Hub : Genes

AP2A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0900	0.0240	2.9e-08	0.041	0.064	0.066	0.064	0.064	9.3e-06	3.3e-08	1.9e-08	3.1e-08	3.2e-08
2	GTEx	Adipose Subcutaneous	0.0810	0.0350	4.2e-03	0.001	NA	0.007	NA	0.003	2.4e-01	NA	7.6e-02	NA	1.7e-01
3	GTEx	Uterus	0.7260	0.1510	6.6e-03	-0.009	NA	0.004	NA	-0.014	5.2e-01	NA	2.6e-01	NA	8.0e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.2083	0.0411	1.9e-09	0.153	0.091	0.153	0.156	0.149	3.3e-19	9.2e-12	3.3e-19	1.7e-19	1.0e-18
5	YFS	Blood	0.0611	0.0179	6.2e-06	0.032	0.018	0.029	0.031	0.030	7.3e-11	1.1e-06	6.2e-10	1.5e-10	2.9e-10
6	TCGA	Breast Invasive Carcinoma	0.0502	0.0215	5.3e-06	0.015	0.032	0.023	NA	0.019	4.0e-04	3.0e-07	1.4e-05	NA	6.9e-05
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0595	0.0310	1.0e-04	0.013	0.040	0.043	NA	0.039	1.2e-02	2.6e-05	1.1e-05	NA	2.9e-05
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1620	0.0650	6.3e-05	0.098	0.107	0.089	NA	0.085	3.0e-06	1.1e-06	8.6e-06	NA	1.3e-05
9	TCGA	Brain Lower Grade Glioma	0.0756	0.0359	1.1e-03	0.024	0.047	0.037	NA	0.041	8.7e-04	4.0e-06	3.9e-05	NA	1.8e-05
10	TCGA	Soft Tissue Sarcoma	0.1150	0.0570	5.7e-03	0.003	0.027	0.010	NA	0.003	2.0e-01	9.5e-03	7.5e-02	NA	2.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.6	2.6	4.5	1.6	0.5	-0.7	2.1	2.1	0.8	2.0	1.8	1.9	1.5
Bipolar Disorder or Schizophrenia	2.0	5.0	7.9	2.1	1.0	-0.7	2.8	2.8	1.9	2.1	2.5	2.8	2.7
Depressed Affect (Nagel 2018)	0.3	0.7	2.0	0.5	0.8	-0.7	1.0	1.0	-0.5	1.1	0.6	-0.3	-1.4
Depression (Nagel 2018)	0.9	1.3	2.6	1.5	1.1	0.4	1.3	1.3	0.2	1.6	1.3	1.2	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.9	7.8	2.8	0.8	-1.6	-1.0	-1.2	0.2	1.5	0.1	-1.0	1.4
Neuroticism (Nagel 2018)	0.4	1.0	4.1	0.3	0.5	-1.3	-0.4	-0.2	-1.3	0.0	-0.5	-1.4	-2.0
Schizophrenia (2018)	1.3	2.7	5.0	1.4	0.9	-0.5	1.9	1.8	1.7	1.2	1.7	2.0	2.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.5	0.4	0.0	-0.5	-0.7	0.4	0.2	0.0	-0.1	-0.4
Worry (Nagel 2018)	0.4	0.8	3.3	-0.0	0.5	-1.2	-0.6	-0.4	-0.9	-0.5	-0.4	-0.8	-1.8
Alzheimer’s Disease (in mother)	0.6	0.6	3.0	0.4	-1.3	1.7	0.1	0.1	-0.2	0.2	-0.6	-0.2	1.1
Alzheimer’s Disease (in father)	0.7	0.8	2.3	0.6	-0.9	-1.5	1.0	0.8	-0.3	0.3	-0.1	0.2	1.5
Alzheimer’s Disease (including proxy)	1.8	2.7	11.1	-1.6	-3.3	0.3	0.0	-0.0	-1.9	-1.7	-2.2	-1.2	0.3
Crohns Disease (2017)	0.8	1.7	3.2	-0.8	0.1	-0.8	1.8	1.8	1.8	0.1	1.6	1.8	0.4
Irritable Bowel Disease (IBD)	1.3	3.1	7.9	-0.5	0.4	-1.2	2.3	2.4	2.8	0.8	2.4	2.1	0.7
Ulcerative Colitis (UC)	1.0	1.9	5.4	-0.3	0.9	-1.0	1.7	1.7	2.3	0.9	1.8	1.3	0.4
Major Depression (MDD)	0.2	0.3	1.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.1	1.2	0.0
Reaction Time	0.2	0.4	1.0	-0.7	-0.8	-0.6	0.8	1.0	0.4	0.1	0.3	0.7	0.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	9.4	3.1	0.5	-1.6	-0.8	-0.7	0.8	1.8	0.8	-0.5	0.9
Breast Cancer	1.2	2.9	8.8	1.4	-3.0	1.1	-1.4	-2.1	0.4	-0.2	-1.1	-1.0	2.8
Ovarian Cancer	0.3	0.4	0.8	0.4	0.6	0.7	0.2	0.1	0.9	0.9	0.9	0.4	-0.3
Prostate Cancer	1.0	1.4	5.9	0.0	0.7	2.4	-1.4	-1.3	0.6	-0.3	0.2	-0.6	-1.8
Age at First Birth	1.4	2.0	5.7	1.5	2.4	-1.9	0.7	1.4	-0.9	1.3	0.5	-0.4	-1.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	6.9	-2.6	-1.7	0.8	-0.7	-0.5	-0.3	-1.4	-0.9	-0.5	-1.1
Coronary Artery Disease (CAD)	1.9	2.3	9.2	0.0	0.0	0.0	0.0	0.0	-2.3	-1.5	-1.8	-1.7	-3.0
Crohns Disease (2012)	1.0	1.6	2.8	-0.4	-0.8	-1.6	1.4	1.2	1.7	0.6	1.5	1.6	1.3
Mean Putamen Volume	0.7	0.8	3.6	-1.9	0.1	0.9	0.9	0.5	-0.1	-1.2	-0.2	0.9	-0.4
Fasting Glucose	1.5	1.7	3.4	-0.8	-1.0	-1.9	1.6	1.8	1.5	-0.1	1.3	1.6	0.2
HbA1C	0.7	0.8	4.4	0.3	-2.1	-0.7	0.9	0.9	-0.0	0.9	0.1	0.3	0.8
HDL Cholesterol	0.3	0.5	2.8	0.5	1.2	0.0	-0.0	0.1	-0.3	0.1	0.7	0.0	-1.7
LDL Cholesterol	0.5	0.8	2.7	-0.1	-0.8	-1.0	-0.9	-1.0	-0.9	-0.3	-0.8	-1.6	-0.3
Lupus	1.0	1.5	4.2	0.4	-1.9	1.2	-1.4	-1.4	0.1	-0.6	-1.2	-0.4	2.1
Neuroticism (2016)	0.4	0.6	2.7	-0.6	0.4	-0.7	0.5	0.6	-1.6	-0.4	-0.9	-0.5	-0.1
Primary Biliary Cirrhosis	0.4	0.5	1.5	0.1	-0.4	-1.2	-0.5	-0.2	-0.9	-0.4	-0.9	-1.2	0.2
Rheumatoid Arthritis	1.0	1.3	3.0	0.4	0.6	-0.3	1.7	1.7	0.8	1.3	0.9	1.5	1.2
Schizophrenia (2014)	1.0	2.2	4.1	2.0	1.3	0.1	1.3	1.3	1.2	1.7	1.5	1.5	1.9
Triglycerides	0.3	0.5	1.9	1.4	-0.1	-0.0	0.1	0.3	-0.5	1.3	-0.2	0.0	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	0.9	1.2	-0.5	-0.6	-0.4	0.3	1.0	0.0	-0.1	0.6
Ulcerative Colitis	0.3	0.5	2.0	-0.1	0.4	0.1	0.7	0.8	1.4	0.1	0.9	0.4	0.6
Blood Eosinophil Count	0.2	1.2	3.9	1.3	-1.1	1.7	-0.6	-0.9	0.1	0.3	-0.9	-0.1	2.0
Blood Platelet Count	0.3	3.8	18.0	-4.2	-0.8	1.0	0.1	0.0	-0.8	-2.2	-0.5	0.7	-3.4
Blood Red Count	0.2	1.7	8.5	-0.2	2.9	-1.0	0.6	1.1	0.9	1.1	1.3	0.6	-1.4
Blood White Count	0.1	0.6	1.2	0.3	-0.4	-0.1	0.7	1.1	0.9	0.9	1.1	1.0	-0.1
Heel T-Score	0.4	2.8	5.0	-2.2	-1.8	-2.1	-0.5	-0.3	-2.0	-1.9	-2.1	-1.5	0.7
BMI	1.6	9.5	40.3	-6.3	-2.9	-1.4	0.1	0.7	-2.5	-4.2	-2.4	-1.8	-3.2
Height	0.5	9.9	25.1	3.5	-1.0	3.3	0.7	-0.3	4.3	4.1	2.9	2.6	5.0
Waist Hip Ratio (WHR)	0.6	2.7	7.1	2.4	-1.5	1.1	0.5	0.1	1.6	1.8	1.4	1.3	2.7
Systolic Blood Pressure	1.9	9.5	25.0	-5.0	-3.1	-1.0	-2.3	-2.6	-2.8	-4.5	-3.5	-2.1	-1.5
Smoking Status	0.5	1.1	3.0	-0.6	-0.9	-0.9	-0.9	-0.8	-0.5	-1.7	-1.4	-1.4	0.8
Allergy or Eczema	0.4	1.1	3.8	-1.9	-1.7	-1.7	0.8	0.5	0.3	-0.7	-0.2	0.3	0.3
Cardiovascular Disease	1.0	3.3	10.9	-3.3	-2.4	-0.5	-0.9	-0.8	-1.1	-2.4	-1.6	-1.6	-1.6
Hypothyroidism (self reported)	0.3	0.6	4.5	0.9	0.4	2.1	-0.0	0.0	0.4	0.3	0.1	-0.1	-0.3
Respiratory disease	1.0	2.2	9.3	-0.6	0.9	-3.1	-0.8	-0.6	-2.0	-0.7	-1.5	-1.7	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.7	-0.3	-0.0	-0.8	-1.9	-1.9	-0.4	-1.0	-0.8	-1.5	-1.0
Lung FEV1/FVC ratio	0.6	2.9	13.8	-3.7	-1.8	-0.2	1.6	1.8	-0.7	-2.1	-1.0	-0.0	0.5
Lung FVC	0.3	1.4	8.7	3.0	1.8	0.3	-0.8	-0.8	0.5	0.6	0.5	-0.0	0.1
Neuroticism	0.6	1.4	6.7	-0.3	0.7	-1.3	0.1	0.3	-1.6	0.1	-0.6	-1.5	-2.6
Chronotype (morning person)	0.3	0.6	1.9	-0.9	-0.7	-0.3	1.0	1.0	0.0	0.6	0.1	0.9	1.4
Hair Pigment	0.0	0.7	1.4	-0.8	-0.8	-0.0	-0.8	-0.7	-0.5	-1.1	-1.2	-1.2	-0.2
Tanning	0.4	5.1	19.4	4.4	1.4	1.2	1.6	1.7	1.9	2.8	2.4	1.6	1.6
Hand grip strength (left)	0.4	1.2	7.5	1.3	-0.5	1.1	0.2	0.2	0.8	0.3	0.0	0.8	2.7
Number of treatments/medications taken	0.3	0.6	3.3	-1.8	-1.2	-0.7	-0.5	-0.4	0.0	-0.7	-0.1	-0.2	-0.1
Average weekly spirits intake	2.1	2.5	4.5	-1.6	-1.6	-2.1	-0.9	-1.3	-2.1	-1.5	-2.1	-1.6	0.2
Sensitivity / hurt feelings	0.4	0.7	3.5	0.6	1.2	-0.7	-0.4	-0.1	-0.6	0.1	0.2	-0.8	-1.9
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.9	0.8	1.5	-0.1	1.1	1.1	0.3	1.2	1.3	1.1	-1.7
Hearing difficulty/problems: Yes	0.5	0.8	3.8	-1.6	-0.1	-0.4	-0.0	0.4	0.4	-0.9	0.7	0.6	-2.0
Relative age of first facial hair	2.5	5.1	10.1	3.2	-0.9	0.1	2.4	2.6	1.8	3.1	2.4	1.9	2.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.6	1.1	0.8	0.4	2.0	2.0	1.7	1.7	2.0	2.1	0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.5	0.5	-0.2	-1.9	-1.3	-1.3	0.1	-0.4	-0.6	-1.3	0.8
Ever had hysterectomy (womb removed)	0.3	0.3	2.5	-1.6	0.2	-0.2	-0.0	-0.4	0.2	-0.1	0.1	0.4	-0.5
Systolic blood pressure, automated reading	1.3	3.7	11.2	-3.3	-2.7	-1.5	-0.8	-0.8	-1.5	-2.8	-1.8	-0.6	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.7	0.1	-1.1	-0.7	-0.8	1.0	0.4	0.7	0.3	0.9
Angina	0.4	0.5	1.9	0.2	-0.1	-0.4	-1.1	-1.0	-0.1	0.1	-0.6	-0.8	1.4
Medication for hormone replacement therapy	1.9	2.2	5.0	-1.8	-1.4	-1.0	-0.7	-0.9	-1.2	-2.2	-1.3	-1.7	-1.8
Vitamin and mineral supplements	0.4	0.5	1.1	1.1	1.0	-0.7	-0.7	-0.4	-0.6	-0.2	-0.5	-1.0	0.3
Supplements: Zinc	0.4	0.4	1.8	-1.2	0.1	0.6	0.6	0.4	-0.1	-0.4	0.2	0.2	-1.3
Medication: Co-codamol	4.4	5.1	12.8	-3.6	-2.5	-0.1	-1.8	-1.8	-1.8	-3.4	-2.1	-1.8	-1.8
Medication: Metformin	0.3	0.4	1.4	-0.2	-0.6	0.3	-0.8	-1.2	0.4	-0.5	-0.5	-0.5	0.7
Diabetes (father)	0.5	0.7	2.0	0.9	1.4	-0.4	-1.2	-0.8	0.0	0.6	0.1	-0.8	-0.9
Diabetes (mother)	0.4	0.6	3.9	0.4	0.1	-2.0	0.7	0.5	0.5	0.0	0.4	0.2	0.7
Severe depression (siblings)	0.2	0.3	1.0	0.2	0.3	-0.8	0.4	0.3	-1.0	0.0	-0.6	0.0	0.7
Pack years adult smoking proportion	0.3	0.4	2.4	0.1	0.8	-1.5	-0.1	0.2	-0.4	0.5	0.4	-0.0	-0.7
Impedance of leg (right)	1.6	7.9	34.8	5.9	2.3	-0.2	0.4	0.1	2.5	3.9	2.8	1.8	2.4
Leg fat-free mass (left)	0.8	4.2	20.9	-4.6	-2.2	1.4	-0.4	-0.4	-1.3	-2.8	-2.1	-0.8	-0.3
Trunk fat percentage	0.4	1.8	7.3	-2.7	-2.4	-0.5	-0.1	-0.1	-0.3	-1.5	-1.0	-0.6	0.8
Hand grip strength (right)	0.6	1.5	5.9	1.7	0.0	2.2	0.1	0.1	0.7	0.6	0.1	0.9	2.4
Townsend deprivation index at recruitment	3.3	4.6	8.5	-2.6	-1.3	-0.3	-1.8	-1.9	-2.9	-2.7	-2.9	-2.5	-0.9
Current tobacco smoking	0.5	0.8	2.0	-0.4	-0.2	-0.3	-1.2	-1.4	-0.6	-0.8	-1.0	-1.2	0.6
Average weekly fortified wine intake	0.1	0.1	0.4	-0.3	0.1	0.0	0.3	-0.2	-0.4	-0.4	-0.4	0.2	0.7
Maternal smoking around birth	3.2	4.7	7.1	-1.5	-0.7	-1.1	-2.2	-2.4	-2.6	-2.4	-2.6	-2.7	-2.3
Fed-up feelings	0.0	0.1	0.3	-0.1	-0.5	-0.5	0.1	-0.1	-0.2	0.1	-0.2	-0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.2	0.4	-0.1	0.4	0.5	0.1	0.2	0.4	0.5	-0.3
Relative age voice broke	2.9	4.4	8.2	2.3	-0.5	-0.6	2.5	2.6	1.9	2.9	2.2	1.7	2.4
Taking other prescription medications	0.6	1.0	2.4	-0.3	-0.1	-1.5	1.1	1.2	1.4	0.1	1.3	0.8	-0.5
Age when periods started (menarche)	0.4	1.1	4.2	2.0	0.7	-0.7	-1.0	-0.7	-0.9	0.3	-0.7	-0.8	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.0	-1.4	0.0	-0.9	-0.4	-0.7	0.3	-0.3	0.3	0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.8	0.3	-0.4	-0.0	0.9	0.9	0.0	0.4	0.2	0.7	1.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.2	0.6	0.9	0.1	0.2	0.3	0.3	1.5	0.8	0.5	-0.6
Qualifications: CSEs or equivalent	1.4	1.9	5.1	-1.3	0.2	1.5	-0.1	-0.1	-2.3	-1.8	-1.8	-1.3	-1.4
Serious illness, injury or assault to yourself	0.6	0.7	2.9	1.1	1.7	-0.4	-0.0	0.4	0.5	0.7	0.7	0.6	-1.0
High blood pressure	1.1	3.2	8.5	-2.8	-2.0	-0.8	-1.5	-1.5	-0.8	-2.9	-2.0	-1.3	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.3	-1.2	-0.8	-0.9	1.5	1.2	0.6	0.2	0.9	1.2	-0.1
Multivitamins +/- minerals	0.2	0.3	1.1	-0.7	-1.1	0.6	0.2	0.1	0.3	-0.2	0.2	0.5	-0.4
Stomach or abdominal pain in last month	2.8	3.5	7.6	-1.2	0.9	-0.6	-2.3	-2.4	-1.7	-1.5	-1.7	-2.8	-2.2
Supplements: Glucosamine	0.7	1.0	3.0	0.7	1.7	-1.0	1.0	1.1	-0.1	1.3	0.9	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	0.8	0.1	0.0	0.4	0.3	0.4	1.2	0.9	0.6	0.4
Medication: Atenolol	0.5	0.6	1.9	-1.4	-0.9	0.3	-0.5	-0.5	1.3	0.7	0.5	0.3	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.4	-0.6	0.2	-0.1	-0.1	0.1	-0.3	-0.4	-0.3	0.3
Sitting height	0.3	1.9	5.8	0.8	0.3	2.4	1.1	0.9	1.7	1.8	1.5	1.2	0.8
Chronic bronchitis/emphysema (father)	0.6	0.8	2.7	0.6	-0.1	1.6	-0.3	-0.4	1.2	0.7	0.7	0.9	1.0
High blood pressure (mother)	0.9	1.3	6.7	-2.6	-0.5	-1.2	0.6	0.6	-0.7	-1.3	-0.4	-0.1	-1.2
Body mass index (BMI)	2.0	8.4	29.7	-5.5	-3.0	-0.8	-0.9	-0.5	-2.6	-4.5	-3.1	-2.2	-1.6
Impedance of leg (left)	1.7	8.0	37.5	6.1	2.0	0.5	0.4	0.1	2.7	3.7	2.8	1.6	2.7
Leg predicted mass (left)	0.8	4.4	21.2	-4.6	-2.2	1.5	-0.5	-0.4	-1.4	-2.8	-2.1	-0.8	-0.4
Trunk fat mass	0.6	2.8	11.1	-3.3	-2.8	-0.1	-0.3	-0.3	-0.7	-2.2	-1.5	-0.9	0.6
Waist circumference	1.2	4.3	13.6	-3.7	-2.9	-0.8	-0.8	-0.8	-1.4	-3.2	-2.1	-1.5	-0.1
Number of incorrect matches in round	0.9	1.6	3.1	0.7	-1.0	1.0	1.4	1.0	1.5	1.1	1.4	1.8	1.3
Past tobacco smoking	1.0	1.8	4.5	1.2	1.6	1.8	0.8	0.6	0.9	2.1	1.6	1.2	-0.6
Alcohol usually taken with meals	3.3	5.3	13.6	2.1	0.6	2.5	0.5	0.3	3.7	2.7	2.4	2.3	3.0
Nervous feelings	0.5	0.8	2.2	-0.4	-0.2	-0.9	-0.7	-0.5	-1.5	-0.7	-1.0	-1.0	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	5.5	-0.1	0.5	-2.4	0.4	0.6	-1.1	0.5	0.3	-0.5	-2.0
Hearing difficulty/problems with background noise	1.0	1.6	8.1	-2.9	-0.8	0.4	-0.9	-0.9	-0.3	-1.8	-0.6	0.0	-1.4
Hair/balding pattern: Pattern 2	0.8	1.1	2.0	0.9	-0.3	1.2	1.3	1.4	1.4	-0.1	1.1	1.1	0.5
Had menopause	0.5	0.7	1.8	-0.3	-0.3	-1.3	-0.9	-0.9	0.4	-1.0	-0.5	-0.2	1.3
Had other major operations	0.6	0.8	4.0	0.2	-1.6	-2.0	0.3	0.5	-0.4	0.7	-0.1	-0.2	0.4
Forced vital capacity (FVC)	0.2	0.9	4.3	2.1	1.7	0.1	0.1	-0.0	0.5	0.9	0.7	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.5	-0.6	-1.3	-0.5	-0.1	-0.3	-0.4	-0.3	-0.7	-0.3	1.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	3.4	-0.0	-1.2	-0.6	0.8	1.1	-0.6	0.5	-0.4	0.4	1.8
Qualifications: None of the above	0.1	0.3	1.2	-1.1	0.0	-0.3	-0.5	-0.4	0.6	-0.4	0.0	0.2	0.6
Financial difficulties in last 2 years	2.0	2.6	8.6	-1.4	-1.4	-2.9	-0.2	0.0	-2.6	-1.4	-2.0	-1.2	-0.2
Mouth/teeth dental problems	0.6	1.0	2.7	-0.5	-0.9	1.6	-1.0	-1.5	-0.4	-0.8	-0.8	-1.0	-0.5
Heart attack	0.1	0.1	0.5	0.4	0.0	-0.7	-0.5	-0.2	-0.2	0.4	0.0	-0.1	-0.1
Allergy	0.3	0.8	2.4	1.6	1.0	1.3	-1.0	-0.8	-0.0	0.4	-0.4	-0.8	0.5
Pain all over the body in last month	0.9	0.9	2.5	-0.2	-0.2	0.4	1.3	0.8	1.4	0.5	0.7	1.2	1.6
Diabetes (self-reported)	2.2	3.3	7.8	-0.2	-0.8	-2.1	-2.8	-2.8	-1.2	-1.3	-1.7	-2.5	-0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.6	-0.5	-0.7	-0.5	-0.0	-0.4	0.2	-0.1	0.0	-0.1	-0.3
Medication: Ramipril	0.6	0.7	2.4	-1.2	-1.6	-1.0	-0.4	-0.1	-0.4	-1.0	-0.9	-0.5	-0.3
Medication: Simvastatin	1.0	1.5	5.5	-1.3	-2.0	-2.4	-0.0	0.1	-0.9	-1.1	-1.0	-0.6	0.5
Fluid intelligence score	0.6	1.2	5.1	2.3	0.7	-1.9	-0.8	-0.7	0.6	1.1	0.5	-0.4	0.1
Illnesses of siblings	0.2	0.3	1.0	1.0	0.7	-0.4	0.4	0.2	0.1	0.7	0.4	0.0	-0.4
Neuroticism score	0.3	0.6	2.5	0.1	0.5	-1.3	0.3	0.4	-0.9	0.3	-0.1	-0.8	-1.6
Weight	0.8	4.0	16.8	-4.1	-2.8	0.6	-0.3	-0.1	-1.1	-3.0	-1.9	-0.9	0.1
Impedance of arm (right)	1.8	8.2	24.2	3.8	2.2	-0.2	1.4	0.9	3.2	4.9	3.5	2.8	2.2
Arm fat percentage (right)	0.9	3.7	17.6	-4.2	-2.4	-0.9	-0.1	-0.0	-1.1	-2.7	-1.7	-1.0	-0.3
Trunk fat-free mass	0.4	2.3	7.3	-2.7	-1.7	1.9	-0.3	-0.3	-0.8	-2.3	-1.6	-0.4	0.5
Hip circumference	1.0	4.5	19.2	-4.4	-2.4	-0.4	-0.2	-0.1	-1.6	-3.2	-2.2	-1.3	-0.3
Time employed in main current job	0.6	0.6	3.1	0.4	0.5	1.8	-0.9	-1.3	0.4	-0.0	-0.0	-0.3	-0.5
Alcohol intake versus 10 years previously	0.9	1.3	4.4	-1.5	-0.2	-2.1	-0.1	0.1	-1.5	-1.2	-0.9	-0.2	-1.4
Father’s age at death	0.2	0.2	0.7	0.4	0.7	-0.1	-0.3	-0.4	0.1	0.3	0.6	0.3	-0.8
Worrier / anxious feelings	0.5	1.0	2.5	1.1	1.4	-1.6	0.0	0.3	0.1	1.3	0.8	-0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.5	-0.4	0.9	-0.3	-0.6	-0.4	-0.1	0.4	0.2	-0.1	-1.6
Falls in the last year	0.5	0.7	2.2	0.7	-0.6	-1.1	0.5	0.8	-0.1	1.5	0.2	0.5	1.2
Hair/balding pattern: Pattern 3	0.8	1.2	3.0	0.4	1.5	0.7	-1.0	-0.8	-1.6	0.4	-1.1	-1.7	-1.1
Number of live births	1.4	2.0	4.9	-1.5	-0.4	1.0	-1.3	-1.8	-1.2	-2.2	-1.8	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.8	0.4	1.4	0.0	0.4	0.5	-0.1	-0.3	0.1	0.2	-0.3
Pulse rate	0.9	1.5	6.3	-1.7	-1.1	0.4	-0.5	-0.7	-0.9	-2.5	-1.6	-0.2	0.5
Happiness	0.7	0.9	2.2	-0.8	-1.5	-0.2	1.2	1.2	0.5	-0.1	0.1	0.7	1.4
Noisy workplace	2.5	3.1	6.4	-2.5	-0.9	0.2	-1.4	-1.4	-1.8	-2.5	-2.1	-1.6	-1.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.6	1.9	0.3	-0.1	-0.1	-0.4	0.3	1.2	0.3	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	7.1	-1.8	0.5	-0.5	-0.3	-0.1	-2.7	-1.2	-1.9	-1.3	-1.8
Mouth/teeth dental problems: Dentures	0.5	0.8	2.5	-0.7	1.1	-0.7	0.7	1.0	1.6	0.0	0.9	0.9	0.3
Asthma	0.5	1.0	4.3	-1.3	-0.3	-2.1	0.1	0.2	-1.0	-1.4	-0.8	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	0.5	-0.4	1.0	-0.0	0.2	-0.2	0.6	-0.1	0.2	0.8
Medication: Cholesterol lowering	0.9	1.3	3.7	-0.9	-1.9	-1.7	-0.3	-0.3	-0.8	-1.0	-1.3	-1.2	1.0
Depression (self-reported)	0.8	1.0	3.7	1.8	1.9	-0.4	0.3	0.5	0.5	1.0	0.7	0.3	0.7
Medication: Lansoprazole	4.9	5.5	8.8	-2.8	-2.8	-2.4	-1.8	-1.8	-2.2	-3.0	-2.5	-2.4	-1.4
Prospective memory result	0.9	1.1	3.5	-1.9	-0.7	1.0	-0.5	-0.6	-0.9	-1.9	-1.2	-0.2	0.5
Lung cancer (father)	1.9	2.2	4.5	-0.1	-0.7	1.8	-1.8	-2.1	-0.9	-1.7	-1.8	-1.8	1.0
Illnesses of mother	2.1	2.6	7.3	2.7	0.7	2.3	0.5	0.6	1.4	1.9	1.0	1.1	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	2.0	0.7	1.4	0.1	0.6	0.6	0.2	0.2	0.7	0.6	-0.3
Pulse wave Arterial Stiffness index	1.8	2.1	4.8	2.2	0.7	-1.5	-1.6	-1.4	-1.5	0.1	-1.5	-2.1	0.7
Impedance of arm (left)	1.6	7.3	23.0	4.1	2.4	0.1	1.0	0.4	2.7	4.8	3.1	2.3	2.1
Arm fat mass (right)	1.2	5.0	21.5	-4.6	-2.8	-0.4	-0.3	-0.1	-1.4	-3.4	-2.2	-1.3	-0.4
Trunk predicted mass	0.4	2.4	7.7	-2.8	-1.7	1.9	-0.4	-0.4	-0.9	-2.4	-1.7	-0.5	0.4
Standing height	0.5	5.0	13.0	2.3	0.1	3.0	1.0	0.5	2.5	2.8	1.8	2.2	3.6
Length of working week for main job	1.8	2.0	9.0	-1.4	0.2	0.7	-1.5	-1.2	-1.3	-0.8	-0.7	-1.4	-3.0
Exposure to tobacco smoke at home	1.7	2.0	5.5	-0.1	-0.7	-1.1	2.2	2.4	0.9	1.4	1.5	1.6	0.3
Breastfed as a baby	0.9	1.2	2.7	1.5	1.0	1.3	-0.3	-0.6	1.2	0.5	0.6	1.2	1.6
Tense / ‘highly strung’	0.1	0.2	0.4	-0.5	-0.4	-0.1	0.6	0.6	0.2	-0.5	0.2	0.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.5	2.1	1.4	-1.4	1.3	1.6	0.6	1.1	1.2	0.8	1.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.9	0.6	0.1	-0.6	-0.1	-0.4	0.7	0.7	0.4	0.6	1.4
Birth weight of first child	1.1	2.0	3.2	0.8	-0.5	0.8	1.8	1.8	1.6	1.5	1.5	1.8	1.4
Peak expiratory flow (PEF)	1.4	3.4	7.5	1.8	1.8	-0.7	2.2	2.7	1.1	1.9	1.7	2.1	1.3
Pulse wave reflection index	1.2	1.5	3.9	2.0	1.3	-1.4	-1.1	-0.8	-0.9	0.6	-0.9	-1.8	0.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.0	-1.4	-0.4	-1.7	-0.4	0.1	-1.3	-0.9	-1.1	-1.2	-1.2
Loud music exposure frequency	1.7	1.8	6.4	-2.1	-2.5	0.4	-0.6	-0.7	-0.6	-2.0	-1.2	-0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.6	-0.2	-0.2	-0.4	0.1	-0.2	-0.1	-0.2	-0.1	-0.1	-0.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.8	2.0	1.5	-0.4	1.0	1.4	0.9	1.9	1.2	1.8	1.9
Blood clot in the leg (DVT)	0.8	1.0	1.9	0.3	1.4	1.3	1.1	1.4	0.9	0.7	1.3	0.9	-0.1
Medication: Paracetamol	0.4	0.6	2.0	-0.5	1.3	-1.3	0.5	0.4	0.0	0.1	0.6	-0.2	-1.4
Headache pain in last month	0.7	1.1	4.7	0.9	1.9	2.2	0.4	-0.0	0.6	0.7	0.7	0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.3	1.2	1.0	1.5	0.3	0.2	-0.0	0.7	0.5	1.2	0.0
Glaucoma (self-reported)	0.4	0.5	1.7	0.8	-1.3	0.7	-0.5	-0.6	1.0	0.4	0.5	0.4	0.5
Gout (self-reported)	1.9	2.5	5.3	-2.3	-1.1	-1.2	-1.5	-1.5	-1.7	-1.1	-1.6	-2.1	-1.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.2	1.0	-0.1	1.5	-0.1	-0.1	-0.0	0.3	0.0	-0.2	-0.2
Medication: Amlodipine	1.5	2.1	4.4	0.2	-1.1	0.0	-2.0	-2.1	-1.6	-1.5	-2.0	-1.7	0.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.4	-0.0	-0.1	-0.2	1.5	1.5	-0.2	0.9	0.5	1.0	0.5
Birth weight	1.8	3.9	6.5	2.2	2.1	1.2	1.6	1.9	1.8	2.5	2.1	1.9	1.9
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.4	-1.3	1.0	-1.9	-1.2	-1.1	-1.3	-1.6	-1.1	-1.3	-2.1
High blood pressure (siblings)	0.5	0.7	2.5	-1.6	-0.9	-0.9	-0.4	-0.5	-0.6	-1.2	-0.8	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	4.2	2.0	1.7	0.4	0.0	-0.0	0.6	0.9	1.0	0.5	-0.2
Body fat percentage	0.6	2.5	9.1	-3.0	-2.6	-0.8	-0.4	-0.4	-0.8	-2.1	-1.5	-1.1	0.5
Leg fat percentage (right)	0.8	2.9	7.6	-2.8	-2.3	-1.5	-0.8	-0.7	-1.0	-2.7	-1.7	-1.3	0.2
Arm fat-free mass (right)	0.8	4.3	11.4	-3.4	-2.2	1.7	-1.0	-0.9	-1.6	-3.3	-2.4	-1.5	-0.1
Exposure to tobacco smoke outside home	0.8	1.0	4.5	-2.1	-1.4	-0.0	0.8	0.7	-0.7	-0.8	-0.6	0.2	-0.8
Comparative body size at age 10	0.6	1.8	8.3	-2.9	-1.3	1.8	1.1	1.0	-0.1	-1.2	-0.3	0.9	-0.1
Number of full brothers	1.1	1.4	3.2	-1.4	-0.7	1.3	-0.4	-0.6	-1.8	-1.4	-1.6	-1.1	0.3
Worry too long after embarrassment	1.6	2.7	7.1	0.6	0.6	-1.9	-1.9	-1.6	-1.8	-0.9	-1.5	-2.7	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.6	1.2	1.9	-1.4	-0.9	-0.5	-0.8	0.3	0.1	-0.9	-0.9
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.5	-0.6	-0.4	0.6	0.7	-0.7	0.2	-0.3	0.2	0.5
Number of children fathered	0.9	1.1	4.6	-2.1	-1.7	0.1	-0.0	-0.2	-0.3	-1.3	-1.0	0.0	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-0.7	-1.4	1.2	-0.6	-0.7	0.4	-0.7	-0.2	0.4	0.9
Age at first live birth	0.7	1.2	4.5	2.1	0.5	-1.1	0.2	0.4	0.9	1.5	1.4	0.8	-0.7
Pulse wave peak to peak time	2.5	2.9	6.7	-1.7	-0.7	1.8	1.9	1.7	2.0	0.5	2.1	2.6	-0.2
Health satisfaction	1.0	1.2	4.3	-1.0	-0.3	-2.1	-1.1	-0.6	-0.4	-0.8	-0.7	-1.5	-1.3
Shortness of breath walking on level ground	0.6	0.8	1.7	-0.1	1.1	-1.3	-1.2	-0.9	0.7	0.1	0.2	-0.4	-1.3
Qualifications: College or University degree	0.5	1.5	5.0	2.2	1.4	0.3	-0.0	0.1	0.4	2.1	1.2	-0.3	-1.5
Eye problems/disorders: None of the above	1.7	1.9	7.2	-2.7	-1.1	-1.7	1.5	1.1	-1.2	-0.8	-0.7	-0.2	-1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.8	-1.3	1.5	-1.7	-0.2	-0.2	-1.3	-0.1	-0.6	-0.6	-1.3
Emphysema/chronic bronchitis	0.4	0.5	1.8	1.4	-0.3	-0.6	-0.7	-0.8	0.1	0.7	-0.3	-0.7	0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	3.0	0.7	0.2	0.1	-1.7	-1.4	-0.8	-0.7	-1.1	-0.8	0.0
Neck or shoulder pain in last month	0.9	1.3	2.5	-0.9	-1.1	-1.1	-1.3	-1.6	-1.2	-1.0	-1.2	-1.1	0.4
Medication: Blood pressure	0.4	0.7	1.3	-0.9	-0.8	-1.0	-1.1	-1.1	0.3	-0.5	-0.2	-1.0	-0.6
Angina (self-reported)	0.5	0.7	1.8	0.4	-0.1	-0.5	-1.4	-1.2	-0.3	0.1	-0.6	-1.0	1.2
Migraine (self-reported)	0.6	0.8	2.4	-1.4	-1.5	0.5	0.4	-0.3	-0.5	-1.2	-0.7	0.7	0.4
Medication: Ibuprofen	0.2	0.3	1.1	0.3	0.4	-0.1	-0.1	0.1	-0.9	0.4	-0.6	-0.0	1.1
Medication: Allopurinol	3.7	4.9	8.1	-2.9	-2.1	-1.6	-2.1	-1.9	-2.2	-2.2	-2.4	-2.7	-1.9
Medication: Omeprazole	0.4	0.5	1.8	0.6	0.5	-1.4	0.7	0.5	0.1	0.9	0.4	0.1	0.6
Medication: Seretide 50 evohaler	1.1	1.3	4.3	2.0	1.2	2.1	-0.9	-0.6	0.4	0.9	0.8	-0.6	-0.2
Mean time to correctly identify matches	0.3	0.6	1.6	-0.4	-0.5	-1.3	0.7	0.9	0.6	0.7	0.7	1.0	0.4
Heart disease (mother)	1.2	1.5	3.0	-0.6	-0.3	-1.3	-1.7	-1.6	-1.1	-0.8	-1.3	-1.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	8.5	-0.4	-0.7	-2.9	2.1	2.0	0.6	1.0	0.6	1.1	2.8
Whole body fat mass	0.9	3.7	14.1	-3.8	-2.9	-0.3	-0.5	-0.4	-1.1	-2.7	-2.0	-1.2	0.3
Leg fat mass (right)	1.1	4.4	14.1	-3.8	-2.8	-0.4	-1.0	-0.8	-1.4	-3.2	-2.3	-1.5	0.2
Arm predicted mass (right)	0.7	3.5	9.5	-3.1	-2.2	1.7	-0.8	-0.6	-1.3	-3.0	-2.1	-1.2	0.1
Pulse rate, automated reading	0.3	0.9	4.3	-0.6	-0.9	0.3	-0.9	-1.1	0.2	-2.1	-0.9	-0.2	0.8
Alcohol intake frequency.	0.4	1.0	3.9	-0.6	2.0	-0.1	0.6	0.7	-0.0	0.6	1.0	1.0	-1.5
Comparative height size at age 10	0.5	2.9	4.6	1.5	0.8	1.4	1.2	0.9	2.1	2.1	2.0	2.1	2.1
Number of full sisters	2.1	2.5	5.3	-1.7	-0.6	-0.5	-1.1	-1.2	-2.3	-2.2	-2.2	-1.7	-1.0
Suffer from ‘nerves’	0.8	1.3	2.9	0.3	-0.8	-0.5	-1.7	-1.6	-0.8	-1.2	-0.9	-1.6	-0.9
Overall health rating	1.5	3.2	7.4	-2.1	-0.6	-0.8	-2.7	-2.6	-0.6	-2.0	-1.1	-1.7	-2.1
Chest pain or discomfort	0.9	1.3	3.8	0.5	-0.6	-1.2	-0.9	-0.7	-1.9	-0.3	-1.6	-1.6	0.5
Had major operations	0.0	0.1	0.3	0.2	0.0	-0.2	0.0	0.1	-0.2	0.3	0.1	0.1	0.5
Age at last live birth	0.5	0.7	3.0	1.7	0.5	-0.7	-0.2	-0.0	-0.1	0.9	0.8	0.6	-1.2
Family relationship satisfaction	0.9	1.0	2.1	0.6	0.4	-0.7	1.2	1.4	1.1	1.3	1.2	1.0	0.7
Leg pain on walking	0.1	0.2	0.6	-0.8	0.1	-0.3	0.3	0.3	0.2	-0.6	-0.1	0.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.2	-1.8	-1.8	-0.6	0.4	0.5	-0.9	-0.9	-0.4	-0.0	-1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	0.4	-0.1	-1.3	-0.5	-0.2	-1.2	-0.1	-0.7	-0.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	6.1	0.1	-0.3	2.5	-0.4	-0.7	0.5	-0.1	0.1	0.3	0.1
Medication: Aspirin	0.9	1.1	3.0	-0.7	-1.4	1.7	1.2	0.9	1.1	0.4	0.8	1.1	0.8
Supplements: Vitamin C	0.6	0.7	2.5	-1.6	-0.6	0.4	1.2	0.9	-0.4	-0.2	0.0	0.6	-0.8
Knee pain experienced in last month	0.6	0.9	2.0	-1.1	-0.4	-1.4	1.0	1.1	-1.0	-0.6	-0.7	0.4	1.2
Hypertension (Self-reported)	0.7	2.0	5.4	-2.3	-1.8	-0.7	-1.1	-1.1	-0.6	-2.3	-1.4	-1.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	8.7	0.1	-0.9	-3.0	-1.6	-1.7	-2.0	-1.1	-1.7	-2.0	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.0	-0.3	-0.3	0.2	0.5	-0.5	-0.2	-0.4	-0.3	0.7
Illnesses of siblings: Diabetes	0.3	0.3	2.1	0.2	0.2	0.4	0.6	0.6	0.0	0.4	-0.0	0.2	1.4
Smoking status: Previous	1.0	1.6	5.2	-1.2	-1.0	-2.3	-0.5	-0.1	-1.0	-1.9	-1.4	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.2	-1.8	-0.5	1.2	0.4	0.1	-0.7	-0.9	-0.4	0.5	-0.3
Whole body fat-free mass	0.5	3.1	12.2	-3.5	-1.9	1.8	-0.3	-0.3	-1.0	-2.6	-1.9	-0.6	0.2
Leg fat-free mass (right)	0.8	4.3	19.1	-4.4	-2.2	1.8	-0.4	-0.3	-1.4	-2.8	-2.1	-0.9	-0.4
Arm fat percentage (left)	1.1	4.3	18.1	-4.3	-2.5	-0.7	-0.4	-0.3	-1.4	-3.0	-2.0	-1.4	-0.5
Average weekly red wine intake	3.1	4.5	14.1	1.0	-0.4	0.7	1.5	1.0	3.0	1.7	2.1	3.0	3.8
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.7	1.7	1.3	-0.8	1.2	1.2	2.1	2.3	2.3	2.4	1.1
Mood swings	0.6	1.0	5.4	-1.1	0.8	-0.0	0.6	0.6	-0.7	-0.7	-0.5	-0.8	-2.3
Loneliness, isolation	0.4	0.6	2.0	-0.4	0.5	-1.4	0.6	0.8	-0.1	0.5	0.6	0.2	-1.3
Long-standing illness, disability or infirmity	0.4	0.6	3.1	-0.8	0.6	-1.8	-0.2	0.1	0.3	-1.1	0.1	0.2	-0.7
Ever had bowel cancer screening	1.7	2.0	4.0	1.3	1.3	-1.5	0.7	0.6	1.8	1.5	1.4	1.2	2.0
Diabetes diagnosed by doctor	0.7	1.1	3.0	0.0	-1.0	-1.0	-1.6	-1.7	-0.4	-0.8	-0.8	-1.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	7.8	-1.1	-0.6	-0.5	-1.9	-1.8	-1.6	-2.2	-1.3	-1.4	-2.8
Friendships satisfaction	1.4	1.7	4.2	0.1	-0.2	-0.8	1.4	1.9	1.4	1.2	1.7	2.0	0.7
Qualifications: nursing, teaching	0.2	0.4	2.5	1.6	0.1	-0.2	-0.1	0.0	0.5	0.6	0.7	0.1	0.2
Commuting to job workplace: Walk	0.2	0.2	0.9	-0.1	-0.6	0.9	0.2	-0.0	0.4	0.1	0.5	0.6	-0.2
Eye problems/disorders: Cataract	1.2	1.4	4.6	2.1	1.1	1.8	-0.3	-0.1	0.9	1.2	1.2	0.9	0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	0.5	-0.3	-0.6	-0.4	-0.1	-0.7	-0.0	-0.4	-0.7	-0.3
Medication for cholesterol	3.4	5.1	14.6	3.8	2.2	0.9	1.4	1.5	1.5	3.5	2.4	1.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.8	-2.0	-1.0	-0.6	-1.8	-1.6	-1.2	-1.6	-1.9	-1.6	-0.0
Back pain experienced in last month	5.4	7.8	17.9	-2.8	-0.5	-0.2	-3.9	-4.2	-1.9	-3.4	-3.5	-3.1	-0.6
Mineral and other dietary supplements	1.0	1.3	3.5	1.1	0.6	0.8	-1.4	-1.2	-1.1	-1.1	-1.3	-1.9	-0.4
Breast cancer (self-reported)	0.5	0.6	1.9	-0.3	0.8	-1.3	-0.7	-0.4	0.5	-0.5	0.1	-0.5	-1.4
Asthma (self-reported)	0.4	0.8	4.4	-1.0	-0.4	-2.1	-0.1	-0.0	-0.9	-1.2	-0.8	-0.2	0.2
Osteoporosis (self-reported)	2.0	2.5	5.3	2.3	0.7	-0.3	1.6	1.7	1.3	2.1	1.9	1.8	0.8
Osteoarthritis (self-reported)	1.1	1.5	4.2	-0.3	1.1	-1.0	2.0	2.0	0.4	0.4	1.0	1.5	0.7
Medication: Aspirin	0.5	0.7	1.2	-0.4	-1.0	1.1	0.9	0.6	1.1	0.5	0.7	0.9	0.9
Medication: Gliclazide	0.4	0.4	1.0	0.2	0.1	-0.9	-1.0	-0.9	0.0	-0.4	-0.4	-0.5	0.9
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.1	0.6	0.6	-0.0	-0.2	-0.3	-0.4	-0.1	-0.3	-0.6
Smoking status: Current	0.3	0.4	1.4	-0.3	-0.1	0.2	-0.9	-1.2	-0.3	-0.6	-0.6	-0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.2	0.3	-0.2	0.1	-1.4	-1.5	-0.5	-0.9	-0.8	-1.5	-0.5
Whole body water mass	0.6	3.5	13.5	-3.7	-2.0	1.7	-0.5	-0.4	-1.2	-2.8	-2.0	-0.7	-0.0
Leg predicted mass (right)	0.8	4.2	18.5	-4.3	-2.2	1.9	-0.4	-0.3	-1.3	-2.7	-2.1	-0.9	-0.4
Arm fat mass (left)	1.4	5.6	21.6	-4.7	-2.8	-0.2	-0.7	-0.5	-1.8	-3.6	-2.6	-1.8	-0.7
Number of self-reported non-cancer illnesses	0.4	0.6	4.3	-0.9	-0.6	-2.1	-0.2	-0.5	-0.2	-0.4	-0.3	-0.5	0.2
Average weekly champagne plus white wine intake	0.1	0.2	1.1	1.0	-0.1	0.5	-0.4	-0.1	0.5	0.2	0.2	-0.2	0.1
Miserableness	0.5	0.9	2.4	1.1	0.5	-0.6	1.2	1.2	0.7	1.6	1.0	0.2	0.1
Guilty feelings	1.1	1.6	4.3	-1.0	-1.8	-0.8	-0.8	-0.8	-2.1	-1.0	-1.8	-1.2	-0.0
Wears glasses or contact lenses	1.1	1.3	4.8	1.9	0.8	-0.8	-0.5	-0.4	1.0	2.2	1.4	0.4	-0.1
Ever taken oral contraceptive pill	1.1	1.2	4.4	0.3	1.1	-0.6	1.4	2.1	-0.5	0.6	0.7	0.6	-1.5
Hearing aid user	0.9	1.0	2.4	-0.2	1.3	-0.0	1.5	1.5	0.8	0.3	1.2	1.2	-0.5
Mother’s age at death	5.2	6.5	12.1	3.0	1.6	0.5	2.6	2.7	2.3	3.5	2.8	2.6	2.7
Financial situation satisfaction	0.6	0.7	2.0	-1.2	-1.4	-0.9	-0.1	-0.1	-1.4	-0.6	-0.9	-0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	-0.6	-0.7	-0.6	-0.9	-1.3	1.1	-0.9	-0.4	-0.3	1.6
Commuting to job workplace: Public transport	0.4	0.4	1.6	0.9	-0.2	-1.3	0.9	0.8	-0.1	0.4	0.2	0.0	0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	0.5	-1.1	0.9	-1.1	-1.3	0.8	-0.0	-0.2	-0.4	0.7
Medication: Blood pressure	2.0	3.9	14.2	-3.8	-2.2	-0.7	-1.2	-1.4	-0.4	-3.4	-1.8	-0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	0.7	0.5	-0.7	0.2	0.2	-0.3	0.5	-0.0	0.3	0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.3	-1.5	-0.7	-1.5	1.1	1.1	0.8	0.4	1.0	1.4	0.1
High cholesterol (Self-reported)	1.0	1.7	6.1	-1.2	-2.5	-0.9	0.2	0.6	-1.3	-1.6	-1.3	-1.4	-0.2
Medication: Bendroflumethiazide	0.9	1.3	4.1	-2.0	-1.2	0.1	-1.1	-1.3	-0.2	-2.0	-0.9	-0.5	-0.2
Medication: Paracetamol	0.6	0.9	4.6	0.3	2.1	-1.4	0.5	0.4	0.2	0.7	0.8	-0.2	-0.8
Medication: Lisinopril	1.9	2.4	14.2	-3.8	-0.9	0.5	-0.2	-0.3	0.3	-2.3	-0.4	0.3	-1.8
Medication: Atorvastatin	0.8	1.0	3.3	-0.3	-1.3	0.6	-0.8	-1.0	-0.6	-0.8	-1.0	-1.8	-0.6
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	-0.6	-0.2	0.3	0.1	-0.5	0.1	-0.1	0.2	-0.5
Alcohol drinker status: Never	1.5	1.8	7.3	1.7	2.7	1.4	0.1	0.0	0.0	2.0	0.9	0.3	-0.8
Ever smoked	0.7	1.2	2.4	-0.5	-1.4	-1.6	-0.4	-0.3	-0.9	-1.5	-1.3	-1.2	0.9
Basal metabolic rate	0.7	3.9	15.5	-3.9	-2.2	1.6	-0.4	-0.4	-1.3	-3.0	-2.1	-0.9	-0.0
Leg fat percentage (left)	0.9	3.3	8.5	-2.8	-2.5	-1.2	-1.0	-0.8	-1.1	-2.9	-1.9	-1.6	0.2
Arm fat-free mass (left)	0.8	4.1	13.0	-3.6	-2.6	1.3	-0.7	-0.5	-1.2	-3.3	-2.2	-1.1	0.2
Number of operations (self-reported)	0.5	0.8	3.9	1.1	0.4	-2.0	-0.7	-0.5	-0.7	0.5	-0.2	-1.0	-0.2
Average weekly beer plus cider intake	1.5	2.2	6.2	-1.5	-0.3	1.6	-0.3	-0.4	-1.8	-1.6	-1.7	-1.4	-2.5
Irritability	2.7	4.6	6.7	-2.6	-2.2	-0.8	-2.0	-2.3	-1.9	-2.5	-2.3	-2.1	-2.1
Risk taking	1.2	1.8	3.9	-1.6	0.5	2.0	-0.9	-0.8	-1.2	-1.6	-1.0	-1.0	-1.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.9	0.3	0.4	0.1	1.7	1.4	1.2	1.6	1.6	1.6	0.8
Fractured/broken bones in last 5 years	0.7	0.9	1.8	1.0	1.1	-0.4	0.7	0.9	0.9	1.1	1.3	1.3	0.0
Age started oral contraceptive pill	0.8	1.0	4.3	-0.6	0.3	-2.1	1.2	1.3	0.4	0.3	0.6	1.1	0.5
Diastolic blood pressure, automated reading	0.7	2.3	6.5	-1.7	-1.4	1.3	-1.1	-0.7	-1.2	-2.5	-1.7	-1.2	-1.5
Ever depressed for a whole week	1.4	1.8	4.9	1.5	-1.5	-0.9	1.5	1.8	-0.8	0.9	0.1	0.7	2.2
Unable to work because of sickness or disability	0.8	1.0	5.1	-1.0	-0.4	-2.2	0.6	1.2	0.5	-0.1	0.8	0.4	-1.0
Commuting to job workplace: Cycle	1.0	1.2	4.8	1.3	1.0	2.2	-0.6	-0.6	-0.6	1.0	-0.7	-0.7	1.4
Myopia	0.4	0.6	1.5	-1.2	-0.6	-0.8	-0.4	-0.7	-0.7	-0.7	-0.6	-0.0	-1.0
Vascular/heart problems diagnosed by doctor	1.1	3.0	7.8	2.8	1.9	1.0	1.6	1.7	0.3	2.7	1.8	1.2	-0.7
Cholesterol lowering medication	0.8	1.1	3.1	-1.6	-1.8	-1.2	-0.1	0.0	-0.5	-1.1	-0.7	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.2	0.6	0.4	-1.1	0.4	0.1	-0.4	0.8	-0.0	-0.8	0.0
Pain experienced in last month	0.4	0.7	1.7	1.1	-0.3	-0.4	0.6	1.0	0.1	1.3	1.0	0.3	-1.3
Supplements: Calcium	0.1	0.2	0.5	-0.0	0.4	-0.5	0.2	0.2	0.1	0.7	0.3	0.6	-0.5
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.4	-1.5	1.1	-1.0	-1.3	-0.1	-0.6	-0.6	-0.3	0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.8	0.5	0.0	-0.9	-0.6	-0.4	-0.3	0.5	-0.0	-0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.8	0.4	1.4	1.1	1.1	1.3	0.9	0.7	1.4	1.0	-0.1
Heart disease (siblings)	1.4	1.8	8.7	-0.1	-0.7	2.9	-0.4	-0.3	1.0	0.3	0.0	0.4	2.7
Alcohol drinker status: Previous	1.9	2.2	3.5	-1.7	0.2	-0.5	-1.5	-1.6	-1.7	-1.9	-1.7	-1.7	-1.0
Pack years of smoking	0.4	0.6	2.7	0.8	0.9	-1.6	-0.2	0.1	0.1	0.9	0.7	0.1	-0.3
Impedance of whole body	1.8	9.0	29.9	5.5	2.2	0.5	0.7	0.2	3.0	4.8	3.2	2.1	2.7
Leg fat mass (left)	1.2	4.7	14.3	-3.8	-2.9	-0.2	-1.1	-0.9	-1.4	-3.4	-2.4	-1.7	0.2
Arm predicted mass (left)	0.7	3.5	12.3	-3.5	-2.3	1.5	-0.5	-0.3	-1.1	-3.0	-2.0	-0.9	0.2