[Hub]/) : Traits : Impedance of leg (right) : ← →

chr11:198,510-1,702,321

Best TWAS P=2.5e-13 · Best GWAS P=3.28e-12 conditioned to 0.0215

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
66	GTEx	Testis	POLR2L	0.16	0.03	enet	10	0.03	1.9e-02	6.3	7.3	2.5e-13	0.74	0.05	0.90	TRUE
88	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHID1	0.06	0.05	blup	67	0.03	2.0e-02	-5.3	7.0	2.5e-12	0.65	0.04	0.25	FALSE
23	GTEx	Brain Frontal Cortex BA9	AP006621.5	0.18	0.03	lasso	6	0.04	2.6e-02	6.5	-7.0	2.8e-12	-0.92	0.03	0.73	FALSE
59	GTEx	Pancreas	EFCAB4A	0.23	0.19	enet	8	0.16	4.1e-07	6.9	-7.0	3.1e-12	-0.97	0.00	1.00	FALSE
24	GTEx	Brain Hypothalamus	PNPLA2	0.23	-0.01	lasso	9	0.00	4.0e-01	6.5	7.0	3.2e-12	0.93	0.04	0.34	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2L	0.09	0.09	enet	16	0.10	4.6e-12	5.8	6.9	4.3e-12	0.62	0.85	0.15	FALSE
49	GTEx	Heart Left Ventricle	AP006621.6	0.23	0.11	lasso	5	0.11	1.4e-06	-6.2	-6.7	1.7e-11	-0.80	0.07	0.93	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PNPLA2	0.07	0.00	blup	51	0.03	1.4e-04	5.7	-6.7	2.2e-11	-0.67	0.01	0.64	FALSE
81	YFS	Blood	POLR2L	0.26	0.19	bslmm	383	0.30	2.4e-98	5.7	-6.6	3.2e-11	-0.48	0.90	0.10	FALSE
90	The Cancer Genome Atlas	Glioblastoma Multiforme	CD151	0.13	0.02	blup	50	0.08	1.8e-03	5.0	-6.6	3.9e-11	-0.73	0.07	0.33	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CHID1	0.07	0.05	blup	68	0.01	8.0e-02	6.3	6.6	4.1e-11	0.74	0.02	0.72	FALSE
22	GTEx	Brain Frontal Cortex BA9	PIDD	0.32	0.15	lasso	2	0.11	6.9e-04	6.5	-6.6	4.8e-11	-0.95	0.02	0.86	FALSE
110	The Cancer Genome Atlas	Stomach Adenocarcinoma	CD151	0.03	0.00	blup	50	0.01	3.6e-02	5.1	-6.5	1.1e-10	-0.79	0.02	0.47	FALSE
5	GTEx	Adipose Subcutaneous	POLR2L	0.19	0.12	enet	18	0.11	3.4e-09	5.6	6.4	1.2e-10	0.58	0.93	0.07	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CEND1	0.04	0.03	lasso	3	0.02	9.6e-04	6.5	-6.4	1.2e-10	-0.92	0.01	0.97	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	TSPAN4	0.09	0.04	enet	9	0.03	1.9e-04	-4.1	-6.4	1.9e-10	-0.60	0.18	0.63	FALSE
77	METSIM	Adipose	POLR2L	0.03	0.02	bslmm	413	0.01	5.0e-03	5.1	6.3	2.2e-10	0.60	0.22	0.20	FALSE
6	GTEx	Adipose Subcutaneous	MIR210HG	0.11	0.01	lasso	6	0.01	7.2e-02	5.8	6.3	4.0e-10	0.51	0.12	0.31	FALSE
56	GTEx	Nerve Tibial	POLR2L	0.15	0.03	enet	17	0.04	1.1e-03	5.1	6.3	4.0e-10	0.54	0.64	0.12	FALSE
4	GTEx	Adipose Subcutaneous	PIDD	0.14	0.13	lasso	3	0.12	8.9e-10	-6.2	-6.3	4.1e-10	-0.83	0.24	0.76	FALSE
48	GTEx	Heart Left Ventricle	CD151	0.27	0.10	enet	47	0.10	5.5e-06	5.1	-6.2	5.4e-10	-0.25	0.87	0.03	FALSE
61	GTEx	Skin Sun Exposed Lower leg	PIDD	0.20	0.17	lasso	4	0.17	9.7e-14	-6.2	-6.2	5.4e-10	-0.81	0.32	0.68	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEND1	0.05	0.00	blup	52	0.02	1.1e-02	5.1	-6.2	6.3e-10	-0.79	0.04	0.40	FALSE
33	GTEx	Cells Transformed fibroblasts	POLR2L	0.12	0.11	lasso	5	0.12	5.2e-09	5.6	6.2	6.9e-10	0.54	0.92	0.07	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRDD	0.11	0.03	enet	14	0.04	4.0e-05	-6.1	-6.1	8.6e-10	-0.72	0.32	0.59	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	AP006621.5	0.37	0.36	lasso	2	0.35	2.1e-13	-6.2	-6.1	8.7e-10	-0.80	0.43	0.57	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	CEND1	0.05	0.04	enet	8	0.03	1.2e-03	-6.1	-6.1	1.1e-09	-0.80	0.09	0.82	FALSE
91	The Cancer Genome Atlas	Glioblastoma Multiforme	LRDD	0.09	0.08	blup	54	0.10	7.8e-04	-6.1	-6.1	1.2e-09	-0.80	0.04	0.34	FALSE
68	GTEx	Thyroid	PIDD	0.18	0.15	lasso	5	0.14	1.6e-10	-6.2	-6.1	1.4e-09	-0.81	0.09	0.91	FALSE
10	GTEx	Artery Aorta	PIDD	0.21	0.22	enet	8	0.21	5.0e-12	-6.2	-6.0	1.5e-09	-0.80	0.40	0.60	FALSE
83	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHID1	0.03	0.01	blup	67	0.01	2.3e-02	5.8	6.0	1.8e-09	0.56	0.08	0.09	FALSE
96	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR2L	0.02	0.02	blup	46	0.02	4.5e-03	5.2	-6.0	2.1e-09	-0.70	0.09	0.11	FALSE
109	The Cancer Genome Atlas	Soft Tissue Sarcoma	CD151	0.11	0.11	blup	52	0.13	4.2e-08	4.0	-6.0	2.3e-09	-0.56	0.88	0.10	FALSE
60	GTEx	Pancreas	AP006621.8	0.28	0.10	lasso	6	0.14	2.5e-06	6.5	-5.9	2.8e-09	-0.85	0.01	0.99	FALSE
51	GTEx	Liver	AP006621.5	0.38	0.18	enet	8	0.17	1.6e-05	-6.2	-5.9	2.9e-09	-0.81	0.04	0.94	FALSE
18	GTEx	Brain Cerebellar Hemisphere	PIDD	0.48	0.24	enet	28	0.30	2.4e-08	-6.2	-5.9	3.1e-09	-0.74	0.06	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AP2A2	0.09	0.04	enet	30	0.07	1.9e-08	-4.3	5.9	3.6e-09	0.40	0.99	0.01	FALSE
76	METSIM	Adipose	PIDD	0.13	0.15	lasso	3	0.15	6.0e-22	-5.8	-5.9	4.1e-09	-0.79	0.42	0.58	FALSE
67	GTEx	Testis	AP006621.5	0.26	0.16	lasso	5	0.19	8.3e-09	-5.2	-5.9	4.9e-09	-0.79	0.04	0.96	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRDD	0.01	0.00	blup	55	0.01	2.9e-03	3.1	-5.8	6.9e-09	-0.75	0.05	0.60	FALSE
12	GTEx	Artery Coronary	AP006621.6	0.26	0.11	enet	20	0.12	5.3e-05	-3.6	-5.8	7.0e-09	-0.81	0.03	0.95	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	CEND1	0.03	0.04	lasso	1	0.03	2.6e-07	-5.8	-5.8	7.4e-09	-0.79	0.15	0.85	FALSE
32	GTEx	Cells Transformed fibroblasts	PIDD	0.14	0.05	enet	13	0.04	2.8e-04	-5.2	-5.8	7.5e-09	-0.80	0.01	0.97	FALSE
62	GTEx	Skin Sun Exposed Lower leg	AP006621.6	0.25	0.20	lasso	7	0.20	4.3e-16	-5.2	-5.8	8.4e-09	-0.83	0.09	0.91	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD151	0.06	0.07	lasso	4	0.06	8.5e-12	5.1	-5.8	8.6e-09	-0.60	1.00	0.00	FALSE
54	GTEx	Muscle Skeletal	AP006621.6	0.15	0.12	enet	10	0.14	1.6e-13	-3.5	-5.8	8.8e-09	-0.80	0.71	0.29	FALSE
52	GTEx	Lung	PIDD	0.19	0.19	lasso	3	0.18	6.3e-14	-6.2	-5.7	9.3e-09	-0.78	0.37	0.63	FALSE
30	GTEx	Breast Mammary Tissue (Female)	RPLP2	0.15	0.00	lasso	2	-0.01	8.2e-01	5.7	-5.7	9.7e-09	-0.74	0.04	0.10	FALSE
34	GTEx	Cells Transformed fibroblasts	AP006621.5	0.38	0.26	lasso	6	0.30	5.0e-23	-5.2	-5.7	1.1e-08	-0.76	0.91	0.09	FALSE
74	GTEx	Whole Blood	AP006621.5	0.15	0.16	lasso	5	0.14	1.1e-12	-5.2	-5.7	1.1e-08	-0.80	0.35	0.65	FALSE
75	METSIM	Adipose	AP006621.5	0.24	0.19	enet	34	0.20	1.5e-28	-5.2	-5.7	1.1e-08	-0.80	0.87	0.13	FALSE
19	GTEx	Brain Cerebellum	TSPAN4	0.21	0.08	enet	15	0.08	1.9e-03	5.6	5.6	1.6e-08	0.61	0.14	0.09	FALSE
70	GTEx	Thyroid	AP006621.6	0.22	0.14	lasso	3	0.14	4.7e-11	-5.2	-5.6	2.4e-08	-0.76	0.46	0.54	FALSE
8	GTEx	Adipose Visceral Omentum	AP006621.5	0.24	0.15	lasso	2	0.15	4.6e-08	-5.2	-5.6	2.8e-08	-0.77	0.51	0.49	FALSE
27	GTEx	Brain Putamen basal ganglia	AP006621.5	0.56	0.26	lasso	11	0.31	3.1e-08	-5.2	-5.6	2.8e-08	-0.72	0.04	0.81	FALSE
65	GTEx	Testis	CD151	0.39	0.29	lasso	11	0.24	6.0e-11	5.1	-5.6	2.8e-08	-0.53	0.99	0.01	FALSE
46	GTEx	Esophagus Muscularis	AP006621.5	0.39	0.33	lasso	8	0.35	2.1e-22	-5.2	-5.5	3.0e-08	-0.79	0.46	0.54	FALSE
108	The Cancer Genome Atlas	Rectum Adenocarcinoma	CHID1	0.25	0.16	blup	68	0.13	6.4e-04	5.8	5.5	3.0e-08	0.50	0.08	0.12	FALSE
11	GTEx	Artery Aorta	AP006621.6	0.35	0.26	enet	13	0.26	9.6e-15	-5.2	-5.5	3.3e-08	-0.76	0.64	0.36	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEND1	0.02	0.01	blup	52	0.01	2.8e-02	-3.4	-5.5	3.4e-08	-0.79	0.04	0.56	FALSE
112	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPLP2	0.12	0.05	blup	54	0.04	1.6e-02	3.7	-5.5	4.0e-08	-0.75	0.06	0.46	FALSE
7	GTEx	Adipose Subcutaneous	AP006621.5	0.33	0.24	enet	25	0.30	1.9e-24	-5.2	-5.5	4.1e-08	-0.67	0.96	0.04	FALSE
31	GTEx	Breast Mammary Tissue (Female)	AP006621.5	0.22	0.19	lasso	2	0.20	1.7e-06	-5.2	-5.5	4.2e-08	-0.76	0.16	0.76	FALSE
53	GTEx	Muscle Skeletal	POLR2L	0.08	0.10	enet	6	0.09	2.8e-09	5.1	5.5	4.3e-08	0.56	0.99	0.01	FALSE
64	GTEx	Testis	AP006621.1	0.45	0.35	lasso	7	0.41	2.2e-19	-5.2	-5.5	4.3e-08	-0.77	0.77	0.23	FALSE
14	GTEx	Artery Tibial	AP006621.1	0.50	0.43	enet	26	0.42	2.5e-35	-5.2	-5.5	4.6e-08	-0.74	0.99	0.01	FALSE
45	GTEx	Esophagus Muscularis	AP006621.6	0.34	0.24	lasso	5	0.25	3.5e-15	-5.2	-5.4	5.1e-08	-0.78	0.49	0.51	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	EFCAB4A	0.04	0.02	lasso	2	0.04	3.0e-05	5.7	-5.4	5.5e-08	-0.74	0.03	0.88	FALSE
35	GTEx	Colon Transverse	AP006621.6	0.33	0.23	lasso	3	0.19	2.6e-09	-5.2	-5.4	5.6e-08	-0.76	0.64	0.36	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CHID1	0.19	0.07	blup	67	0.08	8.9e-05	-4.1	5.4	5.6e-08	0.59	0.07	0.34	FALSE
106	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHID1	0.10	0.07	lasso	5	0.05	4.1e-03	5.6	5.4	5.6e-08	0.52	0.09	0.08	FALSE
29	GTEx	Breast Mammary Tissue	AP006621.5	0.28	0.28	lasso	4	0.32	3.5e-17	-5.2	-5.4	6.0e-08	-0.76	0.57	0.43	FALSE
71	GTEx	Thyroid	AP006621.5	0.33	0.31	lasso	6	0.33	9.4e-26	-5.2	-5.4	6.2e-08	-0.78	0.86	0.14	FALSE
47	GTEx	Heart Atrial Appendage	AP006621.5	0.36	0.21	lasso	4	0.24	2.2e-11	5.7	-5.4	6.3e-08	-0.78	0.77	0.23	FALSE
73	GTEx	Whole Blood	AP006621.6	0.11	0.04	lasso	3	0.06	3.4e-06	7.0	-5.4	6.9e-08	-0.88	0.00	1.00	FALSE
25	GTEx	Brain Nucleus accumbens basal ganglia	AP006621.1	0.70	0.42	lasso	8	0.42	2.0e-12	-5.2	-5.4	7.5e-08	-0.75	0.50	0.49	FALSE
63	GTEx	Stomach	AP006621.6	0.23	0.08	lasso	4	0.06	1.1e-03	-5.2	-5.4	7.5e-08	-0.74	0.16	0.72	FALSE
36	GTEx	Colon Transverse	AP006621.5	0.41	0.34	enet	39	0.37	8.7e-19	-5.2	-5.4	7.7e-08	-0.71	0.66	0.34	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POLR2L	0.04	0.02	blup	48	0.03	5.5e-04	5.2	5.4	8.1e-08	0.48	0.50	0.10	FALSE
41	GTEx	Esophagus Mucosa	PIDD	0.26	0.17	lasso	4	0.18	5.5e-12	-6.2	-5.3	8.8e-08	-0.77	0.40	0.60	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFCAB4A	0.02	0.01	blup	48	0.01	7.3e-03	4.0	-5.3	9.9e-08	-0.50	0.05	0.06	FALSE
13	GTEx	Artery Coronary	AP006621.5	0.41	0.33	lasso	8	0.36	5.1e-13	-5.2	-5.3	1.0e-07	-0.77	0.33	0.67	FALSE
50	GTEx	Liver	CD151	0.37	0.25	enet	19	0.27	3.2e-08	5.1	-5.3	1.0e-07	-0.57	0.78	0.08	FALSE
37	GTEx	Esophagus Gastroesophageal Junction	AP006621.1	0.50	0.40	lasso	7	0.43	3.4e-17	-5.2	-5.3	1.1e-07	-0.77	0.55	0.45	FALSE
89	The Cancer Genome Atlas	Colon Adenocarcinoma	CD151	0.07	0.06	lasso	3	0.05	9.1e-04	5.2	-5.3	1.1e-07	-0.46	0.18	0.04	FALSE
55	GTEx	Muscle Skeletal	AP006621.5	0.09	0.10	lasso	2	0.09	9.9e-09	-5.2	-5.3	1.2e-07	-0.74	0.26	0.74	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EFCAB4A	0.04	0.05	enet	7	0.05	6.1e-06	5.1	-5.3	1.4e-07	-0.48	0.95	0.01	FALSE
111	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPLP2	0.06	0.06	lasso	3	0.04	3.8e-04	3.7	-5.3	1.4e-07	-0.65	0.14	0.26	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	CD151	0.39	0.28	lasso	3	0.28	1.5e-10	5.1	-5.2	1.5e-07	-0.51	0.98	0.01	FALSE
78	NTR	Blood	CD151	0.23	0.28	lasso	6	0.29	3.7e-96	5.1	-5.2	1.5e-07	-0.49	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	CD151	0.18	0.26	blup	52	0.27	1.4e-30	5.0	-5.3	1.5e-07	-0.56	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CD151	0.16	0.16	lasso	4	0.15	3.2e-18	5.0	-5.2	1.6e-07	-0.52	1.00	0.00	FALSE
69	GTEx	Thyroid	CD151	0.47	0.41	lasso	4	0.44	3.2e-36	5.1	-5.2	1.6e-07	-0.51	1.00	0.00	FALSE
9	GTEx	Adrenal Gland	CD151	0.21	0.21	lasso	2	0.17	7.9e-07	5.1	-5.2	1.7e-07	-0.51	0.87	0.03	FALSE
58	GTEx	Nerve Tibial	AP006621.5	0.40	0.29	enet	11	0.34	5.3e-25	-5.2	-5.2	1.7e-07	-0.73	0.93	0.07	FALSE
26	GTEx	Brain Putamen basal ganglia	AP006621.1	0.54	0.40	lasso	8	0.39	2.8e-10	-5.2	-5.2	1.8e-07	-0.77	0.06	0.93	FALSE
42	GTEx	Esophagus Mucosa	AP006621.5	0.32	0.21	enet	13	0.26	3.2e-17	-5.2	-5.2	1.8e-07	-0.77	0.74	0.26	FALSE
17	GTEx	Artery Tibial	AP006621.5	0.37	0.37	enet	18	0.37	1.9e-30	-5.2	-5.2	1.9e-07	-0.73	0.99	0.01	FALSE
57	GTEx	Nerve Tibial	AP006621.6	0.30	0.22	enet	10	0.23	4.2e-16	-5.2	-5.2	1.9e-07	-0.73	0.83	0.17	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	LRDD	0.04	0.05	lasso	5	0.07	2.3e-07	-3.5	-5.2	2.0e-07	-0.76	0.19	0.80	FALSE
21	GTEx	Brain Cortex	AP006621.5	0.35	0.17	lasso	5	0.23	6.5e-07	-5.2	-5.2	2.1e-07	-0.70	0.14	0.82	FALSE
72	GTEx	Whole Blood	CD151	0.31	0.32	lasso	7	0.34	2.1e-32	5.1	-5.2	2.1e-07	-0.49	1.00	0.00	FALSE
105	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CD151	0.14	0.15	lasso	4	0.14	3.8e-06	5.1	-5.2	2.1e-07	-0.52	0.82	0.02	FALSE
15	GTEx	Artery Tibial	CD151	0.25	0.14	lasso	4	0.15	1.3e-11	5.1	-5.2	2.2e-07	-0.51	1.00	0.00	FALSE
43	GTEx	Esophagus Muscularis	AP006621.1	0.52	0.50	lasso	6	0.56	1.2e-40	-5.2	-5.2	2.2e-07	-0.76	0.68	0.32	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CD151	0.13	0.22	enet	13	0.22	1.1e-23	5.2	-5.2	2.2e-07	-0.51	1.00	0.00	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	AP006621.6	0.33	0.21	lasso	4	0.20	9.3e-08	-6.1	-5.2	2.3e-07	-0.75	0.48	0.50	FALSE
28	GTEx	Breast Mammary Tissue	AP006621.6	0.40	0.30	lasso	7	0.28	6.4e-15	-5.2	-5.2	2.4e-07	-0.76	0.72	0.28	FALSE
80	YFS	Blood	PNPLA2	0.11	0.10	lasso	5	0.12	1.2e-38	3.2	5.2	2.4e-07	0.78	0.98	0.02	FALSE
16	GTEx	Artery Tibial	AP006621.6	0.24	0.18	lasso	4	0.20	1.6e-15	-5.2	-5.2	2.6e-07	-0.74	0.82	0.18	FALSE
79	YFS	Blood	CD151	0.44	0.46	lasso	9	0.52	2.5e-205	5.1	-5.1	2.7e-07	-0.48	0.99	0.01	FALSE
20	GTEx	Brain Cortex	AP006621.8	0.18	0.23	enet	8	0.19	5.8e-06	3.7	5.1	2.9e-07	0.69	0.08	0.73	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CD151	0.05	0.08	lasso	1	0.06	3.8e-06	5.1	-5.1	3.0e-07	-0.52	0.94	0.02	FALSE
44	GTEx	Esophagus Muscularis	CD151	0.38	0.31	lasso	9	0.33	5.5e-21	5.2	-5.1	3.1e-07	-0.49	1.00	0.00	FALSE