Best TWAS P=2.95e-24 · Best GWAS P=7.65e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SUPT7L | 0.03 | 0.02 | blup | 303 | 0.02 | 1.4e-03 | -2.81 | -5.2 | 1.7e-07 | -0.01 | 0.03 | 0.92 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | AC074117.10 | 0.06 | 0.01 | lasso | 2 | 0.04 | 2.7e-02 | -7.32 | -8.1 | 8.1e-16 | -0.23 | 0.04 | 0.21 | TRUE |
| 3 | GTEx | Stomach | AC074117.10 | 0.06 | 0.01 | lasso | 7 | 0.01 | 7.8e-02 | -1.98 | -9.4 | 4.3e-21 | -0.36 | 0.17 | 0.18 | FALSE |
| 4 | GTEx | Thyroid | FNDC4 | 0.24 | 0.10 | enet | 23 | 0.16 | 2.2e-12 | -8.34 | -9.3 | 1.3e-20 | -0.69 | 0.73 | 0.27 | FALSE |
| 5 | METSIM | Adipose | BRE | 0.03 | 0.00 | blup | 534 | 0.00 | 1.3e-01 | -0.54 | 5.4 | 6.0e-08 | 0.30 | 0.10 | 0.06 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | KCNK3 | 0.24 | 0.15 | lasso | 3 | 0.15 | 6.5e-19 | -5.07 | 5.3 | 1.0e-07 | 0.09 | 0.00 | 0.99 | TRUE |
| 7 | YFS | Blood | MRPL33 | 0.02 | 0.01 | blup | 385 | 0.01 | 6.4e-05 | -6.83 | 5.3 | 8.8e-08 | 0.22 | 0.86 | 0.11 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPN1 | 0.06 | 0.02 | lasso | 6 | 0.02 | 7.2e-05 | 7.59 | 5.9 | 3.8e-09 | 0.54 | 0.23 | 0.02 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT7L | 0.01 | 0.01 | blup | 29 | 0.01 | 1.3e-02 | -0.43 | -5.4 | 8.5e-08 | 0.03 | 0.04 | 0.72 | FALSE |
| 10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SUPT7L | 0.06 | 0.03 | blup | 29 | 0.05 | 2.0e-03 | -8.73 | -7.2 | 7.1e-13 | -0.04 | 0.01 | 0.83 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SUPT7L | 0.05 | 0.02 | blup | 28 | 0.04 | 5.2e-05 | -8.95 | -10.2 | 3.0e-24 | -0.40 | 0.00 | 0.98 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 9.12 | -9.7 | 2.2e-22 | -0.99 | 0.00 | 0.96 | TRUE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT7L | 0.03 | 0.04 | blup | 29 | 0.03 | 7.2e-05 | -2.81 | -5.3 | 1.1e-07 | 0.07 | 0.08 | 0.84 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | FNDC4 | 0.24 | 0.09 | enet | 9 | 0.17 | 1.9e-16 | -8.43 | -9.2 | 4.7e-20 | -0.70 | 0.22 | 0.78 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | GCKR | 0.18 | 0.08 | enet | 5 | 0.13 | 1.7e-12 | -8.34 | -8.7 | 4.4e-18 | -0.64 | 0.35 | 0.65 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT172 | 0.08 | 0.01 | blup | 43 | 0.02 | 6.1e-03 | -7.83 | -8.8 | 1.7e-18 | -0.54 | 0.02 | 0.28 | FALSE |