Hub : Genes

SNX17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1126	0.0518	1.4e-05	0.069	NA	0.041	NA	0.040	4.5e-06	NA	3.3e-04	NA	4.3e-04
2	GTEx	Muscle Skeletal	0.1849	0.0475	0.0e+00	0.242	NA	0.252	NA	0.265	1.6e-23	NA	1.2e-24	NA	6.2e-26
3	GTEx	Nerve Tibial	0.0399	0.0235	9.7e-03	0.009	NA	-0.001	NA	-0.003	7.0e-02	NA	4.0e-01	NA	7.1e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.2657	0.0564	0.0e+00	0.348	0.321	0.327	0.337	0.344	2.0e-46	3.5e-42	3.8e-43	9.8e-45	7.9e-46
5	YFS	Blood	0.0490	0.0181	6.4e-10	0.032	0.035	0.033	0.035	0.033	7.3e-11	1.0e-11	6.2e-11	1.6e-11	6.3e-11
6	TCGA	Breast Invasive Carcinoma	0.0808	0.0448	5.2e-04	0.007	0.019	0.008	NA	0.019	1.3e-02	6.6e-05	8.0e-03	NA	7.6e-05
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0239	0.0175	1.2e-03	0.007	0.010	0.001	NA	0.003	5.1e-02	2.1e-02	2.3e-01	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.9	3.0	4.2	1.9	2.0	1.4	-1.9	0.6	-2.1	-1.8
Bipolar Disorder or Schizophrenia	0.8	1.9	4.4	-1.7	-1.0	-1.0	1.1	-2.1	-1.0	1.3
Depressed Affect (Nagel 2018)	0.8	1.7	5.5	0.6	1.3	-0.3	-1.3	0.5	-2.4	-1.5
Depression (Nagel 2018)	0.7	1.0	3.3	0.1	1.1	0.4	-1.0	0.4	-1.8	-1.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.7	-1.1	-0.7	0.1	0.7	1.6	0.0	0.5
Neuroticism (Nagel 2018)	0.2	0.5	2.8	-0.4	0.4	-0.4	-0.3	-0.6	-1.7	-0.4
Schizophrenia (2018)	3.9	8.0	13.8	-3.7	-2.8	-2.4	2.9	-3.2	0.4	3.1
Schizophrenia vs Biploar Disorder	8.5	11.2	13.7	-3.7	-3.4	-2.8	3.4	-3.3	3.2	3.6
Worry (Nagel 2018)	0.2	0.4	1.7	-0.0	0.4	0.6	-0.5	-0.4	-1.3	-0.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	-0.4	0.7	0.7	-0.6	0.7	-1.4	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	1.7	-0.2	0.1	0.0	0.1	-0.4	1.3	0.2
Alzheimer’s Disease (including proxy)	0.2	0.2	1.1	-1.0	-0.0	0.6	0.3	-0.3	-0.1	0.1
Crohns Disease (2017)	5.0	11.0	16.6	2.5	4.1	2.2	-4.0	3.5	-2.6	-3.8
Irritable Bowel Disease (IBD)	4.6	10.9	17.2	2.9	4.1	1.8	-4.2	3.0	-2.2	-4.1
Ulcerative Colitis (UC)	2.0	3.8	6.8	2.0	2.5	0.5	-2.6	1.3	-1.1	-2.6
Major Depression (MDD)	3.5	4.2	6.8	-2.6	-2.0	-1.4	2.2	-2.6	-0.3	2.3
Reaction Time	1.1	2.2	4.5	1.0	1.5	2.0	-1.5	2.1	0.8	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.2	-1.2	-1.5	-1.4	1.5	0.4	0.8	1.3
Breast Cancer	0.1	0.2	1.0	-0.1	-0.2	-0.0	0.2	0.7	-1.0	-0.0
Ovarian Cancer	2.5	3.3	6.9	1.6	1.9	1.2	-1.8	2.6	-1.3	-1.8
Prostate Cancer	0.7	1.0	1.8	-1.3	-0.7	-1.1	0.6	-1.4	-0.9	0.6
Age at First Birth	0.8	1.2	3.1	0.6	0.9	1.8	-0.7	1.6	0.5	-0.6
Bipolar Disorder (2011)	3.1	3.0	4.8	0.8	2.1	1.4	-2.1	0.9	-2.2	-1.9
Body Mass Index (BMI) (2010)	1.7	2.3	6.3	-2.5	-1.5	-1.2	1.4	-0.5	1.7	1.3
Coronary Artery Disease (CAD)	0.5	0.6	1.2	-0.5	0.9	0.4	-0.8	1.1	0.9	-0.6
Crohns Disease (2012)	1.5	2.4	3.9	1.4	2.0	0.8	-1.9	1.6	-0.7	-1.9
Mean Putamen Volume	0.2	0.2	0.9	-0.6	0.1	-0.1	-0.1	0.4	-0.9	0.0
Fasting Glucose	20.3	24.3	36.8	-3.0	-5.9	-3.7	5.9	-3.8	5.1	6.1
HbA1C	0.4	0.4	1.7	0.2	-0.4	-1.3	0.6	-0.6	0.2	0.3
HDL Cholesterol	0.9	1.5	2.9	-1.1	-1.3	-1.7	1.1	-1.2	1.1	0.9
LDL Cholesterol	0.8	1.3	4.5	-0.7	0.6	1.1	-0.4	1.4	-2.1	-0.3
Lupus	3.5	5.2	8.0	2.8	2.7	2.1	-2.8	1.6	-0.0	-2.6
Neuroticism (2016)	0.4	0.5	2.1	-0.1	-0.4	-0.4	0.3	-1.1	-1.4	-0.1
Primary Biliary Cirrhosis	2.5	3.6	7.1	1.7	2.7	1.1	-2.3	1.4	-1.6	-2.1
Rheumatoid Arthritis	0.4	0.5	1.3	-1.1	-0.5	-0.2	0.6	0.3	1.0	0.6
Schizophrenia (2014)	3.1	6.8	12.1	-3.5	-2.6	-2.1	2.6	-3.1	0.5	2.7
Triglycerides	82.4	135.0	198.8	6.8	13.2	10.3	-12.4	10.0	-14.1	-12.9
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.7	0.1	-0.7	-0.7	0.5	-1.0	2.2	0.8
Ulcerative Colitis	3.9	5.7	9.3	2.6	2.9	1.9	-3.0	1.0	-1.5	-3.0
Blood Eosinophil Count	0.8	6.2	11.6	2.8	2.5	1.7	-2.6	3.4	-0.3	-2.7
Blood Platelet Count	11.5	133.0	204.5	9.6	13.7	6.3	-13.5	8.9	-12.1	-14.3
Blood Red Count	0.4	4.0	9.9	3.2	1.2	2.8	-1.3	1.2	2.0	-1.2
Blood White Count	11.8	87.4	112.4	7.3	10.5	8.1	-10.1	8.9	-9.4	-10.6
Heel T-Score	0.4	3.6	6.5	-1.4	-1.6	-2.5	1.7	-1.5	2.1	2.0
BMI	0.3	1.9	9.4	-0.8	-1.0	0.0	0.9	-0.4	3.1	1.1
Height	2.8	54.8	71.4	-6.2	-8.4	-5.6	8.2	-7.3	7.4	8.2
Waist Hip Ratio (WHR)	1.1	5.0	15.0	-1.9	-1.7	-0.6	1.7	-3.9	-2.8	1.6
Systolic Blood Pressure	2.5	12.7	21.3	4.0	4.3	2.1	-4.1	3.1	-1.5	-4.6
Smoking Status	0.0	0.1	0.4	-0.4	0.2	0.2	-0.2	0.0	0.6	-0.0
Allergy or Eczema	5.8	15.2	20.6	3.7	4.5	3.5	-4.4	4.2	-1.8	-4.4
Cardiovascular Disease	4.8	15.8	25.4	3.2	4.9	2.5	-4.9	2.9	-3.5	-5.0
Hypothyroidism (self reported)	0.4	0.8	2.2	1.1	0.6	1.5	-0.7	1.0	0.3	-0.6
Respiratory disease	0.0	0.1	0.6	0.1	0.3	0.8	-0.1	-0.0	-0.1	0.2
Type 2 Diabetes (T2D) (2018)	10.5	19.7	25.0	-2.4	-4.9	-4.3	4.8	-5.0	4.3	4.8
Lung FEV1/FVC ratio	0.1	0.4	2.5	-0.4	-0.5	-0.0	0.3	0.3	-1.6	0.0
Lung FVC	0.4	2.2	3.4	1.3	1.6	1.9	-1.5	1.6	-1.1	-1.4
Neuroticism	1.8	4.3	6.9	1.4	2.4	1.5	-2.4	1.3	-2.5	-2.6
Chronotype (morning person)	0.4	0.9	3.6	-0.8	-0.5	1.1	0.4	0.6	-1.9	0.1
Hair Pigment	1.7	49.1	66.1	7.2	8.0	5.0	-7.9	5.5	-6.6	-8.1
Tanning	1.3	16.2	33.1	-2.6	-4.4	-2.9	4.2	-3.0	5.8	4.3
Hand grip strength (left)	1.6	4.3	7.0	-2.3	-2.4	-0.8	2.6	-1.3	1.6	2.6
Number of treatments/medications taken	6.4	11.6	19.3	4.0	3.9	1.5	-4.0	2.1	-2.9	-4.4
Average weekly spirits intake	1.0	1.2	4.5	-0.7	0.2	-2.1	-0.1	-1.3	-1.2	-0.4
Sensitivity / hurt feelings	0.3	0.5	0.7	0.8	0.7	-0.9	-0.5	-0.5	-0.4	-0.7
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.7	0.4	1.4	1.5	-1.4	1.3	-1.9	-1.5
Hearing difficulty/problems: Yes	0.7	1.0	2.4	0.4	1.3	1.6	-1.2	0.7	-0.6	-0.8
Relative age of first facial hair	2.1	4.4	13.9	-0.1	1.8	1.0	-1.7	2.6	-3.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.7	0.5	1.3	0.9	-1.0	0.8	-1.6	-1.1
Ever used hormone-replacement therapy (HRT)	8.6	11.0	16.4	-3.0	-3.9	-3.1	3.7	-4.0	0.4	3.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	1.0	0.4	0.3	-0.3	-0.8	-0.6	-0.4
Systolic blood pressure, automated reading	1.9	5.5	9.0	2.6	2.7	1.6	-2.6	2.3	-0.6	-3.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.8	0.3	-0.3	-0.4	0.3	-0.2	1.3	0.5
Angina	1.3	1.7	7.2	0.2	1.4	0.1	-1.2	0.3	-2.7	-1.2
Medication for hormone replacement therapy	0.7	0.7	3.6	-0.0	-0.5	-1.1	0.3	-1.9	0.0	0.1
Vitamin and mineral supplements	3.6	4.8	9.2	-2.4	-2.6	-1.2	2.8	-1.5	0.8	3.0
Supplements: Zinc	0.6	0.6	4.1	-0.1	0.1	0.5	-0.0	0.2	2.0	-0.2
Medication: Co-codamol	0.2	0.2	1.1	0.0	0.1	-0.2	-0.2	-0.2	-1.0	-0.5
Medication: Metformin	6.0	8.4	10.3	-1.5	-3.1	-3.2	3.1	-3.2	2.8	3.1
Diabetes (father)	3.4	4.1	10.1	-1.3	-2.3	-1.0	2.3	-1.0	3.2	2.2
Diabetes (mother)	1.5	1.9	4.9	-1.5	-1.3	-1.1	1.3	-0.3	2.2	1.4
Severe depression (siblings)	0.3	0.3	0.9	0.5	0.2	-0.1	-0.3	0.9	0.9	-0.1
Pack years adult smoking proportion	0.3	0.4	1.8	0.3	-0.0	1.4	0.1	-0.6	-0.7	-0.2
Impedance of leg (right)	0.8	3.8	23.5	-0.8	0.5	0.1	-0.5	-1.0	-4.8	-0.8
Leg fat-free mass (left)	2.8	15.0	36.6	-2.6	-4.2	-2.2	4.0	-2.6	6.0	4.2
Trunk fat percentage	0.3	1.3	3.3	-1.8	-0.7	-1.6	0.6	-1.4	-0.0	0.5
Hand grip strength (right)	1.5	4.2	6.5	-1.9	-2.4	-1.2	2.5	-1.4	2.0	2.4
Townsend deprivation index at recruitment	1.3	1.9	5.1	-2.2	-1.5	0.2	1.6	-0.5	-0.2	1.7
Current tobacco smoking	0.5	0.9	2.5	-0.2	0.5	1.3	-0.7	0.8	-1.6	-0.6
Average weekly fortified wine intake	0.3	0.4	0.6	-0.8	-0.7	-0.5	0.7	-0.4	0.4	0.7
Maternal smoking around birth	0.2	0.3	0.8	-0.1	-0.4	-0.2	0.7	-0.9	0.5	0.8
Fed-up feelings	1.1	2.0	5.6	0.1	1.3	0.7	-1.3	1.6	-2.4	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	0.7	0.7	0.4	-0.7	0.6	-1.1	-0.8
Relative age voice broke	2.3	3.6	5.8	1.4	2.1	1.6	-2.1	2.4	-1.6	-1.9
Taking other prescription medications	2.6	4.0	7.0	2.7	2.4	1.6	-2.3	1.2	-1.2	-2.2
Age when periods started (menarche)	3.0	7.1	11.9	-3.4	-2.7	-1.6	2.9	-2.5	-2.7	2.6
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	7.3	2.7	2.2	1.3	-2.1	0.8	-1.1	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	8.0	-0.9	-1.4	-0.9	1.5	-0.6	2.8	1.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.7	-1.3	-0.8	-0.5	0.8	-1.1	0.3	0.9
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.4	0.1	-0.6	0.0	-0.3	0.6	-0.1
Serious illness, injury or assault to yourself	1.4	1.7	3.8	2.0	1.4	0.8	-1.5	0.1	-1.1	-1.4
High blood pressure	1.3	3.8	7.0	1.7	2.6	1.1	-2.6	1.0	-1.0	-2.6
Hayfever, allergic rhinitis or eczema	7.5	16.2	22.9	3.5	4.5	4.0	-4.5	4.8	-1.6	-4.3
Multivitamins +/- minerals	2.2	2.8	5.5	1.1	1.9	0.5	-2.1	1.1	-1.7	-2.4
Stomach or abdominal pain in last month	5.1	6.4	10.1	1.8	2.9	1.1	-3.1	1.8	-3.2	-3.0
Supplements: Glucosamine	0.5	0.6	1.2	-1.0	-1.1	-0.2	1.0	-0.5	-0.1	1.0
Diverticular disease/diverticulitis (self-reported)	6.5	7.8	10.4	2.8	3.0	3.1	-2.9	3.2	-0.3	-3.0
Medication: Atenolol	0.2	0.2	1.1	0.3	0.2	0.2	-0.4	0.4	-1.1	-0.3
Medication: Levothyroxine sodium	0.6	1.1	2.5	1.6	0.7	1.4	-0.7	0.8	1.0	-0.7
Sitting height	3.1	22.4	30.8	-4.2	-5.5	-3.1	5.3	-3.6	5.2	5.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.7	-0.1	0.1	-0.1	-0.1	-0.7	-0.8	-0.0
High blood pressure (mother)	3.2	4.5	7.5	2.1	2.6	1.6	-2.3	2.0	-1.2	-2.7
Body mass index (BMI)	0.2	0.8	4.7	-0.3	-0.6	-0.5	0.4	-0.0	2.2	0.5
Impedance of leg (left)	0.9	4.4	26.2	-0.8	0.9	0.2	-0.9	-0.8	-5.1	-1.3
Leg predicted mass (left)	2.8	14.8	36.4	-2.5	-4.1	-2.2	3.9	-2.5	6.0	4.2
Trunk fat mass	1.2	5.2	7.5	-2.7	-2.4	-2.1	2.2	-2.3	2.0	2.2
Waist circumference	1.1	3.9	5.2	-2.1	-2.2	-1.5	2.1	-2.3	1.6	2.0
Number of incorrect matches in round	1.1	1.8	6.1	-0.7	-0.5	-2.5	0.5	-1.4	1.8	0.6
Past tobacco smoking	0.2	0.4	2.4	0.0	-0.3	-0.6	0.1	-0.1	-1.5	0.1
Alcohol usually taken with meals	1.9	3.1	4.5	1.8	2.1	1.6	-2.1	1.5	0.2	-2.1
Nervous feelings	0.1	0.2	0.9	0.1	-0.0	0.8	-0.0	-0.3	-0.9	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.6	0.7	1.1	1.0	-1.2	0.7	-1.3	-1.2
Hearing difficulty/problems with background noise	0.4	0.7	1.6	0.9	1.0	0.2	-0.9	-0.1	1.3	-0.7
Hair/balding pattern: Pattern 2	1.0	1.3	3.9	0.1	1.0	0.2	-1.1	1.3	-2.0	-1.1
Had menopause	24.9	31.1	42.1	-5.8	-6.4	-4.2	6.5	-5.9	2.6	6.5
Had other major operations	0.6	0.7	2.2	1.5	0.2	0.4	-0.1	-1.3	0.5	-0.7
Forced vital capacity (FVC)	0.3	1.3	2.3	-1.5	-1.3	-0.8	1.2	-1.0	-0.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	6.2	-0.4	-1.2	-1.3	1.3	-1.0	2.5	1.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	3.0	-1.4	-0.3	-1.0	0.2	-0.6	-1.7	0.0
Qualifications: None of the above	0.4	0.8	2.2	-1.5	-0.8	-0.5	1.0	-1.1	-0.3	0.7
Financial difficulties in last 2 years	0.3	0.5	2.0	-1.4	-0.2	-0.1	0.3	-0.5	-0.9	0.1
Mouth/teeth dental problems	0.3	0.5	1.2	-0.4	-0.1	-1.1	-0.1	0.8	1.0	0.5
Heart attack	1.0	1.3	3.7	1.9	1.4	0.2	-1.3	0.0	-0.3	-1.3
Allergy	3.2	7.4	12.0	-2.9	-3.0	-3.5	2.8	-2.5	0.8	2.7
Pain all over the body in last month	1.5	1.6	2.3	1.5	1.5	1.4	-1.4	0.1	-0.7	-1.5
Diabetes (self-reported)	11.2	17.2	25.6	-1.2	-4.2	-4.8	4.2	-4.4	5.1	4.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.3	0.9	-0.5	-0.9	1.0	-0.2	-0.8
Medication: Ramipril	0.4	0.5	0.9	0.8	0.8	-0.4	-0.8	0.2	0.9	-0.8
Medication: Simvastatin	3.5	5.1	13.0	1.2	2.3	1.9	-2.2	0.9	-3.6	-2.6
Fluid intelligence score	0.6	1.2	2.0	-0.5	-1.4	-0.7	1.3	0.3	1.2	1.4
Illnesses of siblings	2.8	4.0	8.0	-2.8	-2.2	-0.9	2.3	-1.4	0.5	2.5
Neuroticism score	1.5	3.1	9.3	0.8	1.6	1.2	-1.7	1.3	-3.0	-1.9
Weight	2.1	10.4	18.5	-2.8	-3.5	-2.4	3.3	-2.5	4.3	3.4
Impedance of arm (right)	1.2	5.7	24.4	-0.8	2.2	-0.1	-2.2	0.9	-4.9	-2.2
Arm fat percentage (right)	0.1	0.2	0.9	-0.9	0.1	-0.4	-0.2	0.3	0.4	-0.1
Trunk fat-free mass	3.8	22.1	46.1	-3.1	-5.3	-2.3	5.2	-3.2	6.8	5.3
Hip circumference	0.6	2.5	7.8	-1.3	-1.4	-1.7	1.3	-0.8	2.8	1.1
Time employed in main current job	0.3	0.4	1.2	0.6	0.2	-0.7	-0.3	0.5	1.1	-0.1
Alcohol intake versus 10 years previously	6.1	9.2	13.2	2.6	3.6	2.0	-3.6	2.9	-2.5	-3.6
Father’s age at death	0.4	0.6	2.4	0.1	0.4	1.6	-0.6	0.7	0.7	-0.2
Worrier / anxious feelings	2.3	4.4	9.5	2.0	1.9	3.1	-2.1	2.1	-0.7	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.1	0.6	1.2	-0.2	-1.2	0.4	-2.0	-1.3
Falls in the last year	0.7	1.0	2.5	1.6	1.0	-0.4	-1.1	-0.7	-0.6	-1.2
Hair/balding pattern: Pattern 3	1.9	2.9	4.0	-1.6	-2.0	-1.9	1.9	-1.6	1.0	1.7
Number of live births	1.0	1.4	4.1	2.0	1.1	1.4	-1.1	0.4	0.0	-1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.6	-1.1	-0.7	-0.3	0.6	-0.5	-1.6	0.6
Pulse rate	4.5	7.6	10.0	1.6	3.2	3.0	-2.9	2.8	-2.6	-2.9
Happiness	0.7	0.9	1.5	0.8	0.9	0.7	-1.0	1.2	-0.7	-1.1
Noisy workplace	0.5	0.6	0.8	-0.9	-0.7	-0.8	0.6	-0.9	-0.6	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.5	1.4	1.0	1.0	-1.1	1.9	0.8	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.1	-0.3	-0.3	0.2	-0.8	0.7	0.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.3	-0.2	-1.1	0.0	1.2	-0.9	0.5	0.7
Asthma	0.1	0.2	0.5	0.5	0.1	0.7	0.0	-0.6	0.6	0.3
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.4	10.5	3.2	2.4	0.9	-2.3	1.2	0.4	-2.6
Medication: Cholesterol lowering	7.0	10.9	21.3	1.9	3.7	2.6	-3.6	1.7	-4.6	-3.8
Depression (self-reported)	0.2	0.3	0.9	0.5	-0.3	-0.9	0.3	-0.7	-0.1	0.1
Medication: Lansoprazole	0.2	0.2	0.4	0.0	0.3	-0.6	-0.5	-0.4	-0.6	-0.6
Prospective memory result	0.3	0.3	0.9	-0.8	-0.3	-0.0	0.4	-0.7	0.9	0.3
Lung cancer (father)	0.4	0.5	1.7	-0.2	0.6	0.5	-0.6	0.8	-1.3	-0.4
Illnesses of mother	2.2	2.7	4.7	-1.1	-2.0	-1.2	1.7	-1.4	1.6	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	-0.9	-0.8	-0.5	0.8	-0.7	-0.9	0.7
Pulse wave Arterial Stiffness index	0.2	0.3	1.3	0.5	0.3	-0.2	-0.3	-0.4	-1.1	-0.4
Impedance of arm (left)	1.2	5.5	27.4	-1.0	1.7	-0.5	-1.8	0.1	-5.2	-1.8
Arm fat mass (right)	0.6	2.6	5.6	-1.8	-1.6	-1.2	1.5	-1.0	2.4	1.6
Trunk predicted mass	4.0	22.8	47.6	-3.1	-5.4	-2.5	5.2	-3.2	6.9	5.4
Standing height	3.2	31.8	42.0	-5.5	-6.5	-4.2	6.3	-5.5	4.9	6.3
Length of working week for main job	0.5	0.5	1.3	-0.2	-0.8	-1.2	0.9	-0.5	0.5	0.6
Exposure to tobacco smoke at home	0.5	0.5	1.5	0.9	-0.3	-1.1	-0.1	-0.3	1.2	0.1
Breastfed as a baby	1.2	1.4	2.8	-0.4	-1.3	-1.3	1.1	-1.2	1.7	1.1
Tense / ‘highly strung’	0.8	1.3	7.1	-0.0	0.7	-0.1	-0.8	-0.5	-2.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.6	-0.5	-0.9	0.3	-0.9	-0.5	0.0
Hair/balding pattern: Pattern 4	1.5	3.6	5.7	-0.6	-1.8	-1.4	2.0	-2.4	2.3	2.1
Birth weight of first child	1.3	2.3	3.8	-1.1	-1.9	-0.7	1.7	-1.0	1.8	2.0
Peak expiratory flow (PEF)	0.4	0.8	4.6	0.1	0.6	0.4	-0.7	-0.0	-2.1	-0.7
Pulse wave reflection index	1.7	2.1	3.7	-1.1	-1.6	-1.9	1.4	-1.9	-0.3	1.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.9	0.6	0.5	0.8	-0.5	-0.0	-1.7	-0.8
Loud music exposure frequency	0.3	0.3	0.8	-0.9	-0.5	-0.2	0.5	-0.8	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.6	2.0	1.5	1.0	-1.6	2.4	1.1	-1.5
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	5.6	1.6	2.2	1.5	-2.1	0.6	-2.4	-2.3
Blood clot in the leg (DVT)	0.3	0.4	1.4	0.6	-0.2	1.2	0.2	-0.5	0.7	0.2
Medication: Paracetamol	3.7	6.1	11.1	3.0	3.0	1.3	-3.0	0.6	-1.6	-3.3
Headache pain in last month	3.6	6.2	8.9	2.0	2.6	1.9	-2.7	2.8	-2.3	-3.0
Medication for cholesterol, blood pressure or diabetes	2.9	4.7	7.7	-1.7	-2.7	-1.7	2.6	-1.4	2.0	2.8
Glaucoma (self-reported)	0.6	0.7	1.9	-1.4	-0.6	0.1	0.8	0.1	-1.4	0.6
Gout (self-reported)	26.1	35.8	51.4	4.6	7.1	4.0	-6.9	6.0	-5.1	-7.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.2	0.4	-0.1	-0.2	0.1	0.1	0.3	0.1
Medication: Amlodipine	1.0	1.4	2.6	1.3	0.7	-1.6	-0.8	-0.9	1.6	-0.9
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.3	1.8	1.6	1.6	-1.5	0.9	-0.3	-1.2
Birth weight	0.2	0.4	0.7	0.7	0.4	0.7	-0.5	0.4	0.9	-0.6
Chronic bronchitis/emphysema (mother)	1.2	1.3	2.4	1.5	1.4	0.5	-1.4	0.9	-0.0	-1.5
High blood pressure (siblings)	3.0	4.3	8.1	2.2	2.4	1.4	-2.5	1.5	-1.0	-2.9
Forced vital capacity (FVC), Best measure	0.4	1.4	2.2	-1.5	-1.3	-0.7	1.4	-1.2	0.1	1.3
Body fat percentage	0.1	0.6	2.2	-1.5	-0.3	-0.9	0.2	-0.9	-0.3	0.2
Leg fat percentage (right)	0.0	0.1	0.5	-0.7	-0.2	-0.3	0.1	-0.5	-0.2	0.1
Arm fat-free mass (right)	4.3	21.8	40.4	-3.0	-5.3	-2.5	5.2	-3.8	6.4	5.2
Exposure to tobacco smoke outside home	0.2	0.3	1.6	-0.1	0.0	0.3	-0.2	0.3	-1.3	-0.4
Comparative body size at age 10	2.8	7.8	13.5	2.3	3.2	0.7	-3.2	3.7	-1.8	-3.4
Number of full brothers	1.2	1.6	2.5	-1.3	-1.6	-0.8	1.5	-1.4	0.5	1.3
Worry too long after embarrassment	1.4	2.3	6.6	0.3	1.3	1.6	-1.2	2.6	-1.4	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	7.5	-2.3	-2.1	-1.4	2.1	-2.7	-1.0	2.0
Wheeze or whistling in the chest in last year	0.9	1.6	2.9	0.9	1.4	1.7	-1.3	1.4	-0.6	-1.2
Number of children fathered	1.3	1.5	3.0	-0.9	-1.0	-1.4	1.0	-1.7	-1.4	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	4.8	0.3	-1.2	-0.9	1.2	-1.3	2.2	1.5
Age at first live birth	0.9	1.6	2.8	1.4	1.4	1.1	-1.3	1.7	0.3	-1.3
Pulse wave peak to peak time	0.6	0.7	2.4	-0.8	-0.8	-0.2	0.8	-0.1	1.6	0.8
Health satisfaction	4.1	5.3	8.0	1.2	2.7	2.1	-2.7	2.3	-1.8	-2.8
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	-0.4	-0.4	0.4	-0.4	-0.6	0.3
Qualifications: College or University degree	0.5	1.4	2.3	1.4	1.3	0.7	-1.5	1.4	-0.1	-1.2
Eye problems/disorders: None of the above	3.7	4.3	5.5	-1.6	-2.2	-2.0	2.2	-1.9	2.2	2.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.0	-0.2	0.3	-0.1	-0.2	0.2	-1.0	-0.4
Emphysema/chronic bronchitis	0.4	0.4	0.7	-0.8	-0.8	0.4	0.9	-0.0	0.8	0.7
Medication for pain relief, constipation, heartburn	5.2	8.9	16.7	-4.0	-3.5	-0.9	3.6	-1.3	1.4	4.1
Neck or shoulder pain in last month	0.4	0.6	1.4	1.2	0.3	0.8	-0.5	-1.2	0.7	-0.3
Medication: Blood pressure	0.6	1.1	1.9	1.2	1.3	0.7	-1.4	0.4	-0.1	-1.4
Angina (self-reported)	1.2	1.5	7.1	-0.1	1.2	0.1	-1.1	0.3	-2.7	-1.0
Migraine (self-reported)	0.5	0.6	2.2	-0.1	0.4	0.4	-0.3	-0.7	-1.5	-0.9
Medication: Ibuprofen	2.3	2.8	6.2	2.5	1.9	0.5	-1.8	1.2	-0.1	-2.2
Medication: Allopurinol	16.6	22.1	30.8	3.6	5.5	3.9	-5.3	4.9	-3.7	-5.4
Medication: Omeprazole	0.3	0.4	1.4	1.2	0.4	0.5	-0.4	-0.5	-0.4	-0.5
Medication: Seretide 50 evohaler	0.5	0.5	2.3	0.4	-0.5	0.2	0.5	-0.5	1.5	0.7
Mean time to correctly identify matches	0.7	1.3	2.8	0.9	0.9	1.7	-0.8	1.4	1.3	-0.4
Heart disease (mother)	1.7	2.0	3.2	0.9	1.8	1.3	-1.6	1.2	-1.0	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.8	1.0	1.3	1.3	-1.3	0.9	-0.7	-1.0
Whole body fat mass	0.9	3.6	5.1	-2.2	-2.0	-1.5	1.8	-1.8	2.0	1.9
Leg fat mass (right)	0.9	3.5	4.9	-2.0	-2.0	-1.0	1.9	-1.7	2.2	2.0
Arm predicted mass (right)	3.9	20.2	41.7	-2.6	-5.1	-2.3	4.9	-3.5	6.5	4.9
Pulse rate, automated reading	7.0	22.7	32.1	2.5	5.4	4.6	-5.1	4.1	-5.7	-5.2
Alcohol intake frequency.	12.8	29.8	60.1	3.4	6.2	2.2	-6.0	4.1	-7.8	-6.5
Comparative height size at age 10	2.7	15.1	19.4	-3.9	-4.4	-3.4	4.0	-2.6	4.2	4.2
Number of full sisters	0.4	0.4	2.4	0.4	-0.0	1.5	-0.1	0.3	-0.6	0.2
Suffer from ‘nerves’	0.4	0.6	2.9	-0.6	-0.1	0.3	0.0	0.8	-1.7	-0.0
Overall health rating	2.9	6.3	11.5	2.2	2.8	1.7	-2.9	0.3	-3.4	-2.8
Chest pain or discomfort	1.5	2.1	4.1	0.9	1.6	0.7	-1.4	1.6	-2.0	-1.5
Had major operations	0.2	0.3	0.3	0.6	0.6	0.6	-0.5	-0.1	-0.5	-0.6
Age at last live birth	0.1	0.1	0.3	0.5	0.3	0.4	-0.1	-0.0	0.5	-0.3
Family relationship satisfaction	2.0	2.5	3.5	-1.4	-1.9	-1.0	1.8	-1.7	1.4	1.8
Leg pain on walking	0.5	0.7	2.9	-0.3	-0.6	-0.7	0.7	-1.7	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.0	1.6	1.6	1.5	-1.6	0.3	-1.1	-1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.1	1.0	0.8	0.3	-0.7	-0.6	0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.9	0.7	-0.4	-0.2	0.4	0.1	2.2	0.7
Medication: Aspirin	1.0	1.3	2.5	1.1	1.3	-0.3	-1.4	0.9	-1.0	-1.6
Supplements: Vitamin C	0.9	1.1	3.1	1.8	0.6	0.2	-0.7	-0.3	1.7	-0.9
Knee pain experienced in last month	1.1	1.7	6.0	-0.2	-0.8	-1.9	0.8	-2.4	0.5	0.5
Hypertension (Self-reported)	1.4	3.8	6.8	2.0	2.5	1.1	-2.6	1.2	-0.5	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.2	1.5	0.9	1.1	-1.0	0.2	-0.5	-1.1
Illnesses of father: Heart disease	1.8	2.4	6.2	0.9	1.6	1.5	-1.5	0.6	-2.5	-1.7
Illnesses of siblings: Diabetes	0.6	0.7	3.6	1.0	-0.2	-0.3	0.0	-0.4	1.9	0.5
Smoking status: Previous	0.4	0.6	4.0	-0.0	0.2	0.0	0.1	-0.1	2.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.5	-0.8	-1.6	-0.3	1.5	-1.2	2.1	1.6
Whole body fat-free mass	3.6	20.5	46.2	-2.9	-5.0	-2.3	4.9	-3.0	6.8	5.0
Leg fat-free mass (right)	2.6	13.9	35.4	-2.5	-4.0	-2.1	3.8	-2.4	6.0	4.0
Arm fat percentage (left)	0.1	0.3	1.1	-1.1	-0.1	-0.7	-0.0	-0.1	0.3	0.1
Average weekly red wine intake	0.8	1.1	5.2	0.7	-0.6	-0.5	0.7	-0.8	2.3	0.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.1	-1.4	-0.9	-0.4	0.9	-0.7	-0.7	0.8
Mood swings	2.0	3.6	6.5	1.8	2.0	1.2	-2.0	1.0	-2.6	-2.3
Loneliness, isolation	1.8	2.5	8.1	0.6	1.3	1.8	-1.3	0.9	-2.8	-1.3
Long-standing illness, disability or infirmity	0.5	0.7	1.9	1.4	0.8	-0.2	-0.8	0.0	-0.9	-0.9
Ever had bowel cancer screening	1.0	1.2	2.0	1.1	1.2	1.4	-1.3	0.6	0.4	-1.2
Diabetes diagnosed by doctor	10.3	16.9	21.8	-1.5	-4.3	-4.5	4.3	-4.5	4.7	4.1
Ever had stillbirth, spontaneous miscarriage or termination	3.8	4.0	6.2	1.9	2.4	1.9	-2.2	1.1	-1.7	-2.5
Friendships satisfaction	0.2	0.3	1.4	0.1	0.3	1.2	-0.3	0.5	-0.3	-0.4
Qualifications: nursing, teaching	1.4	2.2	3.7	1.9	1.8	0.8	-1.6	1.0	1.4	-1.7
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.4	-0.3	0.1	0.1	0.7	-0.1	0.1
Eye problems/disorders: Cataract	6.8	7.8	11.4	2.9	3.3	1.6	-3.1	2.5	-2.5	-3.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.2	1.5	1.3	1.4	-1.3	0.4	-0.5	-1.3
Medication for cholesterol	2.6	3.9	7.8	-2.5	-2.2	-0.2	2.4	-0.3	1.3	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	4.1	0.6	1.1	-1.2	-1.3	-0.4	-2.0	-1.7
Back pain experienced in last month	0.9	1.3	2.2	1.5	1.0	1.4	-1.0	-0.3	-1.1	-1.2
Mineral and other dietary supplements	0.1	0.2	0.8	0.9	0.2	-0.0	0.0	-0.1	0.6	0.2
Breast cancer (self-reported)	0.3	0.3	1.6	0.5	0.5	1.3	-0.3	0.2	-0.2	-0.4
Asthma (self-reported)	0.1	0.3	0.7	0.8	0.5	0.8	-0.3	-0.2	0.6	-0.0
Osteoporosis (self-reported)	3.6	4.5	6.5	1.8	2.5	0.7	-2.5	1.9	-2.4	-2.5
Osteoarthritis (self-reported)	1.0	1.2	2.7	1.0	-0.6	-1.6	0.3	-1.7	1.4	0.2
Medication: Aspirin	1.1	1.4	2.6	1.1	1.4	0.2	-1.4	1.2	-0.7	-1.6
Medication: Gliclazide	3.4	3.8	7.2	-1.6	-1.9	-1.2	2.1	-1.5	2.7	2.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	0.5	0.3	-0.7	-0.3	1.2	0.5	-0.3
Smoking status: Current	0.4	0.6	2.1	-0.5	0.2	1.3	-0.4	0.5	-1.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	0.7	0.7	0.8	-0.5	0.7	-0.6	-0.5
Whole body water mass	3.6	20.7	45.8	-3.0	-5.0	-2.4	4.9	-3.1	6.8	5.0
Leg predicted mass (right)	2.6	14.0	35.5	-2.5	-4.0	-2.2	3.8	-2.4	6.0	4.0
Arm fat mass (left)	0.6	2.6	5.2	-1.7	-1.6	-1.3	1.5	-1.2	2.3	1.6
Number of self-reported non-cancer illnesses	5.2	9.0	12.7	2.9	3.5	2.0	-3.4	2.3	-2.8	-3.6
Average weekly champagne plus white wine intake	0.2	0.3	1.5	0.5	-0.2	0.1	0.3	-0.2	1.2	0.5
Miserableness	1.9	3.2	7.7	1.4	1.6	1.4	-1.6	1.6	-2.8	-1.9
Guilty feelings	0.4	0.6	3.2	-0.2	-0.1	-0.6	-0.2	-0.5	-1.8	-0.2
Wears glasses or contact lenses	0.2	0.3	0.7	0.8	0.4	-0.7	-0.3	-0.0	0.4	-0.4
Ever taken oral contraceptive pill	1.7	1.9	7.8	1.9	0.7	0.7	-0.6	0.2	2.8	-0.4
Hearing aid user	2.2	2.5	7.7	0.3	1.6	2.8	-1.4	1.5	-1.2	-1.1
Mother’s age at death	1.6	2.0	3.1	-1.4	-1.3	-1.5	1.4	-1.2	1.8	1.3
Financial situation satisfaction	0.4	0.5	1.2	0.9	0.8	-0.0	-0.7	0.6	0.2	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.1	1.0	1.0	0.7	-1.0	0.9	0.4	-0.9
Commuting to job workplace: Public transport	0.9	1.1	2.1	-1.3	-1.5	-0.3	1.2	-0.3	-0.4	1.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-0.9	-0.6	-0.0	0.7	-0.0	-1.3	0.5
Medication: Blood pressure	0.8	1.5	3.1	1.3	1.5	-0.4	-1.6	0.4	-0.7	-1.8
Pain type(s) experienced in last month: Hip pain	1.3	1.7	5.2	-0.2	-1.2	-1.3	1.1	-2.3	1.1	1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.4	0.0	0.8	0.0	-0.9	0.6	-0.8	-1.2
High cholesterol (Self-reported)	16.6	29.4	54.0	3.3	6.0	4.2	-6.0	3.5	-7.3	-6.2
Medication: Bendroflumethiazide	0.2	0.3	1.3	-0.3	0.4	0.1	-0.5	0.1	-1.1	-0.7
Medication: Paracetamol	2.8	4.3	7.3	2.7	2.4	0.8	-2.4	-0.1	-1.8	-2.7
Medication: Lisinopril	0.1	0.1	0.3	0.0	0.3	-0.6	-0.2	-0.3	0.3	-0.2
Medication: Atorvastatin	9.9	12.2	21.1	2.4	4.1	1.8	-4.1	2.1	-4.6	-4.3
Illnesses of father: High blood pressure	1.8	2.2	3.8	1.7	1.6	1.9	-1.6	0.8	0.3	-1.7
Alcohol drinker status: Never	0.8	0.9	5.7	-0.1	0.2	-0.3	-0.1	-0.7	-2.4	-0.3
Ever smoked	0.2	0.3	1.1	-0.0	0.2	0.8	-0.2	0.2	1.1	-0.2
Basal metabolic rate	3.1	17.4	39.1	-2.8	-4.6	-2.2	4.4	-2.9	6.2	4.6
Leg fat percentage (left)	0.0	0.1	0.4	-0.6	-0.0	-0.2	-0.1	-0.4	-0.1	-0.1
Arm fat-free mass (left)	3.5	17.8	36.4	-2.8	-4.8	-2.1	4.7	-3.1	6.0	4.7
Number of operations (self-reported)	1.9	2.8	6.9	2.6	1.6	2.1	-1.3	-0.0	-0.4	-1.9
Average weekly beer plus cider intake	2.0	2.9	6.2	-2.5	-1.6	-1.3	1.6	-1.6	-1.2	1.7
Irritability	1.1	1.9	4.2	0.2	1.7	0.7	-1.6	0.9	-2.0	-1.5
Risk taking	1.0	1.4	5.2	-0.7	-0.5	-2.3	0.3	-1.9	-0.3	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.7	0.4	0.2	0.0	-0.2	-0.5	0.9	-0.1
Fractured/broken bones in last 5 years	2.4	3.1	4.4	2.1	2.1	1.1	-2.0	1.8	0.2	-2.0
Age started oral contraceptive pill	0.1	0.1	0.3	-0.0	-0.1	0.6	0.3	0.4	-0.4	0.3
Diastolic blood pressure, automated reading	0.4	1.1	1.4	1.1	0.9	1.0	-0.9	1.1	1.2	-1.2
Ever depressed for a whole week	0.4	0.5	1.3	-0.9	-0.5	-0.4	0.5	-0.7	-1.2	0.4
Unable to work because of sickness or disability	3.8	4.9	9.5	-1.7	-2.1	-2.9	2.1	-3.1	-0.7	2.0
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.3	-0.5	-0.5	0.5	0.0	-0.4	0.3
Myopia	0.3	0.5	1.8	-0.2	-0.5	-1.4	0.5	-1.0	-0.0	0.2
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.4	-1.7	-2.6	-0.8	2.6	-0.8	1.6	2.7
Cholesterol lowering medication	6.4	9.5	16.4	2.4	3.5	1.7	-3.4	2.0	-4.0	-3.7
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	1.6	0.9	1.1	-0.9	0.1	-0.8	-1.0
Pain experienced in last month	1.6	2.6	5.3	-2.3	-1.8	-0.9	2.0	0.1	0.7	2.1
Supplements: Calcium	0.3	0.3	0.8	0.9	0.2	0.3	-0.3	-0.7	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	0.8	0.4	0.8	-0.5	0.1	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.8	1.9	1.4	0.1	-1.3	-0.1	-0.4	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.1	0.4	-0.4	1.1	0.3	-0.6	0.6	0.4
Heart disease (siblings)	1.0	1.2	4.4	0.9	0.9	0.8	-0.8	0.3	-2.1	-1.0
Alcohol drinker status: Previous	0.3	0.3	1.4	0.5	0.5	-1.2	-0.2	0.1	0.2	-0.3
Pack years of smoking	0.3	0.4	1.2	-0.2	-0.6	1.1	0.7	-0.9	-0.1	0.3
Impedance of whole body	1.2	6.1	32.7	-1.0	1.6	-0.3	-1.6	-0.3	-5.7	-1.9
Leg fat mass (left)	0.8	3.3	5.6	-1.9	-1.9	-1.0	1.8	-1.6	2.4	1.8
Arm predicted mass (left)	3.6	18.2	36.7	-2.8	-4.8	-2.2	4.7	-3.2	6.1	4.7