TWAS hub - HMGCS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1460	0.0380	4.8e-13	0.156	0.117	0.128	0.131	0.148	1.3e-18	4.7e-14	2.3e-15	1.1e-15	1.2e-17
2	TCGA	Prostate Adenocarcinoma	0.0437	0.0248	6.6e-05	0.032	0.034	0.022	NA	0.029	2.3e-04	1.5e-04	2.1e-03	NA	4.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Risk taking	9.7	14.2	14.8	-3.7	3.9
Noisy workplace	8.6	10.6	11.6	-3.4	3.1
Prostate Cancer	7.3	10.3	10.6	-3.2	3.2
Impedance of leg (right)	5.7	27.5	31.6	-4.8	5.6
Illnesses of father: None of the above (group 1)	5.5	6.9	7.1	-2.6	2.7
Impedance of leg (left)	5.4	26.1	29.5	-4.8	5.4
Peak expiratory flow (PEF)	5.3	12.4	12.5	-3.5	3.5
Diabetes (father)	5.2	6.4	7.4	-2.3	2.7
Basal cell carcinoma (self-reported)	4.9	5.8	6.9	-2.6	2.1
Impedance of whole body	4.9	24.9	27.7	-4.7	5.3
Impedance of arm (right)	4.6	21.4	24.0	-4.3	4.9
Lung FVC	3.7	18.8	19.3	-4.4	4.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.4	4.7	-2.2	2.0
Commuting to job workplace: Public transport	3.6	4.2	4.7	1.9	-2.2
Qualifications: nursing, teaching	3.5	5.4	6.6	2.6	-2.1
Number of self-reported non-cancer illnesses	3.5	6.1	7.5	-2.7	2.2
Medication: Omeprazole (e.g. Zanprol)	3.5	4.3	4.5	-2.1	2.0
Tinnitus: Yes, now most or all of the time	3.4	3.9	4.4	1.9	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.5	11.4	-3.4	3.1
Impedance of arm (left)	3.3	15.2	16.8	-3.7	4.1
Fasting Glucose	3.2	3.9	4.3	-1.9	2.1
Forced expiratory volume in 1-second (FEV1)	3.2	10.7	11.6	-3.4	3.1
Medication: Ibuprofen	3.1	3.8	3.8	-1.9	1.9
Smoking status: Previous	3.1	4.7	4.8	-2.1	2.2
Chronotype (morning person)	3.0	7.0	7.4	-2.7	2.6
Diabetes (mother)	3.0	3.8	4.3	-2.1	1.8
Comparative body size at age 10	3.0	8.3	8.7	2.8	-2.9
Leg fat-free mass (right)	3.0	15.9	19.3	3.5	-4.4
Past tobacco smoking	2.9	5.3	5.4	2.3	-2.3
Lung cancer (father)	2.9	3.4	3.8	-1.7	1.9
Commuting to job workplace: Walk	2.9	3.2	4.0	-2.0	1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	3.3	-1.8	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	6.0	6.6	-2.6	2.3
Leg predicted mass (right)	2.8	15.0	18.3	3.4	-4.3
Multivitamins +/- minerals	2.7	3.4	3.5	1.8	-1.9
Arm fat-free mass (left)	2.7	13.5	16.5	3.2	-4.1
Arm fat-free mass (right)	2.6	13.1	15.8	3.2	-4.0
Neuroticism (2016)	2.5	3.5	4.5	-2.1	1.6
Leg fat-free mass (left)	2.5	13.0	16.2	3.1	-4.0
Leg predicted mass (left)	2.5	13.4	16.6	3.2	-4.1
Whole body fat-free mass	2.5	14.2	17.1	3.4	-4.1
Whole body water mass	2.5	14.3	17.2	3.4	-4.2
Basal metabolic rate	2.5	13.7	16.9	3.2	-4.1
Arm predicted mass (left)	2.5	12.9	15.6	3.2	-4.0
Trunk predicted mass	2.4	13.6	15.7	3.4	-4.0
Eye problems/disorders: Cataract	2.4	2.7	3.1	-1.8	1.5
Schizophrenia vs Biploar Disorder	2.3	3.0	3.1	1.8	-1.7
Forced vital capacity (FVC)	2.3	8.8	9.8	-3.1	2.8
Trunk fat-free mass	2.3	13.3	15.4	3.3	-3.9
Arm predicted mass (right)	2.3	11.9	14.5	3.0	-3.8
Osteoporosis (self-reported)	2.3	2.9	3.2	-1.6	1.8
Medication: Atenolol	2.2	2.8	3.2	1.5	-1.8
Body mass index (BMI)	2.2	9.3	12.2	2.5	-3.5
Weight	2.2	10.6	13.8	2.7	-3.7
Tense / ‘highly strung’	2.2	3.6	4.2	-2.0	1.7
Birth weight of first child	2.2	4.0	4.3	2.1	-1.9
Number of children fathered	2.2	2.5	2.8	1.5	-1.7
Medication for pain relief, constipation, heartburn	2.2	3.8	3.9	2.0	-1.9
Mean time to correctly identify matches	2.2	4.2	5.4	1.7	-2.3
Smoking Status	2.1	5.0	6.6	-2.6	1.8
Loud music exposure frequency	2.1	2.3	2.4	-1.6	1.5
Worrier / anxious feelings	2.0	3.7	4.3	-2.1	1.8
Qualifications: A levels/AS levels or equivalent	2.0	4.4	5.4	2.3	-1.9
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	4.1	2.0	-1.9
Vascular/heart problems diagnosed by doctor	2.0	5.4	6.2	2.5	-2.1
Hip circumference	1.9	8.2	10.8	2.4	-3.3
Reaction Time	1.8	3.3	4.2	1.6	-2.0
Birth weight	1.8	3.8	5.0	2.2	-1.6
Ever smoked	1.8	3.2	3.3	-1.8	1.8
Verbal and Numeric Reasoning (VNR)	1.7	4.0	4.4	2.1	-1.9
Breastfed as a baby	1.7	2.1	2.7	1.2	-1.6
Hair/balding pattern: Pattern 4	1.7	4.2	4.4	2.0	-2.1
Ever had prostate specific antigen (PSA) test	1.7	1.9	2.2	-1.5	1.3
Unable to work because of sickness or disability	1.7	2.2	2.8	-1.7	1.3
Ulcerative Colitis	1.6	2.3	2.5	1.5	-1.6
Chronic bronchitis/emphysema (father)	1.6	1.8	2.8	1.0	-1.7
Medication: Cholesterol lowering	1.6	2.4	2.9	-1.7	1.4
Migraine (self-reported)	1.6	2.0	2.6	-1.6	1.2
High cholesterol (Self-reported)	1.6	2.9	2.9	-1.7	1.7
Primary Biliary Cirrhosis	1.5	2.1	2.8	1.7	-1.2
Angina	1.5	1.9	2.1	1.3	-1.4
Asthma	1.5	3.0	3.3	1.8	-1.6
Gout (self-reported)	1.5	2.1	2.2	-1.5	1.4
Medication: Omeprazole	1.5	1.8	2.0	-1.4	1.3
Mother’s age at death	1.5	1.9	2.5	1.6	-1.1
Supplements: Fish oil (including cod liver oil)	1.5	1.9	2.1	1.4	-1.3
High blood pressure	1.4	3.8	4.9	-2.2	1.6
Forced vital capacity (FVC), Best measure	1.4	5.0	5.9	-2.4	2.0
Irritability	1.4	2.5	2.8	-1.7	1.5
Coronary Artery Disease (CAD)	1.3	1.5	2.2	-1.5	0.9
Medication: Simvastatin	1.3	1.9	2.1	-1.5	1.3
Pulse wave reflection index	1.3	1.6	2.2	1.0	-1.5
Angina (self-reported)	1.3	1.7	1.7	1.3	-1.3
Arm fat mass (left)	1.3	5.5	7.6	1.8	-2.8
Commuting to job workplace: Cycle	1.3	1.6	1.9	1.1	-1.4
Mean Putamen Volume	1.2	1.4	1.7	-1.3	1.0
Hypothyroidism (self reported)	1.2	2.8	3.0	1.7	-1.6
Happiness	1.2	1.4	1.7	-1.1	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	1.8	-1.2	1.3
Ulcerative Colitis (UC)	1.1	2.1	2.4	1.3	-1.6
Systolic blood pressure, automated reading	1.1	3.1	4.3	-2.1	1.4
Supplements: Zinc	1.1	1.2	1.3	1.0	-1.1
Waist circumference	1.1	4.0	5.5	1.6	-2.3
Arm fat mass (right)	1.1	4.7	6.7	1.6	-2.6
Friendships satisfaction	1.1	1.4	1.6	-1.3	1.1
Asthma (self-reported)	1.1	2.2	2.3	1.5	-1.4
Bipolar Disorder (2011)	1.0	1.0	1.0	1.0	-1.0
Body Mass Index (BMI) (2010)	1.0	1.4	1.9	1.0	-1.4
HbA1C	1.0	1.1	1.7	1.3	-0.7
Waist Hip Ratio (WHR)	1.0	4.3	5.0	-1.9	2.2
Financial difficulties in last 2 years	1.0	1.4	1.5	-1.1	1.2
Heart attack	1.0	1.3	1.9	-1.4	0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.1	1.5	-1.1
Worry too long after embarrassment	1.0	1.6	1.7	1.3	-1.3
Leg fat mass (left)	1.0	3.9	5.7	1.4	-2.4
Depression (Nagel 2018)	0.9	1.3	1.9	0.8	-1.4
Intelligence (Savage-Jansen 2018)	0.9	2.7	3.6	1.9	-1.4
BMI	0.9	5.3	7.6	1.7	-2.8
Cardiovascular Disease	0.9	3.0	4.3	-2.1	1.3
Pack years adult smoking proportion	0.9	1.4	1.9	-1.4	1.0
Qualifications: None of the above	0.9	2.0	3.2	-1.8	1.0
Fluid intelligence score	0.9	1.8	1.9	1.4	-1.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.3	1.5	-0.7
Medication: Bendroflumethiazide	0.9	1.3	1.5	1.0	-1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.7	-1.3	0.8
Schizophrenia (2018)	0.8	1.7	1.8	1.3	-1.4
Irritable Bowel Disease (IBD)	0.8	1.9	2.2	1.2	-1.5
Breast Cancer	0.8	2.0	2.1	-1.5	1.3
Sensitivity / hurt feelings	0.8	1.4	1.6	1.1	-1.3
Medication: Co-codamol	0.8	0.9	1.3	0.7	-1.2
Townsend deprivation index at recruitment	0.8	1.2	1.4	-1.2	1.0
Maternal smoking around birth	0.8	1.1	2.1	-1.4	0.4
Hair/balding pattern: Pattern 2	0.8	1.1	1.2	-1.1	1.0
Had other major operations	0.8	0.9	1.0	-1.0	0.9
Prospective memory result	0.8	0.9	1.0	1.0	-0.9
Illnesses of mother	0.8	0.9	1.1	-0.9	1.1
Number of full brothers	0.8	1.0	1.6	-0.6	1.3
Medication: Allopurinol	0.8	1.1	1.3	-1.1	1.0
Leg fat mass (right)	0.8	2.9	4.4	1.2	-2.1
Wears glasses or contact lenses	0.8	1.0	1.1	-1.1	0.9
Blood Eosinophil Count	0.7	5.7	6.4	2.2	-2.5
Systolic Blood Pressure	0.7	3.8	5.3	-2.3	1.5
Lung FEV1/FVC ratio	0.7	3.6	3.7	-1.9	1.9
Average weekly spirits intake	0.7	0.8	1.3	0.5	-1.1
Taking other prescription medications	0.7	1.0	1.6	-1.3	0.7
Stomach or abdominal pain in last month	0.7	0.9	0.9	0.9	-0.9
Medication: Levothyroxine sodium	0.7	1.2	1.4	1.2	-0.9
High blood pressure (mother)	0.7	0.9	1.0	-1.0	0.9
Trunk fat mass	0.7	2.9	4.5	1.1	-2.1
Had menopause	0.7	0.8	0.9	0.9	-0.9
Medication: Lansoprazole	0.7	0.9	0.9	0.9	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.0	-1.0	0.8
Age at first live birth	0.7	1.3	1.9	1.4	-0.8
Health satisfaction	0.7	1.0	1.1	-1.0	0.9
Neck or shoulder pain in last month	0.7	1.0	1.4	-1.2	0.8
Medication: Blood pressure	0.7	1.3	1.7	-1.3	0.9
Whole body fat mass	0.7	3.0	4.6	1.2	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.0	-0.9	1.0
Hypertension (Self-reported)	0.7	2.0	2.7	-1.7	1.1
Illnesses of father: Heart disease	0.7	1.0	1.3	0.9	-1.1
Arm fat percentage (left)	0.7	2.8	4.2	1.2	-2.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.1	0.8	-1.1
Respiratory disease	0.6	1.4	1.7	1.0	-1.3
Number of treatments/medications taken	0.6	1.1	1.5	-1.2	0.8
Relative age voice broke	0.6	0.9	0.9	1.0	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	1.3	-1.1	0.6
Nervous feelings	0.6	1.1	1.2	1.0	-1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	0.9	-0.8	0.9
Eye problems/disorders: None of the above	0.6	0.7	1.0	1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.3	-0.8	1.1
Breast cancer (self-reported)	0.6	0.7	0.8	-0.7	0.9
Financial situation satisfaction	0.6	0.8	1.0	-0.7	1.0
Schizophrenia (2014)	0.5	1.1	1.3	1.1	-1.0
Blood White Count	0.5	3.7	4.2	1.8	-2.0
Heel T-Score	0.5	3.9	4.9	-1.7	2.2
Tanning	0.5	5.7	7.8	-1.9	2.8
Severe depression (siblings)	0.5	0.5	0.7	-0.8	0.6
Pain all over the body in last month	0.5	0.5	0.6	-0.6	0.8
Medication: Ramipril	0.5	0.6	0.9	-0.9	0.6
Arm fat percentage (right)	0.5	2.1	3.2	1.0	-1.8
Exposure to tobacco smoke at home	0.5	0.6	0.6	0.8	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	0.9	-1.0	0.7
Blood clot in the leg (DVT)	0.5	0.6	0.8	-0.7	0.9
Qualifications: College or University degree	0.5	1.4	2.1	1.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	0.6	-0.9
Emphysema/chronic bronchitis	0.5	0.6	1.0	0.4	-1.0
Mood swings	0.5	0.9	1.2	-1.1	0.8
Leg fat percentage (left)	0.5	1.7	2.8	0.8	-1.7
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.8	-0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.5	-0.6	0.7
Allergy or Eczema	0.4	0.9	1.5	1.2	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	0.6	0.8	-0.6
Supplements: Glucosamine	0.4	0.5	0.6	0.8	-0.6
Number of incorrect matches in round	0.4	0.7	1.0	-1.0	0.7
Diabetes (self-reported)	0.4	0.7	1.0	0.6	-1.0
Alcohol intake versus 10 years previously	0.4	0.6	0.6	0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.5	0.7	-0.7
Mineral and other dietary supplements	0.4	0.6	0.8	-0.9	0.6
Miserableness	0.4	0.7	1.0	0.7	-1.0
Medication: Paracetamol	0.4	0.6	0.7	-0.9	0.8
Pain experienced in last month	0.4	0.6	0.8	0.9	-0.7
Pack years of smoking	0.4	0.5	0.8	-0.9	0.5
Bipolar Disorder or Schizophrenia	0.3	0.7	0.7	0.9	-0.8
Major Depression (MDD)	0.3	0.4	0.7	0.4	-0.8
Rheumatoid Arthritis	0.3	0.4	0.5	-0.6	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.9	0.6	-0.9
Medication for hormone replacement therapy	0.3	0.3	0.4	-0.6	0.5
Allergy	0.3	0.7	1.3	-1.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	-0.5	0.7
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	0.1	-0.9
Leg fat percentage (right)	0.3	1.0	1.7	0.6	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.9	-0.4
Pulse rate, automated reading	0.3	1.1	1.3	1.1	-1.0
Comparative height size at age 10	0.3	1.8	2.4	1.1	-1.6
Had major operations	0.3	0.3	0.4	-0.5	0.6
Family relationship satisfaction	0.3	0.4	0.6	-0.5	0.8
Medication: Lisinopril	0.3	0.4	0.6	0.4	-0.8
Average weekly beer plus cider intake	0.3	0.4	0.5	-0.5	0.7
Supplements: Calcium	0.3	0.3	0.6	-0.1	0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.6	-0.1
Age at First Birth	0.2	0.2	0.4	-0.2	0.6
Lupus	0.2	0.4	0.7	-0.8	0.2
Blood Platelet Count	0.2	2.0	2.4	-1.2	1.6
Height	0.2	3.1	3.2	1.7	-1.8
Hand grip strength (left)	0.2	0.5	0.7	-0.9	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.2	-0.7
Relative age of first facial hair	0.2	0.4	0.5	-0.7	0.6
Medication: Metformin	0.2	0.2	0.3	0.4	-0.6
Trunk fat percentage	0.2	0.8	1.6	0.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.6	0.3
Age when periods started (menarche)	0.2	0.5	0.9	0.2	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.7	0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.5	-0.4	0.7
Depression (self-reported)	0.2	0.3	0.3	-0.6	0.5
Medication: Paracetamol	0.2	0.3	0.4	-0.6	0.5
Headache pain in last month	0.2	0.3	0.4	-0.6	0.4
Body fat percentage	0.2	0.9	1.6	0.3	-1.3
Pulse wave peak to peak time	0.2	0.2	0.3	0.6	-0.3
Suffer from ‘nerves’	0.2	0.4	0.5	0.5	-0.7
Supplements: Vitamin C	0.2	0.2	0.2	-0.5	0.4
Knee pain experienced in last month	0.2	0.3	0.3	-0.5	0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.5	-0.7	0.7
Ever had bowel cancer screening	0.2	0.3	0.5	0.7	-0.2
Diabetes diagnosed by doctor	0.2	0.4	0.6	0.5	-0.8
Medication for cholesterol	0.2	0.3	0.4	0.6	-0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	0.4	0.1
Crohns Disease (2017)	0.1	0.2	0.2	0.4	-0.5
HDL Cholesterol	0.1	0.1	0.2	0.5	-0.2
LDL Cholesterol	0.1	0.1	0.1	0.4	0.2
Blood Red Count	0.1	0.6	1.1	-1.0	0.4
Neuroticism	0.1	0.2	0.3	0.2	-0.6
Hair Pigment	0.1	2.6	3.1	1.8	-1.4
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.3	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	0.5	-0.3
Vitamin and mineral supplements	0.1	0.2	0.2	-0.4	0.3
Current tobacco smoking	0.1	0.1	0.3	-0.5	-0.1
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.1	-0.5
Sitting height	0.1	0.6	0.6	-0.7	0.8
Alcohol usually taken with meals	0.1	0.1	0.2	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.3	0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.3	0.3
Mouth/teeth dental problems	0.1	0.1	0.2	0.1	0.4
Neuroticism score	0.1	0.2	0.4	-0.7	0.1
Father’s age at death	0.1	0.1	0.2	0.1	0.5
Falls in the last year	0.1	0.1	0.1	-0.2	0.3
Pulse rate	0.1	0.2	0.4	0.6	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.0	0.4
Standing height	0.1	0.8	0.9	0.8	-0.9
Length of working week for main job	0.1	0.1	0.1	-0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.2	-0.3
Glaucoma (self-reported)	0.1	0.2	0.3	0.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.3	-0.3
High blood pressure (siblings)	0.1	0.1	0.2	0.2	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.3	0.2
Heart disease (mother)	0.1	0.2	0.3	0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.4	0.1
Number of full sisters	0.1	0.1	0.2	-0.0	0.4
Chest pain or discomfort	0.1	0.2	0.3	-0.5	-0.2
Age at last live birth	0.1	0.2	0.3	0.2	0.6
Leg pain on walking	0.1	0.1	0.2	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.3	-0.3
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	-0.0
Average weekly red wine intake	0.1	0.1	0.2	0.4	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.2	-0.5	0.3
Smoking status: Current	0.1	0.1	0.2	-0.3	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.4	-0.2
Hearing aid user	0.1	0.1	0.2	0.0	-0.4
Medication: Blood pressure	0.1	0.1	0.3	-0.5	0.1
Medication: Atorvastatin	0.1	0.1	0.1	-0.3	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.1	0.1	-0.4
Number of operations (self-reported)	0.1	0.2	0.3	-0.3	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.3	0.4
Age started oral contraceptive pill	0.1	0.1	0.1	0.3	-0.3
Myopia	0.1	0.2	0.4	0.2	-0.6
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.2	0.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.2	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.0	-0.2
Worry (Nagel 2018)	0.0	0.1	0.1	-0.3	0.3
Ovarian Cancer	0.0	0.0	0.0	0.1	-0.1
Crohns Disease (2012)	0.0	0.0	0.1	0.1	-0.2
Triglycerides	0.0	0.0	0.0	0.0	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.2	-0.2
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	-0.3	0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	0.2
Hand grip strength (right)	0.0	0.1	0.1	-0.2	-0.3
Fed-up feelings	0.0	0.0	0.1	-0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.1	-0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.1	0.1
Illnesses of siblings	0.0	0.0	0.0	-0.2	-0.0
Time employed in main current job	0.0	0.0	0.1	-0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.1	-0.3
Number of live births	0.0	0.0	0.0	0.1	-0.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.3	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.3	-0.1
Medication: Amlodipine	0.0	0.0	0.1	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.0	-0.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	-0.3	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	-0.0
Alcohol intake frequency.	0.0	0.1	0.1	-0.3	-0.0
Overall health rating	0.0	0.1	0.1	-0.1	-0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.2	-0.0
Loneliness, isolation	0.0	0.0	0.0	-0.1	0.0
Back pain experienced in last month	0.0	0.1	0.1	-0.2	-0.3
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.3	-0.0
Medication: Aspirin	0.0	0.0	0.0	0.1	-0.1
Medication: Gliclazide	0.0	0.0	0.1	0.2	-0.2
Guilty feelings	0.0	0.1	0.1	-0.1	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.2	-0.1
Alcohol drinker status: Never	0.0	0.0	0.0	-0.0	-0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	-0.1
Ever depressed for a whole week	0.0	0.0	0.1	0.1	0.3
Cholesterol lowering medication	0.0	0.1	0.1	-0.2	0.2
Heart disease (siblings)	0.0	0.1	0.1	0.3	-0.2
Alcohol drinker status: Previous	0.0	0.0	0.1	-0.1	0.3

Hub : Genes

HMGCS1

Models

Trait associations