Hub : Genes

HMGCS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1460 0.0380 4.8e-13 0.156 0.117 0.128 0.131 0.148 1.3e-18 4.7e-14 2.3e-15 1.1e-15 1.2e-17
2 TCGA Prostate Adenocarcinoma 0.0437 0.0248 6.6e-05 0.032 0.034 0.022 NA 0.029 2.3e-04 1.5e-04 2.1e-03 NA 4.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.1 0.1 -0.2 0.3
Bipolar Disorder or Schizophrenia 0.3 0.7 0.7 0.9 -0.8
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 -0.2 -0.2
Depression (Nagel 2018) 0.9 1.3 1.9 0.8 -1.4
Intelligence (Savage-Jansen 2018) 0.9 2.7 3.6 1.9 -1.4
Neuroticism (Nagel 2018) 0.0 0.0 0.0 0.0 -0.2
Schizophrenia (2018) 0.8 1.7 1.8 1.3 -1.4
Schizophrenia vs Biploar Disorder 2.3 3.0 3.1 1.8 -1.7
Worry (Nagel 2018) 0.0 0.1 0.1 -0.3 0.3
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.6 -0.1
Alzheimer’s Disease (in father) 0.4 0.4 0.7 0.8 -0.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 0.4 0.1
Crohns Disease (2017) 0.1 0.2 0.2 0.4 -0.5
Irritable Bowel Disease (IBD) 0.8 1.9 2.2 1.2 -1.5
Ulcerative Colitis (UC) 1.1 2.1 2.4 1.3 -1.6
Major Depression (MDD) 0.3 0.4 0.7 0.4 -0.8
Reaction Time 1.8 3.3 4.2 1.6 -2.0
Verbal and Numeric Reasoning (VNR) 1.7 4.0 4.4 2.1 -1.9
Breast Cancer 0.8 2.0 2.1 -1.5 1.3
Ovarian Cancer 0.0 0.0 0.0 0.1 -0.1
Prostate Cancer 7.3 10.3 10.6 -3.2 3.2
Age at First Birth 0.2 0.2 0.4 -0.2 0.6
Bipolar Disorder (2011) 1.0 1.0 1.0 1.0 -1.0
Body Mass Index (BMI) (2010) 1.0 1.4 1.9 1.0 -1.4
Coronary Artery Disease (CAD) 1.3 1.5 2.2 -1.5 0.9
Crohns Disease (2012) 0.0 0.0 0.1 0.1 -0.2
Mean Putamen Volume 1.2 1.4 1.7 -1.3 1.0
Fasting Glucose 3.2 3.9 4.3 -1.9 2.1
HbA1C 1.0 1.1 1.7 1.3 -0.7
HDL Cholesterol 0.1 0.1 0.2 0.5 -0.2
LDL Cholesterol 0.1 0.1 0.1 0.4 0.2
Lupus 0.2 0.4 0.7 -0.8 0.2
Neuroticism (2016) 2.5 3.5 4.5 -2.1 1.6
Primary Biliary Cirrhosis 1.5 2.1 2.8 1.7 -1.2
Rheumatoid Arthritis 0.3 0.4 0.5 -0.6 0.7
Schizophrenia (2014) 0.5 1.1 1.3 1.1 -1.0
Triglycerides 0.0 0.0 0.0 0.0 0.1
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.5 -0.6 0.7
Ulcerative Colitis 1.6 2.3 2.5 1.5 -1.6
Blood Eosinophil Count 0.7 5.7 6.4 2.2 -2.5
Blood Platelet Count 0.2 2.0 2.4 -1.2 1.6
Blood Red Count 0.1 0.6 1.1 -1.0 0.4
Blood White Count 0.5 3.7 4.2 1.8 -2.0
Heel T-Score 0.5 3.9 4.9 -1.7 2.2
BMI 0.9 5.3 7.6 1.7 -2.8
Height 0.2 3.1 3.2 1.7 -1.8
Waist Hip Ratio (WHR) 1.0 4.3 5.0 -1.9 2.2
Systolic Blood Pressure 0.7 3.8 5.3 -2.3 1.5
Smoking Status 2.1 5.0 6.6 -2.6 1.8
Allergy or Eczema 0.4 0.9 1.5 1.2 -0.6
Cardiovascular Disease 0.9 3.0 4.3 -2.1 1.3
Hypothyroidism (self reported) 1.2 2.8 3.0 1.7 -1.6
Respiratory disease 0.6 1.4 1.7 1.0 -1.3
Type 2 Diabetes (T2D) (2018) 0.3 0.6 0.9 0.6 -0.9
Lung FEV1/FVC ratio 0.7 3.6 3.7 -1.9 1.9
Lung FVC 3.7 18.8 19.3 -4.4 4.3
Neuroticism 0.1 0.2 0.3 0.2 -0.6
Chronotype (morning person) 3.0 7.0 7.4 -2.7 2.6
Hair Pigment 0.1 2.6 3.1 1.8 -1.4
Tanning 0.5 5.7 7.8 -1.9 2.8
Hand grip strength (left) 0.2 0.5 0.7 -0.9 0.5
Number of treatments/medications taken 0.6 1.1 1.5 -1.2 0.8
Average weekly spirits intake 0.7 0.8 1.3 0.5 -1.1
Sensitivity / hurt feelings 0.8 1.4 1.6 1.1 -1.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.5 0.2 -0.7
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.3 0.6
Relative age of first facial hair 0.2 0.4 0.5 -0.7 0.6
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.1 0.2 -0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.2 0.5 -0.3
Ever had hysterectomy (womb removed) 0.0 0.1 0.1 -0.3 0.2
Systolic blood pressure, automated reading 1.1 3.1 4.3 -2.1 1.4
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.2 0.2
Angina 1.5 1.9 2.1 1.3 -1.4
Medication for hormone replacement therapy 0.3 0.3 0.4 -0.6 0.5
Vitamin and mineral supplements 0.1 0.2 0.2 -0.4 0.3
Supplements: Zinc 1.1 1.2 1.3 1.0 -1.1
Medication: Co-codamol 0.8 0.9 1.3 0.7 -1.2
Medication: Metformin 0.2 0.2 0.3 0.4 -0.6
Diabetes (father) 5.2 6.4 7.4 -2.3 2.7
Diabetes (mother) 3.0 3.8 4.3 -2.1 1.8
Severe depression (siblings) 0.5 0.5 0.7 -0.8 0.6
Pack years adult smoking proportion 0.9 1.4 1.9 -1.4 1.0
Impedance of leg (right) 5.7 27.5 31.6 -4.8 5.6
Leg fat-free mass (left) 2.5 13.0 16.2 3.1 -4.0
Trunk fat percentage 0.2 0.8 1.6 0.3 -1.3
Hand grip strength (right) 0.0 0.1 0.1 -0.2 -0.3
Townsend deprivation index at recruitment 0.8 1.2 1.4 -1.2 1.0
Current tobacco smoking 0.1 0.1 0.3 -0.5 -0.1
Average weekly fortified wine intake 0.1 0.1 0.1 0.4 -0.2
Maternal smoking around birth 0.8 1.1 2.1 -1.4 0.4
Fed-up feelings 0.0 0.0 0.1 -0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.4 -0.6 0.3
Relative age voice broke 0.6 0.9 0.9 1.0 -1.0
Taking other prescription medications 0.7 1.0 1.6 -1.3 0.7
Age when periods started (menarche) 0.2 0.5 0.9 0.2 0.9
Bilateral oophorectomy (both ovaries removed) 0.0 0.1 0.1 -0.2 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.1 0.2 -0.2
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 -0.1 0.1
Qualifications: CSEs or equivalent 0.6 0.8 1.3 -1.1 0.6
Serious illness, injury or assault to yourself 0.4 0.5 0.6 0.8 -0.6
High blood pressure 1.4 3.8 4.9 -2.2 1.6
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.3 0.6 0.4
Multivitamins +/- minerals 2.7 3.4 3.5 1.8 -1.9
Stomach or abdominal pain in last month 0.7 0.9 0.9 0.9 -0.9
Supplements: Glucosamine 0.4 0.5 0.6 0.8 -0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.1 -0.5
Medication: Atenolol 2.2 2.8 3.2 1.5 -1.8
Medication: Levothyroxine sodium 0.7 1.2 1.4 1.2 -0.9
Sitting height 0.1 0.6 0.6 -0.7 0.8
Chronic bronchitis/emphysema (father) 1.6 1.8 2.8 1.0 -1.7
High blood pressure (mother) 0.7 0.9 1.0 -1.0 0.9
Body mass index (BMI) 2.2 9.3 12.2 2.5 -3.5
Impedance of leg (left) 5.4 26.1 29.5 -4.8 5.4
Leg predicted mass (left) 2.5 13.4 16.6 3.2 -4.1
Trunk fat mass 0.7 2.9 4.5 1.1 -2.1
Waist circumference 1.1 4.0 5.5 1.6 -2.3
Number of incorrect matches in round 0.4 0.7 1.0 -1.0 0.7
Past tobacco smoking 2.9 5.3 5.4 2.3 -2.3
Alcohol usually taken with meals 0.1 0.1 0.2 0.2 0.4
Nervous feelings 0.6 1.1 1.2 1.0 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 -0.7 0.2
Hearing difficulty/problems with background noise 0.2 0.3 0.5 -0.4 0.7
Hair/balding pattern: Pattern 2 0.8 1.1 1.2 -1.1 1.0
Had menopause 0.7 0.8 0.9 0.9 -0.9
Had other major operations 0.8 0.9 1.0 -1.0 0.9
Forced vital capacity (FVC) 2.3 8.8 9.8 -3.1 2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.3 0.6 -0.4
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 -0.3 0.3
Qualifications: None of the above 0.9 2.0 3.2 -1.8 1.0
Financial difficulties in last 2 years 1.0 1.4 1.5 -1.1 1.2
Mouth/teeth dental problems 0.1 0.1 0.2 0.1 0.4
Heart attack 1.0 1.3 1.9 -1.4 0.8
Allergy 0.3 0.7 1.3 -1.1 0.3
Pain all over the body in last month 0.5 0.5 0.6 -0.6 0.8
Diabetes (self-reported) 0.4 0.7 1.0 0.6 -1.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.5 -0.5 0.7
Medication: Ramipril 0.5 0.6 0.9 -0.9 0.6
Medication: Simvastatin 1.3 1.9 2.1 -1.5 1.3
Fluid intelligence score 0.9 1.8 1.9 1.4 -1.4
Illnesses of siblings 0.0 0.0 0.0 -0.2 -0.0
Neuroticism score 0.1 0.2 0.4 -0.7 0.1
Weight 2.2 10.6 13.8 2.7 -3.7
Impedance of arm (right) 4.6 21.4 24.0 -4.3 4.9
Arm fat percentage (right) 0.5 2.1 3.2 1.0 -1.8
Trunk fat-free mass 2.3 13.3 15.4 3.3 -3.9
Hip circumference 1.9 8.2 10.8 2.4 -3.3
Time employed in main current job 0.0 0.0 0.1 -0.2 0.1
Alcohol intake versus 10 years previously 0.4 0.6 0.6 0.8 -0.7
Father’s age at death 0.1 0.1 0.2 0.1 0.5
Worrier / anxious feelings 2.0 3.7 4.3 -2.1 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 -0.2 -0.3
Falls in the last year 0.1 0.1 0.1 -0.2 0.3
Hair/balding pattern: Pattern 3 0.0 0.1 0.1 0.1 -0.3
Number of live births 0.0 0.0 0.0 0.1 -0.0
Forced expiratory volume in 1-second (FEV1) 3.2 10.7 11.6 -3.4 3.1
Pulse rate 0.1 0.2 0.4 0.6 -0.2
Happiness 1.2 1.4 1.7 -1.1 1.3
Noisy workplace 8.6 10.6 11.6 -3.4 3.1
Qualifications: A levels/AS levels or equivalent 2.0 4.4 5.4 2.3 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.0 0.4
Mouth/teeth dental problems: Dentures 0.3 0.4 0.9 0.1 -0.9
Asthma 1.5 3.0 3.3 1.8 -1.6
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.6 1.8 -1.2 1.3
Medication: Cholesterol lowering 1.6 2.4 2.9 -1.7 1.4
Depression (self-reported) 0.2 0.3 0.3 -0.6 0.5
Medication: Lansoprazole 0.7 0.9 0.9 0.9 -0.9
Prospective memory result 0.8 0.9 1.0 1.0 -0.9
Lung cancer (father) 2.9 3.4 3.8 -1.7 1.9
Illnesses of mother 0.8 0.9 1.1 -0.9 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.3 10.5 11.4 -3.4 3.1
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 -0.3 0.1
Impedance of arm (left) 3.3 15.2 16.8 -3.7 4.1
Arm fat mass (right) 1.1 4.7 6.7 1.6 -2.6
Trunk predicted mass 2.4 13.6 15.7 3.4 -4.0
Standing height 0.1 0.8 0.9 0.8 -0.9
Length of working week for main job 0.1 0.1 0.1 -0.2 0.4
Exposure to tobacco smoke at home 0.5 0.6 0.6 0.8 -0.8
Breastfed as a baby 1.7 2.1 2.7 1.2 -1.6
Tense / ‘highly strung’ 2.2 3.6 4.2 -2.0 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 0.9 -1.0 0.7
Hair/balding pattern: Pattern 4 1.7 4.2 4.4 2.0 -2.1
Birth weight of first child 2.2 4.0 4.3 2.1 -1.9
Peak expiratory flow (PEF) 5.3 12.4 12.5 -3.5 3.5
Pulse wave reflection index 1.3 1.6 2.2 1.0 -1.5
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.3 -0.1
Loud music exposure frequency 2.1 2.3 2.4 -1.6 1.5
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.3 1.5 -0.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.1 0.2 -0.3
Blood clot in the leg (DVT) 0.5 0.6 0.8 -0.7 0.9
Medication: Paracetamol 0.2 0.3 0.4 -0.6 0.5
Headache pain in last month 0.2 0.3 0.4 -0.6 0.4
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 2.1 1.5 -1.1
Glaucoma (self-reported) 0.1 0.2 0.3 0.1 -0.6
Gout (self-reported) 1.5 2.1 2.2 -1.5 1.4
Hypothyroidism/myxoedema (self-reported) 2.0 3.9 4.1 2.0 -1.9
Medication: Amlodipine 0.0 0.0 0.1 0.2 0.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 0.3 -0.3
Birth weight 1.8 3.8 5.0 2.2 -1.6
Chronic bronchitis/emphysema (mother) 0.6 0.7 0.9 -0.8 0.9
High blood pressure (siblings) 0.1 0.1 0.2 0.2 -0.5
Forced vital capacity (FVC), Best measure 1.4 5.0 5.9 -2.4 2.0
Body fat percentage 0.2 0.9 1.6 0.3 -1.3
Leg fat percentage (right) 0.3 1.0 1.7 0.6 -1.3
Arm fat-free mass (right) 2.6 13.1 15.8 3.2 -4.0
Exposure to tobacco smoke outside home 0.3 0.4 0.7 0.9 -0.4
Comparative body size at age 10 3.0 8.3 8.7 2.8 -2.9
Number of full brothers 0.8 1.0 1.6 -0.6 1.3
Worry too long after embarrassment 1.0 1.6 1.7 1.3 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.0 -0.1
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 -0.3 0.2
Number of children fathered 2.2 2.5 2.8 1.5 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.0 -1.0 0.8
Age at first live birth 0.7 1.3 1.9 1.4 -0.8
Pulse wave peak to peak time 0.2 0.2 0.3 0.6 -0.3
Health satisfaction 0.7 1.0 1.1 -1.0 0.9
Shortness of breath walking on level ground 0.1 0.1 0.1 -0.3 0.2
Qualifications: College or University degree 0.5 1.4 2.1 1.5 -0.8
Eye problems/disorders: None of the above 0.6 0.7 1.0 1.0 -0.7
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.8 0.6 -0.9
Emphysema/chronic bronchitis 0.5 0.6 1.0 0.4 -1.0
Medication for pain relief, constipation, heartburn 2.2 3.8 3.9 2.0 -1.9
Neck or shoulder pain in last month 0.7 1.0 1.4 -1.2 0.8
Medication: Blood pressure 0.7 1.3 1.7 -1.3 0.9
Angina (self-reported) 1.3 1.7 1.7 1.3 -1.3
Migraine (self-reported) 1.6 2.0 2.6 -1.6 1.2
Medication: Ibuprofen 3.1 3.8 3.8 -1.9 1.9
Medication: Allopurinol 0.8 1.1 1.3 -1.1 1.0
Medication: Omeprazole 1.5 1.8 2.0 -1.4 1.3
Medication: Seretide 50 evohaler 0.0 0.0 0.0 -0.1 -0.0
Mean time to correctly identify matches 2.2 4.2 5.4 1.7 -2.3
Heart disease (mother) 0.1 0.2 0.3 0.1 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 0.4 0.1
Whole body fat mass 0.7 3.0 4.6 1.2 -2.2
Leg fat mass (right) 0.8 2.9 4.4 1.2 -2.1
Arm predicted mass (right) 2.3 11.9 14.5 3.0 -3.8
Pulse rate, automated reading 0.3 1.1 1.3 1.1 -1.0
Alcohol intake frequency. 0.0 0.1 0.1 -0.3 -0.0
Comparative height size at age 10 0.3 1.8 2.4 1.1 -1.6
Number of full sisters 0.1 0.1 0.2 -0.0 0.4
Suffer from ‘nerves’ 0.2 0.4 0.5 0.5 -0.7
Overall health rating 0.0 0.1 0.1 -0.1 -0.3
Chest pain or discomfort 0.1 0.2 0.3 -0.5 -0.2
Had major operations 0.3 0.3 0.4 -0.5 0.6
Age at last live birth 0.1 0.2 0.3 0.2 0.6
Family relationship satisfaction 0.3 0.4 0.6 -0.5 0.8
Leg pain on walking 0.1 0.1 0.2 0.3 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.0 -0.9 1.0
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.1 0.2 -0.0
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.3 -0.3
Medication: Aspirin 0.1 0.1 0.2 -0.4 0.3
Supplements: Vitamin C 0.2 0.2 0.2 -0.5 0.4
Knee pain experienced in last month 0.2 0.3 0.3 -0.5 0.5
Hypertension (Self-reported) 0.7 2.0 2.7 -1.7 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.5 -0.0
Illnesses of father: Heart disease 0.7 1.0 1.3 0.9 -1.1
Illnesses of siblings: Diabetes 0.2 0.3 0.5 0.7 0.1
Smoking status: Previous 3.1 4.7 4.8 -2.1 2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.5 -0.7 0.7
Whole body fat-free mass 2.5 14.2 17.1 3.4 -4.1
Leg fat-free mass (right) 3.0 15.9 19.3 3.5 -4.4
Arm fat percentage (left) 0.7 2.8 4.2 1.2 -2.0
Average weekly red wine intake 0.1 0.1 0.2 0.4 0.1
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.5 0.7 -0.7
Mood swings 0.5 0.9 1.2 -1.1 0.8
Loneliness, isolation 0.0 0.0 0.0 -0.1 0.0
Long-standing illness, disability or infirmity 0.1 0.2 0.2 -0.5 0.3
Ever had bowel cancer screening 0.2 0.3 0.5 0.7 -0.2
Diabetes diagnosed by doctor 0.2 0.4 0.6 0.5 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 3.3 -1.8 1.6
Friendships satisfaction 1.1 1.4 1.6 -1.3 1.1
Qualifications: nursing, teaching 3.5 5.4 6.6 2.6 -2.1
Commuting to job workplace: Walk 2.9 3.2 4.0 -2.0 1.5
Eye problems/disorders: Cataract 2.4 2.7 3.1 -1.8 1.5
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.3 -0.8 1.1
Medication for cholesterol 0.2 0.3 0.4 0.6 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.7 4.4 4.7 -2.2 2.0
Back pain experienced in last month 0.0 0.1 0.1 -0.2 -0.3
Mineral and other dietary supplements 0.4 0.6 0.8 -0.9 0.6
Breast cancer (self-reported) 0.6 0.7 0.8 -0.7 0.9
Asthma (self-reported) 1.1 2.2 2.3 1.5 -1.4
Osteoporosis (self-reported) 2.3 2.9 3.2 -1.6 1.8
Osteoarthritis (self-reported) 0.0 0.0 0.1 -0.3 -0.0
Medication: Aspirin 0.0 0.0 0.0 0.1 -0.1
Medication: Gliclazide 0.0 0.0 0.1 0.2 -0.2
Illnesses of father: None of the above (group 1) 5.5 6.9 7.1 -2.6 2.7
Smoking status: Current 0.1 0.1 0.2 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.8 6.0 6.6 -2.6 2.3
Whole body water mass 2.5 14.3 17.2 3.4 -4.2
Leg predicted mass (right) 2.8 15.0 18.3 3.4 -4.3
Arm fat mass (left) 1.3 5.5 7.6 1.8 -2.8
Number of self-reported non-cancer illnesses 3.5 6.1 7.5 -2.7 2.2
Average weekly champagne plus white wine intake 0.2 0.3 0.4 0.6 -0.4
Miserableness 0.4 0.7 1.0 0.7 -1.0
Guilty feelings 0.0 0.1 0.1 -0.1 -0.3
Wears glasses or contact lenses 0.8 1.0 1.1 -1.1 0.9
Ever taken oral contraceptive pill 0.1 0.1 0.1 0.4 -0.2
Hearing aid user 0.1 0.1 0.2 0.0 -0.4
Mother’s age at death 1.5 1.9 2.5 1.6 -1.1
Financial situation satisfaction 0.6 0.8 1.0 -0.7 1.0
Tinnitus: Yes, now most or all of the time 3.4 3.9 4.4 1.9 -2.1
Commuting to job workplace: Public transport 3.6 4.2 4.7 1.9 -2.2
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 -0.2 -0.1
Medication: Blood pressure 0.1 0.1 0.3 -0.5 0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.1 0.8 -1.1
Supplements: Fish oil (including cod liver oil) 1.5 1.9 2.1 1.4 -1.3
High cholesterol (Self-reported) 1.6 2.9 2.9 -1.7 1.7
Medication: Bendroflumethiazide 0.9 1.3 1.5 1.0 -1.2
Medication: Paracetamol 0.4 0.6 0.7 -0.9 0.8
Medication: Lisinopril 0.3 0.4 0.6 0.4 -0.8
Medication: Atorvastatin 0.1 0.1 0.1 -0.3 0.2
Illnesses of father: High blood pressure 0.1 0.1 0.1 0.1 -0.4
Alcohol drinker status: Never 0.0 0.0 0.0 -0.0 -0.2
Ever smoked 1.8 3.2 3.3 -1.8 1.8
Basal metabolic rate 2.5 13.7 16.9 3.2 -4.1
Leg fat percentage (left) 0.5 1.7 2.8 0.8 -1.7
Arm fat-free mass (left) 2.7 13.5 16.5 3.2 -4.1
Number of operations (self-reported) 0.1 0.2 0.3 -0.3 0.5
Average weekly beer plus cider intake 0.3 0.4 0.5 -0.5 0.7
Irritability 1.4 2.5 2.8 -1.7 1.5
Risk taking 9.7 14.2 14.8 -3.7 3.9
Ever had prostate specific antigen (PSA) test 1.7 1.9 2.2 -1.5 1.3
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.3 0.4
Age started oral contraceptive pill 0.1 0.1 0.1 0.3 -0.3
Diastolic blood pressure, automated reading 0.0 0.1 0.2 -0.5 -0.1
Ever depressed for a whole week 0.0 0.0 0.1 0.1 0.3
Unable to work because of sickness or disability 1.7 2.2 2.8 -1.7 1.3
Commuting to job workplace: Cycle 1.3 1.6 1.9 1.1 -1.4
Myopia 0.1 0.2 0.4 0.2 -0.6
Vascular/heart problems diagnosed by doctor 2.0 5.4 6.2 2.5 -2.1
Cholesterol lowering medication 0.0 0.1 0.1 -0.2 0.2
Medication: Omeprazole (e.g. Zanprol) 3.5 4.3 4.5 -2.1 2.0
Pain experienced in last month 0.4 0.6 0.8 0.9 -0.7
Supplements: Calcium 0.3 0.3 0.6 -0.1 0.8
Basal cell carcinoma (self-reported) 4.9 5.8 6.9 -2.6 2.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 1.7 -1.3 0.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.3 0.6
Heart disease (siblings) 0.0 0.1 0.1 0.3 -0.2
Alcohol drinker status: Previous 0.0 0.0 0.1 -0.1 0.3
Pack years of smoking 0.4 0.5 0.8 -0.9 0.5
Impedance of whole body 4.9 24.9 27.7 -4.7 5.3
Leg fat mass (left) 1.0 3.9 5.7 1.4 -2.4
Arm predicted mass (left) 2.5 12.9 15.6 3.2 -4.0