Best TWAS P=1.16e-09 · Best GWAS P=1.3e-11 conditioned to 0.00197
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | NNT | 0.15 | 0.03 | enet | 21 | 0.07 | 3.3e-06 | -3.10 | -5.4 | 5.4e-08 | 0.07 | 0.18 | 0.76 | FALSE |
2 | GTEx | Adipose Subcutaneous | CCDC152 | 0.09 | 0.04 | lasso | 4 | 0.02 | 6.4e-03 | -6.01 | -6.1 | 1.2e-09 | 0.46 | 0.18 | 0.80 | TRUE |
3 | GTEx | Adipose Visceral Omentum | CCDC152 | 0.09 | 0.06 | lasso | 9 | 0.05 | 1.9e-03 | -5.92 | -5.8 | 6.2e-09 | 0.45 | 0.11 | 0.38 | FALSE |
4 | GTEx | Adrenal Gland | NNT | 0.17 | 0.15 | lasso | 4 | 0.07 | 1.3e-03 | 4.51 | -5.3 | 9.0e-08 | 0.06 | 0.14 | 0.75 | FALSE |
5 | GTEx | Artery Aorta | CCDC152 | 0.31 | 0.24 | lasso | 8 | 0.24 | 2.5e-13 | -5.92 | -5.9 | 3.6e-09 | 0.45 | 0.18 | 0.82 | FALSE |
6 | GTEx | Artery Coronary | CCDC152 | 0.20 | 0.13 | lasso | 2 | 0.12 | 7.7e-05 | -5.92 | -5.9 | 3.1e-09 | 0.46 | 0.18 | 0.74 | FALSE |
7 | GTEx | Brain Caudate basal ganglia | C5orf34 | 0.14 | -0.01 | enet | 14 | 0.00 | 3.3e-01 | -4.51 | -6.0 | 1.6e-09 | 0.07 | 0.08 | 0.37 | TRUE |
8 | GTEx | Brain Frontal Cortex BA9 | GHR | 0.14 | 0.02 | lasso | 9 | 0.06 | 9.9e-03 | -5.91 | 5.7 | 1.2e-08 | -0.31 | 0.12 | 0.11 | TRUE |
9 | GTEx | Cells Transformed fibroblasts | C5orf34 | 0.10 | 0.01 | enet | 20 | 0.01 | 3.0e-02 | -0.83 | -5.4 | 8.6e-08 | -0.04 | 0.07 | 0.18 | FALSE |
10 | GTEx | Esophagus Mucosa | NNT | 0.31 | 0.24 | lasso | 8 | 0.26 | 1.4e-17 | -4.81 | -5.9 | 2.8e-09 | 0.15 | 0.06 | 0.93 | FALSE |
11 | GTEx | Esophagus Muscularis | CCDC152 | 0.13 | 0.09 | lasso | 8 | 0.10 | 7.9e-07 | -4.96 | -5.3 | 1.1e-07 | 0.48 | 0.23 | 0.76 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | NNT | 0.05 | 0.04 | enet | 11 | 0.04 | 4.3e-04 | -4.48 | -5.5 | 4.1e-08 | 0.05 | 0.15 | 0.74 | FALSE |
13 | GTEx | Small Intestine Terminal Ileum | NNT | 0.19 | 0.05 | enet | 31 | 0.10 | 3.8e-03 | -4.43 | -5.4 | 7.1e-08 | 0.10 | 0.09 | 0.47 | FALSE |
14 | GTEx | Thyroid | C5orf34 | 0.08 | 0.08 | lasso | 3 | 0.06 | 1.4e-05 | -4.80 | -5.5 | 3.6e-08 | 0.08 | 0.06 | 0.91 | FALSE |
15 | GTEx | Thyroid | CCDC152 | 0.10 | 0.07 | lasso | 4 | 0.04 | 4.2e-04 | -5.94 | -6.0 | 2.4e-09 | 0.45 | 0.17 | 0.79 | FALSE |
16 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | -5.71 | 6.0 | 1.5e-09 | -0.48 | 0.20 | 0.80 | FALSE |
17 | YFS | Blood | CCDC152 | 0.07 | 0.06 | enet | 16 | 0.06 | 2.0e-19 | -6.01 | -6.0 | 2.5e-09 | 0.47 | 0.15 | 0.85 | FALSE |
18 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C5orf34 | 0.04 | 0.01 | enet | 4 | 0.03 | 1.5e-03 | -4.47 | -5.5 | 4.6e-08 | 0.04 | 0.01 | 0.52 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C5orf34 | 0.11 | 0.12 | enet | 13 | 0.11 | 2.9e-12 | -4.47 | -5.2 | 2.6e-07 | 0.03 | 0.01 | 0.95 | FALSE |
20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NNT | 0.04 | 0.01 | enet | 9 | 0.02 | 3.4e-03 | -3.99 | -5.3 | 1.1e-07 | 0.07 | 0.01 | 0.57 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C5orf34 | 0.05 | 0.06 | blup | 39 | 0.05 | 3.2e-06 | -4.47 | -5.5 | 4.3e-08 | 0.05 | 0.01 | 0.95 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC152 | 0.06 | 0.06 | blup | 40 | 0.07 | 1.6e-08 | -5.58 | 5.4 | 6.5e-08 | -0.43 | 0.02 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC152 | 0.15 | 0.12 | lasso | 6 | 0.12 | 1.0e-12 | -5.65 | 5.6 | 2.1e-08 | -0.46 | 0.05 | 0.95 | FALSE |
24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GHR | 0.12 | 0.11 | enet | 6 | 0.13 | 2.5e-13 | 4.97 | 5.7 | 1.1e-08 | -0.26 | 0.90 | 0.10 | FALSE |
25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HMGCS1 | 0.04 | 0.03 | blup | 37 | 0.03 | 1.5e-04 | -4.74 | 5.3 | 1.4e-07 | -0.04 | 0.02 | 0.96 | FALSE |
26 | The Cancer Genome Atlas | Stomach Adenocarcinoma | NNT | 0.04 | 0.01 | blup | 48 | 0.02 | 1.2e-02 | 4.47 | -5.2 | 1.7e-07 | 0.11 | 0.01 | 0.41 | FALSE |