Hub : Genes

HSP90AA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0571	0.0158	9.6e-10	0.040	0.035	0.036	0.042	0.037	4.8e-13	1.8e-11	9.9e-12	1.6e-13	6.1e-12
2	YFS	Blood	0.0171	0.0088	4.1e-04	0.021	0.011	0.018	0.015	0.020	1.7e-07	1.3e-04	1.1e-06	6.5e-06	3.2e-07
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0324	0.0212	9.1e-03	-0.001	0.012	0.005	NA	0.002	4.2e-01	1.4e-02	8.7e-02	NA	2.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	1.6	-1.1	1.3	1.0
Bipolar Disorder or Schizophrenia	0.5	1.1	2.2	-0.9	1.5	0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.4	0.7	-0.6
Depression (Nagel 2018)	1.0	1.5	3.4	1.9	0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.1	-0.0	0.3	-0.4
Neuroticism (Nagel 2018)	0.3	0.7	1.8	0.6	1.3	0.1
Schizophrenia (2018)	0.1	0.3	0.8	-0.3	0.9	-0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-1.0	-0.6	0.4
Worry (Nagel 2018)	1.0	2.2	5.4	2.3	-0.4	-1.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	-0.2	1.0	1.2
Alzheimer’s Disease (in father)	0.5	0.6	0.9	-0.1	0.9	0.9
Alzheimer’s Disease (including proxy)	1.2	1.8	3.0	-0.2	1.5	1.7
Crohns Disease (2017)	0.8	1.7	3.4	-1.1	1.8	0.8
Irritable Bowel Disease (IBD)	1.4	3.4	5.8	-1.7	2.4	1.1
Ulcerative Colitis (UC)	1.2	2.2	3.2	-1.6	1.8	1.0
Major Depression (MDD)	0.7	0.8	1.4	-0.7	-1.2	-0.7
Reaction Time	2.1	3.9	8.2	-0.9	2.9	1.7
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.6	0.2	0.2
Breast Cancer	0.5	1.2	3.1	-0.3	1.8	0.6
Ovarian Cancer	0.1	0.1	0.2	0.3	-0.5	-0.3
Prostate Cancer	1.2	1.6	2.1	1.5	-0.9	-1.4
Age at First Birth	0.6	0.8	1.1	1.0	-0.5	-1.0
Bipolar Disorder (2011)	1.6	1.6	3.9	-2.0	0.1	0.9
Body Mass Index (BMI) (2010)	3.2	4.4	4.7	2.1	-2.2	-2.0
Coronary Artery Disease (CAD)	0.5	0.6	1.1	-1.0	0.8	0.4
Crohns Disease (2012)	2.5	4.1	6.5	-1.3	2.6	2.0
Mean Putamen Volume	4.4	5.0	7.2	1.5	-2.7	-2.4
Fasting Glucose	4.2	5.0	7.4	2.7	-1.6	-2.2
HbA1C	0.8	0.9	2.2	-1.5	-0.6	-0.2
HDL Cholesterol	0.7	1.1	1.5	-0.8	1.1	1.2
LDL Cholesterol	0.4	0.7	1.2	0.8	-0.5	-1.1
Lupus	0.2	0.4	0.9	-1.0	-0.4	0.3
Neuroticism (2016)	0.5	0.8	1.9	-1.4	0.7	0.1
Primary Biliary Cirrhosis	0.6	0.9	2.2	0.4	-0.6	-1.5
Rheumatoid Arthritis	0.4	0.6	1.0	-0.9	-1.0	0.1
Schizophrenia (2014)	0.1	0.2	0.5	-0.7	0.4	-0.1
Triglycerides	0.1	0.2	0.4	0.2	-0.2	-0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.2	0.4	-1.5	-1.1
Ulcerative Colitis	0.9	1.3	1.8	-1.1	1.3	0.9
Blood Eosinophil Count	0.5	3.5	5.7	0.9	-2.0	-2.4
Blood Platelet Count	2.1	23.8	30.6	-5.5	5.5	3.3
Blood Red Count	0.1	0.6	1.3	0.7	1.2	0.1
Blood White Count	0.1	1.1	2.4	0.9	-0.3	-1.6
Heel T-Score	0.2	1.8	3.1	-1.2	-1.8	-1.0
BMI	2.6	14.9	25.0	3.7	-2.4	-5.0
Height	0.5	8.8	13.8	-3.7	1.7	3.1
Waist Hip Ratio (WHR)	0.1	0.3	0.7	-0.8	-0.4	-0.4
Systolic Blood Pressure	0.1	0.4	1.1	-1.0	-0.4	-0.2
Smoking Status	0.7	1.6	2.9	-0.8	1.1	1.7
Allergy or Eczema	0.4	1.0	1.8	1.3	0.1	-1.1
Cardiovascular Disease	0.3	0.9	1.2	0.9	-0.9	-1.1
Hypothyroidism (self reported)	0.5	1.2	3.3	-0.0	1.8	0.6
Respiratory disease	0.2	0.4	0.8	-0.9	0.5	-0.4
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.2	1.0	-0.6	-1.8
Lung FEV1/FVC ratio	0.4	1.9	2.4	-1.4	-1.6	-1.1
Lung FVC	1.2	6.2	10.9	2.6	-3.3	-0.9
Neuroticism	0.5	1.1	1.8	1.1	1.4	-0.5
Chronotype (morning person)	0.2	0.4	0.5	0.2	-0.7	-0.7
Hair Pigment	0.1	2.5	3.2	1.3	-1.6	-1.8
Tanning	0.2	2.7	5.1	-0.7	2.3	1.6
Hand grip strength (left)	0.1	0.2	0.4	-0.7	-0.1	0.2
Number of treatments/medications taken	0.3	0.6	1.2	-0.7	1.1	0.2
Average weekly spirits intake	1.3	1.6	2.1	1.2	-1.1	-1.5
Sensitivity / hurt feelings	2.5	4.2	7.3	-1.7	2.7	1.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	1.2	1.3	-0.4
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-0.9	0.5	0.5
Relative age of first facial hair	2.0	4.1	5.0	-2.2	1.7	2.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	-0.4	1.4	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	-0.6	-0.5	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.5	-0.5	0.0
Systolic blood pressure, automated reading	0.4	1.1	3.1	-0.0	-1.8	-0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.9	0.5	0.5
Angina	0.5	0.7	1.0	0.2	1.0	-1.0
Medication for hormone replacement therapy	1.3	1.4	2.1	0.3	-1.4	-1.5
Vitamin and mineral supplements	0.9	1.2	1.7	-1.1	-1.3	-0.9
Supplements: Zinc	0.6	0.7	0.8	-0.7	0.9	0.9
Medication: Co-codamol	1.7	1.9	2.7	1.7	-0.6	-1.6
Medication: Metformin	1.7	2.4	3.0	1.6	-1.2	-1.7
Diabetes (father)	0.0	0.0	0.1	0.1	-0.1	-0.3
Diabetes (mother)	0.0	0.0	0.0	-0.2	-0.1	-0.0
Severe depression (siblings)	4.1	4.5	6.6	-1.5	2.6	2.2
Pack years adult smoking proportion	0.8	1.2	1.8	0.9	-1.0	-1.3
Impedance of leg (right)	1.3	6.2	7.3	-2.7	2.2	2.5
Leg fat-free mass (left)	0.4	2.4	3.8	1.6	-0.8	-1.9
Trunk fat percentage	1.0	3.9	10.9	-0.8	3.3	0.0
Hand grip strength (right)	0.1	0.2	0.4	-0.6	-0.5	0.1
Townsend deprivation index at recruitment	1.2	1.7	2.0	-1.3	1.4	1.2
Current tobacco smoking	0.4	0.7	1.4	-1.2	-0.1	0.9
Average weekly fortified wine intake	0.7	0.8	1.0	1.0	-0.7	-0.9
Maternal smoking around birth	3.5	5.1	6.0	-2.3	2.4	2.0
Fed-up feelings	1.3	2.3	5.0	-2.2	1.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.0	1.0	0.5	-0.5
Relative age voice broke	0.4	0.6	0.8	-0.9	-0.7	0.8
Taking other prescription medications	1.3	2.1	4.1	-2.0	0.8	1.2
Age when periods started (menarche)	0.7	1.8	3.8	-2.0	0.3	1.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-0.9	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	0.3	0.1	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.1	-0.6	-0.6	-1.4
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.1	-0.0	-0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	-0.0	-0.1
High blood pressure	0.1	0.2	0.3	-0.3	-0.6	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.7	0.4	-0.8
Multivitamins +/- minerals	0.7	0.9	2.4	1.6	0.5	0.3
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.2	0.7	0.5
Supplements: Glucosamine	0.6	0.8	1.0	0.6	-1.0	-1.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.3	-0.1	-0.1
Medication: Atenolol	0.7	0.9	2.5	-1.6	-0.3	0.2
Medication: Levothyroxine sodium	0.3	0.5	1.2	-1.1	-0.5	-0.2
Sitting height	0.0	0.3	0.7	0.1	-0.8	-0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	0.8	-0.9	-0.3
High blood pressure (mother)	1.3	1.8	4.0	0.1	-2.0	-1.2
Body mass index (BMI)	1.0	4.3	8.7	1.9	-0.6	-2.9
Impedance of leg (left)	1.3	6.3	7.7	-2.8	2.3	2.4
Leg predicted mass (left)	0.5	2.4	3.9	1.7	-0.8	-2.0
Trunk fat mass	0.5	1.9	5.0	-0.1	2.2	-0.9
Waist circumference	0.4	1.3	3.4	0.7	0.1	-1.8
Number of incorrect matches in round	0.3	0.4	1.1	0.1	-1.1	-0.4
Past tobacco smoking	2.2	4.0	6.1	1.2	-2.5	-2.1
Alcohol usually taken with meals	0.7	1.1	1.2	-1.1	1.0	1.1
Nervous feelings	0.3	0.5	1.5	-0.1	1.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.5	0.3	1.6	-0.0
Hearing difficulty/problems with background noise	1.2	2.0	3.0	-0.8	1.5	1.7
Hair/balding pattern: Pattern 2	1.1	1.3	1.7	-1.2	1.0	1.3
Had menopause	0.7	0.9	1.8	-0.1	-1.4	-0.9
Had other major operations	6.4	7.8	9.8	2.0	-3.1	-3.1
Forced vital capacity (FVC)	0.9	3.3	4.9	2.2	-2.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.4	0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	0.5	0.4	-0.3
Qualifications: None of the above	0.1	0.2	0.5	-0.7	-0.4	-0.1
Financial difficulties in last 2 years	0.8	1.0	1.5	-0.9	1.2	0.9
Mouth/teeth dental problems	0.4	0.6	0.8	-0.8	0.9	0.7
Heart attack	0.8	1.0	1.3	1.1	0.9	-0.9
Allergy	0.1	0.3	0.7	-0.2	-0.5	0.8
Pain all over the body in last month	0.1	0.1	0.3	0.5	-0.0	-0.3
Diabetes (self-reported)	0.2	0.3	0.5	0.6	0.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.7	-0.1	-0.5
Medication: Ramipril	0.3	0.3	0.6	0.8	-0.6	-0.2
Medication: Simvastatin	0.1	0.2	0.3	-0.4	-0.6	0.0
Fluid intelligence score	0.1	0.2	0.4	-0.6	-0.2	0.0
Illnesses of siblings	0.4	0.5	1.0	-0.2	0.7	1.0
Neuroticism score	0.7	1.4	4.0	-0.4	2.0	0.2
Weight	0.3	1.7	4.2	1.0	-0.1	-2.0
Impedance of arm (right)	5.9	27.6	32.4	-4.4	5.7	5.6
Arm fat percentage (right)	0.4	1.4	3.3	0.4	1.8	-0.9
Trunk fat-free mass	1.2	6.6	8.0	2.1	-2.8	-2.7
Hip circumference	0.3	1.4	2.2	1.3	0.3	-1.5
Time employed in main current job	0.1	0.1	0.1	-0.0	0.4	0.3
Alcohol intake versus 10 years previously	0.4	0.5	1.3	1.1	0.2	-0.5
Father’s age at death	0.6	0.8	1.5	1.2	-0.6	-0.7
Worrier / anxious feelings	0.4	0.7	1.3	-0.3	1.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.8	-0.3	2.2	0.6
Falls in the last year	0.2	0.2	0.3	-0.5	-0.3	-0.6
Hair/balding pattern: Pattern 3	2.6	3.9	5.6	1.6	-1.9	-2.4
Number of live births	0.1	0.2	0.3	-0.5	-0.5	-0.0
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	6.0	1.9	-2.5	-1.4
Pulse rate	1.0	1.6	2.4	1.4	-0.8	-1.5
Happiness	0.5	0.6	0.9	1.0	0.9	-0.5
Noisy workplace	0.3	0.3	0.9	-0.9	0.4	-0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.0	-1.5	1.2	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.4	0.9	0.2
Mouth/teeth dental problems: Dentures	2.7	4.6	5.9	2.3	-1.6	-2.4
Asthma	0.2	0.3	0.5	-0.7	0.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	0.1	0.1	-1.7
Medication: Cholesterol lowering	0.9	1.5	2.2	1.5	-1.0	-1.1
Depression (self-reported)	0.2	0.2	0.5	-0.7	0.3	-0.4
Medication: Lansoprazole	1.3	1.4	2.9	1.7	-0.9	-0.8
Prospective memory result	1.7	2.0	5.0	2.2	-0.6	-0.9
Lung cancer (father)	0.8	0.9	1.1	-1.1	0.9	0.9
Illnesses of mother	0.0	0.0	0.1	0.3	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	5.5	2.4	-2.2	-1.3
Pulse wave Arterial Stiffness index	5.7	6.7	9.0	2.4	-2.3	-3.0
Impedance of arm (left)	6.7	31.0	37.7	-4.5	6.1	5.9
Arm fat mass (right)	0.4	1.7	3.2	1.1	0.7	-1.8
Trunk predicted mass	1.2	6.9	8.2	2.2	-2.9	-2.8
Standing height	0.2	2.2	3.5	-1.9	1.0	1.4
Length of working week for main job	2.1	2.3	3.4	1.8	-0.6	-1.8
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.3	-0.2	0.3
Breastfed as a baby	7.7	9.5	10.9	2.7	-3.2	-3.3
Tense / ‘highly strung’	0.2	0.4	0.6	0.8	0.7	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.0	-1.0	1.0	0.3
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	0.2	1.2	0.8
Birth weight of first child	0.5	0.9	2.7	-1.6	-0.0	0.3
Peak expiratory flow (PEF)	0.4	0.9	1.8	0.6	-1.3	-0.8
Pulse wave reflection index	0.8	1.0	1.5	0.3	-1.1	-1.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	0.5	0.1	-0.8
Loud music exposure frequency	3.3	3.6	6.2	-1.3	2.5	1.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	-0.6	0.6	0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.3	0.2	0.9
Blood clot in the leg (DVT)	0.0	0.1	0.1	0.0	-0.3	-0.2
Medication: Paracetamol	0.2	0.3	0.9	-0.0	-0.0	-0.9
Headache pain in last month	0.7	1.2	2.6	-0.5	1.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	-0.6	0.6	0.9
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	-0.2	-0.1
Gout (self-reported)	1.5	2.0	3.1	1.0	-1.4	-1.8
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.4	-1.1	1.5	1.5
Medication: Amlodipine	0.7	0.9	0.9	1.0	-1.0	-1.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.9	-1.4	-0.3	0.2
Birth weight	0.2	0.3	0.7	-0.2	0.8	0.5
Chronic bronchitis/emphysema (mother)	2.5	2.9	4.9	-2.2	1.4	1.5
High blood pressure (siblings)	0.5	0.8	1.3	-0.0	-1.1	-1.0
Forced vital capacity (FVC), Best measure	1.4	5.2	7.6	2.8	-2.5	-1.4
Body fat percentage	0.5	2.0	5.2	-0.2	2.3	-0.8
Leg fat percentage (right)	0.6	2.3	5.7	1.0	0.4	-2.4
Arm fat-free mass (right)	1.4	7.3	10.8	2.2	-2.5	-3.3
Exposure to tobacco smoke outside home	1.9	2.6	2.8	-1.6	1.5	1.7
Comparative body size at age 10	1.3	3.6	6.0	2.4	-1.1	-1.9
Number of full brothers	0.2	0.3	0.7	0.2	-0.3	-0.8
Worry too long after embarrassment	1.8	3.0	6.5	-0.7	2.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	0.5	-0.5
Wheeze or whistling in the chest in last year	0.8	1.4	3.1	-1.8	0.9	0.5
Number of children fathered	0.4	0.5	0.6	-0.8	-0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.5	-0.8	-0.3
Age at first live birth	0.2	0.4	1.0	0.2	1.0	0.6
Pulse wave peak to peak time	6.1	7.2	9.0	-2.5	2.5	3.0
Health satisfaction	0.8	1.0	1.7	-0.9	1.3	0.8
Shortness of breath walking on level ground	0.0	0.0	0.0	0.2	0.0	-0.0
Qualifications: College or University degree	0.5	1.4	2.0	-0.7	1.4	1.4
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.1	-0.6	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.1	-0.6	-0.8
Emphysema/chronic bronchitis	0.4	0.4	0.7	-0.5	-0.6	-0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	1.7	0.2	-1.3	0.4
Neck or shoulder pain in last month	3.3	4.6	6.4	1.4	-2.4	-2.5
Medication: Blood pressure	0.2	0.3	0.6	0.2	-0.5	-0.8
Angina (self-reported)	0.5	0.7	1.2	0.4	0.9	-1.1
Migraine (self-reported)	0.3	0.4	1.1	-1.1	-0.2	-0.3
Medication: Ibuprofen	1.2	1.4	3.9	0.4	-0.4	-2.0
Medication: Allopurinol	2.3	3.1	4.9	0.9	-1.9	-2.2
Medication: Omeprazole	1.3	1.5	1.8	-1.1	1.3	1.3
Medication: Seretide 50 evohaler	1.3	1.5	1.8	1.3	-1.0	-1.4
Mean time to correctly identify matches	2.6	4.9	9.1	-1.3	3.0	2.0
Heart disease (mother)	0.9	1.1	1.6	-1.3	0.4	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.7	-1.1	-1.3	-0.3
Whole body fat mass	0.4	1.6	2.9	0.6	1.3	-1.7
Leg fat mass (right)	0.8	3.2	7.2	1.6	0.1	-2.7
Arm predicted mass (right)	1.2	6.1	9.0	2.1	-2.2	-3.0
Pulse rate, automated reading	6.5	21.0	27.2	3.1	-5.2	-5.1
Alcohol intake frequency.	0.3	0.7	1.4	-0.4	1.2	-0.7
Comparative height size at age 10	0.1	0.4	0.7	-0.5	0.8	0.4
Number of full sisters	0.2	0.3	0.8	-0.0	0.9	0.0
Suffer from ‘nerves’	0.3	0.5	1.5	-0.4	1.2	0.1
Overall health rating	0.2	0.5	0.7	0.7	0.8	-0.6
Chest pain or discomfort	0.1	0.1	0.2	-0.2	0.3	-0.5
Had major operations	0.4	0.4	1.0	-0.1	-1.0	-0.5
Age at last live birth	0.3	0.5	0.8	-0.7	0.4	0.9
Family relationship satisfaction	0.1	0.1	0.2	0.5	0.3	-0.1
Leg pain on walking	1.7	2.1	4.1	0.7	-2.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.9	1.4	-0.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	-0.8	1.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-0.4	-0.3	1.2
Medication: Aspirin	0.7	0.9	2.2	-0.2	1.5	0.7
Supplements: Vitamin C	0.3	0.3	0.5	0.4	-0.7	-0.6
Knee pain experienced in last month	0.1	0.1	0.2	0.5	0.3	-0.2
Hypertension (Self-reported)	0.1	0.3	0.8	-0.9	-0.4	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.1	0.7	0.1
Illnesses of father: Heart disease	1.9	2.6	3.6	0.9	-1.9	-1.8
Illnesses of siblings: Diabetes	0.7	0.9	1.5	-1.2	1.1	-0.2
Smoking status: Previous	2.1	3.2	6.0	-0.8	2.5	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.9	-0.9	1.4	1.1
Whole body fat-free mass	1.0	5.4	7.2	2.1	-2.2	-2.7
Leg fat-free mass (right)	0.5	2.6	4.0	1.7	-0.8	-2.0
Arm fat percentage (left)	0.5	1.9	5.3	0.1	2.3	-0.5
Average weekly red wine intake	2.7	4.0	7.1	2.7	-1.0	-2.0
Handedness (chirality/laterality): Left-handed	5.9	7.1	8.8	3.0	-2.2	-2.8
Mood swings	1.0	1.8	3.7	-1.2	1.9	0.4
Loneliness, isolation	0.6	0.8	1.6	-1.0	1.2	0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.2	0.9	0.1
Ever had bowel cancer screening	3.8	4.4	6.7	1.7	-2.6	-1.9
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.5	0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	2.5	1.5	-1.6	-1.4
Friendships satisfaction	0.2	0.3	0.5	0.6	0.1	-0.7
Qualifications: nursing, teaching	1.3	2.0	2.8	-1.7	0.7	1.6
Commuting to job workplace: Walk	2.1	2.2	3.3	-1.3	1.8	1.3
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	0.4	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	-0.4	-0.6	0.6
Medication for cholesterol	0.1	0.1	0.2	0.3	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	0.4	1.1	-0.2
Back pain experienced in last month	0.3	0.4	0.9	0.9	-0.6	0.0
Mineral and other dietary supplements	0.3	0.3	0.7	-0.9	-0.5	0.1
Breast cancer (self-reported)	0.2	0.2	0.3	0.4	-0.5	-0.5
Asthma (self-reported)	0.2	0.4	0.7	-0.6	0.0	-0.8
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	0.1	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.6	-0.1	-0.3
Medication: Aspirin	0.4	0.6	1.3	0.1	1.2	0.6
Medication: Gliclazide	0.9	1.0	2.0	1.4	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	-0.7	0.5	0.8
Smoking status: Current	0.5	0.8	1.5	-1.2	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.9	0.6	-1.4	-0.8
Whole body water mass	1.0	5.8	7.5	2.2	-2.3	-2.7
Leg predicted mass (right)	0.4	2.3	3.6	1.6	-0.7	-1.9
Arm fat mass (left)	0.4	1.5	2.9	1.0	0.8	-1.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.2	-0.2	-0.7
Average weekly champagne plus white wine intake	1.1	1.6	2.8	-1.3	-0.5	1.7
Miserableness	0.3	0.6	1.6	-0.1	1.2	-0.3
Guilty feelings	0.2	0.3	0.5	-0.7	0.7	0.0
Wears glasses or contact lenses	0.4	0.4	0.7	0.6	-0.8	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.3	0.4	0.4
Hearing aid user	0.1	0.1	0.2	0.3	-0.5	-0.4
Mother’s age at death	0.5	0.6	1.5	-0.6	-1.2	0.0
Financial situation satisfaction	3.3	4.1	8.1	-1.4	2.8	1.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	0.7	0.9	-0.6
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.8	-0.3	1.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	0.3	-0.1
Medication: Blood pressure	0.1	0.1	0.3	-0.6	-0.0	0.2
Pain type(s) experienced in last month: Hip pain	3.1	3.9	6.7	2.1	-0.8	-2.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.2	0.2	0.9
High cholesterol (Self-reported)	0.6	1.1	2.7	0.4	-1.6	-0.6
Medication: Bendroflumethiazide	1.0	1.5	2.5	-1.6	1.2	0.7
Medication: Paracetamol	1.0	1.6	3.3	1.0	-0.6	-1.8
Medication: Lisinopril	0.5	0.7	1.2	0.9	0.2	-1.1
Medication: Atorvastatin	0.3	0.4	0.7	0.8	-0.4	-0.5
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	-0.2	-0.3
Alcohol drinker status: Never	0.2	0.3	0.7	0.3	-0.2	-0.8
Ever smoked	0.8	1.4	2.5	-0.7	1.1	1.6
Basal metabolic rate	0.7	4.1	6.4	1.9	-1.5	-2.5
Leg fat percentage (left)	0.7	2.5	6.4	1.0	0.3	-2.5
Arm fat-free mass (left)	1.9	9.4	12.8	2.7	-2.9	-3.6
Number of operations (self-reported)	1.8	2.7	4.0	0.4	-2.0	-2.0
Average weekly beer plus cider intake	0.9	1.3	3.2	1.8	-0.7	-0.5
Irritability	1.5	2.5	6.5	0.0	2.5	1.0
Risk taking	0.1	0.1	0.2	0.4	0.1	-0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	0.6	-1.0	-0.5
Fractured/broken bones in last 5 years	0.6	0.7	1.3	-0.8	0.5	1.2
Age started oral contraceptive pill	1.3	1.6	3.5	0.3	-1.9	-1.1
Diastolic blood pressure, automated reading	1.4	4.3	6.1	1.1	-2.5	-2.4
Ever depressed for a whole week	0.2	0.3	0.3	-0.6	0.5	-0.5
Unable to work because of sickness or disability	0.3	0.4	0.9	0.6	0.1	-0.9
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.7	0.0	0.2
Myopia	1.0	1.4	2.1	-1.4	0.7	1.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.5	0.6	0.6
Cholesterol lowering medication	2.0	3.0	4.9	-2.2	1.0	1.7
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	4.6	-1.7	1.6	2.1
Pain experienced in last month	0.1	0.1	0.2	-0.5	0.1	0.4
Supplements: Calcium	3.8	4.2	6.8	-1.1	2.6	2.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-1.1	-0.0	1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.3	1.2	0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.4	-0.5	-0.5
Heart disease (siblings)	0.3	0.4	0.9	0.3	-1.0	-0.2
Alcohol drinker status: Previous	1.1	1.2	2.3	0.9	-0.7	-1.5
Pack years of smoking	0.7	1.0	1.8	0.8	-0.8	-1.3
Impedance of whole body	4.2	21.6	25.1	-4.2	5.0	4.7
Leg fat mass (left)	0.9	3.7	8.2	1.7	-0.1	-2.9
Arm predicted mass (left)	2.2	11.0	15.4	3.0	-2.9	-3.9