Best TWAS P=5.42e-23 · Best GWAS P=1.19e-20 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Breast Mammary Tissue (Female) | AC074117.10 | 0.06 | 0.01 | lasso | 2 | 0.04 | 2.7e-02 | -6.7 | -7.4 | 1.1e-13 | -0.23 | 0.04 | 0.05 | TRUE |
2 | GTEx | Stomach | AC074117.10 | 0.06 | 0.01 | lasso | 7 | 0.01 | 7.8e-02 | -2.5 | -9.1 | 9.1e-20 | -0.36 | 0.19 | 0.08 | FALSE |
3 | GTEx | Thyroid | FNDC4 | 0.24 | 0.10 | enet | 23 | 0.16 | 2.2e-12 | -7.9 | -9.2 | 5.7e-20 | -0.69 | 0.67 | 0.33 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | KCNK3 | 0.24 | 0.15 | lasso | 3 | 0.15 | 6.5e-19 | -5.5 | 5.8 | 7.5e-09 | 0.09 | 0.01 | 0.99 | TRUE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPN1 | 0.06 | 0.02 | lasso | 6 | 0.02 | 7.2e-05 | 7.6 | 6.0 | 1.7e-09 | 0.54 | 0.23 | 0.03 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNX17 | 0.08 | 0.01 | blup | 25 | 0.02 | 6.6e-05 | -4.0 | -5.1 | 3.1e-07 | -0.55 | 0.02 | 0.34 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SUPT7L | 0.06 | 0.03 | blup | 29 | 0.05 | 2.0e-03 | -8.3 | -6.7 | 1.6e-11 | -0.04 | 0.01 | 0.84 | TRUE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SUPT7L | 0.05 | 0.02 | blup | 28 | 0.04 | 5.2e-05 | -8.4 | -9.7 | 3.7e-22 | -0.40 | 0.00 | 0.98 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 9.3 | -9.9 | 5.4e-23 | -0.99 | 0.00 | 0.96 | TRUE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | FNDC4 | 0.24 | 0.09 | enet | 9 | 0.17 | 1.9e-16 | -8.0 | -9.1 | 1.1e-19 | -0.70 | 0.41 | 0.59 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | GCKR | 0.18 | 0.08 | enet | 5 | 0.13 | 1.7e-12 | -7.9 | -8.5 | 2.1e-17 | -0.64 | 0.90 | 0.10 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT172 | 0.08 | 0.01 | blup | 43 | 0.02 | 6.1e-03 | -7.6 | -8.5 | 2.8e-17 | -0.54 | 0.02 | 0.27 | FALSE |