.6e-22 0.84 0.75 0.25 FALSE
35 The Cancer Genome Atlas Breast Invasive Carcinoma RFTN2 0.02 0.02 lasso 2 0.01 1.1e-03 5.41 5.2 2.3e-07 0.52 0.21 0.27 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLCL1 0.04 0.00 blup 130 0.02 4.0e-03 -2.41 9.4 7.3e-21 0.66 0.04 0.44 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MOBKL3 0.03 0.01 blup 32 0.02 6.3e-03 10.29 7.9 3.0e-15 0.72 0.01 0.56 FALSE
38 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RFTN2 0.05 0.01 blup 61 0.02 3.1e-02 7.49 10.3 1.1e-24 0.81 0.04 0.39 FALSE