[Hub]/) : Traits : Impedance of leg (left) : ← →

chr1:38,762,381-40,737,589

Best TWAS P=4.49e-21 · Best GWAS P=1.99e-20 conditioned to 0.706

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	BMP8A	0.05	0.01	blup	48	0.04	6.8e-05	-8.7	-9.4	4.5e-21	0.68	0.00	0.98	TRUE
39	GTEx	Ovary	RP11-69E11.4	0.25	0.05	enet	11	0.03	6.7e-02	-8.3	-9.2	2.2e-20	0.68	0.05	0.39	TRUE
55	YFS	Blood	NDUFS5	0.39	0.26	lasso	16	0.37	2.2e-128	-5.2	-5.8	5.9e-09	0.09	1.00	0.00	TRUE
7	GTEx	Adrenal Gland	PABPC4	0.20	0.09	lasso	8	0.06	3.0e-03	-7.7	9.4	6.5e-21	-0.77	0.03	0.89	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BMP8A	0.04	0.03	blup	48	0.04	3.5e-05	-7.1	-9.3	1.1e-20	0.68	0.02	0.97	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	PABPC4	0.09	0.07	enet	5	0.08	4.1e-08	-7.7	9.0	3.0e-19	-0.62	0.00	1.00	FALSE
20	GTEx	Breast Mammary Tissue (Female)	PABPC4	0.10	0.00	enet	9	0.01	1.5e-01	-9.2	8.9	7.0e-19	-0.83	0.03	0.47	FALSE
8	GTEx	Adrenal Gland	RP11-69E11.4	0.11	0.05	lasso	3	0.00	2.4e-01	-7.6	-8.8	1.0e-18	0.52	0.05	0.59	FALSE
53	NTR	Blood	PABPC4	0.01	0.00	blup	383	0.00	2.8e-02	-7.7	8.4	4.0e-17	-0.68	0.04	0.60	FALSE
52	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	1.2	-8.3	1.5e-16	0.62	0.05	0.88	FALSE
44	GTEx	Skin Sun Exposed Lower leg	RP11-69E11.4	0.13	0.12	lasso	6	0.15	1.3e-12	-7.7	-8.2	2.8e-16	0.72	0.94	0.06	FALSE
45	GTEx	Spleen	RP11-69E11.4	0.25	0.12	lasso	4	0.15	9.3e-05	-7.1	-8.1	3.9e-16	0.70	0.14	0.70	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PABPC4	0.04	0.05	blup	31	0.04	1.2e-05	-7.7	8.1	4.1e-16	-0.57	0.00	0.99	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC4	0.03	0.03	lasso	2	0.04	1.3e-08	-7.7	8.1	4.3e-16	-0.62	0.00	1.00	FALSE
38	GTEx	Nerve Tibial	RP11-69E11.8	0.05	0.00	lasso	3	0.01	6.9e-02	-7.7	8.1	4.4e-16	-0.75	0.04	0.85	FALSE
47	GTEx	Stomach	RP11-69E11.4	0.31	0.20	lasso	4	0.20	4.0e-10	-7.1	-7.9	3.7e-15	0.54	0.76	0.24	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BMP8A	0.05	0.03	lasso	3	0.02	8.8e-04	-7.5	-7.8	4.1e-15	0.71	0.03	0.94	FALSE
22	GTEx	Cells Transformed fibroblasts	PABPC4	0.07	0.09	lasso	1	0.06	2.7e-05	-7.7	7.7	1.0e-14	-0.68	0.08	0.89	FALSE
29	GTEx	Esophagus Mucosa	PPIEL	0.11	0.02	lasso	3	0.02	9.4e-03	-7.5	-7.7	1.3e-14	0.76	0.08	0.75	FALSE
28	GTEx	Esophagus Mucosa	BMP8A	0.08	0.02	lasso	2	0.01	1.4e-01	3.3	-7.6	3.4e-14	0.69	0.04	0.94	FALSE
16	GTEx	Brain Frontal Cortex BA9	RP11-69E11.4	0.23	0.10	lasso	6	0.11	7.2e-04	-7.7	-7.6	3.7e-14	0.47	0.13	0.20	FALSE
27	GTEx	Esophagus Mucosa	RP11-69E11.4	0.18	0.06	lasso	9	0.07	2.2e-05	-7.1	-7.6	3.9e-14	0.64	0.63	0.35	FALSE
5	GTEx	Adipose Subcutaneous	BMP8A	0.06	0.05	lasso	1	0.04	3.5e-04	-7.6	-7.6	4.2e-14	0.46	0.14	0.27	FALSE
26	GTEx	Esophagus Mucosa	PABPC4	0.06	0.06	lasso	3	0.08	7.3e-06	-7.5	7.5	4.4e-14	-0.73	0.18	0.78	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	PABPC4	0.04	0.03	enet	8	0.04	4.5e-05	-7.5	7.5	4.5e-14	-0.62	0.00	0.99	FALSE
35	GTEx	Lung	RP11-69E11.4	0.26	0.09	lasso	9	0.20	3.8e-15	3.3	-7.5	6.1e-14	0.49	0.87	0.12	FALSE
12	GTEx	Artery Tibial	PABPC4	0.10	0.10	lasso	4	0.10	3.4e-08	-7.7	7.5	9.4e-14	-0.72	0.54	0.46	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	PABPC4	0.12	0.10	lasso	3	0.05	1.0e-03	-7.5	7.4	1.1e-13	-0.71	0.21	0.56	FALSE
46	GTEx	Spleen	BMP8A	0.16	0.08	lasso	3	0.05	1.6e-02	-7.7	-7.4	1.2e-13	0.75	0.06	0.37	FALSE
9	GTEx	Adrenal Gland	PPIEL	0.29	0.01	lasso	3	0.00	2.9e-01	4.4	-7.4	1.7e-13	0.25	0.04	0.10	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	BMP8A	0.05	0.01	lasso	6	0.02	5.5e-05	-7.5	-7.3	3.1e-13	0.55	0.52	0.11	FALSE
42	GTEx	Skin Sun Exposed Lower leg	PABPC4	0.11	0.09	lasso	7	0.08	2.7e-07	-7.5	7.2	4.6e-13	-0.71	0.17	0.83	FALSE
36	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	-7.7	7.2	5.9e-13	-0.73	0.11	0.89	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPC4	0.03	0.01	enet	4	0.02	4.3e-03	-7.7	7.2	7.7e-13	-0.68	0.00	0.98	FALSE
34	GTEx	Lung	PABPC4	0.05	0.03	lasso	3	0.02	1.3e-02	-7.7	7.2	8.7e-13	-0.64	0.17	0.59	FALSE
18	GTEx	Breast Mammary Tissue	PABPC4	0.13	0.02	enet	14	0.04	3.4e-03	-7.5	7.2	8.8e-13	-0.70	0.05	0.87	FALSE
11	GTEx	Artery Coronary	RP11-69E11.4	0.63	-0.01	lasso	9	0.10	2.2e-04	-7.7	-7.0	2.5e-12	0.55	0.12	0.19	FALSE
37	GTEx	Nerve Tibial	RP11-69E11.4	0.18	0.08	lasso	5	0.18	1.3e-12	-7.0	-7.0	2.5e-12	0.66	0.30	0.70	FALSE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PPIEL	0.06	0.08	lasso	1	0.05	1.4e-03	-7.0	-7.0	2.7e-12	0.43	0.02	0.88	FALSE
49	GTEx	Thyroid	PABPC4	0.08	0.03	lasso	6	0.05	1.3e-04	-8.9	7.0	3.2e-12	-0.78	0.04	0.95	FALSE
4	GTEx	Adipose Subcutaneous	RP11-69E11.4	0.14	0.08	enet	22	0.10	1.4e-08	-7.7	-6.9	3.8e-12	0.59	0.98	0.02	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPIEL	0.04	0.02	lasso	4	0.02	1.7e-03	-7.1	-6.9	6.5e-12	0.55	0.02	0.68	FALSE
3	GTEx	Adipose Subcutaneous	PABPC4	0.15	0.04	lasso	8	0.04	3.3e-04	-3.3	6.8	7.9e-12	-0.77	0.02	0.97	FALSE
50	GTEx	Thyroid	RP11-69E11.4	0.17	0.04	lasso	9	0.06	4.4e-05	-7.1	-6.8	1.4e-11	0.55	0.15	0.72	FALSE
25	GTEx	Colon Transverse	RP11-69E11.4	0.23	0.12	lasso	4	0.15	1.8e-07	-7.5	-6.6	3.3e-11	0.67	0.16	0.83	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-69E11.4	0.22	0.08	enet	16	0.08	4.5e-03	-7.1	-6.5	7.6e-11	0.63	0.16	0.60	FALSE
13	GTEx	Artery Tibial	RP11-69E11.4	0.15	0.16	lasso	6	0.16	8.3e-13	-7.1	-6.5	8.6e-11	0.54	1.00	0.00	FALSE
33	GTEx	Heart Left Ventricle	RP11-69E11.4	0.10	0.10	lasso	4	0.08	3.8e-05	-7.1	-6.4	2.0e-10	0.49	0.44	0.34	FALSE
19	GTEx	Breast Mammary Tissue	RP11-69E11.4	0.15	0.05	enet	32	0.05	8.8e-04	-4.3	-6.3	2.3e-10	0.59	0.27	0.69	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-69E11.4	0.10	0.07	lasso	2	0.07	1.3e-04	-7.1	-6.3	3.3e-10	0.47	0.26	0.67	FALSE
51	METSIM	Adipose	PABPC4	0.05	0.02	lasso	6	0.03	6.0e-05	-7.5	6.3	3.6e-10	-0.71	0.10	0.90	FALSE
10	GTEx	Artery Aorta	RP11-69E11.4	0.13	0.10	enet	14	0.14	2.5e-08	-7.5	-6.2	4.8e-10	0.63	0.56	0.43	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPIEL	0.03	0.03	lasso	4	0.02	5.1e-03	-7.7	-6.2	4.9e-10	0.48	0.01	0.97	FALSE
40	GTEx	Pancreas	RP11-69E11.4	0.19	-0.01	enet	16	0.01	1.3e-01	2.0	-6.1	9.2e-10	0.51	0.07	0.39	FALSE
31	GTEx	Esophagus Muscularis	BMP8A	0.08	0.05	enet	10	0.05	3.5e-04	-3.4	-6.0	2.7e-09	0.69	0.14	0.81	FALSE
24	GTEx	Cells Transformed fibroblasts	RP11-69E11.4	0.15	0.08	enet	17	0.11	9.9e-09	-3.3	-6.0	2.8e-09	0.50	0.95	0.05	FALSE
48	GTEx	Testis	RP11-69E11.4	0.40	0.02	enet	52	0.14	1.0e-06	2.0	-5.8	6.8e-09	0.41	0.11	0.61	FALSE
54	YFS	Blood	AKIRIN1	0.22	0.14	enet	44	0.26	3.0e-83	-5.2	-5.8	7.2e-09	0.09	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PABPC4	0.05	0.05	enet	4	0.05	5.5e-04	-7.5	5.8	8.1e-09	-0.64	0.01	0.92	FALSE
43	GTEx	Skin Sun Exposed Lower leg	MACF1	0.08	0.08	lasso	2	0.06	5.3e-06	-5.4	5.6	1.7e-08	-0.70	0.69	0.30	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFS5	0.12	0.11	enet	9	0.13	3.7e-14	-5.2	-5.6	1.7e-08	0.09	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKIRIN1	0.05	0.00	blup	29	0.03	4.6e-04	3.1	-5.6	2.3e-08	0.14	0.01	0.60	FALSE
32	GTEx	Heart Atrial Appendage	RP11-69E11.4	0.20	0.16	lasso	5	0.15	3.1e-07	-7.7	-5.6	2.6e-08	0.46	0.95	0.01	FALSE
21	GTEx	Breast Mammary Tissue (Female)	RP11-69E11.4	0.16	0.00	enet	19	0.04	2.9e-02	3.1	-5.5	3.7e-08	0.44	0.04	0.29	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NDUFS5	0.15	0.09	lasso	7	0.10	9.5e-13	-5.2	-5.4	6.1e-08	0.11	1.00	0.00	FALSE
17	GTEx	Brain Hypothalamus	RP11-69E11.4	0.23	0.12	lasso	6	0.20	1.5e-05	-5.8	-5.4	7.3e-08	0.59	0.14	0.55	FALSE
60	The Cancer Genome Atlas	Glioblastoma Multiforme	NDUFS5	0.28	0.08	blup	30	0.20	8.3e-07	4.0	-5.4	7.6e-08	0.06	0.00	0.96	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	BMP8A	0.07	0.06	enet	7	0.07	5.8e-08	-3.4	-5.3	8.7e-08	0.56	0.78	0.22	FALSE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NDUFS5	0.25	0.10	blup	28	0.08	3.5e-04	3.8	-5.3	9.0e-08	0.06	0.04	0.53	FALSE
15	GTEx	Brain Cortex	BMP8A	0.27	0.01	enet	26	0.07	4.7e-03	-3.3	-5.3	1.4e-07	0.35	0.20	0.36	FALSE
30	GTEx	Esophagus Muscularis	RP11-69E11.4	0.11	0.14	enet	16	0.15	2.6e-09	-3.3	-5.2	1.9e-07	0.58	0.91	0.09	FALSE
23	GTEx	Cells Transformed fibroblasts	AKIRIN1	0.19	0.08	lasso	2	0.08	2.4e-06	-5.2	-5.2	2.1e-07	0.14	0.95	0.00	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	AKIRIN1	0.03	0.01	blup	29	0.01	4.4e-04	-5.1	-5.2	2.2e-07	0.06	0.00	0.98	FALSE