[Hub]/) : Traits : Impedance of leg (left) :

chr1:38,762,381-40,737,589

Best TWAS P=4.49e-21 · Best GWAS P=1.99e-20 conditioned to 0.706

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BMP8A 0.05 0.03 lasso 3 0.02 8.8e-04 -7.5 -7.8 4.1e-15 0.71 0.03 0.94 FALSE
2 CommonMind Brain Pre-frontal Cortex NDUFS5 0.15 0.09 lasso 7 0.10 9.5e-13 -5.2 -5.4 6.1e-08 0.11 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous PABPC4 0.15 0.04 lasso 8 0.04 3.3e-04 -3.3 6.8 7.9e-12 -0.77 0.02 0.97 FALSE
4 GTEx Adipose Subcutaneous RP11-69E11.4 0.14 0.08 enet 22 0.10 1.4e-08 -7.7 -6.9 3.8e-12 0.59 0.98 0.02 FALSE
5 GTEx Adipose Subcutaneous BMP8A 0.06 0.05 lasso 1 0.04 3.5e-04 -7.6 -7.6 4.2e-14 0.46 0.14 0.27 FALSE
6 GTEx Adipose Visceral Omentum RP11-69E11.4 0.10 0.07 lasso 2 0.07 1.3e-04 -7.1 -6.3 3.3e-10 0.47 0.26 0.67 FALSE
7 GTEx Adrenal Gland PABPC4 0.20 0.09 lasso 8 0.06 3.0e-03 -7.7 9.4 6.5e-21 -0.77 0.03 0.89 FALSE
8 GTEx Adrenal Gland RP11-69E11.4 0.11 0.05 lasso 3 0.00 2.4e-01 -7.6 -8.8 1.0e-18 0.52 0.05 0.59 FALSE
9 GTEx Adrenal Gland PPIEL 0.29 0.01 lasso 3 0.00 2.9e-01 4.4 -7.4 1.7e-13 0.25 0.04 0.10 FALSE
10 GTEx Artery Aorta RP11-69E11.4 0.13 0.10 enet 14 0.14 2.5e-08 -7.5 -6.2 4.8e-10 0.63 0.56 0.43 FALSE
11 GTEx Artery Coronary RP11-69E11.4 0.63 -0.01 lasso 9 0.10 2.2e-04 -7.7 -7.0 2.5e-12 0.55 0.12 0.19 FALSE
12 GTEx Artery Tibial PABPC4 0.10 0.10 lasso 4 0.10 3.4e-08 -7.7 7.5 9.4e-14 -0.72 0.54 0.46 FALSE
13 GTEx Artery Tibial RP11-69E11.4 0.15 0.16 lasso 6 0.16 8.3e-13 -7.1 -6.5 8.6e-11 0.54 1.00 0.00 FALSE
14 GTEx Brain Cerebellar Hemisphere RP11-69E11.4 0.22 0.08 enet 16 0.08 4.5e-03 -7.1 -6.5 7.6e-11 0.63 0.16 0.60 FALSE
15 GTEx Brain Cortex BMP8A 0.27 0.01 enet 26 0.07 4.7e-03 -3.3 -5.3 1.4e-07 0.35 0.20 0.36 FALSE
16 GTEx Brain Frontal Cortex BA9 RP11-69E11.4 0.23 0.10 lasso 6 0.11 7.2e-04 -7.7 -7.6 3.7e-14 0.47 0.13 0.20 FALSE
17 GTEx Brain Hypothalamus RP11-69E11.4 0.23 0.12 lasso 6 0.20 1.5e-05 -5.8 -5.4 7.3e-08 0.59 0.14 0.55 FALSE
18 GTEx Breast Mammary Tissue PABPC4 0.13 0.02 enet 14 0.04 3.4e-03 -7.5 7.2 8.8e-13 -0.70 0.05 0.87 FALSE
19 GTEx Breast Mammary Tissue RP11-69E11.4 0.15 0.05 enet 32 0.05 8.8e-04 -4.3 -6.3 2.3e-10 0.59 0.27 0.69 FALSE
20 GTEx Breast Mammary Tissue (Female) PABPC4 0.10 0.00 enet 9 0.01 1.5e-01 -9.2 8.9 7.0e-19 -0.83 0.03 0.47 FALSE
21 GTEx Breast Mammary Tissue (Female) RP11-69E11.4 0.16 0.00 enet 19 0.04 2.9e-02 3.1 -5.5 3.7e-08 0.44 0.04 0.29 FALSE
22 GTEx Cells Transformed fibroblasts PABPC4 0.07 0.09 lasso 1 0.06 2.7e-05 -7.7 7.7 1.0e-14 -0.68 0.08 0.89 FALSE
23 GTEx Cells Transformed fibroblasts AKIRIN1 0.19 0.08 lasso 2 0.08 2.4e-06 -5.2 -5.2 2.1e-07 0.14 0.95 0.00 FALSE
24 GTEx Cells Transformed fibroblasts RP11-69E11.4 0.15 0.08 enet 17 0.11 9.9e-09 -3.3 -6.0 2.8e-09 0.50 0.95 0.05 FALSE
25 GTEx Colon Transverse RP11-69E11.4 0.23 0.12 lasso 4 0.15 1.8e-07 -7.5 -6.6 3.3e-11 0.67 0.16 0.83 FALSE
26 GTEx Esophagus Mucosa PABPC4 0.06 0.06 lasso 3 0.08 7.3e-06 -7.5 7.5 4.4e-14 -0.73 0.18 0.78 FALSE
27 GTEx Esophagus Mucosa RP11-69E11.4 0.18 0.06 lasso 9 0.07 2.2e-05 -7.1 -7.6 3.9e-14 0.64 0.63 0.35 FALSE
28 GTEx Esophagus Mucosa BMP8A 0.08 0.02 lasso 2 0.01 1.4e-01 3.3 -7.6 3.4e-14 0.69 0.04 0.94 FALSE
29 GTEx Esophagus Mucosa PPIEL 0.11 0.02 lasso 3 0.02 9.4e-03 -7.5 -7.7 1.3e-14 0.76 0.08 0.75 FALSE
30 GTEx Esophagus Muscularis RP11-69E11.4 0.11 0.14 enet 16 0.15 2.6e-09 -3.3 -5.2 1.9e-07 0.58 0.91 0.09 FALSE
31 GTEx Esophagus Muscularis BMP8A 0.08 0.05 enet 10 0.05 3.5e-04 -3.4 -6.0 2.7e-09 0.69 0.14 0.81 FALSE
32 GTEx Heart Atrial Appendage RP11-69E11.4 0.20 0.16 lasso 5 0.15 3.1e-07 -7.7 -5.6 2.6e-08 0.46 0.95 0.01 FALSE
33 GTEx Heart Left Ventricle RP11-69E11.4 0.10 0.10 lasso 4 0.08 3.8e-05 -7.1 -6.4 2.0e-10 0.49 0.44 0.34 FALSE
34 GTEx Lung PABPC4 0.05 0.03 lasso 3 0.02 1.3e-02 -7.7 7.2 8.7e-13 -0.64 0.17 0.59 FALSE
35 GTEx Lung RP11-69E11.4 0.26 0.09 lasso 9 0.20 3.8e-15 3.3 -7.5 6.1e-14 0.49 0.87 0.12 FALSE
36 GTEx Nerve Tibial PABPC4 0.17 0.08 enet 12 0.05 2.7e-04 -7.7 7.2 5.9e-13 -0.73 0.11 0.89 FALSE
37 GTEx Nerve Tibial RP11-69E11.4 0.18 0.08 lasso 5 0.18 1.3e-12 -7.0 -7.0 2.5e-12 0.66 0.30 0.70 FALSE
38 GTEx Nerve Tibial RP11-69E11.8 0.05 0.00 lasso 3 0.01 6.9e-02 -7.7 8.1 4.4e-16 -0.75 0.04 0.85 FALSE
39 GTEx Ovary RP11-69E11.4 0.25 0.05 enet 11 0.03 6.7e-02 -8.3 -9.2 2.2e-20 0.68 0.05 0.39 TRUE
40 GTEx Pancreas RP11-69E11.4 0.19 -0.01 enet 16 0.01 1.3e-01 2.0 -6.1 9.2e-10 0.51 0.07 0.39 FALSE
41 GTEx Skin Not Sun Exposed Suprapubic PABPC4 0.12 0.10 lasso 3 0.05 1.0e-03 -7.5 7.4 1.1e-13 -0.71 0.21 0.56 FALSE
42 GTEx Skin Sun Exposed Lower leg PABPC4 0.11 0.09 lasso 7 0.08 2.7e-07 -7.5 7.2 4.6e-13 -0.71 0.17 0.83 FALSE
43 GTEx Skin Sun Exposed Lower leg MACF1 0.08 0.08 lasso 2 0.06 5.3e-06 -5.4 5.6 1.7e-08 -0.70 0.69 0.30 FALSE
44 GTEx Skin Sun Exposed Lower leg RP11-69E11.4 0.13 0.12 lasso 6 0.15 1.3e-12 -7.7 -8.2 2.8e-16 0.72 0.94 0.06 FALSE
45 GTEx Spleen RP11-69E11.4 0.25 0.12 lasso 4 0.15 9.3e-05 -7.1 -8.1 3.9e-16 0.70 0.14 0.70 FALSE
46 GTEx Spleen BMP8A 0.16 0.08 lasso 3 0.05 1.6e-02 -7.7 -7.4 1.2e-13 0.75 0.06 0.37 FALSE
47 GTEx Stomach RP11-69E11.4 0.31 0.20 lasso 4 0.20 4.0e-10 -7.1 -7.9 3.7e-15 0.54 0.76 0.24 FALSE
48 GTEx Testis RP11-69E11.4 0.40 0.02 enet 52 0.14 1.0e-06 2.0 -5.8 6.8e-09 0.41 0.11 0.61 FALSE
49 GTEx Thyroid PABPC4 0.08 0.03 lasso 6 0.05 1.3e-04 -8.9 7.0 3.2e-12 -0.78 0.04 0.95 FALSE
50 GTEx Thyroid RP11-69E11.4 0.17 0.04 lasso 9 0.06 4.4e-05 -7.1 -6.8 1.4e-11 0.55 0.15 0.72 FALSE
51 METSIM Adipose PABPC4 0.05 0.02 lasso 6 0.03 6.0e-05 -7.5 6.3 3.6e-10 -0.71 0.10 0.90 FALSE
52 NTR Blood KIAA0754 0.03 0.00 bslmm 366 0.01 1.6e-03 1.2 -8.3 1.5e-16 0.62 0.05 0.88 FALSE
53 NTR Blood PABPC4 0.01 0.00 blup 383 0.00 2.8e-02 -7.7 8.4 4.0e-17 -0.68 0.04 0.60 FALSE
54 YFS Blood AKIRIN1 0.22 0.14 enet 44 0.26 3.0e-83 -5.2 -5.8 7.2e-09 0.09 1.00 0.00 FALSE
55 YFS Blood NDUFS5 0.39 0.26 lasso 16 0.37 2.2e-128 -5.2 -5.8 5.9e-09 0.09 1.00 0.00 TRUE
56 The Cancer Genome Atlas Breast Invasive Carcinoma AKIRIN1 0.03 0.01 blup 29 0.01 4.4e-04 -5.1 -5.2 2.2e-07 0.06 0.00 0.98 FALSE
57 The Cancer Genome Atlas Breast Invasive Carcinoma BMP8A 0.05 0.01 lasso 6 0.02 5.5e-05 -7.5 -7.3 3.1e-13 0.55 0.52 0.11 FALSE
58 The Cancer Genome Atlas Breast Invasive Carcinoma PABPC4 0.03 0.03 lasso 2 0.04 1.3e-08 -7.7 8.1 4.3e-16 -0.62 0.00 1.00 FALSE
59 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PPIEL 0.06 0.08 lasso 1 0.05 1.4e-03 -7.0 -7.0 2.7e-12 0.43 0.02 0.88 FALSE
60 The Cancer Genome Atlas Glioblastoma Multiforme NDUFS5 0.28 0.08 blup 30 0.20 8.3e-07 4.0 -5.4 7.6e-08 0.06 0.00 0.96 FALSE
61 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BMP8A 0.04 0.03 blup 48 0.04 3.5e-05 -7.1 -9.3 1.1e-20 0.68 0.02 0.97 FALSE
62 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PABPC4 0.03 0.01 enet 4 0.02 4.3e-03 -7.7 7.2 7.7e-13 -0.68 0.00 0.98 FALSE
63 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PABPC4 0.04 0.05 blup 31 0.04 1.2e-05 -7.7 8.1 4.1e-16 -0.57 0.00 0.99 FALSE
64 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPIEL 0.03 0.03 lasso 4 0.02 5.1e-03 -7.7 -6.2 4.9e-10 0.48 0.01 0.97 FALSE
65 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PABPC4 0.05 0.05 enet 4 0.05 5.5e-04 -7.5 5.8 8.1e-09 -0.64 0.01 0.92 FALSE
66 The Cancer Genome Atlas Brain Lower Grade Glioma BMP8A 0.05 0.01 blup 48 0.04 6.8e-05 -8.7 -9.4 4.5e-21 0.68 0.00 0.98 TRUE
67 The Cancer Genome Atlas Brain Lower Grade Glioma NDUFS5 0.12 0.11 enet 9 0.13 3.7e-14 -5.2 -5.6 1.7e-08 0.09 0.00 1.00 FALSE
68 The Cancer Genome Atlas Lung Adenocarcinoma PABPC4 0.04 0.03 enet 8 0.04 4.5e-05 -7.5 7.5 4.5e-14 -0.62 0.00 0.99 FALSE
69 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AKIRIN1 0.05 0.00 blup 29 0.03 4.6e-04 3.1 -5.6 2.3e-08 0.14 0.01 0.60 FALSE
70 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma NDUFS5 0.25 0.10 blup 28 0.08 3.5e-04 3.8 -5.3 9.0e-08 0.06 0.04 0.53 FALSE
71 The Cancer Genome Atlas Prostate Adenocarcinoma BMP8A 0.07 0.06 enet 7 0.07 5.8e-08 -3.4 -5.3 8.7e-08 0.56 0.78 0.22 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma PPIEL 0.04 0.02 lasso 4 0.02 1.7e-03 -7.1 -6.9 6.5e-12 0.55 0.02 0.68 FALSE
73 The Cancer Genome Atlas Thyroid Carcinoma PABPC4 0.09 0.07 enet 5 0.08 4.1e-08 -7.7 9.0 3.0e-19 -0.62 0.00 1.00 FALSE